Class information for:
Level 1: PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
27533 227 34.3 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
27533 1                   PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL 227

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET BIOANAL address 3549136 22% 54% 49
2 HUMANIZED LIVER authKW 823915 3% 88% 7
3 PL DEV BIOL address 586968 5% 36% 12
4 P450 SUBSTRATES authKW 560486 2% 83% 5
5 KEIO ADV address 369905 5% 25% 11
6 TK NOG MOUSE authKW 302662 1% 75% 3
7 UPA SCID MOUSE authKW 302662 1% 75% 3
8 21ST CENTURY COE PROGRAM ADV RADIAT CASUALTY MED address 284852 3% 35% 6
9 COOPERAT LINK UNIQUE SCI TECHNOL ECON REVITALIZ address 280238 2% 42% 5
10 CYNOMOLGUS MONKEY authKW 269819 14% 6% 31

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 2720 63% 0% 143
2 Toxicology 1860 27% 0% 62
3 Medicine, Legal 88 2% 0% 5
4 Transplantation 27 3% 0% 6
5 Gastroenterology & Hepatology 25 4% 0% 9
6 Chemistry, Medicinal 20 4% 0% 8
7 Multidisciplinary Sciences 18 2% 0% 4
8 Biochemistry & Molecular Biology 17 12% 0% 27
9 Biophysics 14 4% 0% 9
10 Medicine, Research & Experimental 12 4% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET BIOANAL 3549136 22% 54% 49
2 PL DEV BIOL 586968 5% 36% 12
3 KEIO ADV 369905 5% 25% 11
4 21ST CENTURY COE PROGRAM ADV RADIAT CASUALTY MED 284852 3% 35% 6
5 COOPERAT LINK UNIQUE SCI TECHNOL ECON REVITALIZ 280238 2% 42% 5
6 YOSHIZATO PROJECT 253196 4% 24% 8
7 LIVER PROJECT 229608 6% 13% 13
8 PXB MOUSE PROD 179355 1% 67% 2
9 DRUG METAB PHARMACOKINET 149102 25% 2% 57
10 21ST CENTURY COE PROGRAM ADV RADIAT CASULATY MED 134517 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND PHARMACOKINETICS 53886 7% 2% 17
2 XENOBIOTICA 40218 15% 1% 34
3 DRUG METABOLISM AND DISPOSITION 21990 15% 0% 35
4 BIOPHARMACEUTICS & DRUG DISPOSITION 2506 3% 0% 6
5 HUMAN GENE THERAPY CLINICAL DEVELOPMENT 1659 0% 1% 1
6 DRUG METABOLISM REVIEWS 1212 1% 0% 3
7 REGULATORY TOXICOLOGY AND PHARMACOLOGY 1148 2% 0% 5
8 CURRENT DRUG METABOLISM 1101 1% 0% 3
9 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 966 1% 0% 3
10 CHEMICAL RESEARCH IN TOXICOLOGY 923 3% 0% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HUMANIZED LIVER 823915 3% 88% 7 Search HUMANIZED+LIVER Search HUMANIZED+LIVER
2 P450 SUBSTRATES 560486 2% 83% 5 Search P450+SUBSTRATES Search P450+SUBSTRATES
3 TK NOG MOUSE 302662 1% 75% 3 Search TK+NOG+MOUSE Search TK+NOG+MOUSE
4 UPA SCID MOUSE 302662 1% 75% 3 Search UPA+SCID+MOUSE Search UPA+SCID+MOUSE
5 CYNOMOLGUS MONKEY 269819 14% 6% 31 Search CYNOMOLGUS+MONKEY Search CYNOMOLGUS+MONKEY
6 CYP2C76 269034 1% 100% 2 Search CYP2C76 Search CYP2C76
7 CYP2D17 269034 1% 100% 2 Search CYP2D17 Search CYP2D17
8 FRG MOUSE 269034 1% 100% 2 Search FRG+MOUSE Search FRG+MOUSE
9 HUMAN CHIMERIC MICE 269034 1% 100% 2 Search HUMAN+CHIMERIC+MICE Search HUMAN+CHIMERIC+MICE
10 LIVER HUMANIZATION 269034 1% 100% 2 Search LIVER+HUMANIZATION Search LIVER+HUMANIZATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KITAMURA, S , SUGIHARA, K , (2014) CURRENT STATUS OF PREDICTION OF DRUG DISPOSITION AND TOXICITY IN HUMANS USING CHIMERIC MICE WITH HUMANIZED LIVER.XENOBIOTICA. VOL. 44. ISSUE 2. P. 123 -134 43 67% 9
2 ITO, S , KAMIMURA, H , (2016) ASSESSMENT OF CHIMERIC MICE WITH HUMANIZED LIVERS IN NEW DRUG DEVELOPMENT: GENERATION OF PHARMACOKINETICS, METABOLISM AND TOXICITY DATA FOR SELECTING THE FINAL CANDIDATE COMPOUND.XENOBIOTICA. VOL. 46. ISSUE 6. P. 557 -569 39 59% 0
3 UNO, Y , UEHARA, S , YAMAZAKI, H , (2016) UTILITY OF NON-HUMAN PRIMATES IN DRUG DEVELOPMENT: COMPARISON OF NON-HUMAN PRIMATE AND HUMAN DRUG-METABOLIZING CYTOCHROME P450 ENZYMES.BIOCHEMICAL PHARMACOLOGY. VOL. 121. ISSUE . P. 1 -7 36 58% 1
4 FOSTER, JR , LUND, G , SAPELNIKOVA, S , TYRRELL, DL , KNETEMAN, NM , (2014) CHIMERIC RODENTS WITH HUMANIZED LIVER: BRIDGING THE PRECLINICAL/CLINICAL TRIAL GAP IN ADME/TOXICITY STUDIES.XENOBIOTICA. VOL. 44. ISSUE 2. P. 109-122 41 35% 10
5 UEHARA, S , MURAYAMA, N , NAKANISHI, Y , ZELDIN, DC , YAMAZAKI, H , UNO, Y , (2011) IMMUNOCHEMICAL DETECTION OF CYTOCHROME P450 ENZYMES IN LIVER MICROSOMES OF 27 CYNOMOLGUS MONKEYS.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 339. ISSUE 2. P. 654-661 26 59% 5
6 SCHEER, N , WILSON, ID , (2016) A COMPARISON BETWEEN GENETICALLY HUMANIZED AND CHIMERIC LIVER HUMANIZED MOUSE MODELS FOR STUDIES IN DRUG METABOLISM AND TOXICITY.DRUG DISCOVERY TODAY. VOL. 21. ISSUE 2. P. 250 -263 38 27% 4
7 UNO, Y , MATSUNO, K , MURAYAMA, N , NAKAMURA, C , YAMAZAKI, H , (2011) METABOLISM OF P450 PROBE SUBSTRATES BY CYNOMOLGUS MONKEY CYP2C76.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. VOL. 109. ISSUE 4. P. 315 -318 16 89% 1
8 SANOH, S , OHTA, S , (2014) CHIMERIC MICE TRANSPLANTED WITH HUMAN HEPATOCYTES AS A MODEL FOR PREDICTION OF HUMAN DRUG METABOLISM AND PHARMACOKINETICS.BIOPHARMACEUTICS & DRUG DISPOSITION. VOL. 35. ISSUE 2. P. 71-86 31 40% 5
9 IWASAKI, K , KITSUGI, Y , IKEDA, K , YOSHIKAWA, T , HOSAKA, S , UEHARA, S , UNO, Y , UTOH, M , YAMAZAKI, H , (2016) IN VIVO INDIVIDUAL VARIATIONS IN PHARMACOKINETICS OF EFAVIRENZ IN CYNOMOLGUS MONKEYS GENOTYPED FOR CYTOCHROME P450 2C9.BIOPHARMACEUTICS & DRUG DISPOSITION. VOL. 37. ISSUE 6. P. 379 -383 13 87% 0
10 UEHARA, S , UNO, Y , INOUE, T , KAWANO, M , SHIMIZU, M , TODA, A , UTOH, M , SASAKI, E , YAMAZAKI, H , (2016) INDIVIDUAL DIFFERENCES IN METABOLIC CLEARANCE OF S-WARFARIN EFFICIENTLY MEDIATED BY POLYMORPHIC MARMOSET CYTOCHROME P450 2C19 IN LIVERS.DRUG METABOLISM AND DISPOSITION. VOL. 44. ISSUE 7. P. 911 -915 15 71% 0

Classes with closest relation at Level 1


Rank Class id link
1 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
2 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
3 8674 HEPATOCYTE TRANSPLANTATION//MARION BESSIN LIVER//LIVER REPOPULATION
4 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
5 13862 ALDEHYDE OXIDASE//XANTHINE DEHYDROGENASE//XANTHINE OXIDOREDUCTASE
6 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
7 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
8 12542 REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB
9 8416 HUMANIZED MICE//SCID MICE//SCID MOUSE
10 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM

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