Class information for:
Level 1: HEPARG CELLS//HEPARG//NEOHEPATOCYTES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
28818 199 45.4 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
537 3       BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 19236
908 2             BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 11255
28818 1                   HEPARG CELLS//HEPARG//NEOHEPATOCYTES 199

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HEPARG CELLS authKW 958072 8% 39% 16
2 HEPARG authKW 903903 9% 33% 18
3 NEOHEPATOCYTES authKW 460333 2% 100% 3
4 IDMOC authKW 345248 2% 75% 3
5 CYP ENGINEERED CELL LINE authKW 306889 1% 100% 2
6 HEPG2 TRANSFORMANTS authKW 306889 1% 100% 2
7 NONCLIN DEV EARLY EXPLANATORY TOXICOL address 306889 1% 100% 2
8 PRIMARY HUMAN HEPATOCYTES authKW 214278 5% 16% 9
9 PROGRAMMABLE CELLS OF MONOCYTIC ORIGIN authKW 204591 1% 67% 2
10 MERCK SERONO address 187110 5% 12% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 5455 49% 0% 98
2 Pharmacology & Pharmacy 892 40% 0% 79
3 Integrative & Complementary Medicine 47 2% 0% 4
4 Cell & Tissue Engineering 47 2% 0% 3
5 Gastroenterology & Hepatology 16 4% 0% 7
6 Medicine, Research & Experimental 16 5% 0% 9
7 Biochemistry & Molecular Biology 15 12% 0% 24
8 Pathology 13 3% 0% 6
9 Cell Biology 11 6% 0% 12
10 Transplantation 6 2% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NONCLIN DEV EARLY EXPLANATORY TOXICOL 306889 1% 100% 2
2 MERCK SERONO 187110 5% 12% 10
3 AIMMS IS MOL TOXICOL 153444 1% 100% 1
4 BG CLIN 153444 1% 100% 1
5 BIOSTAT MED BIOSTAT C060 153444 1% 100% 1
6 BVT 153444 1% 100% 1
7 CN BIO 153444 1% 100% 1
8 DR EDUARDO LICEAGA MED 153444 1% 100% 1
9 EA MDC U522 153444 1% 100% 1
10 EA MDC U620 153444 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TOXICOLOGY IN VITRO 27850 14% 1% 28
2 DRUG METABOLISM AND DISPOSITION 9017 11% 0% 21
3 ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN 7432 2% 1% 4
4 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 4425 3% 0% 6
5 VITAE-REVISTA DE LA FACULTAD DE QUIMICA FARMACEUTICA 3425 1% 1% 2
6 CHEMICO-BIOLOGICAL INTERACTIONS 3276 6% 0% 11
7 TOXICOLOGICAL SCIENCES 3137 5% 0% 10
8 CELL BIOLOGY AND TOXICOLOGY 2092 2% 0% 4
9 TOXICOLOGY AND APPLIED PHARMACOLOGY 990 4% 0% 8
10 XENOBIOTICA 984 3% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HEPARG CELLS 958072 8% 39% 16 Search HEPARG+CELLS Search HEPARG+CELLS
2 HEPARG 903903 9% 33% 18 Search HEPARG Search HEPARG
3 NEOHEPATOCYTES 460333 2% 100% 3 Search NEOHEPATOCYTES Search NEOHEPATOCYTES
4 IDMOC 345248 2% 75% 3 Search IDMOC Search IDMOC
5 CYP ENGINEERED CELL LINE 306889 1% 100% 2 Search CYP+ENGINEERED+CELL+LINE Search CYP+ENGINEERED+CELL+LINE
6 HEPG2 TRANSFORMANTS 306889 1% 100% 2 Search HEPG2+TRANSFORMANTS Search HEPG2+TRANSFORMANTS
7 PRIMARY HUMAN HEPATOCYTES 214278 5% 16% 9 Search PRIMARY+HUMAN+HEPATOCYTES Search PRIMARY+HUMAN+HEPATOCYTES
8 PROGRAMMABLE CELLS OF MONOCYTIC ORIGIN 204591 1% 67% 2 Search PROGRAMMABLE+CELLS+OF+MONOCYTIC+ORIGIN Search PROGRAMMABLE+CELLS+OF+MONOCYTIC+ORIGIN
9 1 AMINOBENZOTRIZOLE 153444 1% 100% 1 Search 1+AMINOBENZOTRIZOLE Search 1+AMINOBENZOTRIZOLE
10 3D MICRO SCAFFOLD 153444 1% 100% 1 Search 3D+MICRO+SCAFFOLD Search 3D+MICRO+SCAFFOLD

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 JETTEN, MJA , KLEINJANS, JCS , CLAESSEN, SM , CHESNE, C , VAN DELFT, JHM , (2013) BASELINE AND GENOTOXIC COMPOUND INDUCED GENE EXPRESSION PROFILES IN HEPG2 AND HEPARG COMPARED TO PRIMARY HUMAN HEPATOCYTES.TOXICOLOGY IN VITRO. VOL. 27. ISSUE 7. P. 2031-2040 21 40% 15
2 HERZOG, N , HANSEN, M , MIETHBAUER, S , SCHMIDTKE, KU , ANDERER, U , LUPP, A , SPERLING, S , SEEHOFER, D , DAMM, G , SCHEIBNER, K , ET AL (2016) PRIMARY-LIKE HUMAN HEPATOCYTES GENETICALLY ENGINEERED TO OBTAIN PROLIFERATION COMPETENCE DISPLAY HEPATIC DIFFERENTIATION CHARACTERISTICS IN MONOLAYER AND ORGANOTYPICAL SPHEROID CULTURES.CELL BIOLOGY INTERNATIONAL. VOL. 40. ISSUE 3. P. 341 -353 19 40% 0
3 HUANG, LZ , ZOU, SX , DENG, JF , DAI, TM , JIANG, JW , JIA, Y , DAI, RK , XIE, SL , (2016) DEVELOPMENT OF AN OPTIMIZED CYTOTOXICITY ASSAY SYSTEM FOR CYP3A4-MEDIATED METABOLIC ACTIVATION VIA MODIFIED PIGGYBAC TRANSPOSITION.TOXICOLOGY IN VITRO. VOL. 32. ISSUE . P. 132 -137 12 55% 1
4 ANDERSSON, TB , KANEBRATT, KP , KENNA, JG , (2012) THE HEPARG CELL LINE: A UNIQUE IN VITRO TOOL FOR UNDERSTANDING DRUG METABOLISM AND TOXICOLOGY IN HUMAN.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 8. ISSUE 7. P. 909 -920 17 39% 39
5 ANTHERIEU, S , CHESNE, C , LI, RY , GUGUEN-GUILLOUZO, C , GUILLOUZO, A , (2012) OPTIMIZATION OF THE HEPARG CELL MODEL FOR DRUG METABOLISM AND TOXICITY STUDIES.TOXICOLOGY IN VITRO. VOL. 26. ISSUE 8. P. 1278-1285 19 35% 33
6 SAVARY, CC , JIANG, XQ , AUBRY, M , JOSSE, R , KOPP-SCHNEIDER, A , HEWITT, P , GUILLOUZO, A , (2015) TRANSCRIPTOMIC ANALYSIS OF UNTREATED AND DRUG-TREATED DIFFERENTIATED HEPARG CELLS OVER A 2-WEEK PERIOD.TOXICOLOGY IN VITRO. VOL. 30. ISSUE 1. P. 27 -35 13 46% 2
7 FERREIRA, A , RODRIGUES, M , SILVESTRE, S , FALCAO, A , ALVES, G , (2014) HEPARG CELL LINE AS AN IN VITRO MODEL FOR SCREENING DRUG-DRUG INTERACTIONS MEDIATED BY METABOLIC INDUCTION: AMIODARONE USED AS A MODEL SUBSTANCE.TOXICOLOGY IN VITRO. VOL. 28. ISSUE 8. P. 1531 -1535 15 38% 0
8 ROGUE, A , LAMBERT, C , SPIRE, C , CLAUDE, N , GUILLOUZO, A , (2012) INTERINDIVIDUAL VARIABILITY IN GENE EXPRESSION PROFILES IN HUMAN HEPATOCYTES AND COMPARISON WITH HEPARG CELLS.DRUG METABOLISM AND DISPOSITION. VOL. 40. ISSUE 1. P. 151-158 12 46% 12
9 GOMEZ-LECHON, MJ , TOLOSA, L , CONDE, I , DONATO, MT , (2014) COMPETENCY OF DIFFERENT CELL MODELS TO PREDICT HUMAN HEPATOTOXIC DRUGS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 10. ISSUE 11. P. 1553 -1568 24 21% 14
10 GERETS, HHJ , TILMANT, K , GERIN, B , CHANTEUX, H , DEPELCHIN, BO , DHALLUIN, S , ATIENZAR, FA , (2012) CHARACTERIZATION OF PRIMARY HUMAN HEPATOCYTES, HEPG2 CELLS, AND HEPARG CELLS AT THE MRNA LEVEL AND CYP ACTIVITY IN RESPONSE TO INDUCERS AND THEIR PREDICTIVITY FOR THE DETECTION OF HUMAN HEPATOTOXINS.CELL BIOLOGY AND TOXICOLOGY. VOL. 28. ISSUE 2. P. 69-87 12 30% 111

Classes with closest relation at Level 1


Rank Class id link
1 14486 TOXICOGENOMICS//CELLULAR MOL TOXICOL//TOXICOGENOM INFORMAT PROJECT
2 3584 BIOARTIFICIAL LIVER//HEPATOCYTES//PORCINE HEPATOCYTES
3 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
4 15462 IN VITRO MITOGENIC STIMULATION//UMR 0938//URIDINE UPTAKE ASSAY
5 33965 HSA MIR 29A 3P//PHARMACOEPIGENETICS//ABCC2 HAPLOTYPE
6 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
7 21702 GREENSCREEN HC//MISLEADING POSITIVE RESULTS//VIRACEPT
8 16805 PHOSPHOLIPIDOSIS//CATIONIC AMPHIPHILIC DRUGS//DRUG INDUCED PHOSPHOLIPIDOSIS
9 12542 REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB
10 25846 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE

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