Class information for:
Level 1: LOGBB//BLOOD BRAIN PARTITIONING//PAMPA BBB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
20325 466 44.7 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
1155 2             PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1 9490
20325 1                   LOGBB//BLOOD BRAIN PARTITIONING//PAMPA BBB 466

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LOGBB authKW 583763 3% 64% 14
2 BLOOD BRAIN PARTITIONING authKW 327628 1% 100% 5
3 PAMPA BBB authKW 209680 1% 80% 4
4 UNBOUND BRAIN TO PLASMA CONCENTRATION RATIO authKW 196577 1% 100% 3
5 BLOOD BRAIN PARTITION COEFFICIENT authKW 174732 1% 67% 4
6 BLOOD BRAIN BARRIER PARTITIONING authKW 131051 0% 100% 2
7 BRAIN PERMEABILITY SURFACE AREA PS authKW 131051 0% 100% 2
8 RODENT IN SITU BRAIN PERFUSION authKW 131051 0% 100% 2
9 SAR METHODS authKW 131051 0% 100% 2
10 UNBOUND BRAIN CONCENTRATION authKW 131051 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 4604 30% 0% 138
2 Pharmacology & Pharmacy 4323 56% 0% 260
3 Computer Science, Interdisciplinary Applications 953 13% 0% 59
4 Chemistry, Multidisciplinary 536 24% 0% 111
5 Biochemical Research Methods 296 9% 0% 43
6 Mathematical & Computational Biology 198 4% 0% 19
7 Chemistry, Analytical 165 9% 0% 44
8 Computer Science, Information Systems 55 3% 0% 16
9 Biochemistry & Molecular Biology 49 13% 0% 61
10 Toxicology 36 3% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMPHARM DEV 131047 1% 50% 4
2 LEAD GENERAT DMPK PHYS CHEM 87366 0% 67% 2
3 DURHAM SCI 86210 1% 26% 5
4 PHARMACOCINET METAB 84244 1% 43% 3
5 TRANSLAT PKPD GRP 73712 1% 38% 3
6 ADME IOX 65526 0% 100% 1
7 ANALYT DEVELOPABIL 65526 0% 100% 1
8 ASTRAZENECA TRANSLAT ASTRAZENECA RD 65526 0% 100% 1
9 BA DMPK 65526 0% 100% 1
10 CHANNEL ISL ALZHEIMERS 65526 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 11297 8% 0% 36
2 JOURNAL OF PHARMACEUTICAL SCIENCES 7985 8% 0% 37
3 JOURNAL OF CHEMICAL INFORMATION AND MODELING 5378 3% 1% 16
4 QSAR & COMBINATORIAL SCIENCE 5165 2% 1% 7
5 PHARMACEUTICAL RESEARCH 3591 5% 0% 21
6 CURRENT DRUG METABOLISM 2921 2% 1% 7
7 MOLECULAR PHARMACEUTICS 2066 2% 0% 10
8 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 1883 1% 0% 6
9 JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES 1868 2% 0% 9
10 JOURNAL OF MOLECULAR GRAPHICS & MODELLING 1709 2% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LOGBB 583763 3% 64% 14 Search LOGBB Search LOGBB
2 BLOOD BRAIN PARTITIONING 327628 1% 100% 5 Search BLOOD+BRAIN+PARTITIONING Search BLOOD+BRAIN+PARTITIONING
3 PAMPA BBB 209680 1% 80% 4 Search PAMPA+BBB Search PAMPA+BBB
4 UNBOUND BRAIN TO PLASMA CONCENTRATION RATIO 196577 1% 100% 3 Search UNBOUND+BRAIN+TO+PLASMA+CONCENTRATION+RATIO Search UNBOUND+BRAIN+TO+PLASMA+CONCENTRATION+RATIO
5 BLOOD BRAIN PARTITION COEFFICIENT 174732 1% 67% 4 Search BLOOD+BRAIN+PARTITION+COEFFICIENT Search BLOOD+BRAIN+PARTITION+COEFFICIENT
6 BLOOD BRAIN BARRIER PARTITIONING 131051 0% 100% 2 Search BLOOD+BRAIN+BARRIER+PARTITIONING Search BLOOD+BRAIN+BARRIER+PARTITIONING
7 BRAIN PERMEABILITY SURFACE AREA PS 131051 0% 100% 2 Search BRAIN+PERMEABILITY+SURFACE+AREA+PS Search BRAIN+PERMEABILITY+SURFACE+AREA+PS
8 RODENT IN SITU BRAIN PERFUSION 131051 0% 100% 2 Search RODENT+IN+SITU+BRAIN+PERFUSION Search RODENT+IN+SITU+BRAIN+PERFUSION
9 SAR METHODS 131051 0% 100% 2 Search SAR+METHODS Search SAR+METHODS
10 UNBOUND BRAIN CONCENTRATION 131051 0% 100% 2 Search UNBOUND+BRAIN+CONCENTRATION Search UNBOUND+BRAIN+CONCENTRATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LANEVSKIJ, K , JAPERTAS, P , DIDZIAPETRIS, R , (2013) IMPROVING THE PREDICTION OF DRUG DISPOSITION IN THE BRAIN.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 9. ISSUE 4. P. 473-486 52 71% 11
2 BRITO-SANCHEZ, Y , MARRERO-PONCE, Y , BARIGYE, SJ , YABER-GOENAGA, I , PEREZ, CM , HUONG, LTT , CHERKASOV, A , (2015) TOWARDS BETTER BBB PASSAGE PREDICTION USING AN EXTENSIVE AND CURATED DATA SET.MOLECULAR INFORMATICS. VOL. 34. ISSUE 5. P. 308 -330 49 64% 4
3 ANDRES, C , HUTTER, MC , (2006) CNS PERMEABILITY OF DRUGS PREDICTED BY A DECISION TREE.QSAR & COMBINATORIAL SCIENCE. VOL. 25. ISSUE 4. P. 305-309 37 86% 15
4 ZHANG, DQ , XIAO, JF , ZHOU, NN , ZHENG, MY , LUO, XM , JIANG, HL , CHEN, KX , (2015) A GENETIC ALGORITHM BASED SUPPORT VECTOR MACHINE MODEL FOR BLOOD-BRAIN BARRIER PENETRATION PREDICTION.BIOMED RESEARCH INTERNATIONAL. VOL. . ISSUE . P. - 40 60% 0
5 SHEN, J , DU, YP , ZHAO, YX , LIU, GX , TANG, Y , (2008) IN SILICO PREDICTION OF BLOOD-BRAIN PARTITIONING USING A CHEMOMETRIC METHOD CALLED GENETIC ALGORITHM BASED VARIABLE SELECTION.QSAR & COMBINATORIAL SCIENCE. VOL. 27. ISSUE 6. P. 704-717 34 77% 9
6 KUMAR, R , SHARMA, A , TIWARI, R , (2013) CAN WE PREDICT BLOOD BRAIN BARRIER PERMEABILITY OF LIGANDS USING COMPUTATIONAL APPROACHES?.INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES. VOL. 5. ISSUE 2. P. 95-101 29 81% 1
7 READ, KD , BRAGGIO, S , (2010) ASSESSING BRAIN FREE FRACTION IN EARLY DRUG DISCOVERY.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 6. ISSUE 3. P. 337-344 25 83% 27
8 MUEHLBACHER, M , SPITZER, GM , LIEDL, KR , KORNHUBER, J , (2011) QUALITATIVE PREDICTION OF BLOOD-BRAIN BARRIER PERMEABILITY ON A LARGE AND REFINED DATASET.JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. VOL. 25. ISSUE 12. P. 1095-1106 37 55% 19
9 LANEVSKIJ, K , DAPKUNAS, J , JUSKA, L , JAPERTAS, P , DIDZIAPETRIS, R , (2011) QSAR ANALYSIS OF BLOOD-BRAIN DISTRIBUTION: THE INFLUENCE OF PLASMA AND BRAIN TISSUE BINDING.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 100. ISSUE 6. P. 2147 -2160 32 58% 19
10 MENSCH, J , OYARZABAL, J , MACKIE, C , AUGUSTIJNS, P , (2009) IN VIVO, IN VITRO AND IN SILICO METHODS FOR SMALL MOLECULE TRANSFER ACROSS THE BBB.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 98. ISSUE 12. P. 4429 -4468 66 27% 61

Classes with closest relation at Level 1


Rank Class id link
1 9862 P GLYCOPROTEIN//PHARMACORESISTANCE//TARIQUIDAR
2 30937 INNER BLOOD RETINAL BARRIER//PROTON COUPLED ORGANIC CATION ANTIPORTER//RETINAL CAPILLARY ENDOTHELIAL CELLS
3 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
4 1901 BIOPHARMACEUTICS CLASSIFICATION SYSTEM//ORAL ABSORPTION//CACO 2
5 4989 BLOOD BRAIN BARRIER//BBB//TIGHT JUNCTION
6 7913 MICRODIALYSIS//MICRODIALYSIS SAMPLING//RELATIVE RECOVERY
7 17560 K TOVS SOLUT CHEM//AQUEOUS SOLUBILITY//GENERAL SOLUBILITY EQUATION
8 1013 LIFE SCI INFORMAT//B IT//LIMES PROGRAM UNIT CHEM BIOL MED CHEM
9 10176 SOLVATION PARAMETER MODEL//MOLECULAR SOLUTE DESCRIPTORS//LINEAR SOLVATION ENERGY RELATIONSHIPS
10 4126 LIPOPHILICITY//RP TLC//IMMOBILIZED ARTIFICIAL MEMBRANE

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