Class information for:
Level 1: CYP3A5//ABCB1//MDR1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5907 1560 41.2 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
747 2             P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1 12474
5907 1                   CYP3A5//ABCB1//MDR1 1560

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYP3A5 authKW 2198401 12% 59% 189
2 ABCB1 authKW 1079794 12% 29% 193
3 MDR1 authKW 697348 11% 21% 172
4 C3435T POLYMORPHISM authKW 336453 1% 90% 19
5 TACROLIMUS authKW 304167 14% 7% 214
6 CYTOCHROME P450 3A5 authKW 289949 1% 74% 20
7 CYP3A53 authKW 271743 1% 73% 19
8 MDR1 GENE authKW 238024 3% 28% 43
9 P GLYCOPROTEIN authKW 197007 15% 4% 235
10 PHARMACOGENETICS authKW 196846 13% 5% 206

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 10882 49% 0% 761
2 Transplantation 3437 10% 0% 157
3 Medical Laboratory Technology 1627 6% 0% 87
4 Genetics & Heredity 1012 12% 0% 184
5 Oncology 416 10% 0% 163
6 Toxicology 375 5% 0% 84
7 Surgery 251 9% 0% 140
8 Immunology 183 7% 0% 110
9 Gastroenterology & Hepatology 108 3% 0% 52
10 Biotechnology & Applied Microbiology 90 5% 0% 74

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIDAD FARMACOGENET 83501 1% 53% 8
2 IND ENVIRONM TOXICOL UNIT 81549 0% 83% 5
3 CARDIAC VASC SCI ANALYT UNIT 78289 0% 100% 4
4 MOL BIOL PHARMACOGENOM 61160 0% 63% 5
5 TRANSPLANTAT SOLID ORGANS 58717 0% 100% 3
6 UMR S490 44733 0% 57% 4
7 UMRS 1147 44733 0% 57% 4
8 NEPHROLRHEUMATOL 39144 0% 100% 2
9 PEDIAT NEPHOL KIDNEY TRANSPLANTAT 39144 0% 100% 2
10 AREA MEDICAMENTO 35228 0% 60% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENOMICS 58820 5% 4% 73
2 PHARMACOGENETICS AND GENOMICS 56017 4% 5% 57
3 PHARMACOGENETICS 22491 2% 3% 33
4 PHARMACOGENOMICS JOURNAL 18032 2% 3% 27
5 CLINICAL PHARMACOLOGY & THERAPEUTICS 14129 4% 1% 65
6 THERAPEUTIC DRUG MONITORING 12011 3% 1% 48
7 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 5545 3% 1% 45
8 DRUG METABOLISM AND PHARMACOKINETICS 5293 1% 2% 14
9 PHARMACOLOGICAL REPORTS 4337 1% 1% 20
10 ANNALS OF TRANSPLANTATION 2187 1% 1% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYP3A5 2198401 12% 59% 189 Search CYP3A5 Search CYP3A5
2 ABCB1 1079794 12% 29% 193 Search ABCB1 Search ABCB1
3 MDR1 697348 11% 21% 172 Search MDR1 Search MDR1
4 C3435T POLYMORPHISM 336453 1% 90% 19 Search C3435T+POLYMORPHISM Search C3435T+POLYMORPHISM
5 TACROLIMUS 304167 14% 7% 214 Search TACROLIMUS Search TACROLIMUS
6 CYTOCHROME P450 3A5 289949 1% 74% 20 Search CYTOCHROME+P450+3A5 Search CYTOCHROME+P450+3A5
7 CYP3A53 271743 1% 73% 19 Search CYP3A53 Search CYP3A53
8 MDR1 GENE 238024 3% 28% 43 Search MDR1+GENE Search MDR1+GENE
9 P GLYCOPROTEIN 197007 15% 4% 235 Search P+GLYCOPROTEIN Search P+GLYCOPROTEIN
10 PHARMACOGENETICS 196846 13% 5% 206 Search PHARMACOGENETICS Search PHARMACOGENETICS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 STAATZ, CE , GOODMAN, LK , TETT, SE , (2010) EFFECT OF CYP3A AND ABCB1 SINGLE NUCLEOTIDE POLYMORPHISMS ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF CALCINEURIN INHIBITORS: PART I.CLINICAL PHARMACOKINETICS. VOL. 49. ISSUE 3. P. 141-175 102 79% 143
2 WOLKING, S , SCHAEFFELER, E , LERCHE, H , SCHWAB, M , NIES, AT , (2015) IMPACT OF GENETIC POLYMORPHISMS OF ABCB1 (MDR1, P-GLYCOPROTEIN) ON DRUG DISPOSITION AND POTENTIAL CLINICAL IMPLICATIONS: UPDATE OF THE LITERATURE.CLINICAL PHARMACOKINETICS. VOL. 54. ISSUE 7. P. 709 -735 143 50% 8
3 HESSELINK, DA , BOUAMAR, R , ELENS, L , VAN SCHAIK, RHN , VAN GELDER, T , (2014) THE ROLE OF PHARMACOGENETICS IN THE DISPOSITION OF AND RESPONSE TO TACROLIMUS IN SOLID ORGAN TRANSPLANTATION.CLINICAL PHARMACOKINETICS. VOL. 53. ISSUE 2. P. 123-139 98 59% 47
4 ELENS, L , BOUAMAR, R , SHUKER, N , HESSELINK, DA , VAN GELDER, T , VAN SCHAIK, RHN , (2014) CLINICAL IMPLEMENTATION OF PHARMACOGENETICS IN KIDNEY TRANSPLANTATION: CALCINEURIN INHIBITORS IN THE STARTING BLOCKS.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 77. ISSUE 4. P. 715-728 79 84% 16
5 WARE, N , MACPHEE, IA , (2010) CURRENT PROGRESS IN PHARMACOGENETICS AND INDIVIDUALIZED IMMUNOSUPPRESSIVE DRUG DOSING IN ORGAN TRANSPLANTATION.CURRENT OPINION IN MOLECULAR THERAPEUTICS. VOL. 12. ISSUE 3. P. 270-283 95 83% 15
6 TANG, JT , ANDREWS, LM , VAN GELDER, T , SHI, YY , VAN SCHAIK, RHN , WANG, LL , HESSELINK, DA , (2016) PHARMACOGENETIC ASPECTS OF THE USE OF TACROLIMUS IN RENAL TRANSPLANTATION: RECENT DEVELOPMENTS AND ETHNIC CONSIDERATIONS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 12. ISSUE 5. P. 555 -565 82 67% 2
7 PICARD, N , BERGAN, S , MARQUET, P , VAN GELDER, T , WALLEMACQ, P , HESSELINK, DA , HAUFROID, V , (2016) PHARMACOGENETIC BIOMARKERS PREDICTIVE OF THE PHARMACOKINETICS AND PHARMACODYNAMICS OF IMMUNOSUPPRESSIVE DRUGS.THERAPEUTIC DRUG MONITORING. VOL. 38. ISSUE . P. S57 -S69 86 60% 3
8 PROVENZANI, A , SANTEUSANIO, A , MATHIS, E , NOTARBARTOLO, M , LABBOZZETTA, M , POMA, P , PROVENZANI, A , POLIDORI, C , VIZZINI, G , POLIDORI, P , ET AL (2013) PHARMACOGENETIC CONSIDERATIONS FOR OPTIMIZING TACROLIMUS DOSING IN LIVER AND KIDNEY TRANSPLANT PATIENTS.WORLD JOURNAL OF GASTROENTEROLOGY. VOL. 19. ISSUE 48. P. 9156-9173 84 72% 17
9 ROJAS, L , NEUMANN, I , HERRERO, MJ , BOSO, V , REIG, J , POVEDA, JL , MEGIAS, J , BEA, S , ALINO, SF , (2015) EFFECT OF CYP3A5*3 ON KIDNEY TRANSPLANT RECIPIENTS TREATED WITH TACROLIMUS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES.PHARMACOGENOMICS JOURNAL. VOL. 15. ISSUE 1. P. 38 -48 46 87% 19
10 WERK, AN , CASCORBI, I , (2014) FUNCTIONAL GENE VARIANTS OF CYP3A4.CLINICAL PHARMACOLOGY & THERAPEUTICS. VOL. 96. ISSUE 3. P. 340 -348 53 77% 28

Classes with closest relation at Level 1


Rank Class id link
1 33973 MDR I//RHEUMATOLOTA KU//BIOLOGIC AGENT THERAPY
2 5164 TACROLIMUS//FK506//TRANSPLANTATION PROCEEDINGS
3 9862 P GLYCOPROTEIN//PHARMACORESISTANCE//TARIQUIDAR
4 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
5 33965 HSA MIR 29A 3P//PHARMACOEPIGENETICS//ABCC2 HAPLOTYPE
6 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
7 5456 OATP1B1//SLCO1B1//OATP
8 15425 ONCE DAILY TACROLIMUS//PROLONGED RELEASE TACROLIMUS//IMMUNOSUPPRESSANT ADHERENCE
9 216 MULTIDRUG RESISTANCE//P GLYCOPROTEIN//PSC 833
10 22211 IMMUKNOW//IMMUNE MONITORING//PHARMACODYNAMIC MONITORING

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