Class information for:
Level 1: OATP1B1//SLCO1B1//OATP

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5456 1621 47.5 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
1155 2             PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1 9490
5456 1                   OATP1B1//SLCO1B1//OATP 1621

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OATP1B1 authKW 1380301 6% 81% 91
2 SLCO1B1 authKW 1003712 5% 73% 73
3 OATP authKW 746060 5% 53% 75
4 ORGANIC ANION TRANSPORTING POLYPEPTIDE authKW 668733 4% 51% 70
5 MOL PHARMACOKINET address 657844 5% 42% 84
6 OATP1B3 authKW 289363 2% 59% 26
7 OATP2B1 authKW 251828 1% 70% 19
8 SANDWICH CULTURED HEPATOCYTES authKW 241090 1% 80% 16
9 ESTRONE 3 SULFATE authKW 211894 1% 75% 15
10 ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP authKW 184581 1% 70% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 27599 75% 0% 1208
2 Toxicology 958 8% 0% 129
3 Chemistry, Medicinal 218 4% 0% 68
4 Medicine, Research & Experimental 193 5% 0% 85
5 Genetics & Heredity 117 5% 0% 81
6 Gastroenterology & Hepatology 91 3% 0% 50
7 Chemistry, Multidisciplinary 55 7% 0% 114
8 Biochemistry & Molecular Biology 47 10% 0% 154
9 Physiology 46 3% 0% 47
10 Biotechnology & Applied Microbiology 27 3% 0% 54

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PHARMACOKINET 657844 5% 42% 84
2 RIKEN INNOVAT 129824 1% 38% 18
3 SUGIYAMA 98385 1% 33% 16
4 CNS PAIN INNOVAT MED DMPK 75343 0% 100% 4
5 PHARMACOTHER Y EXPT THER EUT 75275 2% 11% 38
6 MEMBRANE TRANSPORT BIOPHARMACEUT 72368 1% 27% 14
7 PHARMACOKINET DYNAM METAB 60646 3% 6% 53
8 RETINAL THER EUT GRP 57676 0% 44% 7
9 CARDIOVASC METAB DIS INNOVAT MED DMPK 56507 0% 100% 3
10 PHARMACOKINETCIS DYNAM METAB 56507 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 138795 14% 3% 235
2 DRUG METABOLISM AND PHARMACOKINETICS 48223 3% 6% 43
3 CLINICAL PHARMACOLOGY & THERAPEUTICS 24409 5% 2% 87
4 PHARMACOGENETICS AND GENOMICS 22688 2% 3% 37
5 MOLECULAR PHARMACEUTICS 18032 3% 2% 55
6 XENOBIOTICA 12592 3% 1% 51
7 PHARMACOGENOMICS 9524 2% 2% 30
8 PHARMACEUTICAL RESEARCH 6058 3% 1% 51
9 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 5782 2% 1% 33
10 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 4866 1% 1% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 OATP1B1 1380301 6% 81% 91 Search OATP1B1 Search OATP1B1
2 SLCO1B1 1003712 5% 73% 73 Search SLCO1B1 Search SLCO1B1
3 OATP 746060 5% 53% 75 Search OATP Search OATP
4 ORGANIC ANION TRANSPORTING POLYPEPTIDE 668733 4% 51% 70 Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE
5 OATP1B3 289363 2% 59% 26 Search OATP1B3 Search OATP1B3
6 OATP2B1 251828 1% 70% 19 Search OATP2B1 Search OATP2B1
7 SANDWICH CULTURED HEPATOCYTES 241090 1% 80% 16 Search SANDWICH+CULTURED+HEPATOCYTES Search SANDWICH+CULTURED+HEPATOCYTES
8 ESTRONE 3 SULFATE 211894 1% 75% 15 Search ESTRONE+3+SULFATE Search ESTRONE+3+SULFATE
9 ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP 184581 1% 70% 14 Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE+OATP Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE+OATP
10 ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1 175313 1% 85% 11 Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE+1B1 Search ORGANIC+ANION+TRANSPORTING+POLYPEPTIDE+1B1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 NIEMI, M , PASANEN, MK , NEUVONEN, PJ , (2011) ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1: A GENETICALLY POLYMORPHIC TRANSPORTER OF MAJOR IMPORTANCE FOR HEPATIC DRUG UPTAKE.PHARMACOLOGICAL REVIEWS. VOL. 63. ISSUE 1. P. 157-181 151 69% 234
2 KALLIOKOSKI, A , NIEMI, M , (2009) IMPACT OF OATP TRANSPORTERS ON PHARMACOKINETICS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 158. ISSUE 3. P. 693 -705 116 79% 330
3 ROTH, M , OBAIDAT, A , HAGENBUCH, B , (2012) OATPS, OATS AND OCTS: THE ORGANIC ANION AND CATION TRANSPORTERS OF THE SLCO AND SLC22A GENE SUPERFAMILIES.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 165. ISSUE 5. P. 1260 -1287 151 52% 134
4 GONG, IY , KIM, RB , (2013) IMPACT OF GENETIC VARIATION IN OATP TRANSPORTERS TO DRUG DISPOSITION AND RESPONSE.DRUG METABOLISM AND PHARMACOKINETICS. VOL. 28. ISSUE 1. P. 4-18 113 82% 33
5 HAGENBUCH, B , STIEGER, B , (2013) THE SLCO (FORMER SLC21) SUPERFAMILY OF TRANSPORTERS.MOLECULAR ASPECTS OF MEDICINE. VOL. 34. ISSUE 2-3. P. 396-412 110 74% 56
6 SHITARA, Y , MAEDA, K , IKEJIRI, K , YOSHIDA, K , HORIE, T , SUGIYAMA, Y , (2013) CLINICAL SIGNIFICANCE OF ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS) IN DRUG DISPOSITION: THEIR ROLES IN HEPATIC CLEARANCE AND INTESTINAL ABSORPTION.BIOPHARMACEUTICS & DRUG DISPOSITION. VOL. 34. ISSUE 1. P. 45-78 102 67% 87
7 HAGENBUCH, B , GUI, C , (2008) XENOBIOTIC TRANSPORTERS OF THE HUMAN ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATP) FAMILY.XENOBIOTICA. VOL. 38. ISSUE 7-8. P. 778 -801 95 77% 211
8 NAKANISHI, T , TAMAI, I , (2012) GENETIC POLYMORPHISMS OF OATP TRANSPORTERS AND THEIR IMPACT ON INTESTINAL ABSORPTION AND HEPATIC DISPOSITION OF DRUGS.DRUG METABOLISM AND PHARMACOKINETICS. VOL. 27. ISSUE 1. P. 106-121 89 77% 43
9 STIEGER, B , HAGENBUCH, B , (2014) ORGANIC ANION-TRANSPORTING POLYPEPTIDES.EXCHANGERS. VOL. 73. ISSUE . P. 205 -232 100 70% 10
10 SVOBODA, M , RIHA, J , WLCEK, K , JAEGER, W , THALHAMMER, T , (2011) ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS): REGULATION OF EXPRESSION AND FUNCTION.CURRENT DRUG METABOLISM. VOL. 12. ISSUE 2. P. 139-153 90 67% 48

Classes with closest relation at Level 1


Rank Class id link
1 3077 ORGANIC CATION TRANSPORTER//ORGANIC ANION TRANSPORTER//ORGANIC CATION TRANSPORT
2 7494 STATINS//RHABDOMYOLYSIS//STATIN INTOLERANCE
3 4616 MRP1//MULTIDRUG RESISTANCE ASSOCIATED PROTEIN//MULTIDRUG RESISTANCE PROTEIN
4 9334 ABCG2//BCRP//BREAST CANCER RESISTANCE PROTEIN
5 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
6 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
7 16225 REPAGLINIDE//NATEGLINIDE//MITIGLINIDE
8 3044 ORGANIC ANIONS//CANALICULAR MEMBRANE//BILITRANSLOCASE
9 18946 ATORVASTATIN CALCIUM//EZETIMIBE//ROSUVASTATIN CALCIUM
10 18626 PITAVASTATIN//NK 104//CAS 147526 32 7

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