Class information for:
Level 2: P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
747 12474 43.6 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
747 2             P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1 12474
216 1                   MULTIDRUG RESISTANCE//P GLYCOPROTEIN//PSC 833 3904
4059 1                   P GLYCOPROTEIN//MULTIDRUG RESISTANCE//LMRA 1855
4616 1                   MRP1//MULTIDRUG RESISTANCE ASSOCIATED PROTEIN//MULTIDRUG RESISTANCE PROTEIN 1755
5907 1                   CYP3A5//ABCB1//MDR1 1560
9334 1                   ABCG2//BCRP//BREAST CANCER RESISTANCE PROTEIN 1165
9862 1                   P GLYCOPROTEIN//PHARMACORESISTANCE//TARIQUIDAR 1114
24945 1                   MULTIXENOBIOTIC RESISTANCE//MXR//MOL ECOTOXICOL 296
25795 1                   MAJOR VAULT PROTEIN//VAULT//VPARP 272
26461 1                   CIAPIN1//MG7 AG//ZNRD1 254
33214 1                   MOL PHYSIOL GENET//L1210 CELL LINE//APOPTOSIS EFFECTOR GENES 128
33973 1                   MDR I//RHEUMATOLOTA KU//BIOLOGIC AGENT THERAPY 118
37603 1                   HLTH IMPROVING//BIOMED ENGN NANOSCI TRANSLAT NANOMED//CANCER CHERNOTHERAPY 53

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 P GLYCOPROTEIN authKW 2309978 18% 42% 2275
2 MULTIDRUG RESISTANCE authKW 1529085 15% 33% 1912
3 MDR1 authKW 440947 3% 47% 387
4 ABCB1 authKW 438501 3% 52% 348
5 ABCG2 authKW 367644 2% 53% 285
6 BCRP authKW 288445 2% 59% 200
7 CYP3A5 authKW 280448 2% 60% 191
8 MRP1 authKW 270345 2% 59% 189
9 ABC TRANSPORTER authKW 229689 3% 27% 355
10 MULTIDRUG RESISTANCE ASSOCIATED PROTEIN authKW 200272 1% 53% 156

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 33031 28% 0% 3457
2 Pharmacology & Pharmacy 21619 26% 0% 3221
3 Biochemistry & Molecular Biology 4780 20% 0% 2501
4 Hematology 2882 5% 0% 676
5 Chemistry, Medicinal 1967 4% 0% 558
6 Biophysics 1695 5% 0% 663
7 Cell Biology 1309 7% 0% 912
8 Toxicology 988 3% 0% 431
9 Medicine, Research & Experimental 486 4% 0% 444
10 Medical Laboratory Technology 342 1% 0% 141

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOL TOXICOL PHARM 41221 1% 17% 100
2 MOL ECOTOXICOL 38041 0% 68% 23
3 MEMBRANE GRP 38020 0% 38% 41
4 CANC S 27705 0% 20% 58
5 TUMOR BIOCHEM 27536 0% 28% 41
6 GRP MEMBRANE BIOL 20794 0% 43% 20
7 EXPT THER Y 17702 1% 12% 63
8 PHYSICOCHIM BIOMOL CELLULAIRE 14856 0% 23% 26
9 BRAIN BARRIERS 13319 0% 42% 13
10 DESARROLLO GANADERO SANIDAD ANIM INDEGSAL 12578 0% 86% 6

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENOMICS 16525 1% 6% 110
2 PHARMACOGENETICS AND GENOMICS 15441 1% 8% 85
3 DRUG METABOLISM AND DISPOSITION 9577 1% 2% 174
4 BIOCHEMICAL PHARMACOLOGY 8806 2% 1% 264
5 CANCER CHEMOTHERAPY AND PHARMACOLOGY 8692 1% 2% 164
6 CANCER RESEARCH 7965 3% 1% 369
7 ANTICANCER RESEARCH 7602 2% 1% 250
8 MOLECULAR PHARMACOLOGY 6069 1% 2% 159
9 BRITISH JOURNAL OF CANCER 6020 2% 1% 216
10 PHARMACOGENOMICS JOURNAL 5134 0% 5% 41

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 P GLYCOPROTEIN 2309978 18% 42% 2275 Search P+GLYCOPROTEIN Search P+GLYCOPROTEIN
2 MULTIDRUG RESISTANCE 1529085 15% 33% 1912 Search MULTIDRUG+RESISTANCE Search MULTIDRUG+RESISTANCE
3 MDR1 440947 3% 47% 387 Search MDR1 Search MDR1
4 ABCB1 438501 3% 52% 348 Search ABCB1 Search ABCB1
5 ABCG2 367644 2% 53% 285 Search ABCG2 Search ABCG2
6 BCRP 288445 2% 59% 200 Search BCRP Search BCRP
7 CYP3A5 280448 2% 60% 191 Search CYP3A5 Search CYP3A5
8 MRP1 270345 2% 59% 189 Search MRP1 Search MRP1
9 ABC TRANSPORTER 229689 3% 27% 355 Search ABC+TRANSPORTER Search ABC+TRANSPORTER
10 MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 200272 1% 53% 156 Search MULTIDRUG+RESISTANCE+ASSOCIATED+PROTEIN Search MULTIDRUG+RESISTANCE+ASSOCIATED+PROTEIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DEELEY, RG , WESTLAKE, C , COLE, SPC , (2006) TRANSMEMBRANE TRANSPORT OF ENDO- AND XENOBIOTICS BY MAMMALIAN ATP-BINDING CASSETTE MULTIDRUG RESISTANCE PROTEINS.PHYSIOLOGICAL REVIEWS. VOL. 86. ISSUE 3. P. 849-899 413 75% 393
2 ECKFORD, PDW , SHAROM, FJ , (2009) ABC EFFLUX PUMP-BASED RESISTANCE TO CHEMOTHERAPY DRUGS.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2989-3011 261 86% 236
3 HAIMEUR, A , CONSEIL, G , DEELEY, RG , COLE, SPC , (2004) THE MRP-RELATED AND BCRP/ABCG2 MULTIDRUG RESISTANCE PROTEINS: BIOLOGY, SUBSTRATE SPECIFICITY AND REGULATION.CURRENT DRUG METABOLISM. VOL. 5. ISSUE 1. P. 21-53 330 82% 331
4 GOTTESMAN, MM , PASTAN, I , (1993) BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 62. ISSUE . P. 385-427 181 81% 3198
5 SZAKACS, G , PATERSON, JK , LUDWIG, JA , BOOTH-GENTHE, C , GOTTESMAN, MM , (2006) TARGETING MULTIDRUG RESISTANCE IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 5. ISSUE 3. P. 219-234 168 70% 1543
6 PALMEIRA, A , SOUSA, E , VASCONCELOS, MH , PINTO, MM , (2012) THREE DECADES OF P-GP INHIBITORS: SKIMMING THROUGH SEVERAL GENERATIONS AND SCAFFOLDS.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 13. P. 1946 -2025 302 64% 104
7 HE, SM , LI, R , KANWAR, JR , ZHOU, SF , (2011) STRUCTURAL AND FUNCTIONAL PROPERTIES OF HUMAN MULTIDRUG RESISTANCE PROTEIN 1 (MRP1/ABCC1).CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 3. P. 439 -481 327 74% 42
8 TIWARI, AK , SODANI, K , DAI, CL , ASHBY, CR , CHEN, ZS , CHEN, ZS , (2011) REVISITING THE ABCS OF MULTIDRUG RESISTANCE IN CANCER CHEMOTHERAPY.CURRENT PHARMACEUTICAL BIOTECHNOLOGY. VOL. 12. ISSUE 4. P. 570-594 264 77% 67
9 SHAROM, FJ , (2008) ABC MULTIDRUG TRANSPORTERS: STRUCTURE, FUNCTION AND ROLE IN CHEMORESISTANCE.PHARMACOGENOMICS. VOL. 9. ISSUE 1. P. 105-127 165 91% 395
10 SARKADI, B , HOMOLYA, L , SZAKACS, G , VARADI, A , (2006) HUMAN MULTIDRUG RESISTANCE ABCB AND ABCG TRANSPORTERS: PARTICIPATION IN A CHEMOIMMUNITY DEFENSE SYSTEM.PHYSIOLOGICAL REVIEWS. VOL. 86. ISSUE 4. P. 1179-1236 273 67% 294

Classes with closest relation at Level 2


Rank Class id link
1 1155 PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1
2 1488 CAMPTOTHECIN//TOPOISOMERASE I//SN 38
3 2252 ANGUCYCLINE//IDARUBICIN//ANGUCYCLINONE
4 2409 BLOOD BRAIN BARRIER//CEREBROLYSIN//TYR MIF 1
5 1019 BILE ACIDS//FARNESOID X RECEPTOR//CHOLESTASIS
6 1102 PACLITAXEL//TAXANES//EPOTHILONES
7 1741 GSTM1//GSTT1//GLUTATHIONE S TRANSFERASE
8 415 CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR
9 2496 IFOSFAMIDE//CHEMOSENSITIVITY TEST//MESNA
10 1853 CANCER STEM CELLS//CD133//SIDE POPULATION

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