Class information for:
Level 1: CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1626 2563 41.5 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
1626 1                   CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM 2563

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYP2D6 authKW 2650155 19% 45% 490
2 DEBRISOQUINE authKW 1061464 5% 77% 116
3 CYP2D6 POLYMORPHISM authKW 292968 1% 72% 34
4 POOR METABOLIZER authKW 271879 2% 53% 43
5 DEXTROMETHORPHAN authKW 252064 4% 19% 113
6 CYTOCHROME P450 2D6 authKW 234375 2% 40% 49
7 PHARMACOGENETICS journal 175311 5% 12% 118
8 CYP2D610 authKW 148272 1% 66% 19
9 ULTRARAPID METABOLIZER authKW 127621 1% 71% 15
10 DEBRISOQUINE 4 HYDROXYLASE authKW 122875 1% 74% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 33291 65% 0% 1678
2 Medical Laboratory Technology 3520 6% 0% 163
3 Psychiatry 3018 13% 0% 339
4 Toxicology 1616 8% 0% 210
5 Medicine, Legal 236 1% 0% 29
6 Genetics & Heredity 215 5% 0% 135
7 Clinical Neurology 143 5% 0% 125
8 Chemistry, Analytical 96 4% 0% 108
9 Neurosciences 46 5% 0% 136
10 Biochemical Research Methods 43 2% 0% 61

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CICAB CLIN 122156 1% 51% 20
2 SECT DEV PHARMACOL EXPT THER EUT 72946 1% 44% 14
3 CLIN PHARMACOL TOXICOL THER EUT INNOVAT 35021 0% 29% 10
4 DEV PHARMACOL EXPT THER EUT 26801 0% 75% 3
5 CLIN PHARMACOL TOXICOL INNOVAT THER EUT 23824 0% 100% 2
6 S HLTH CHEM 23824 0% 100% 2
7 EASTERN STATE HOSP 22550 0% 16% 12
8 NUCLEOTIDE POLYMORPHISM 21439 0% 60% 3
9 CLIN PHARMACOL 21324 8% 1% 211
10 CICAB 20412 0% 29% 6

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENETICS 175311 5% 12% 118
2 CLINICAL PHARMACOLOGY & THERAPEUTICS 55595 6% 3% 165
3 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 38313 6% 2% 151
4 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 28664 5% 2% 140
5 THERAPEUTIC DRUG MONITORING 25727 4% 2% 90
6 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 18514 3% 2% 65
7 PHARMACOGENOMICS 18107 2% 3% 52
8 DRUG METABOLISM AND DISPOSITION 9061 3% 1% 76
9 PHARMACOGENOMICS JOURNAL 8650 1% 3% 24
10 PHARMACOGENETICS AND GENOMICS 4166 1% 2% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYP2D6 2650155 19% 45% 490 Search CYP2D6 Search CYP2D6
2 DEBRISOQUINE 1061464 5% 77% 116 Search DEBRISOQUINE Search DEBRISOQUINE
3 CYP2D6 POLYMORPHISM 292968 1% 72% 34 Search CYP2D6+POLYMORPHISM Search CYP2D6+POLYMORPHISM
4 POOR METABOLIZER 271879 2% 53% 43 Search POOR+METABOLIZER Search POOR+METABOLIZER
5 DEXTROMETHORPHAN 252064 4% 19% 113 Search DEXTROMETHORPHAN Search DEXTROMETHORPHAN
6 CYTOCHROME P450 2D6 234375 2% 40% 49 Search CYTOCHROME+P450+2D6 Search CYTOCHROME+P450+2D6
7 PHARMACOGENETICS 173516 10% 6% 248 Search PHARMACOGENETICS Search PHARMACOGENETICS
8 CYP2D610 148272 1% 66% 19 Search CYP2D610 Search CYP2D610
9 ULTRARAPID METABOLIZER 127621 1% 71% 15 Search ULTRARAPID+METABOLIZER Search ULTRARAPID+METABOLIZER
10 DEBRISOQUINE 4 HYDROXYLASE 122875 1% 74% 14 Search DEBRISOQUINE+4+HYDROXYLASE Search DEBRISOQUINE+4+HYDROXYLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LLERENA, A , NARANJO, MEG , RODRIGUES-SOARES, F , PENAS-LLEDO, EM , FARINAS, H , TARAZONA-SANTOS, E , (2014) INTERETHNIC VARIABILITY OF CYP2D6 ALLELES AND OF PREDICTED AND MEASURED METABOLIC PHENOTYPES ACROSS WORLD POPULATIONS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 11. P. 1569 -1583 162 92% 18
2 ZHOU, SF , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 2D6 AND ITS CLINICAL SIGNIFICANCE PART I.CLINICAL PHARMACOKINETICS. VOL. 48. ISSUE 11. P. 689-723 211 51% 251
3 ZANGER, UM , RAIMUNDO, S , EICHELBAUM, M , (2004) CYTOCHROME P450 2D6: OVERVIEW AND UPDATE ON PHARMACOLOGY, GENETICS, BIOCHEMISTRY.NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. VOL. 369. ISSUE 1. P. 23-37 110 84% 429
4 TEH, LK , BERTILSSON, L , (2012) PHARMACOGENOMICS OF CYP2D6: MOLECULAR GENETICS, INTERETHNIC DIFFERENCES AND CLINICAL IMPORTANCE.DRUG METABOLISM AND PHARMACOKINETICS. VOL. 27. ISSUE 1. P. 55-67 107 79% 63
5 ZHOU, SF , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 2D6 AND ITS CLINICAL SIGNIFICANCE PART II.CLINICAL PHARMACOKINETICS. VOL. 48. ISSUE 12. P. 761-804 174 43% 136
6 HICKS, JK , SWEN, JJ , GAEDIGK, A , (2014) CHALLENGES IN CYP2D6 PHENOTYPE ASSIGNMENT FROM GENOTYPE DATA: A CRITICAL ASSESSMENT AND CALL FOR STANDARDIZATION.CURRENT DRUG METABOLISM. VOL. 15. ISSUE 2. P. 218-232 82 81% 29
7 ZHOU, SF , CHOWBAY, B , LIU, JP , (2009) POLYMORPHISM OF HUMAN CYTOCHROME P450 ENZYMES AND ITS CLINICAL IMPACT.DRUG METABOLISM REVIEWS. VOL. 41. ISSUE 2. P. 89 -295 311 18% 269
8 GAEDIGK, A , (2013) COMPLEXITIES OF CYP2D6 GENE ANALYSIS AND INTERPRETATION.INTERNATIONAL REVIEW OF PSYCHIATRY. VOL. 25. ISSUE 5. P. 534-553 91 71% 29
9 NEAFSEY, P , GINSBERG, G , HATTIS, D , SONAWANE, B , (2009) GENETIC POLYMORPHISM IN CYTOCHROME P450 2D6 (CYP2D6): POPULATION DISTRIBUTION OF CYP2D6 ACTIVITY.JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. VOL. 12. ISSUE 5-6. P. 334 -361 93 67% 43
10 LLORET-LINARES, C , BELLIVIER, F , HAFFEN, E , AUBRY, JM , DAALI, Y , HERON, K , BERNEY, P , DESMEULES, J , BESSON, M , (2015) MARKERS OF INDIVIDUAL DRUG METABOLISM: TOWARDS THE DEVELOPMENT OF A PERSONALIZED ANTIDEPRESSANT PRESCRIPTION.CURRENT DRUG METABOLISM. VOL. 16. ISSUE 1. P. 17 -45 103 55% 3

Classes with closest relation at Level 1


Rank Class id link
1 22160 5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM
2 19527 ENDOXIFEN//TAMOXIFEN//N DESMETHYLTAMOXIFEN
3 6086 CYP2C19//OMEPRAZOLE//PANTOPRAZOLE
4 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
5 12254 NORFLUOXETINE//CITALOPRAM//FLUOXETINE
6 8529 TRICYCLIC ANTIDEPRESSANTS//NORTRIPTYLINE//DOXEPIN
7 7609 9 HYDROXYRISPERIDONE//NORCLOZAPINE//CLOZAPINE
8 8662 PHARMACOGENOMICS//HLA B5701//PERSONALIZED MEDICINE
9 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
10 17688 DEXTROMETHORPHAN//COUGH AND COLD MEDICATIONS//DIMEMORFAN

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