Class information for:
Level 2: ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1613 7077 35.8 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
547 3       ACETAMINOPHEN//CARBON MONOXIDE POISONING//POISONING 18371
1613 2             ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY 7077
1628 1                   ACETAMINOPHEN//PARACETAMOL//HEPATOTOXICITY 2562
5104 1                   DRUG INDUCED LIVER INJURY//HEPATOTOXICITY//HERB INDUCED LIVER INJURY 1672
11878 1                   CHLOROFLUOROCARBON SUBSTITUTE//HALOTHANE//CARDIAC SENSITIZATION 947
15943 1                   TRICHLOROMETHYLPEROXYL//TRICHLOROMETHYL//CELL SURFACE BLEBS 682
16328 1                   CHLOROFORM//LOUISIANA TOXICOL//HEPATOCELLULAR REGENERATION 660
25344 1                   THIOACETAMIDE//THIOACETAMIDE HEPATOTOXICITY//U72 RECH GRP 284
25846 1                   IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE 270

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACETAMINOPHEN authKW 875486 10% 28% 739
2 DRUG INDUCED LIVER INJURY authKW 519656 3% 49% 246
3 HEPATOTOXICITY authKW 510891 9% 18% 664
4 PARACETAMOL authKW 112424 3% 11% 233
5 THIOACETAMIDE authKW 92462 1% 21% 101
6 HERB INDUCED LIVER INJURY authKW 78411 0% 91% 20
7 DILI authKW 73507 1% 47% 36
8 ACETAMINOPHEN HEPATOTOXICITY authKW 73144 0% 81% 21
9 CAUSALITY ASSESSMENT authKW 58470 0% 47% 29
10 LIVER INJURY authKW 54390 2% 9% 136

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Toxicology 54044 26% 1% 1868
2 Pharmacology & Pharmacy 21328 33% 0% 2342
3 Gastroenterology & Hepatology 14801 14% 0% 1019
4 Anesthesiology 2643 4% 0% 282
5 Medicine, General & Internal 1124 7% 0% 529
6 Pathology 1040 4% 0% 291
7 Emergency Medicine 337 1% 0% 78
8 Integrative & Complementary Medicine 268 1% 0% 63
9 Chemistry, Medicinal 222 2% 0% 174
10 Medicine, Research & Experimental 191 3% 0% 225

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IND ENVIRONM SOCIAL MED 30667 0% 89% 8
2 KLINIKUM HANAU 29563 0% 57% 12
3 MOL CELLULAR TOXICOL SECT 26268 0% 38% 16
4 PHARMACOL TOXICOL THER EUT 26040 1% 8% 80
5 LOUISIANA TOXICOL 21129 0% 70% 7
6 HOSP UNIV VIRGEN VICTORIA 19593 0% 45% 10
7 SECT CLIN PHARMACOL TOXICOL 17966 0% 30% 14
8 NPIS EDINBURGH 17381 0% 37% 11
9 SCOTTISH POISONS INFORMAT BUR 15953 0% 22% 17
10 CLIN TOXICOL PROGRAM 15088 0% 50% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TOXICOLOGY AND APPLIED PHARMACOLOGY 39199 4% 3% 300
2 TOXICOLOGY 12611 2% 2% 144
3 TOXICOLOGY LETTERS 11407 2% 2% 150
4 BIOCHEMICAL PHARMACOLOGY 11391 3% 1% 224
5 TOXICOLOGICAL SCIENCES 10718 2% 2% 111
6 CLINICAL TOXICOLOGY 10690 1% 4% 61
7 FUNDAMENTAL AND APPLIED TOXICOLOGY 9329 1% 3% 68
8 HEPATOLOGY 8166 2% 1% 152
9 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 7373 1% 3% 63
10 DRUG METABOLISM AND DISPOSITION 6160 1% 1% 105

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ACETAMINOPHEN 875486 10% 28% 739 Search ACETAMINOPHEN Search ACETAMINOPHEN
2 DRUG INDUCED LIVER INJURY 519656 3% 49% 246 Search DRUG+INDUCED+LIVER+INJURY Search DRUG+INDUCED+LIVER+INJURY
3 HEPATOTOXICITY 510891 9% 18% 664 Search HEPATOTOXICITY Search HEPATOTOXICITY
4 PARACETAMOL 112424 3% 11% 233 Search PARACETAMOL Search PARACETAMOL
5 THIOACETAMIDE 92462 1% 21% 101 Search THIOACETAMIDE Search THIOACETAMIDE
6 HERB INDUCED LIVER INJURY 78411 0% 91% 20 Search HERB+INDUCED+LIVER+INJURY Search HERB+INDUCED+LIVER+INJURY
7 DILI 73507 1% 47% 36 Search DILI Search DILI
8 ACETAMINOPHEN HEPATOTOXICITY 73144 0% 81% 21 Search ACETAMINOPHEN+HEPATOTOXICITY Search ACETAMINOPHEN+HEPATOTOXICITY
9 CAUSALITY ASSESSMENT 58470 0% 47% 29 Search CAUSALITY+ASSESSMENT Search CAUSALITY+ASSESSMENT
10 LIVER INJURY 54390 2% 9% 136 Search LIVER+INJURY Search LIVER+INJURY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BESSEMS, JGM , VERMEULEN, NPE , (2001) PARACETAMOL (ACETAMINOPHEN)-INDUCED TOXICITY: MOLECULAR AND BIOCHEMICAL MECHANISMS, ANALOGUES AND PROTECTIVE APPROACHES.CRITICAL REVIEWS IN TOXICOLOGY. VOL. 31. ISSUE 1. P. 55 -138 267 73% 322
2 DANAN, G , TESCHKE, R , (2016) RUCAM IN DRUG AND HERB INDUCED LIVER INJURY: THE UPDATE.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. VOL. 17. ISSUE 1. P. - 86 80% 7
3 MCGILL, MR , JAESCHKE, H , (2013) METABOLISM AND DISPOSITION OF ACETAMINOPHEN: RECENT ADVANCES IN RELATION TO HEPATOTOXICITY AND DIAGNOSIS.PHARMACEUTICAL RESEARCH. VOL. 30. ISSUE 9. P. 2174-2187 111 67% 72
4 LEWIS, JH , (2015) THE ART AND SCIENCE OF DIAGNOSING AND MANAGING DRUG-INDUCED LIVER INJURY IN 2015 AND BEYOND.CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. VOL. 13. ISSUE 12. P. 2173 -+ 121 66% 9
5 TESCHKE, R , EICKHOFF, A , (2015) HERBAL HEPATOTOXICITY IN TRADITIONAL AND MODERN MEDICINE: ACTUAL KEY ISSUES AND NEW ENCOURAGING STEPS.FRONTIERS IN PHARMACOLOGY. VOL. 6. ISSUE . P. - 110 64% 6
6 FRENZEL, C , TESCHKE, R , (2016) HERBAL HEPATOTOXICITY: CLINICAL CHARACTERISTICS AND LISTING COMPILATION.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. VOL. 17. ISSUE 5. P. - 100 59% 4
7 JAESCHKE, H , MCGILL, MR , RAMACHANDRAN, A , (2012) OXIDANT STRESS, MITOCHONDRIA, AND CELL DEATH MECHANISMS IN DRUG-INDUCED LIVER INJURY: LESSONS LEARNED FROM ACETAMINOPHEN HEPATOTOXICITY.DRUG METABOLISM REVIEWS. VOL. 44. ISSUE 1. P. 88 -106 102 49% 151
8 PRESCOTT, LF , (2000) PARACETAMOL, ALCOHOL AND THE LIVER.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 49. ISSUE 4. P. 291 -301 106 88% 84
9 JAESCHKE, H , MCGILL, MR , WILLIAMS, CD , RAMACHANDRAN, A , (2011) CURRENT ISSUES WITH ACETAMINOPHEN HEPATOTOXICITY-A CLINICALLY RELEVANT MODEL TO TEST THE EFFICACY OF NATURAL PRODUCTS.LIFE SCIENCES. VOL. 88. ISSUE 17-18. P. 737-745 78 79% 71
10 JAESCHKE, H , WILLIAMS, CD , MCGILL, MR , XIE, YC , RAMACHANDRAN, A , (2013) MODELS OF DRUG-INDUCED LIVER INJURY FOR EVALUATION OF PHYTOTHERAPEUTICS AND OTHER NATURAL PRODUCTS.FOOD AND CHEMICAL TOXICOLOGY. VOL. 55. ISSUE . P. 279-289 93 67% 26

Classes with closest relation at Level 2


Rank Class id link
1 2783 PLASTIC BRONCHITIS//LIPOID PNEUMONIA//POISONING
2 2563 TRAMADOL//DIPYRONE//TAPENTADOL
3 2978 PHARMACOVIGILANCE//ADVERSE DRUG REACTIONS//DRUG SAFETY
4 1310 HEPATIC STELLATE CELLS//LIVER FIBROSIS//LIVER REGENERATION
5 2486 PYRAZINAMIDE//ISONIAZID//RIFAMPICIN
6 3033 CARCINOGENESIS//HEPATOCARCINOGENESIS//MEDIUM TERM BIOASSAY
7 908 BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION
8 1550 TOXIC EPIDERMAL NECROLYSIS//STEVENS JOHNSON SYNDROME//DRUG ALLERGY
9 3501 AMBROXOL//ERDOSTEINE//N ACETYLCYSTEINE
10 3459 REGUCALCIN//ENDOCRINOL MOL METAB//SMP30

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