Class information for:
Level 2: CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
415 16559 42.0 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
1626 1                   CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM 2563
1927 1                   CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT 2419
3305 1                   P450BM 3//CYTOCHROME P450CAM//CYTOCHROME P450 BM3 2016
3955 1                   PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR 1875
4852 1                   6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A 1714
6572 1                   SITE OF METABOLISM//CYTOCHROME P450//ATYPICAL KINETICS 1468
10330 1                   CYTOCHROME P450 REDUCTASE//CYTOCHROME P4502B4//NADPH CYTOCHROME P450 REDUCTASE 1073
10357 1                   CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE 1070
11861 1                   THERAPEUTIC PROTEIN DRUG INTERACTION//ROLLINS 5119//9000 X G SUPERNATANT 948
14058 1                   CYTOCHROME B5//NADH CYTOCHROME B5 REDUCTASE//CYTOCHROME B5 REDUCTASE 795
22160 1                   5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM 391
27533 1                   PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL 227

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CYTOCHROME P450 authKW 716903 11% 22% 1807
2 CYP2D6 authKW 504681 3% 50% 544
3 PREGNANE X RECEPTOR authKW 282583 1% 71% 216
4 DRUG METABOLISM AND DISPOSITION journal 250803 6% 14% 1012
5 PXR authKW 213713 1% 62% 186
6 DRUG METABOLISM authKW 184936 3% 24% 420
7 CONSTITUTIVE ANDROSTANE RECEPTOR authKW 182683 1% 80% 124
8 DEBRISOQUINE authKW 181524 1% 81% 122
9 CYP3A4 authKW 165281 2% 28% 319
10 CYTOCHROME B5 authKW 135335 1% 46% 160

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 83050 42% 1% 6925
2 Biochemistry & Molecular Biology 22277 33% 0% 5423
3 Toxicology 17327 10% 1% 1707
4 Biophysics 11109 10% 0% 1707
5 Chemistry, Medicinal 1774 4% 0% 635
6 Biochemical Research Methods 728 3% 0% 530
7 Medical Laboratory Technology 633 1% 0% 213
8 Biotechnology & Applied Microbiology 314 3% 0% 568
9 Psychiatry 138 2% 0% 370
10 Chemistry, Analytical 113 3% 0% 459

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENET SECT 81937 1% 42% 107
2 PHARMACOKINET BIOANAL 56817 0% 58% 53
3 MOL TOXICOL 30966 1% 9% 193
4 DRUG METAB 30951 1% 10% 165
5 DRUG METAB PHARMACOKINET 30586 1% 8% 222
6 REPROD DEV TOXICOL 28114 1% 16% 95
7 CICAB CLIN 22841 0% 56% 22
8 CLIN PHARMACOL 22352 3% 2% 557
9 SECT DEV PHARMACOL EXPT THER EUT 18635 0% 56% 18
10 TECH BIOCHEM 18581 1% 12% 84

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 DRUG METABOLISM AND DISPOSITION 250803 6% 14% 1012
2 XENOBIOTICA 81845 3% 11% 416
3 PHARMACOGENETICS 45972 1% 16% 154
4 CURRENT DRUG METABOLISM 37627 1% 14% 150
5 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 35441 3% 3% 578
6 BIOCHEMICAL PHARMACOLOGY 34980 4% 3% 599
7 CLINICAL PHARMACOLOGY & THERAPEUTICS 30329 2% 5% 312
8 DRUG METABOLISM REVIEWS 27822 1% 12% 123
9 DRUG METABOLISM AND PHARMACOKINETICS 19631 1% 12% 88
10 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 14612 1% 8% 100

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 CYTOCHROME P450 716903 11% 22% 1807 Search CYTOCHROME+P450 Search CYTOCHROME+P450
2 CYP2D6 504681 3% 50% 544 Search CYP2D6 Search CYP2D6
3 PREGNANE X RECEPTOR 282583 1% 71% 216 Search PREGNANE+X+RECEPTOR Search PREGNANE+X+RECEPTOR
4 PXR 213713 1% 62% 186 Search PXR Search PXR
5 DRUG METABOLISM 184936 3% 24% 420 Search DRUG+METABOLISM Search DRUG+METABOLISM
6 CONSTITUTIVE ANDROSTANE RECEPTOR 182683 1% 80% 124 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR
7 DEBRISOQUINE 181524 1% 81% 122 Search DEBRISOQUINE Search DEBRISOQUINE
8 CYP3A4 165281 2% 28% 319 Search CYP3A4 Search CYP3A4
9 CYTOCHROME B5 135335 1% 46% 160 Search CYTOCHROME+B5 Search CYTOCHROME+B5
10 CYP3A 126059 1% 34% 202 Search CYP3A Search CYP3A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WHITEHOUSE, CJC , BELL, SG , WONG, LL , (2012) P450(BM3) (CYP102A1): CONNECTING THE DOTS.CHEMICAL SOCIETY REVIEWS. VOL. 41. ISSUE 3. P. 1218 -1260 339 83% 158
2 HLAVICA, P , (2015) MECHANISTIC BASIS OF ELECTRON TRANSFER TO CYTOCHROMES P450 BY NATURAL REDOX PARTNERS AND ARTIFICIAL DONOR CONSTRUCTS.MONOOXYGENASE, PEROXIDASE AND PEROXYGENASE PROPERTIES AND MECHANISMS OF CYTOCHROME P450. VOL. 851. ISSUE . P. 247 -297 329 74% 0
3 NELSON, DR , KAMATAKI, T , WAXMAN, DJ , GUENGERICH, FP , ESTABROOK, RW , FEYEREISEN, R , GONZALEZ, FJ , COON, MJ , GUNSALUS, IC , GOTOH, O , ET AL (1993) THE P450 SUPERFAMILY - UPDATE ON NEW SEQUENCES, GENE-MAPPING, ACCESSION NUMBERS, EARLY TRIVIAL NAMES OF ENZYMES, AND NOMENCLATURE.DNA AND CELL BIOLOGY. VOL. 12. ISSUE 1. P. 1-51 282 52% 1415
4 RYAN, DE , LEVIN, W , (1990) PURIFICATION AND CHARACTERIZATION OF HEPATIC-MICROSOMAL CYTOCHROME-P-450.PHARMACOLOGY & THERAPEUTICS. VOL. 45. ISSUE 2. P. 153 -239 309 80% 419
5 ZHOU, SF , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 2D6 AND ITS CLINICAL SIGNIFICANCE PART I.CLINICAL PHARMACOKINETICS. VOL. 48. ISSUE 11. P. 689-723 228 55% 251
6 LLERENA, A , NARANJO, MEG , RODRIGUES-SOARES, F , PENAS-LLEDO, EM , FARINAS, H , TARAZONA-SANTOS, E , (2014) INTERETHNIC VARIABILITY OF CYP2D6 ALLELES AND OF PREDICTED AND MEASURED METABOLIC PHENOTYPES ACROSS WORLD POPULATIONS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 11. P. 1569 -1583 162 92% 18
7 HANDSCHIN, C , MEYER, UA , (2003) INDUCTION OF DRUG METABOLISM: THE ROLE OF NUCLEAR RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 55. ISSUE 4. P. 649-673 205 76% 276
8 STANLEY, LA , HORSBURGH, BC , ROSS, J , SCHEER, N , WOLF, CR , (2006) PXR AND CAR: NUCLEAR RECEPTORS WHICH PLAY A PIVOTAL ROLE IN DRUG DISPOSITION AND CHEMICAL TOXICITY.DRUG METABOLISM REVIEWS. VOL. 38. ISSUE 3. P. 515-597 192 88% 82
9 ZHOU, SF , CHOWBAY, B , LIU, JP , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 ENZYMES AND ITS CLINICAL IMPACT.DRUG METABOLISM REVIEWS. VOL. 41. ISSUE 2. P. 89 -295 408 23% 269
10 CHAI, SC , CHERIAN, MT , WANG, YM , CHEN, TS , (2016) SMALL-MOLECULE MODULATORS OF PXR AND CAR.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS. VOL. 1859. ISSUE 9. P. 1141 -1154 139 91% 0

Classes with closest relation at Level 2


Rank Class id link
1 1171 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM
2 1092 PEROXIDASE//REVERSE MICELLES//CHLOROPEROXIDASE
3 1741 GSTM1//GSTT1//GLUTATHIONE S TRANSFERASE
4 3464 FLAVIN CONTAINING MONOOXYGENASE//FMO3//TRIMETHYLAMINURIA
5 1613 ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY
6 3033 CARCINOGENESIS//HEPATOCARCINOGENESIS//MEDIUM TERM BIOASSAY
7 908 BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION
8 1733 ST JOHNS WORT//GINKGO BILOBA//HYPERICUM PERFORATUM
9 3624 DEXTROMETHORPHAN//LEVODROPROPIZINE//COUGH AND COLD MEDICATIONS
10 747 P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1

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