Class information for:
Level 1: P GLYCOPROTEIN//MULTIDRUG RESISTANCE//LMRA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4059 1855 49.0 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
747 2             P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1 12474
4059 1                   P GLYCOPROTEIN//MULTIDRUG RESISTANCE//LMRA 1855

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 P GLYCOPROTEIN authKW 834130 28% 10% 527
2 MULTIDRUG RESISTANCE authKW 443615 21% 7% 397
3 LMRA authKW 206807 1% 74% 17
4 ABC TRANSPORTER authKW 201165 7% 10% 128
5 MDR MODULATORS authKW 156831 1% 53% 18
6 HZ08 authKW 121197 0% 82% 9
7 MSBA authKW 118498 1% 60% 12
8 NUCLEOTIDE BINDING DOMAIN authKW 110577 1% 27% 25
9 GRP MEMBRANE BIOL address 101186 1% 36% 17
10 KB C2 CELL authKW 82297 0% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 6284 49% 0% 904
2 Chemistry, Medicinal 4635 15% 0% 284
3 Pharmacology & Pharmacy 2904 25% 0% 458
4 Biophysics 2166 13% 0% 245
5 Oncology 333 9% 0% 167
6 Cell Biology 322 9% 0% 162
7 Biochemical Research Methods 102 3% 0% 64
8 Mathematical & Computational Biology 65 1% 0% 26
9 Computer Science, Interdisciplinary Applications 56 2% 0% 40
10 Chemistry, Multidisciplinary 35 6% 0% 114

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GRP MEMBRANE BIOL 101186 1% 36% 17
2 CANADIAN HLTH GRP MEMBRANE BIOL 75236 0% 57% 8
3 PHYSICOCHIM BIOMOL CELLULAIRE 53499 1% 17% 19
4 QUIM MED CEQUIMED UP 52668 0% 80% 4
5 BIO N210 39495 0% 40% 6
6 UP A 7033 34285 0% 42% 5
7 BIOCHIM STRUCT FONCT 32919 0% 100% 2
8 DRDC BIOPHYS MOL CELLULAIRE 32919 0% 100% 2
9 LEHRSTUHL TECH MIKROBIOL WEIHENSTEPHAN 32919 0% 100% 2
10 NAN JING DEV 32919 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMISTRY 6336 8% 0% 145
2 JOURNAL OF BIOLOGICAL CHEMISTRY 3272 10% 0% 179
3 BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 3177 2% 1% 35
4 MOLECULAR PHARMACOLOGY 2129 2% 0% 36
5 JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 1916 1% 1% 15
6 JOURNAL OF MEDICINAL CHEMISTRY 1692 3% 0% 48
7 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 1656 1% 1% 19
8 BIOORGANIC & MEDICINAL CHEMISTRY 1409 2% 0% 34
9 BIOCHEMICAL PHARMACOLOGY 1361 2% 0% 40
10 DRUG RESISTANCE UPDATES 1212 0% 1% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 P GLYCOPROTEIN 834130 28% 10% 527 Search P+GLYCOPROTEIN Search P+GLYCOPROTEIN
2 MULTIDRUG RESISTANCE 443615 21% 7% 397 Search MULTIDRUG+RESISTANCE Search MULTIDRUG+RESISTANCE
3 LMRA 206807 1% 74% 17 Search LMRA Search LMRA
4 ABC TRANSPORTER 201165 7% 10% 128 Search ABC+TRANSPORTER Search ABC+TRANSPORTER
5 MDR MODULATORS 156831 1% 53% 18 Search MDR+MODULATORS Search MDR+MODULATORS
6 HZ08 121197 0% 82% 9 Search HZ08 Search HZ08
7 MSBA 118498 1% 60% 12 Search MSBA Search MSBA
8 NUCLEOTIDE BINDING DOMAIN 110577 1% 27% 25 Search NUCLEOTIDE+BINDING+DOMAIN Search NUCLEOTIDE+BINDING+DOMAIN
9 KB C2 CELL 82297 0% 100% 5 Search KB+C2+CELL Search KB+C2+CELL
10 N N BISCYCLOHEXANOLAMINE ARYL ESTERS 82297 0% 100% 5 Search N+N+BISCYCLOHEXANOLAMINE+ARYL+ESTERS Search N+N+BISCYCLOHEXANOLAMINE+ARYL+ESTERS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FERREIRA, RJ , FERREIRA, MJU , DOS SANTOS, DJVA , (2015) REVERSING CANCER MULTIDRUG RESISTANCE: INSIGHTS INTO THE EFFLUX BY ABC TRANSPORTS FROM IN SILICO STUDIES.WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE. VOL. 5. ISSUE 1. P. 27 -55 126 69% 5
2 ECKFORD, PDW , SHAROM, FJ , (2009) ABC EFFLUX PUMP-BASED RESISTANCE TO CHEMOTHERAPY DRUGS.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2989-3011 146 48% 236
3 HENNESSY, M , SPIERS, JP , (2007) A PRIMER ON THE MECHANICS OF P-GLYCOPROTEIN THE MULTIDRUG TRANSPORTER.PHARMACOLOGICAL RESEARCH. VOL. 55. ISSUE 1. P. 1-15 126 68% 103
4 SHAROM, FJ , (2006) SHEDDING LIGHT ON DRUG TRANSPORT: STRUCTURE AND FUNCTION OF THE P-GLYCOPROTEIN MULTIDRUG TRANSPORTER (ABCB1).BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE. VOL. 84. ISSUE 6. P. 979 -992 110 87% 52
5 SEEGER, MA , VAN VEEN, HW , (2009) MOLECULAR BASIS OF MULTIDRUG TRANSPORT BY ABC TRANSPORTERS.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1794. ISSUE 5. P. 725 -737 101 78% 75
6 AMBUDKAR, SV , DEY, S , HRYCYNA, CA , RAMACHANDRA, M , PASTAN, I , GOTTESMAN, MM , (1999) BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 39. ISSUE . P. 361 -398 92 58% 1365
7 LOO, TW , CLARKE, DM , (2005) RECENT PROGRESS IN UNDERSTANDING THE MECHANISM OF P-GLYCOPROTEIN-MEDIATED DRUG EFFLUX.JOURNAL OF MEMBRANE BIOLOGY. VOL. 206. ISSUE 3. P. 173-185 108 78% 127
8 PRAJAPATI, R , SANGAMWAR, AT , (2014) TRANSLOCATION MECHANISM OF P-GLYCOPROTEIN AND CONFORMATIONAL CHANGES OCCURRING AT DRUG-BINDING SITE: INSIGHTS FROM MULTI-TARGETED MOLECULAR DYNAMICS.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. VOL. 1838. ISSUE 11. P. 2882 -2898 70 95% 10
9 GEORGE, AM , JONES, PM , (2012) PERSPECTIVES ON THE STRUCTURE-FUNCTION OF ABC TRANSPORTERS: THE SWITCH AND CONSTANT CONTACT MODELS.PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. VOL. 109. ISSUE 3. P. 95 -107 90 69% 41
10 LAWSON, J , O'MARA, ML , KERR, ID , (2008) STRUCTURE-BASED INTERPRETATION OF THE MUTAGENESIS DATABASE FOR THE NUCLEOTIDE BINDING DOMAINS OF P-GLYCOPROTEIN.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. VOL. 1778. ISSUE 2. P. 376-391 86 81% 20

Classes with closest relation at Level 1


Rank Class id link
1 216 MULTIDRUG RESISTANCE//P GLYCOPROTEIN//PSC 833
2 9334 ABCG2//BCRP//BREAST CANCER RESISTANCE PROTEIN
3 24945 MULTIXENOBIOTIC RESISTANCE//MXR//MOL ECOTOXICOL
4 4616 MRP1//MULTIDRUG RESISTANCE ASSOCIATED PROTEIN//MULTIDRUG RESISTANCE PROTEIN
5 8564 PERIPLASMIC BINDING PROTEIN//BIOL BAKTERIENPHYSIOL//MALTOSE TRANSPORT
6 33214 MOL PHYSIOL GENET//L1210 CELL LINE//APOPTOSIS EFFECTOR GENES
7 9862 P GLYCOPROTEIN//PHARMACORESISTANCE//TARIQUIDAR
8 37603 HLTH IMPROVING//BIOMED ENGN NANOSCI TRANSLAT NANOMED//CANCER CHERNOTHERAPY
9 2342 CFTR//CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR//CYSTIC FIBROSIS
10 3970 EFFLUX PUMP INHIBITOR//EFFLUX PUMPS//EMRE

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