Class information for: |
Basic class information |
Class id | #P | Avg. number of references |
Database coverage of references |
---|---|---|---|
415 | 16559 | 42.0 | 74% |
Hierarchy of classes |
The table includes all classes above and classes immediately below the current class. |
Terms with highest relevance score |
rank | Term | termType | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|---|
1 | CYTOCHROME P450 | authKW | 716903 | 11% | 22% | 1807 |
2 | CYP2D6 | authKW | 504681 | 3% | 50% | 544 |
3 | PREGNANE X RECEPTOR | authKW | 282583 | 1% | 71% | 216 |
4 | DRUG METABOLISM AND DISPOSITION | journal | 250803 | 6% | 14% | 1012 |
5 | PXR | authKW | 213713 | 1% | 62% | 186 |
6 | DRUG METABOLISM | authKW | 184936 | 3% | 24% | 420 |
7 | CONSTITUTIVE ANDROSTANE RECEPTOR | authKW | 182683 | 1% | 80% | 124 |
8 | DEBRISOQUINE | authKW | 181524 | 1% | 81% | 122 |
9 | CYP3A4 | authKW | 165281 | 2% | 28% | 319 |
10 | CYTOCHROME B5 | authKW | 135335 | 1% | 46% | 160 |
Web of Science journal categories |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | Pharmacology & Pharmacy | 83050 | 42% | 1% | 6925 |
2 | Biochemistry & Molecular Biology | 22277 | 33% | 0% | 5423 |
3 | Toxicology | 17327 | 10% | 1% | 1707 |
4 | Biophysics | 11109 | 10% | 0% | 1707 |
5 | Chemistry, Medicinal | 1774 | 4% | 0% | 635 |
6 | Biochemical Research Methods | 728 | 3% | 0% | 530 |
7 | Medical Laboratory Technology | 633 | 1% | 0% | 213 |
8 | Biotechnology & Applied Microbiology | 314 | 3% | 0% | 568 |
9 | Psychiatry | 138 | 2% | 0% | 370 |
10 | Chemistry, Analytical | 113 | 3% | 0% | 459 |
Address terms |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | PHARMACOGENET SECT | 81937 | 1% | 42% | 107 |
2 | PHARMACOKINET BIOANAL | 56817 | 0% | 58% | 53 |
3 | MOL TOXICOL | 30966 | 1% | 9% | 193 |
4 | DRUG METAB | 30951 | 1% | 10% | 165 |
5 | DRUG METAB PHARMACOKINET | 30586 | 1% | 8% | 222 |
6 | REPROD DEV TOXICOL | 28114 | 1% | 16% | 95 |
7 | CICAB CLIN | 22841 | 0% | 56% | 22 |
8 | CLIN PHARMACOL | 22352 | 3% | 2% | 557 |
9 | SECT DEV PHARMACOL EXPT THER EUT | 18635 | 0% | 56% | 18 |
10 | TECH BIOCHEM | 18581 | 1% | 12% | 84 |
Journals |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | DRUG METABOLISM AND DISPOSITION | 250803 | 6% | 14% | 1012 |
2 | XENOBIOTICA | 81845 | 3% | 11% | 416 |
3 | PHARMACOGENETICS | 45972 | 1% | 16% | 154 |
4 | CURRENT DRUG METABOLISM | 37627 | 1% | 14% | 150 |
5 | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 35441 | 3% | 3% | 578 |
6 | BIOCHEMICAL PHARMACOLOGY | 34980 | 4% | 3% | 599 |
7 | CLINICAL PHARMACOLOGY & THERAPEUTICS | 30329 | 2% | 5% | 312 |
8 | DRUG METABOLISM REVIEWS | 27822 | 1% | 12% | 123 |
9 | DRUG METABOLISM AND PHARMACOKINETICS | 19631 | 1% | 12% | 88 |
10 | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 14612 | 1% | 8% | 100 |
Author Key Words |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
LCSH search | Wikipedia search |
---|---|---|---|---|---|---|---|
1 | CYTOCHROME P450 | 716903 | 11% | 22% | 1807 | Search CYTOCHROME+P450 | Search CYTOCHROME+P450 |
2 | CYP2D6 | 504681 | 3% | 50% | 544 | Search CYP2D6 | Search CYP2D6 |
3 | PREGNANE X RECEPTOR | 282583 | 1% | 71% | 216 | Search PREGNANE+X+RECEPTOR | Search PREGNANE+X+RECEPTOR |
4 | PXR | 213713 | 1% | 62% | 186 | Search PXR | Search PXR |
5 | DRUG METABOLISM | 184936 | 3% | 24% | 420 | Search DRUG+METABOLISM | Search DRUG+METABOLISM |
6 | CONSTITUTIVE ANDROSTANE RECEPTOR | 182683 | 1% | 80% | 124 | Search CONSTITUTIVE+ANDROSTANE+RECEPTOR | Search CONSTITUTIVE+ANDROSTANE+RECEPTOR |
7 | DEBRISOQUINE | 181524 | 1% | 81% | 122 | Search DEBRISOQUINE | Search DEBRISOQUINE |
8 | CYP3A4 | 165281 | 2% | 28% | 319 | Search CYP3A4 | Search CYP3A4 |
9 | CYTOCHROME B5 | 135335 | 1% | 46% | 160 | Search CYTOCHROME+B5 | Search CYTOCHROME+B5 |
10 | CYP3A | 126059 | 1% | 34% | 202 | Search CYP3A | Search CYP3A |
Core articles |
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c: (1) Number of references referring to publications in the class. (2) Share of total number of active references referring to publications in the class. (3) Age of the article. New articles get higher score than old articles. (4) Citation rate, normalized to year. |
Rank | Reference | # ref. in cl. |
Shr. of ref. in cl. |
Citations |
---|---|---|---|---|
1 | WHITEHOUSE, CJC , BELL, SG , WONG, LL , (2012) P450(BM3) (CYP102A1): CONNECTING THE DOTS.CHEMICAL SOCIETY REVIEWS. VOL. 41. ISSUE 3. P. 1218 -1260 | 339 | 83% | 158 |
2 | HLAVICA, P , (2015) MECHANISTIC BASIS OF ELECTRON TRANSFER TO CYTOCHROMES P450 BY NATURAL REDOX PARTNERS AND ARTIFICIAL DONOR CONSTRUCTS.MONOOXYGENASE, PEROXIDASE AND PEROXYGENASE PROPERTIES AND MECHANISMS OF CYTOCHROME P450. VOL. 851. ISSUE . P. 247 -297 | 329 | 74% | 0 |
3 | NELSON, DR , KAMATAKI, T , WAXMAN, DJ , GUENGERICH, FP , ESTABROOK, RW , FEYEREISEN, R , GONZALEZ, FJ , COON, MJ , GUNSALUS, IC , GOTOH, O , ET AL (1993) THE P450 SUPERFAMILY - UPDATE ON NEW SEQUENCES, GENE-MAPPING, ACCESSION NUMBERS, EARLY TRIVIAL NAMES OF ENZYMES, AND NOMENCLATURE.DNA AND CELL BIOLOGY. VOL. 12. ISSUE 1. P. 1-51 | 282 | 52% | 1415 |
4 | RYAN, DE , LEVIN, W , (1990) PURIFICATION AND CHARACTERIZATION OF HEPATIC-MICROSOMAL CYTOCHROME-P-450.PHARMACOLOGY & THERAPEUTICS. VOL. 45. ISSUE 2. P. 153 -239 | 309 | 80% | 419 |
5 | ZHOU, SF , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 2D6 AND ITS CLINICAL SIGNIFICANCE PART I.CLINICAL PHARMACOKINETICS. VOL. 48. ISSUE 11. P. 689-723 | 228 | 55% | 251 |
6 | LLERENA, A , NARANJO, MEG , RODRIGUES-SOARES, F , PENAS-LLEDO, EM , FARINAS, H , TARAZONA-SANTOS, E , (2014) INTERETHNIC VARIABILITY OF CYP2D6 ALLELES AND OF PREDICTED AND MEASURED METABOLIC PHENOTYPES ACROSS WORLD POPULATIONS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 11. P. 1569 -1583 | 162 | 92% | 18 |
7 | HANDSCHIN, C , MEYER, UA , (2003) INDUCTION OF DRUG METABOLISM: THE ROLE OF NUCLEAR RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 55. ISSUE 4. P. 649-673 | 205 | 76% | 276 |
8 | STANLEY, LA , HORSBURGH, BC , ROSS, J , SCHEER, N , WOLF, CR , (2006) PXR AND CAR: NUCLEAR RECEPTORS WHICH PLAY A PIVOTAL ROLE IN DRUG DISPOSITION AND CHEMICAL TOXICITY.DRUG METABOLISM REVIEWS. VOL. 38. ISSUE 3. P. 515-597 | 192 | 88% | 82 |
9 | ZHOU, SF , CHOWBAY, B , LIU, JP , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 ENZYMES AND ITS CLINICAL IMPACT.DRUG METABOLISM REVIEWS. VOL. 41. ISSUE 2. P. 89 -295 | 408 | 23% | 269 |
10 | CHAI, SC , CHERIAN, MT , WANG, YM , CHEN, TS , (2016) SMALL-MOLECULE MODULATORS OF PXR AND CAR.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS. VOL. 1859. ISSUE 9. P. 1141 -1154 | 139 | 91% | 0 |
Classes with closest relation at Level 2 |