Class information for:
Level 1: THERAPEUTIC PROTEIN DRUG INTERACTION//ROLLINS 5119//9000 X G SUPERNATANT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11861 948 38.0 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
11861 1                   THERAPEUTIC PROTEIN DRUG INTERACTION//ROLLINS 5119//9000 X G SUPERNATANT 948

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THERAPEUTIC PROTEIN DRUG INTERACTION authKW 128835 0% 100% 4
2 ROLLINS 5119 address 72468 0% 75% 3
3 9000 X G SUPERNATANT authKW 64418 0% 100% 2
4 CYTOCHROME P450 INFLAMMATION authKW 64418 0% 100% 2
5 DISEASE DRUG INTERACTION authKW 64418 0% 100% 2
6 PHARMACOINFORMAT MED UNIT address 64418 0% 100% 2
7 CYTOCHROME P450 authKW 49863 12% 1% 114
8 CYTOCHROME P4502B1 2 authKW 42944 0% 67% 2
9 PHYSIOL PHARM CLIN address 42944 0% 67% 2
10 CANC PHARMACOL UNIT address 36593 1% 23% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 10836 62% 0% 584
2 Toxicology 933 10% 0% 95
3 Immunology 81 6% 0% 60
4 Biochemistry & Molecular Biology 66 12% 0% 111
5 Parasitiology 47 2% 0% 16
6 Gastroenterology & Hepatology 47 3% 0% 28
7 Medicine, Research & Experimental 45 4% 0% 36
8 Biophysics 39 3% 0% 33
9 Chemistry, Medicinal 37 3% 0% 25
10 Critical Care Medicine 20 1% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ROLLINS 5119 72468 0% 75% 3
2 PHARMACOINFORMAT MED UNIT 64418 0% 100% 2
3 PHYSIOL PHARM CLIN 42944 0% 67% 2
4 CANC PHARMACOL UNIT 36593 1% 23% 5
5 BIOCHEM MKT 32209 0% 100% 1
6 BIOL EVALUAT PROD QUAL CONTROL 32209 0% 100% 1
7 BIOL SCIOSWALDO CRUZ FDN 32209 0% 100% 1
8 BIOMED CLIN SCICNR NEUROSCI 32209 0% 100% 1
9 BIOPHARMACEUT BIOPHARMACEUT 32209 0% 100% 1
10 CANC PHARAMCOL UNIT 32209 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 27437 8% 1% 80
2 BIOCHEMICAL PHARMACOLOGY 6863 7% 0% 63
3 XENOBIOTICA 3638 2% 1% 21
4 CURRENT DRUG METABOLISM 3541 1% 1% 11
5 INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 1905 1% 1% 11
6 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 1720 4% 0% 34
7 JOURNAL OF INTERFERON RESEARCH 1613 1% 1% 7
8 CLINICAL PHARMACOLOGY & THERAPEUTICS 1571 2% 0% 17
9 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 1390 1% 0% 10
10 DRUG METABOLISM REVIEWS 1155 1% 1% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THERAPEUTIC PROTEIN DRUG INTERACTION 128835 0% 100% 4 Search THERAPEUTIC+PROTEIN+DRUG+INTERACTION Search THERAPEUTIC+PROTEIN+DRUG+INTERACTION
2 9000 X G SUPERNATANT 64418 0% 100% 2 Search 9000+X+G+SUPERNATANT Search 9000+X+G+SUPERNATANT
3 CYTOCHROME P450 INFLAMMATION 64418 0% 100% 2 Search CYTOCHROME+P450+INFLAMMATION Search CYTOCHROME+P450+INFLAMMATION
4 DISEASE DRUG INTERACTION 64418 0% 100% 2 Search DISEASE+DRUG+INTERACTION Search DISEASE+DRUG+INTERACTION
5 CYTOCHROME P450 49863 12% 1% 114 Search CYTOCHROME+P450 Search CYTOCHROME+P450
6 CYTOCHROME P4502B1 2 42944 0% 67% 2 Search CYTOCHROME+P4502B1+2 Search CYTOCHROME+P4502B1+2
7 21 AMINOSTEROID U74389G 32209 0% 100% 1 Search 21+AMINOSTEROID+U74389G Search 21+AMINOSTEROID+U74389G
8 4 9 DICHLORODIBENZODIOXIN 32209 0% 100% 1 Search 4+9+DICHLORODIBENZODIOXIN Search 4+9+DICHLORODIBENZODIOXIN
9 5 CFDA 32209 0% 100% 1 Search 5+CFDA Search 5+CFDA
10 ACUTE PHASE RESPONSES DRUG METABOLISM 32209 0% 100% 1 Search ACUTE+PHASE+RESPONSES+DRUG+METABOLISM Search ACUTE+PHASE+RESPONSES+DRUG+METABOLISM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RENTON, KW , (2001) ALTERATION OF DRUG BIOTRANSFORMATION AND ELIMINATION DURING INFECTION AND INFLAMMATION.PHARMACOLOGY & THERAPEUTICS. VOL. 92. ISSUE 2-3. P. 147 -163 129 71% 119
2 MORGAN, ET , (1997) REGULATION OF CYTOCHROMES P450 DURING INFLAMMATION AND INFECTION.DRUG METABOLISM REVIEWS. VOL. 29. ISSUE 4. P. 1129 -1188 124 52% 303
3 RENTON, KW , (2004) CYTOCHROME P450 REGULATION AND DRUG BIOTRANSFORMATION DURING INFLAMMATION AND INFECTION.CURRENT DRUG METABOLISM. VOL. 5. ISSUE 3. P. 235-243 72 66% 92
4 EVERS, R , DALLAS, S , DICKMANN, LJ , FAHMI, OA , KENNY, JR , KRAYNOV, E , NGUYEN, T , PATEL, AH , SLATTER, JG , ZHANG, L , (2013) CRITICAL REVIEW OF PRECLINICAL APPROACHES TO INVESTIGATE CYTOCHROME P450-MEDIATED THERAPEUTIC PROTEIN DRUG-DRUG INTERACTIONS AND RECOMMENDATIONS FOR BEST PRACTICES: A WHITE PAPER.DRUG METABOLISM AND DISPOSITION. VOL. 41. ISSUE 9. P. 1598-1609 43 75% 15
5 MORGAN, ET , GORALSKI, KB , PIQUETTE-MILLER, M , RENTON, KW , ROBERTSON, GR , CHALUVADI, MR , CHARLES, KA , CLARKE, SJ , KACEVSKA, M , LIDDLE, C , ET AL (2008) REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFECTION, INFLAMMATION, AND CANCER.DRUG METABOLISM AND DISPOSITION. VOL. 36. ISSUE 2. P. 205-216 36 63% 163
6 AITKEN, AE , RICHARDSON, TA , MORGAN, ET , (2006) REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFLAMMATION.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 46. ISSUE . P. 123 -149 56 37% 175
7 MORGAN, ET , (2009) IMPACT OF INFECTIOUS AND INFLAMMATORY DISEASE ON CYTOCHROME P450-MEDIATED DRUG METABOLISM AND PHARMACOKINETICS.CLINICAL PHARMACOLOGY & THERAPEUTICS. VOL. 85. ISSUE 4. P. 434-438 25 78% 106
8 LEE, JI , ZHANG, L , MEN, AY , KENNA, LA , HUANG, SM , (2010) CYP-MEDIATED THERAPEUTIC PROTEIN-DRUG INTERACTIONS CLINICAL FINDINGS, PROPOSED MECHANISMS AND REGULATORY IMPLICATIONS.CLINICAL PHARMACOKINETICS. VOL. 49. ISSUE 5. P. 295 -310 29 69% 36
9 RENTON, KW , (2000) HEPATIC DRUG METABOLISM AND IMMUNOSTIMULATION.TOXICOLOGY. VOL. 142. ISSUE 3. P. 173 -178 39 72% 21
10 CHRISTENSEN, H , HERMANN, M , (2012) IMMUNOLOGICAL RESPONSE AS A SOURCE TO VARIABILITY IN DRUG METABOLISM AND TRANSPORT.FRONTIERS IN PHARMACOLOGY. VOL. 3. ISSUE . P. - 45 43% 13

Classes with closest relation at Level 1


Rank Class id link
1 17720 ANTIPYRINE//ZAKLAD CHEM FIZJOL//ZAKLAD CHEM FIZJOLOGICZNEJ
2 27027 CAMEL TISSUES//4 HNE 4 HYDROXYNONENAL//CALCIUM ATP PHOSPHOHYDROLASE
3 30098 ADRENAL GLAND CORTICOSTERONE//BIOCHEMICAL INDICATOR ANALYSIS//CARDIO GREEN
4 34706 BURSAL DISEASE VIRUS BDV//VIRUS VACCINE THERAPY//ACTA MICROBIOLOGICA HUNGARICA
5 25846 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE
6 10357 CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE
7 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
8 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
9 28454 KLEBSIELLA PNEUMONIAE ENDOTOXIN//BACTERIAL TOXIN//5 CHLORO 7 IODO 8 HYDROXYQUINOLINE
10 22160 5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM

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