Class information for:
Level 1: 5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22160 391 45.2 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
22160 1                   5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM 391

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 5 METHOXYTRYPTAMINE O DEMETHYLATION authKW 156189 1% 100% 2
2 BRAIN CYPS authKW 156189 1% 100% 2
3 BRAIN DRUG METABOLISM authKW 156189 1% 100% 2
4 CHIMERIC SIGNALS authKW 156189 1% 100% 2
5 CYTOCHROME P4502D authKW 156189 1% 100% 2
6 MICROSOMAL P450S authKW 156189 1% 100% 2
7 TYRAMINE HYDROXYLATION authKW 156189 1% 100% 2
8 CYP2D authKW 138823 2% 22% 8
9 MARIE LOWE COMPARAT ONCOL address 117139 1% 50% 3
10 MARI LOWE COMPARAT ONCOL address 110230 3% 12% 12

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 1191 33% 0% 130
2 Neurosciences 881 29% 0% 113
3 Biochemistry & Molecular Biology 431 30% 0% 118
4 Toxicology 360 10% 0% 38
5 Biophysics 154 8% 0% 32
6 BIOLOGY, MISCELLANEOUS 49 0% 0% 1
7 Endocrinology & Metabolism 21 4% 0% 16
8 Cell Biology 18 6% 0% 22
9 Clinical Neurology 15 4% 0% 17
10 Psychiatry 11 3% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MARIE LOWE COMPARAT ONCOL 117139 1% 50% 3
2 MARI LOWE COMPARAT ONCOL 110230 3% 12% 12
3 ANIM PHYSIOTHER Y 78095 0% 100% 1
4 CNRS URA 1288 78095 0% 100% 1
5 DCTDCFCRDC 78095 0% 100% 1
6 DTP EXPTL THER EUT METAB 78095 0% 100% 1
7 MENTAL HELATH ADDICT 78095 0% 100% 1
8 SCIENTIST DEV TOXICOL 78095 0% 100% 1
9 SIGNALING PLAST CANC 78095 0% 100% 1
10 TOXOCOL UNIT 78095 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FOLIA PSYCHIATRICA ET NEUROLOGICA JAPONICA 3248 1% 1% 3
2 CURRENT DRUG METABOLISM 2558 2% 1% 6
3 DRUG METABOLISM REVIEWS 1954 1% 1% 5
4 DRUG METABOLISM AND DISPOSITION 1741 3% 0% 13
5 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 1558 1% 0% 5
6 BIOCHEMICAL PHARMACOLOGY 1200 4% 0% 17
7 JOURNAL OF NEUROCHEMISTRY 1192 5% 0% 18
8 JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 883 1% 0% 3
9 VITAMINS AND HORMONES SERIES 875 0% 1% 1
10 GENERAL PHARMACOLOGY 818 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 5 METHOXYTRYPTAMINE O DEMETHYLATION 156189 1% 100% 2 Search 5+METHOXYTRYPTAMINE+O+DEMETHYLATION Search 5+METHOXYTRYPTAMINE+O+DEMETHYLATION
2 BRAIN CYPS 156189 1% 100% 2 Search BRAIN+CYPS Search BRAIN+CYPS
3 BRAIN DRUG METABOLISM 156189 1% 100% 2 Search BRAIN+DRUG+METABOLISM Search BRAIN+DRUG+METABOLISM
4 CHIMERIC SIGNALS 156189 1% 100% 2 Search CHIMERIC+SIGNALS Search CHIMERIC+SIGNALS
5 CYTOCHROME P4502D 156189 1% 100% 2 Search CYTOCHROME+P4502D Search CYTOCHROME+P4502D
6 MICROSOMAL P450S 156189 1% 100% 2 Search MICROSOMAL+P450S Search MICROSOMAL+P450S
7 TYRAMINE HYDROXYLATION 156189 1% 100% 2 Search TYRAMINE+HYDROXYLATION Search TYRAMINE+HYDROXYLATION
8 CYP2D 138823 2% 22% 8 Search CYP2D Search CYP2D
9 3D AGGREGATING BRAIN CELL CULTURES 78095 0% 100% 1 Search 3D+AGGREGATING+BRAIN+CELL+CULTURES Search 3D+AGGREGATING+BRAIN+CELL+CULTURES
10 9 METHOXY N 2 METHYLELLIPTICINUM ACETATE 78095 0% 100% 1 Search 9+METHOXY+N+2+METHYLELLIPTICINUM+ACETATE Search 9+METHOXY+N+2+METHYLELLIPTICINUM+ACETATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TOSELLI, F , DODD, PR , GILLAM, EMJ , (2016) EMERGING ROLES FOR BRAIN DRUG-METABOLIZING CYTOCHROME P450 ENZYMES IN NEUROPSYCHIATRIC CONDITIONS AND RESPONSES TO DRUGS.DRUG METABOLISM REVIEWS. VOL. 48. ISSUE 3. P. 379 -404 89 33% 1
2 MIKSYS, S , TYNDALE, RF , (2013) CYTOCHROME P450-MEDIATED DRUG METABOLISM IN THE BRAIN.JOURNAL OF PSYCHIATRY & NEUROSCIENCE. VOL. 38. ISSUE 3. P. 152-163 59 39% 32
3 STROBEL, HW , THOMPSON, CM , ANTONOVIC, L , (2001) CYTOCHROMES P450 IN BRAIN: FUNCTION AND SIGNIFICANCE.CURRENT DRUG METABOLISM. VOL. 2. ISSUE 2. P. 199 -214 57 39% 52
4 KAPOOR, N , PANT, AB , DHAWAN, A , DWIEVEDI, UN , SETH, PK , PARMAR, D , (2007) DIFFERENCES IN THE EXPRESSION AND INDUCIBILITY OF CYTOCHROME P4502B ISOENZYMES IN CULTURED RAT BRAIN NEURONAL AND GLIAL CELLS.MOLECULAR AND CELLULAR BIOCHEMISTRY. VOL. 305. ISSUE 1-2. P. 199 -207 25 68% 5
5 GARCIA-SUASTEGUI, WA , RAMOS-CHAVEZ, LA , RUBIO-OSORNIO, M , CALVILLO-VELASCO, M , ATZIN-MENDEZ, JA , GUEVARA, J , SILVA-ADAYA, D , (2017) THE ROLE OF CYP2E1 IN THE DRUG METABOLISM OR BIOACTIVATION IN THE BRAIN.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. VOL. . ISSUE . P. - 43 31% 0
6 PARMAR, D , DHAWAN, A , DAYAL, M , SETH, PK , (1998) IMMUNOCHEMICAL AND BIOCHEMICAL EVIDENCE FOR EXPRESSION OF PHENOBARBITAL- AND 3-METHYLCHOLANTHRENE-INDUCIBLE ISOENZYMES OF CYTOCHROME P450 IN RAT BRAIN.INTERNATIONAL JOURNAL OF TOXICOLOGY. VOL. 17. ISSUE 6. P. 619-630 30 73% 12
7 GERVASINI, G , CARRILLO, JA , BENITEZ, J , (2004) POTENTIAL ROLE OF CEREBRAL CYTOCHROME P450 IN CLINICAL PHARMACOKINETICS - MODULATION BY ENDOGENOUS COMPOUNDS.CLINICAL PHARMACOKINETICS. VOL. 43. ISSUE 11. P. 693-706 50 34% 40
8 RAVINDRANATH, V , BOYD, MR , (1995) XENOBIOTIC METABOLISM IN BRAIN.DRUG METABOLISM REVIEWS. VOL. 27. ISSUE 3. P. 419-448 43 51% 38
9 RAVINDRANATH, V , (1998) METABOLISM OF XENOBIOTICS IN THE CENTRAL NERVOUS SYSTEM - IMPLICATIONS AND CHALLENGES.BIOCHEMICAL PHARMACOLOGY. VOL. 56. ISSUE 5. P. 547 -551 27 69% 35
10 STROBEL, HW , GENG, J , KAWASHIMA, H , WANG, HM , (1997) CYTOCHROME P450-DEPENDENT BIOTRANSFORMATION OF DRUGS AND OTHER XENOBIOTIC SUBSTRATES IN NEURAL TISSUE.DRUG METABOLISM REVIEWS. VOL. 29. ISSUE 4. P. 1079 -1105 41 47% 18

Classes with closest relation at Level 1


Rank Class id link
1 10357 CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE
2 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM
3 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
4 37263 PHENOBARBITAL HYDROCORTISONE//COLORECTAL TUMOR TISSUE//SENSITIVITY TO HORMONES
5 19656 ACETALDEHYDE//BRAIN CATALASE//AREA PSICOBIOL
6 10330 CYTOCHROME P450 REDUCTASE//CYTOCHROME P4502B4//NADPH CYTOCHROME P450 REDUCTASE
7 36807 ANEMIA IRON DEFICIENCY CARDIOMYOPATHIES//CANADIAN PAEDIAT EPILEPSY NETWORK//COMPLICATIONS KYPHOSCOLIOSIS
8 36429 KETOBEMIDONE//BUCCAL ABSORPTION PRODRUG//KAROLINSKA PHARM PEDIAT CANC UNIT
9 14933 CYP1B1//CYP2S1//CYP2W1
10 24758 AHH INDUCTION//BADEN WUERTTEMBERG HESSE//BIOCHEMICAL SKIN BARRIER

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