Class information for:
Level 3: P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
230 49374 39.2 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
747 2             P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1 12474
1155 2             PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1 9490
1171 2             JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM 9352
3464 2             FLAVIN CONTAINING MONOOXYGENASE//FMO3//TRIMETHYLAMINURIA 1499

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 P GLYCOPROTEIN authKW 836521 6% 49% 2688
2 FMO3 authKW 713320 3% 85% 41
3 TRIMETHYLAMINURIA authKW 708469 3% 87% 40
4 TRIMETHYLAMINE N OXIDE authKW 424187 4% 39% 54
5 MULTIDRUG RESISTANCE authKW 410276 4% 33% 1947
6 DRUG METABOLISM AND DISPOSITION journal 340613 4% 27% 2009
7 CYTOCHROME P450 authKW 309546 4% 24% 2027
8 PHARMACOLOGY & PHARMACY WoSSC 302723 47% 2% 22304
9 FISH ODOUR SYNDROME authKW 264794 1% 100% 13
10 FISH ODOR SYNDROME authKW 244426 1% 100% 12

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 302723 47% 2% 22304
2 Toxicology 20169 7% 1% 3281
3 Biochemistry & Molecular Biology 17436 20% 1% 9424
4 Chemistry, Medicinal 14137 6% 1% 2783
5 Biophysics 8224 6% 1% 2788
6 Oncology 7471 9% 1% 4097
7 Chemistry, Multidisciplinary 1580 7% 0% 3350
8 Medicine, Research & Experimental 1351 3% 0% 1543
9 Biochemical Research Methods 1162 3% 0% 1268
10 Gastroenterology & Hepatology 1155 2% 0% 1114

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 UNITE TOXICOL METAB COMPA XENOBIOT 104752 0% 86% 6
2 MOL PHARMACOKINET 65187 0% 71% 144
3 DRUG METAB PHARMACOKINET 58975 1% 18% 525
4 CLIN PHARMACOL 58889 3% 6% 1539
5 PHARMACEUT SCI 46657 7% 3% 3196
6 PHARM 45194 9% 2% 4539
7 INVEST BIOMED ARTADO POSTAL 70228 40738 0% 100% 2
8 OCCUPAT HLTH SURG 40738 0% 100% 2
9 ST MARYS HOSP MED PHARMACOL TOXICOL 40738 0% 100% 2
10 PL TOXICOL GRP 40726 1% 25% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 DRUG METABOLISM AND DISPOSITION 340613 4% 27% 2009
2 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 116149 1% 50% 367
3 XENOBIOTICA 94928 2% 20% 764
4 JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 91906 1% 50% 292
5 PHARMACEUTICAL RESEARCH 69127 2% 12% 941
6 CLINICAL PHARMACOLOGY & THERAPEUTICS 60042 2% 13% 748
7 BIOPHARMACEUTICS & DRUG DISPOSITION 56297 1% 22% 415
8 JOURNAL OF PHARMACEUTICAL SCIENCES 49619 2% 9% 948
9 DRUG METABOLISM AND PHARMACOKINETICS 46744 0% 32% 231
10 BIOCHEMICAL PHARMACOLOGY 42519 2% 6% 1133

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 P GLYCOPROTEIN 836521 6% 49% 2688 Search P+GLYCOPROTEIN Search P+GLYCOPROTEIN
2 FMO3 713320 3% 85% 41 Search FMO3 Search FMO3
3 TRIMETHYLAMINURIA 708469 3% 87% 40 Search TRIMETHYLAMINURIA Search TRIMETHYLAMINURIA
4 TRIMETHYLAMINE N OXIDE 424187 4% 39% 54 Search TRIMETHYLAMINE+N+OXIDE Search TRIMETHYLAMINE+N+OXIDE
5 MULTIDRUG RESISTANCE 410276 4% 33% 1947 Search MULTIDRUG+RESISTANCE Search MULTIDRUG+RESISTANCE
6 CYTOCHROME P450 309546 4% 24% 2027 Search CYTOCHROME+P450 Search CYTOCHROME+P450
7 FISH ODOUR SYNDROME 264794 1% 100% 13 Search FISH+ODOUR+SYNDROME Search FISH+ODOUR+SYNDROME
8 FISH ODOR SYNDROME 244426 1% 100% 12 Search FISH+ODOR+SYNDROME Search FISH+ODOR+SYNDROME
9 FLAVIN CONTAINING MONOOXYGENASE 3 241203 1% 79% 15 Search FLAVIN+CONTAINING+MONOOXYGENASE+3 Search FLAVIN+CONTAINING+MONOOXYGENASE+3
10 CYP2D6 180319 1% 51% 554 Search CYP2D6 Search CYP2D6

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KLAASSEN, CD , ALEKSUNES, LM , (2010) XENOBIOTIC, BILE ACID, AND CHOLESTEROL TRANSPORTERS: FUNCTION AND REGULATION.PHARMACOLOGICAL REVIEWS. VOL. 62. ISSUE 1. P. 1 -96 706 58% 293
2 WHITEHOUSE, CJC , BELL, SG , WONG, LL , (2012) P450(BM3) (CYP102A1): CONNECTING THE DOTS.CHEMICAL SOCIETY REVIEWS. VOL. 41. ISSUE 3. P. 1218 -1260 339 83% 158
3 DEELEY, RG , WESTLAKE, C , COLE, SPC , (2006) TRANSMEMBRANE TRANSPORT OF ENDO- AND XENOBIOTICS BY MAMMALIAN ATP-BINDING CASSETTE MULTIDRUG RESISTANCE PROTEINS.PHYSIOLOGICAL REVIEWS. VOL. 86. ISSUE 3. P. 849-899 417 76% 393
4 GIACOMINI, KM , HUANG, SM , TWEEDIE, DJ , BENET, LZ , BROUWER, KLR , CHU, XY , DAHLIN, A , EVERS, R , FISCHER, V , HILLGREN, KM , ET AL (2010) MEMBRANE TRANSPORTERS IN DRUG DEVELOPMENT.NATURE REVIEWS DRUG DISCOVERY. VOL. 9. ISSUE 3. P. 215 -236 181 88% 1007
5 WRIGHT, SH , DANTZLER, WH , (2004) MOLECULAR AND CELLULAR PHYSIOLOGY OF RENAL ORGANIC CATION AND ANION TRANSPORT.PHYSIOLOGICAL REVIEWS. VOL. 84. ISSUE 3. P. 987-1049 404 80% 234
6 HAIMEUR, A , CONSEIL, G , DEELEY, RG , COLE, SPC , (2004) THE MRP-RELATED AND BCRP/ABCG2 MULTIDRUG RESISTANCE PROTEINS: BIOLOGY, SUBSTRATE SPECIFICITY AND REGULATION.CURRENT DRUG METABOLISM. VOL. 5. ISSUE 1. P. 21-53 337 83% 331
7 ECKFORD, PDW , SHAROM, FJ , (2009) ABC EFFLUX PUMP-BASED RESISTANCE TO CHEMOTHERAPY DRUGS.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2989-3011 264 87% 236
8 ROTH, M , OBAIDAT, A , HAGENBUCH, B , (2012) OATPS, OATS AND OCTS: THE ORGANIC ANION AND CATION TRANSPORTERS OF THE SLCO AND SLC22A GENE SUPERFAMILIES.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 165. ISSUE 5. P. 1260 -1287 240 82% 134
9 SILVA, R , VILAS-BOAS, V , CARMO, H , DINIS-OLIVEIRA, RJ , CARVALHO, F , BASTOS, MD , REMIAO, F , (2015) MODULATION OF P-GLYCOPROTEIN EFFLUX PUMP: INDUCTION AND ACTIVATION AS A THERAPEUTIC STRATEGY.PHARMACOLOGY & THERAPEUTICS. VOL. 149. ISSUE . P. 1 -123 306 65% 23
10 SZAKACS, G , PATERSON, JK , LUDWIG, JA , BOOTH-GENTHE, C , GOTTESMAN, MM , (2006) TARGETING MULTIDRUG RESISTANCE IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 5. ISSUE 3. P. 219-234 172 72% 1543

Classes with closest relation at Level 3


Rank Class id link
1 285 ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE
2 537 BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION
3 116 MUTATION RESEARCH//TOXICOLOGY//CARCINOGENESIS
4 547 ACETAMINOPHEN//CARBON MONOXIDE POISONING//POISONING
5 641 PYRROLIZIDINE ALKALOIDS//MATRINE//POISONOUS PLANTS
6 468 GLUCOSINOLATES//BILIRUBIN//HEME OXYGENASE
7 697 LYSYL OXIDASE//SULFOTRANSFERASE//PYRROLOQUINOLINE QUINONE
8 496 WHIPPLES DISEASE//POLYAMINES//TROPHERYMA WHIPPLEI
9 502 HOMOCYSTEINE//FOLATE//FOLIC ACID
10 471 ACETYLCHOLINESTERASE//PARAOXONASE//SULFUR MUSTARD

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