Class information for:
Level 1: BIOPHARMACEUTICS CLASSIFICATION SYSTEM//ORAL ABSORPTION//CACO 2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1901 2436 40.1 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
1155 2             PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1 9490
1901 1                   BIOPHARMACEUTICS CLASSIFICATION SYSTEM//ORAL ABSORPTION//CACO 2 2436

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPHARMACEUTICS CLASSIFICATION SYSTEM authKW 592189 3% 71% 67
2 ORAL ABSORPTION authKW 434036 5% 28% 125
3 CACO 2 authKW 405653 8% 16% 206
4 DRUG ABSORPTION authKW 318728 3% 30% 85
5 BIORELEVANT MEDIA authKW 303804 2% 61% 40
6 BIOWAIVER authKW 286440 2% 57% 40
7 BIOPHARMACEUTICS CLASSIFICATION SYSTEM BCS authKW 243671 1% 56% 35
8 PAMPA authKW 241068 2% 36% 53
9 HUMAN INTESTINAL FLUID authKW 213723 1% 95% 18
10 INTESTINAL ABSORPTION authKW 201869 6% 11% 143

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 53184 84% 0% 2046
2 Chemistry, Medicinal 8623 18% 0% 440
3 Chemistry, Multidisciplinary 3715 27% 0% 655
4 Medicine, Research & Experimental 403 6% 0% 145
5 Toxicology 230 4% 0% 90
6 Computer Science, Interdisciplinary Applications 60 2% 0% 49
7 Integrative & Complementary Medicine 25 1% 0% 13
8 Mathematical & Computational Biology 24 1% 0% 22
9 Biochemical Research Methods 15 2% 0% 45
10 Chemistry, Analytical 7 2% 0% 58

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPHARMACEUT PHARMACEUT SCI CLIN SUPPLY 83548 0% 67% 10
2 BIOPHARMACEUT PHARMACOKINET 78196 2% 11% 56
3 GRP BIOPHARMACEUT 50133 0% 100% 4
4 BIOPHARMACEUT GRP 48192 0% 38% 10
5 THER EUT EQUIVALENCE 44759 0% 71% 5
6 AREA PHARM PHARMACEUT TECHNOL 39163 0% 63% 5
7 COMPETENCE SYST BIOL COMPUTAT SOLUT 39163 0% 63% 5
8 PHARMACOTECHNOL BIOPHARM 38507 1% 13% 23
9 PHARMACOKINET PHARMACEUT TECHNOL 37600 0% 100% 3
10 FORMULAT 31531 1% 11% 23

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUTICAL RESEARCH 122102 11% 4% 279
2 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 114135 7% 5% 179
3 DISSOLUTION TECHNOLOGIES 107780 2% 20% 42
4 JOURNAL OF PHARMACEUTICAL SCIENCES 67659 10% 2% 246
5 MOLECULAR PHARMACEUTICS 58188 5% 4% 121
6 AAPS JOURNAL 46739 3% 6% 65
7 INTERNATIONAL JOURNAL OF PHARMACEUTICS 21652 7% 1% 166
8 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 20479 3% 2% 78
9 DRUG METABOLISM AND DISPOSITION 7852 3% 1% 69
10 BIOPHARMACEUTICS & DRUG DISPOSITION 7468 1% 2% 34

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BIOPHARMACEUTICS CLASSIFICATION SYSTEM 592189 3% 71% 67 Search BIOPHARMACEUTICS+CLASSIFICATION+SYSTEM Search BIOPHARMACEUTICS+CLASSIFICATION+SYSTEM
2 ORAL ABSORPTION 434036 5% 28% 125 Search ORAL+ABSORPTION Search ORAL+ABSORPTION
3 CACO 2 405653 8% 16% 206 Search CACO+2 Search CACO+2
4 DRUG ABSORPTION 318728 3% 30% 85 Search DRUG+ABSORPTION Search DRUG+ABSORPTION
5 BIORELEVANT MEDIA 303804 2% 61% 40 Search BIORELEVANT+MEDIA Search BIORELEVANT+MEDIA
6 BIOWAIVER 286440 2% 57% 40 Search BIOWAIVER Search BIOWAIVER
7 BIOPHARMACEUTICS CLASSIFICATION SYSTEM BCS 243671 1% 56% 35 Search BIOPHARMACEUTICS+CLASSIFICATION+SYSTEM+BCS Search BIOPHARMACEUTICS+CLASSIFICATION+SYSTEM+BCS
8 PAMPA 241068 2% 36% 53 Search PAMPA Search PAMPA
9 HUMAN INTESTINAL FLUID 213723 1% 95% 18 Search HUMAN+INTESTINAL+FLUID Search HUMAN+INTESTINAL+FLUID
10 INTESTINAL ABSORPTION 201869 6% 11% 143 Search INTESTINAL+ABSORPTION Search INTESTINAL+ABSORPTION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BUCKLEY, ST , FISCHER, SM , FRICKER, G , BRANDL, M , (2012) IN VITRO MODELS TO EVALUATE THE PERMEABILITY OF POORLY SOLUBLE DRUG ENTITIES: CHALLENGES AND PERSPECTIVES.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 45. ISSUE 3. P. 235-250 102 79% 35
2 LARREGIEU, CA , BENET, LZ , (2013) DRUG DISCOVERY AND REGULATORY CONSIDERATIONS FOR IMPROVING IN SILICO AND IN VITRO PREDICTIONS THAT USE CACO-2 AS A SURROGATE FOR HUMAN INTESTINAL PERMEABILITY MEASUREMENTS.AAPS JOURNAL. VOL. 15. ISSUE 2. P. 483-497 90 71% 17
3 SUGANO, K , (2009) INTRODUCTION TO COMPUTATIONAL ORAL ABSORPTION SIMULATION.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 5. ISSUE 3. P. 259-293 111 56% 31
4 LENNERNAS, H , (2014) REGIONAL INTESTINAL DRUG PERMEATION: BIOPHARMACEUTICS AND DRUG DEVELOPMENT.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 57. ISSUE . P. 333 -341 62 83% 15
5 MACHERAS, P , KARALIS, V , VALSAMI, G , (2013) KEEPING A CRITICAL EYE ON THE SCIENCE AND THE REGULATION OF ORAL DRUG ABSORPTION: A REVIEW.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 102. ISSUE 9. P. 3018-3036 91 61% 6
6 WU, CN , LIU, Y , HE, ZG , SUN, J , (2016) INSIGHT INTO THE DEVELOPMENT OF DISSOLUTION MEDIA FOR BCS CLASS II DRUGS: A REVIEW FROM QUALITY CONTROL AND PREDICTION OF IN VIVO PERFORMANCE PERSPECTIVES.CURRENT DRUG DELIVERY. VOL. 13. ISSUE 7. P. 1004 -1020 89 59% 0
7 AVDEEF, A , TAM, KY , (2010) HOW WELL CAN THE CACO-2/MADIN-DARBY CANINE KIDNEY MODELS PREDICT EFFECTIVE HUMAN JEJUNAL PERMEABILITY?.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 53. ISSUE 9. P. 3566-3584 75 75% 24
8 LENNERNAS, H , (2014) HUMAN IN VIVO REGIONAL INTESTINAL PERMEABILITY: IMPORTANCE FOR PHARMACEUTICAL DRUG DEVELOPMENT.MOLECULAR PHARMACEUTICS. VOL. 11. ISSUE 1. P. 12-23 68 71% 14
9 KOSTEWICZ, ES , AARONS, L , BERGSTRAND, M , BOLGER, MB , GALETIN, A , HATLEY, O , JAMEI, M , LLOYD, R , PEPIN, X , ROSTAMI-HODJEGAN, A , ET AL (2014) PBPK MODELS FOR THE PREDICTION OF IN VIVO PERFORMANCE OF ORAL DOSAGE FORMS.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 57. ISSUE . P. 300 -321 88 45% 41
10 DAHLGREN, D , ROOS, C , SJOREN, E , LENNERNA, H , (2015) DIRECT IN VIVO HUMAN INTESTINAL PERMEABILITY (P-EFF) DETERMINED WITH DIFFERENT CLINICAL PERFUSION AND INTUBATION METHODS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 104. ISSUE 9. P. 2702 -2726 86 55% 4

Classes with closest relation at Level 1


Rank Class id link
1 34850 CEFADROXIL INTESTINAL ABSORPTION//CAS 50370 12 2//QUINOLONE ANTIMICROBIAL AGENT
2 16187 GAMMA SCINTIGRAPHY//GASTROINTESTINAL TRANSIT//ENTERIC COATINGS
3 17081 DISSOLUTION TECHNOLOGIES//UV IMAGING//DISSOLUTION TEST
4 20325 LOGBB//BLOOD BRAIN PARTITIONING//PAMPA BBB
5 17560 K TOVS SOLUT CHEM//AQUEOUS SOLUBILITY//GENERAL SOLUBILITY EQUATION
6 6445 SELF EMULSIFYING DRUG DELIVERY SYSTEM//SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM//SMEDDS
7 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
8 7903 PEPT1//PEPT2//PEPTIDE TRANSPORTER
9 10488 ABSORPTION ENHANCER//SODIUM CAPRATE//RECTAL ABSORPTION
10 14290 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//IVIVC//NONLINEAR COMPARTMENTAL MODEL

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