Class information for:
Level 1: 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4852 1714 42.7 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
4852 1                   6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A 1714

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 6 BETA HYDROXYCORTISOL authKW 414552 2% 73% 32
2 COCKTAIL authKW 329323 3% 43% 43
3 CYP3A authKW 305237 6% 17% 101
4 4 BETA HYDROXYCHOLESTEROL authKW 206115 1% 64% 18
5 DRUG METABOLISM AND DISPOSITION journal 195872 17% 4% 287
6 CYP3A4 authKW 176778 6% 9% 106
7 MECHANISM BASED INHIBITION authKW 133762 2% 29% 26
8 TIME DEPENDENT INHIBITION authKW 130603 1% 33% 22
9 DRUG DRUG INTERACTIONS authKW 126715 4% 10% 74
10 CYP INHIBITION authKW 124981 1% 35% 20

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 32999 79% 0% 1355
2 Toxicology 2527 12% 0% 207
3 Biochemical Research Methods 430 6% 0% 106
4 Chemistry, Analytical 278 7% 0% 119
5 Chemistry, Medicinal 223 4% 0% 71
6 Medical Laboratory Technology 186 2% 0% 34
7 Anesthesiology 80 2% 0% 28
8 Integrative & Complementary Medicine 29 1% 0% 11
9 Biochemistry & Molecular Biology 7 7% 0% 121
10 Chemistry, Multidisciplinary 1 4% 0% 70

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BLADES ENTERPRISE 64744 1% 18% 20
2 POST MKT PROD DEV 53441 0% 100% 3
3 METAB CHEM 49323 0% 46% 6
4 DRUG METAB PHARMACOKINET 42750 5% 3% 84
5 UNIT CLIN PHARMACOL 39771 1% 11% 20
6 DRUG METAB 37225 3% 4% 58
7 BIOPHARMACEUT PHARMACOKINET S 37096 1% 21% 10
8 COMP ASSISTED THER EUT 35627 0% 100% 2
9 CORNING GENTEST CONTRACT SERV 35627 0% 100% 2
10 OCPBDPE 1 35627 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 195872 17% 4% 287
2 XENOBIOTICA 55627 6% 3% 110
3 CLINICAL PHARMACOLOGY & THERAPEUTICS 35612 6% 2% 108
4 CURRENT DRUG METABOLISM 23439 2% 3% 38
5 JOURNAL OF CLINICAL PHARMACOLOGY 15094 4% 1% 68
6 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 12603 4% 1% 76
7 DRUG METABOLISM AND PHARMACOKINETICS 10855 1% 3% 21
8 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 6744 3% 1% 52
9 CLINICAL PHARMACOKINETICS 6318 2% 1% 29
10 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 6269 1% 2% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 6 BETA HYDROXYCORTISOL 414552 2% 73% 32 Search 6+BETA+HYDROXYCORTISOL Search 6+BETA+HYDROXYCORTISOL
2 COCKTAIL 329323 3% 43% 43 Search COCKTAIL Search COCKTAIL
3 CYP3A 305237 6% 17% 101 Search CYP3A Search CYP3A
4 4 BETA HYDROXYCHOLESTEROL 206115 1% 64% 18 Search 4+BETA+HYDROXYCHOLESTEROL Search 4+BETA+HYDROXYCHOLESTEROL
5 CYP3A4 176778 6% 9% 106 Search CYP3A4 Search CYP3A4
6 MECHANISM BASED INHIBITION 133762 2% 29% 26 Search MECHANISM+BASED+INHIBITION Search MECHANISM+BASED+INHIBITION
7 TIME DEPENDENT INHIBITION 130603 1% 33% 22 Search TIME+DEPENDENT+INHIBITION Search TIME+DEPENDENT+INHIBITION
8 DRUG DRUG INTERACTIONS 126715 4% 10% 74 Search DRUG+DRUG+INTERACTIONS Search DRUG+DRUG+INTERACTIONS
9 CYP INHIBITION 124981 1% 35% 20 Search CYP+INHIBITION Search CYP+INHIBITION
10 MIDAZOLAM 106946 6% 6% 105 Search MIDAZOLAM Search MIDAZOLAM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GUEST, EJ , ROWLAND-YEO, K , ROSTAMI-HODJEGAN, A , TUCKER, GT , HOUSTON, JB , GALETIN, A , (2011) ASSESSMENT OF ALGORITHMS FOR PREDICTING DRUG-DRUG INTERACTIONS VIA INHIBITION MECHANISMS: COMPARISON OF DYNAMIC AND STATIC MODELS.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 71. ISSUE 1. P. 72 -87 57 77% 27
2 STRESSER, DM , MAO, JL , KENNY, JR , JONES, BC , GRIME, K , (2014) EXPLORING CONCEPTS OF IN VITRO TIME-DEPENDENT CYP INHIBITION ASSAYS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 2. P. 157-174 49 86% 5
3 MAO, JL , MOHUTSKY, MA , HARRELSON, JP , WRIGHTON, SA , HALL, SD , (2011) PREDICTION OF CYP3A-MEDIATED DRUG-DRUG INTERACTIONS USING HUMAN HEPATOCYTES SUSPENDED IN HUMAN PLASMA.DRUG METABOLISM AND DISPOSITION. VOL. 39. ISSUE 4. P. 591-602 50 81% 12
4 ZHOU, SF , CHAN, SY , GOH, BC , CHAN, E , DUAN, W , HUANG, M , MCLEOD, HL , (2005) MECHANISM-BASED INHIBITION OF CYTOCHROME P450 3A4 BY THERAPEUTIC DRUGS.CLINICAL PHARMACOKINETICS. VOL. 44. ISSUE 3. P. 279 -304 100 33% 249
5 NETTLETON, DO , EINOLF, HJ , (2011) ASSESSMENT OF CYTOCHROME P450 ENZYME INHIBITION AND INACTIVATION IN DRUG DISCOVERY AND DEVELOPMENT.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 4. P. 382-403 58 62% 21
6 ZHOU, SF , (2008) DRUGS BEHAVE AS SUBSTRATES, INHIBITORS AND INDUCERS OF HUMAN CYTOCHROME P450 3A4.CURRENT DRUG METABOLISM. VOL. 9. ISSUE 4. P. 310-322 62 43% 243
7 HOHMANN, N , HAEFELI, WE , MIKUS, G , (2016) CYP3A ACTIVITY: TOWARDS DOSE ADAPTATION TO THE INDIVIDUAL.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 12. ISSUE 5. P. 479 -497 63 46% 1
8 WONG, SG , (2011) PREDICTION OF DRUG-DRUG INTERACTIONS ARISING FROM MECHANISM-BASED INACTIVATION: KEY INPUT PARAMETERS AND IMPACT ON RISK ASSESSMENT.CURRENT DRUG METABOLISM. VOL. 12. ISSUE 9. P. 871-890 58 59% 4
9 QIN, CZ , REN, X , TAN, ZR , CHEN, Y , YIN, JY , YU, J , QU, J , ZHOU, HH , LIU, ZQ , (2014) A HIGH-THROUGHPUT INHIBITION SCREENING OF MAJOR HUMAN CYTOCHROME P450 ENZYMES USING AN IN VITRO COCKTAIL AND LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY.BIOMEDICAL CHROMATOGRAPHY. VOL. 28. ISSUE 2. P. 197-203 28 88% 29
10 THUMMEL, KE , WILKINSON, GR , (1998) IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 38. ISSUE . P. 389 -430 82 33% 594

Classes with closest relation at Level 1


Rank Class id link
1 6572 SITE OF METABOLISM//CYTOCHROME P450//ATYPICAL KINETICS
2 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
3 6576 GRAPEFRUIT JUICE//HERB DRUG INTERACTION//ST JOHNS WORT
4 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
5 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM
6 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
7 5907 CYP3A5//ABCB1//MDR1
8 33978 AGROCHEMICAL INTERACTIONS//ATENOLOL METABOLIC ACTIONS//METOPROLOL METABOLIC ACTIONS
9 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
10 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR

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