Class information for:
Level 2: CAMPTOTHECIN//TOPOISOMERASE I//SN 38

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1488 7627 39.7 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
1644 1                   CAMPTOTHECIN//SN 38//TOPOTECAN 2558
2662 1                   TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA 2181
6168 1                   DNA GYRASE//GYRASE//REVERSE GYRASE 1519
7420 1                   TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE 1369

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CAMPTOTHECIN authKW 1024577 8% 44% 578
2 TOPOISOMERASE I authKW 605008 4% 52% 290
3 SN 38 authKW 374932 2% 58% 162
4 TOPOISOMERASE authKW 373084 3% 36% 261
5 TOPOTECAN authKW 369561 4% 33% 278
6 TOPOISOMERASE II authKW 365355 3% 36% 254
7 DNA TOPOISOMERASE I authKW 245051 1% 62% 99
8 CPT 11 authKW 244442 2% 39% 155
9 IRINOTECAN authKW 217104 4% 17% 328
10 DNA GYRASE authKW 214110 2% 44% 122

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 20035 28% 0% 2106
2 Biochemistry & Molecular Biology 11926 35% 0% 2660
3 Pharmacology & Pharmacy 5592 18% 0% 1361
4 Chemistry, Medicinal 5173 8% 0% 639
5 Microbiology 945 6% 0% 465
6 Cell Biology 811 7% 0% 560
7 Biophysics 779 5% 0% 364
8 Chemistry, Organic 567 6% 0% 427
9 Toxicology 524 3% 0% 250
10 Genetics & Heredity 455 5% 0% 358

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PHARMACOL 47017 4% 4% 291
2 DANIEL DEN HOED KLIN 32001 0% 26% 31
3 ENZYMOL ACIDES NUCL 27007 0% 75% 9
4 STEHLIN FDN CANC 25003 0% 63% 10
5 DEV THER EUT BRANCH 24856 0% 22% 28
6 G MORUZZI BIOCHEM 20250 0% 56% 9
7 PURDUE CANC 17690 1% 10% 44
8 BIOL PHARMACOL DNA TOPOISOMERASES 14289 0% 71% 5
9 MED HEMATOL ONCOL 13684 1% 5% 75
10 PEDIAT PHARMACOKINET THER EUT 12087 0% 17% 18

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 23307 3% 3% 208
2 ANTI-CANCER DRUGS 9137 1% 3% 87
3 NUCLEIC ACIDS RESEARCH 8673 4% 1% 300
4 CANCER RESEARCH 7858 4% 1% 284
5 CLINICAL CANCER RESEARCH 5208 2% 1% 142
6 JOURNAL OF BIOLOGICAL CHEMISTRY 4368 6% 0% 435
7 INVESTIGATIONAL NEW DRUGS 3830 1% 2% 50
8 BIOCHEMICAL PHARMACOLOGY 3334 2% 1% 128
9 BIOCHEMISTRY 3250 3% 0% 219
10 MOLECULAR PHARMACOLOGY 2681 1% 1% 83

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CAMPTOTHECIN 1024577 8% 44% 578 Search CAMPTOTHECIN Search CAMPTOTHECIN
2 TOPOISOMERASE I 605008 4% 52% 290 Search TOPOISOMERASE+I Search TOPOISOMERASE+I
3 SN 38 374932 2% 58% 162 Search SN+38 Search SN+38
4 TOPOISOMERASE 373084 3% 36% 261 Search TOPOISOMERASE Search TOPOISOMERASE
5 TOPOTECAN 369561 4% 33% 278 Search TOPOTECAN Search TOPOTECAN
6 TOPOISOMERASE II 365355 3% 36% 254 Search TOPOISOMERASE+II Search TOPOISOMERASE+II
7 DNA TOPOISOMERASE I 245051 1% 62% 99 Search DNA+TOPOISOMERASE+I Search DNA+TOPOISOMERASE+I
8 CPT 11 244442 2% 39% 155 Search CPT+11 Search CPT+11
9 IRINOTECAN 217104 4% 17% 328 Search IRINOTECAN Search IRINOTECAN
10 DNA GYRASE 214110 2% 44% 122 Search DNA+GYRASE Search DNA+GYRASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WANG, JC , (1996) DNA TOPOISOMERASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 635-692 401 81% 1741
2 SCHOEFFLER, AJ , BERGER, JM , (2008) DNA TOPOISOMERASES: HARNESSING AND CONSTRAINING ENERGY TO GOVERN CHROMOSOME TOPOLOGY.QUARTERLY REVIEWS OF BIOPHYSICS. VOL. 41. ISSUE 1. P. 41-101 214 78% 204
3 CHAMPOUX, JJ , (2001) DNA TOPOISOMERASES: STRUCTURE, FUNCTION, AND MECHANISM.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 70. ISSUE . P. 369-413 147 80% 1421
4 FORTUNE, JM , OSHEROFF, N , (2000) TOPOISOMERASE II AS A TARGET FOR ANTICANCER DRUGS: WHEN ENZYMES STOP BEING NICE.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 64. VOL. 64. ISSUE . P. 221 -253 215 90% 229
5 VENDITTO, VJ , SIMANEK, EE , (2010) CANCER THERAPIES UTILIZING THE CAMPTOTHECINS: A REVIEW OF THE IN VIVO LITERATURE.MOLECULAR PHARMACEUTICS. VOL. 7. ISSUE 2. P. 307-349 194 68% 108
6 POMMIER, Y , (2013) DRUGGING TOPOISOMERASES: LESSONS AND CHALLENGES.ACS CHEMICAL BIOLOGY. VOL. 8. ISSUE 1. P. 82 -95 108 79% 188
7 POMMIER, Y , LEO, E , ZHANG, HL , MARCHAND, C , (2010) DNA TOPOISOMERASES AND THEIR POISONING BY ANTICANCER AND ANTIBACTERIAL DRUGS.CHEMISTRY & BIOLOGY. VOL. 17. ISSUE 5. P. 421-433 92 88% 468
8 POMMIER, Y , (2009) DNA TOPOISOMERASE I INHIBITORS: CHEMISTRY, BIOLOGY, AND INTERFACIAL INHIBITION.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2894-2902 116 89% 253
9 CHEN, SH , CHAN, NL , HSIEH, TS , (2013) NEW MECHANISTIC AND FUNCTIONAL INSIGHTS INTO DNA TOPOISOMERASES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82. VOL. 82. ISSUE . P. 139 -+ 169 61% 75
10 BAKSHI, RP , GALANDE, S , MUNIYAPPA, K , (2001) FUNCTIONAL AND REGULATORY CHARACTERISTICS OF EUKARYOTIC TYPE II DNA TOPOISOMERASE.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 36. ISSUE 1. P. 1 -37 220 84% 40

Classes with closest relation at Level 2


Rank Class id link
1 3716 CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2
2 1654 DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE
3 889 FLUOROQUINOLONES//QUINOLONES//CIPROFLOXACIN
4 747 P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1
5 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
6 1094 NUCLEAR MATRIX//LINKER HISTONE//HISTONE H1
7 160 WERNER SYNDROME//DNA POLYMERASE//DNA REPAIR
8 1612 SMALL CELL LUNG CANCER//BOMBESIN//GASTRIN RELEASING PEPTIDE
9 371 RNA POLYMERASE//HFQ//JOURNAL OF BACTERIOLOGY
10 1422 XRCC1//GEMCITABINE//ERCC1

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