Class information for:
Level 1: PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3955 1875 50.6 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
3955 1                   PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR 1875

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PREGNANE X RECEPTOR authKW 2339644 11% 69% 209
2 PXR authKW 1790035 10% 61% 181
3 CONSTITUTIVE ANDROSTANE RECEPTOR authKW 1538081 6% 78% 121
4 PHARMACOGENET SECT address 524575 5% 35% 91
5 CAR authKW 377718 6% 20% 114
6 PREGNANE X RECEPTOR PXR authKW 297493 1% 70% 26
7 NUCLEAR RECEPTOR authKW 274758 11% 8% 213
8 REPROD DEV TOXICOL address 244542 5% 16% 94
9 CONSTITUTIVE ANDROSTANE RECEPTOR CAR authKW 202692 1% 66% 19
10 CYP3A4 authKW 174013 6% 10% 110

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 14084 51% 0% 947
2 Toxicology 5178 16% 0% 304
3 Biochemistry & Molecular Biology 1461 26% 0% 492
4 Biophysics 277 5% 0% 103
5 Endocrinology & Metabolism 167 5% 0% 92
6 Chemistry, Medicinal 148 3% 0% 64
7 Integrative & Complementary Medicine 64 1% 0% 16
8 Cell Biology 64 5% 0% 97
9 Gastroenterology & Hepatology 61 3% 0% 48
10 Medicine, Research & Experimental 33 3% 0% 53

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENET SECT 524575 5% 35% 91
2 REPROD DEV TOXICOL 244542 5% 16% 94
3 NUCL RECEPTOR DISCOVERY 92536 1% 32% 18
4 PL PHARMACEUT EDUC 61371 0% 54% 7
5 DRUG METAB MOL TOXICOL 57008 1% 15% 23
6 PHARMACOGENET 53462 3% 6% 53
7 U632 50639 1% 22% 14
8 CHEM BIOL THER EUT 45434 2% 9% 31
9 PHARMACOL NEUROBIOL 40765 1% 12% 21
10 HLTH SCI MED TOXICOL 32568 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 81665 10% 3% 194
2 CURRENT DRUG METABOLISM 22564 2% 4% 39
3 DRUG METABOLISM AND PHARMACOKINETICS 21645 2% 4% 31
4 MOLECULAR PHARMACOLOGY 16933 5% 1% 101
5 TOXICOLOGICAL SCIENCES 8614 3% 1% 51
6 DRUG METABOLISM REVIEWS 5877 1% 2% 19
7 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 5727 1% 2% 21
8 XENOBIOTICA 5702 2% 1% 37
9 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 3470 1% 1% 15
10 BIOCHEMICAL PHARMACOLOGY 3192 3% 0% 61

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PREGNANE X RECEPTOR 2339644 11% 69% 209 Search PREGNANE+X+RECEPTOR Search PREGNANE+X+RECEPTOR
2 PXR 1790035 10% 61% 181 Search PXR Search PXR
3 CONSTITUTIVE ANDROSTANE RECEPTOR 1538081 6% 78% 121 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR
4 CAR 377718 6% 20% 114 Search CAR Search CAR
5 PREGNANE X RECEPTOR PXR 297493 1% 70% 26 Search PREGNANE+X+RECEPTOR+PXR Search PREGNANE+X+RECEPTOR+PXR
6 NUCLEAR RECEPTOR 274758 11% 8% 213 Search NUCLEAR+RECEPTOR Search NUCLEAR+RECEPTOR
7 CONSTITUTIVE ANDROSTANE RECEPTOR CAR 202692 1% 66% 19 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR+CAR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR+CAR
8 CYP3A4 174013 6% 10% 110 Search CYP3A4 Search CYP3A4
9 XENOBIOTIC RECEPTOR 131350 1% 73% 11 Search XENOBIOTIC+RECEPTOR Search XENOBIOTIC+RECEPTOR
10 HPXR 115794 0% 89% 8 Search HPXR Search HPXR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CHAI, SC , CHERIAN, MT , WANG, YM , CHEN, TS , (2016) SMALL-MOLECULE MODULATORS OF PXR AND CAR.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS. VOL. 1859. ISSUE 9. P. 1141 -1154 139 91% 0
2 STANLEY, LA , HORSBURGH, BC , ROSS, J , SCHEER, N , WOLF, CR , (2006) PXR AND CAR: NUCLEAR RECEPTORS WHICH PLAY A PIVOTAL ROLE IN DRUG DISPOSITION AND CHEMICAL TOXICITY.DRUG METABOLISM REVIEWS. VOL. 38. ISSUE 3. P. 515-597 175 80% 82
3 HANDSCHIN, C , MEYER, UA , (2003) INDUCTION OF DRUG METABOLISM: THE ROLE OF NUCLEAR RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 55. ISSUE 4. P. 649-673 181 68% 276
4 DI MASI, A , DE MARINIS, E , ASCENZI, P , MARINO, M , (2009) NUCLEAR RECEPTORS CAR AND PXR: MOLECULAR, FUNCTIONAL, AND BIOMEDICAL ASPECTS.MOLECULAR ASPECTS OF MEDICINE. VOL. 30. ISSUE 5. P. 297-343 167 58% 134
5 CHERIAN, MT , CHAI, SC , CHEN, TS , (2015) SMALL-MOLECULE MODULATORS OF THE CONSTITUTIVE ANDROSTANE RECEPTOR.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 11. ISSUE 7. P. 1099 -1114 127 83% 1
6 CHAI, XJ , ZENG, S , XIE, W , (2013) NUCLEAR RECEPTORS PXR AND CAR: IMPLICATIONS FOR DRUG METABOLISM REGULATION, PHARMACOGENOMICS AND BEYOND.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 9. ISSUE 3. P. 253-266 97 72% 41
7 WANG, YM , ONG, SS , CHAI, SC , CHEN, TS , (2012) ROLE OF CAR AND PXR IN XENOBIOTIC SENSING AND METABOLISM.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 8. ISSUE 7. P. 803 -817 98 76% 41
8 BANERJEE, M , ROBBINS, D , CHEN, TS , (2015) TARGETING XENOBIOTIC RECEPTORS PXR AND CAR IN HUMAN DISEASES.DRUG DISCOVERY TODAY. VOL. 20. ISSUE 5. P. 618 -628 77 81% 17
9 CHEN, YK , TANG, Y , GUO, CX , WANG, JH , BORAL, D , NIE, DT , (2012) NUCLEAR RECEPTORS IN THE MULTIDRUG RESISTANCE THROUGH THE REGULATION OF DRUG-METABOLIZING ENZYMES AND DRUG TRANSPORTERS.BIOCHEMICAL PHARMACOLOGY. VOL. 83. ISSUE 8. P. 1112-1126 127 50% 77
10 TOLSON, AH , WANG, HB , (2010) REGULATION OF DRUG-METABOLIZING ENZYMES BY XENOBIOTIC RECEPTORS: PXR AND CAR.ADVANCED DRUG DELIVERY REVIEWS. VOL. 62. ISSUE 13. P. 1238-1249 108 63% 103

Classes with closest relation at Level 1


Rank Class id link
1 33965 HSA MIR 29A 3P//PHARMACOEPIGENETICS//ABCC2 HAPLOTYPE
2 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
3 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
4 5462 FARNESOID X RECEPTOR//FXR//TGR5
5 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
6 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
7 5907 CYP3A5//ABCB1//MDR1
8 11861 THERAPEUTIC PROTEIN DRUG INTERACTION//ROLLINS 5119//9000 X G SUPERNATANT
9 37689 LIRIOPE PLATYPHYLLA//NCI H716//WELLBEING PROD
10 37204 17 BETA ESTRADIOLUM//26S PROTEASOME NON ATPASE REGULATORY SUBUNIT 13//BIOMED SEVILLE IBISSERV INFECT DIS

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