Class information for:
Level 2: BILE ACIDS//FARNESOID X RECEPTOR//CHOLESTASIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1019 10277 38.9 68%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
212 3       GASTROENTEROLOGY & HEPATOLOGY//LAPAROSCOPIC CHOLECYSTECTOMY//PRIMARY BILIARY CIRRHOSIS 51420
1019 2             BILE ACIDS//FARNESOID X RECEPTOR//CHOLESTASIS 10277
3044 1                   ORGANIC ANIONS//CANALICULAR MEMBRANE//BILITRANSLOCASE 2081
5462 1                   FARNESOID X RECEPTOR//FXR//TGR5 1620
5778 1                   BILE ACIDS//SULFATED BILE ACID//TAURINE CONJUGATE 1576
9039 1                   CEREBROTENDINOUS XANTHOMATOSIS//CHOLESTEROL 7 ALPHA HYDROXYLASE//STEROL 27 HYDROXYLASE 1193
9748 1                   INTRAHEPATIC CHOLESTASIS OF PREGNANCY//PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS//ABCB11 1124
9757 1                   URSODEOXYCHOLIC ACID//TAUROURSODEOXYCHOLIC ACID//BILE ACIDS 1123
16617 1                   BILE ACID MALABSORPTION//SEHCAT//ASBT 644
18131 1                   CHOLANGIOCYTES//INTRAHEPATIC BILIARY EPITHELIUM//SCOTT WHITE DIGEST DIS 564
23258 1                   7 ALPHA DEHYDROXYLATION//7 ALPHA HYDROXYSTEROID DEHYDROGENASE//CLOSTRIDIUM SCINDENS 352

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 BILE ACIDS authKW 1399679 12% 40% 1189
2 FARNESOID X RECEPTOR authKW 482632 2% 74% 219
3 CHOLESTASIS authKW 412796 5% 25% 547
4 URSODEOXYCHOLIC ACID authKW 353975 3% 38% 317
5 CEREBROTENDINOUS XANTHOMATOSIS authKW 320478 1% 91% 118
6 FXR authKW 282553 1% 65% 147
7 INTRAHEPATIC CHOLESTASIS OF PREGNANCY authKW 245139 1% 81% 102
8 TGR5 authKW 189273 1% 83% 77
9 CHENODEOXYCHOLIC ACID authKW 177178 1% 55% 109
10 PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS authKW 176690 1% 86% 69

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Gastroenterology & Hepatology 78671 27% 1% 2749
2 Biochemistry & Molecular Biology 6740 25% 0% 2521
3 Pharmacology & Pharmacy 2325 11% 0% 1156
4 Physiology 2287 6% 0% 627
5 Medicine, Research & Experimental 2017 6% 0% 654
6 Biophysics 1316 5% 0% 534
7 Endocrinology & Metabolism 864 5% 0% 494
8 Chemistry, Medicinal 511 3% 0% 296
9 Nutrition & Dietetics 418 2% 0% 239
10 Medical Laboratory Technology 414 1% 0% 135

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT MOL HEPATOL 55645 0% 49% 38
2 SCOTT WHITE DIGEST DIS 44151 0% 55% 27
3 EXPT HEPATOL DRUG TARGETING 37378 0% 55% 23
4 CENT TEXAS VET HLTH CARE SYST 32552 0% 37% 30
5 MATERNAL FETAL DIS GRP 31358 0% 81% 13
6 GENE REGULAT DRUG DISCOVERY 28952 0% 51% 19
7 LIVER DIGEST METAB DIS 20031 0% 14% 50
8 PATOGENESE MOL 18599 0% 18% 34
9 EXPT HEPATOL DRUG TARGETING HEVEFARM 17563 0% 39% 15
10 BASIC DIGEST DIS 16314 0% 15% 36

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HEPATOLOGY 81722 6% 5% 573
2 JOURNAL OF LIPID RESEARCH 74304 5% 5% 463
3 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 31816 3% 4% 260
4 JOURNAL OF HEPATOLOGY 22976 2% 3% 244
5 GASTROENTEROLOGY 21755 3% 2% 314
6 STEROIDS 11535 1% 3% 131
7 SEMINARS IN LIVER DISEASE 8387 1% 5% 62
8 HEPATOLOGY RESEARCH 4740 1% 2% 66
9 PROGRESS IN LIVER DISEASES 3995 0% 14% 10
10 INTERNATIONAL HEPATOLOGY COMMUNICATIONS 3698 0% 6% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 BILE ACIDS 1399679 12% 40% 1189 Search BILE+ACIDS Search BILE+ACIDS
2 FARNESOID X RECEPTOR 482632 2% 74% 219 Search FARNESOID+X+RECEPTOR Search FARNESOID+X+RECEPTOR
3 CHOLESTASIS 412796 5% 25% 547 Search CHOLESTASIS Search CHOLESTASIS
4 URSODEOXYCHOLIC ACID 353975 3% 38% 317 Search URSODEOXYCHOLIC+ACID Search URSODEOXYCHOLIC+ACID
5 CEREBROTENDINOUS XANTHOMATOSIS 320478 1% 91% 118 Search CEREBROTENDINOUS+XANTHOMATOSIS Search CEREBROTENDINOUS+XANTHOMATOSIS
6 FXR 282553 1% 65% 147 Search FXR Search FXR
7 INTRAHEPATIC CHOLESTASIS OF PREGNANCY 245139 1% 81% 102 Search INTRAHEPATIC+CHOLESTASIS+OF+PREGNANCY Search INTRAHEPATIC+CHOLESTASIS+OF+PREGNANCY
8 TGR5 189273 1% 83% 77 Search TGR5 Search TGR5
9 CHENODEOXYCHOLIC ACID 177178 1% 55% 109 Search CHENODEOXYCHOLIC+ACID Search CHENODEOXYCHOLIC+ACID
10 PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS 176690 1% 86% 69 Search PROGRESSIVE+FAMILIAL+INTRAHEPATIC+CHOLESTASIS Search PROGRESSIVE+FAMILIAL+INTRAHEPATIC+CHOLESTASIS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LEFEBVRE, P , CARIOU, B , LIEN, F , KUIPERS, F , STAELS, B , (2009) ROLE OF BILE ACIDS AND BILE ACID RECEPTORS IN METABOLIC REGULATION.PHYSIOLOGICAL REVIEWS. VOL. 89. ISSUE 1. P. 147 -191 221 65% 495
2 MARIN, JJG , MACIAS, RIR , BRIZ, O , BANALES, JM , MONTE, MJ , (2016) BILE ACIDS IN PHYSIOLOGY, PATHOLOGY AND PHARMACOLOGY.CURRENT DRUG METABOLISM. VOL. 17. ISSUE 1. P. 4 -29 237 68% 5
3 DAWSON, PA , LAN, T , RAO, A , (2009) BILE ACID TRANSPORTERS.JOURNAL OF LIPID RESEARCH. VOL. 50. ISSUE 12. P. 2340 -2357 199 82% 161
4 BOYER, JL , (2013) BILE FORMATION AND SECRETION.COMPREHENSIVE PHYSIOLOGY. VOL. 3. ISSUE 3. P. 1035 -1078 286 54% 52
5 DORING, B , LUTTEKE, T , GEYER, J , PETZINGER, E , (2012) THE SLC10 CARRIER FAMILY: TRANSPORT FUNCTIONS AND MOLECULAR STRUCTURE.CO-TRANSPORT SYSTEMS. VOL. 70. ISSUE . P. 105 -168 212 73% 25
6 MAZUY, C , HELLEBOID, A , STAELS, B , LEFEBVRE, P , (2015) NUCLEAR BILE ACID SIGNALING THROUGH THE FARNESOID X RECEPTOR.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 72. ISSUE 9. P. 1631 -1650 167 78% 13
7 KUBITZ, R , DROGE, C , STINDT, J , WEISSENBERGER, K , HAUSSINGER, D , (2012) THE BILE SALT EXPORT PUMP (BSEP) IN HEALTH AND DISEASE.CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY. VOL. 36. ISSUE 6. P. 536-553 170 79% 39
8 TRAUNER, M , BOYER, JL , (2003) BILE SALT TRANSPORTERS: MOLECULAR CHARACTERIZATION, FUNCTION, AND REGULATION.PHYSIOLOGICAL REVIEWS. VOL. 83. ISSUE 2. P. 633-671 208 58% 473
9 KOSTERS, A , KARPEN, SJ , (2008) BILE ACID TRANSPORTERS IN HEALTH AND DISEASE.XENOBIOTICA. VOL. 38. ISSUE 7-8. P. 1043 -1071 171 86% 60
10 HOFMANN, AF , HAGEY, LR , (2014) KEY DISCOVERIES IN BILE ACID CHEMISTRY AND BIOLOGY AND THEIR CLINICAL APPLICATIONS: HISTORY OF THE LAST EIGHT DECADES.JOURNAL OF LIPID RESEARCH. VOL. 55. ISSUE 8. P. 1553 -1595 169 68% 28

Classes with closest relation at Level 2


Rank Class id link
1 1807 PRIMARY BILIARY CIRRHOSIS//AUTOIMMUNE HEPATITIS//PRIMARY SCLEROSING CHOLANGITIS
2 1155 PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1
3 2916 OXYSTEROLS//CHOLESTEROL OXIDES//CHOLESTEROL OXIDATION PRODUCTS
4 2474 ABERRANT CRYPT FOCI//ANTINEOPLASTIC DRUGS//COLON CARCINOGENESIS
5 240 LAPAROSCOPIC CHOLECYSTECTOMY//GALLSTONES//CHOLECYSTECTOMY
6 2141 FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR
7 747 P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1
8 2101 OBSTRUCTIVE JAUNDICE//MALIGNANT BILIARY OBSTRUCTION//DUODENOGASTRIC REFLUX
9 2293 BILIARY ATRESIA//CHOLEDOCHAL CYST//ALAGILLE SYNDROME
10 1434 BILIRUBIN//HYPERBILIRUBINEMIA//KERNICTERUS

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