Class information for:
Level 1: INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10654 1044 36.1 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
1171 2             JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM 9352
10654 1                   INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION 1044

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERSPECIES SCALING authKW 424520 3% 48% 30
2 VOLUME OF DISTRIBUTION authKW 255858 3% 25% 35
3 STEADY STATE VOLUME OF DISTRIBUTION authKW 247731 1% 71% 12
4 WELL STIRRED MODEL authKW 247127 1% 65% 13
5 COMPUTATIONAL ADME authKW 211289 2% 43% 17
6 TISSUE PLASMA PARTITION COEFFICIENT authKW 204728 1% 100% 7
7 INTRINSIC CLEARANCE authKW 185780 2% 35% 18
8 QSPKR authKW 182785 1% 63% 10
9 TERMINAL VOLUME OF DISTRIBUTION authKW 175481 1% 100% 6
10 HEPATIC CLEARANCE authKW 153568 2% 21% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 22747 84% 0% 876
2 Chemistry, Medicinal 3754 18% 0% 190
3 Toxicology 2046 14% 0% 144
4 Chemistry, Multidisciplinary 820 20% 0% 212
5 Computer Science, Interdisciplinary Applications 43 2% 0% 25
6 Mathematical & Computational Biology 27 1% 0% 13
7 Medical Informatics 12 1% 0% 6
8 Medicine, Legal 12 0% 0% 5
9 Integrative & Complementary Medicine 1 0% 0% 3
10 Social Sciences, Mathematical Methods 1 0% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 WOODMONT OFF 2 143978 1% 62% 8
2 DMPK TRANSLAT SCI 131608 1% 75% 6
3 PL PHARMACOKINET 97940 3% 12% 28
4 CLIN PHARMACOL TOXICOL BRANCH HFD 579 87741 0% 100% 3
5 THER EUT DRUGS FOOD ANIM HFV 130 87741 0% 100% 3
6 PHARMACOKINET DYNAM METAB 80530 5% 6% 49
7 LOCAL DISCOVERY CNS PAIN 58494 0% 100% 2
8 MED MED PATHOL MICROBIOL 58494 0% 100% 2
9 MED PHARM PHARMACEUT SCI 58494 0% 100% 2
10 METABOLISM PHARMACOKINET 58494 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 73494 4% 6% 43
2 DRUG METABOLISM AND DISPOSITION 61911 12% 2% 126
3 JOURNAL OF PHARMACEUTICAL SCIENCES 44832 13% 1% 131
4 XENOBIOTICA 44773 7% 2% 77
5 JOURNAL OF PHARMACOBIO-DYNAMICS 23226 3% 2% 36
6 BIOPHARMACEUTICS & DRUG DISPOSITION 15511 3% 2% 32
7 JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 9722 1% 2% 14
8 PHARMACEUTICAL RESEARCH 7356 4% 1% 45
9 CURRENT DRUG METABOLISM 5212 1% 1% 14
10 CLINICAL PHARMACOKINETICS 4939 2% 1% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INTERSPECIES SCALING 424520 3% 48% 30 Search INTERSPECIES+SCALING Search INTERSPECIES+SCALING
2 VOLUME OF DISTRIBUTION 255858 3% 25% 35 Search VOLUME+OF+DISTRIBUTION Search VOLUME+OF+DISTRIBUTION
3 STEADY STATE VOLUME OF DISTRIBUTION 247731 1% 71% 12 Search STEADY+STATE+VOLUME+OF+DISTRIBUTION Search STEADY+STATE+VOLUME+OF+DISTRIBUTION
4 WELL STIRRED MODEL 247127 1% 65% 13 Search WELL+STIRRED+MODEL Search WELL+STIRRED+MODEL
5 COMPUTATIONAL ADME 211289 2% 43% 17 Search COMPUTATIONAL+ADME Search COMPUTATIONAL+ADME
6 TISSUE PLASMA PARTITION COEFFICIENT 204728 1% 100% 7 Search TISSUE+PLASMA+PARTITION+COEFFICIENT Search TISSUE+PLASMA+PARTITION+COEFFICIENT
7 INTRINSIC CLEARANCE 185780 2% 35% 18 Search INTRINSIC+CLEARANCE Search INTRINSIC+CLEARANCE
8 QSPKR 182785 1% 63% 10 Search QSPKR Search QSPKR
9 TERMINAL VOLUME OF DISTRIBUTION 175481 1% 100% 6 Search TERMINAL+VOLUME+OF+DISTRIBUTION Search TERMINAL+VOLUME+OF+DISTRIBUTION
10 HEPATIC CLEARANCE 153568 2% 21% 25 Search HEPATIC+CLEARANCE Search HEPATIC+CLEARANCE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 JONES, HM , GARDNER, IB , WATSON, KJ , (2009) MODELLING AND PBPK SIMULATION IN DRUG DISCOVERY.AAPS JOURNAL. VOL. 11. ISSUE 1. P. 155-166 51 91% 54
2 FAGERHOLM, U , (2007) PREDICTION OF HUMAN PHARMACOKINETICS - EVALUATION OF METHODS FOR PREDICTION OF HEPATIC METABOLIC CLEARANCE.JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL. 59. ISSUE 6. P. 803 -828 113 44% 34
3 SUN, DX , YU, LX , YANG, YS , ZHENG, N , ZOU, P , (2012) PREDICTION OF VOLUME OF DISTRIBUTION AT STEADY STATE IN HUMANS: COMPARISON OF DIFFERENT APPROACHES.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 8. ISSUE 7. P. 855 -872 50 82% 5
4 JONES, HM , PARROTT, N , JORGA, K , LAVE, T , (2006) A NOVEL STRATEGY FOR PHYSIOLOGICALLY BASED PREDICTIONS OF HUMAN PHARMACOKINETICS.CLINICAL PHARMACOKINETICS. VOL. 45. ISSUE 5. P. 511-542 46 75% 170
5 ZOU, P , YU, YK , ZHENG, N , YANG, YS , PAHOLAK, HJ , YU, LX , SUN, DX , (2012) APPLICATIONS OF HUMAN PHARMACOKINETIC PREDICTION IN FIRST-IN-HUMAN DOSE ESTIMATION.AAPS JOURNAL. VOL. 14. ISSUE 2. P. 262-281 56 63% 11
6 ESPIE, P , TYTGAT, D , SARGENTINI-MAIER, ML , POGGESI, I , WATELET, JB , (2009) PHYSIOLOGICALLY BASED PHARMACOKINETICS (PBPK).DRUG METABOLISM REVIEWS. VOL. 41. ISSUE 3. P. 391-407 51 63% 36
7 DE BUCK, SS , MACKIE, CE , (2007) PHYSIOLOGICALLY BASED APPROACHES TOWARDS THE PREDICTION OF PHARMACOKINETICS: IN VITRO-IN VIVO EXTRAPOLATION.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 3. ISSUE 6. P. 865-878 58 59% 28
8 LOMBARDO, F , WATERS, NJ , ARGIKAR, UA , DENNEHY, MK , ZHAN, J , GUNDUZ, M , HARRIMAN, SP , BERELLINI, G , RAJLIC, IL , OBACH, RS , (2013) COMPREHENSIVE ASSESSMENT OF HUMAN PHARMACOKINETIC PREDICTION BASED ON IN VIVO ANIMAL PHARMACOKINETIC DATA, PART 2: CLEARANCE.JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 53. ISSUE 2. P. 178-191 30 91% 18
9 TEITELBAUM, Z , LAVE, T , FREIJER, J , COHEN, AF , (2010) RISK ASSESSMENT IN EXTRAPOLATION OF PHARMACOKINETICS FROM PRECLINICAL DATA TO HUMANS.CLINICAL PHARMACOKINETICS. VOL. 49. ISSUE 9. P. 619-632 40 77% 4
10 HUANG, QB , RIVIERE, JE , (2014) THE APPLICATION OF ALLOMETRIC SCALING PRINCIPLES TO PREDICT PHARMACOKINETIC PARAMETERS ACROSS SPECIES.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 9. P. 1241 -1253 33 79% 9

Classes with closest relation at Level 1


Rank Class id link
1 12791 SECT PHARMACOKINET//BOF 4272//JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS
2 20325 LOGBB//BLOOD BRAIN PARTITIONING//PAMPA BBB
3 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
4 35824 INO 2628 CZ//EFFICIENCY OF ENTEROHEPATIC CIRCULATION//MNP001
5 5456 OATP1B1//SLCO1B1//OATP
6 8450 PBPK MODELING//HIPPURIC ACID//METHYLHIPPURIC ACID
7 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
8 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
9 1901 BIOPHARMACEUTICS CLASSIFICATION SYSTEM//ORAL ABSORPTION//CACO 2
10 23257 LIVER SLICES//PRECISION CUT LIVER SLICES//PRECISION CUT TISSUE SLICES

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