Class information for:
Level 1: LIVER SLICES//PRECISION CUT LIVER SLICES//PRECISION CUT TISSUE SLICES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23257 352 37.8 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
537 3       BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 19236
908 2             BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 11255
23257 1                   LIVER SLICES//PRECISION CUT LIVER SLICES//PRECISION CUT TISSUE SLICES 352

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LIVER SLICES authKW 998043 9% 36% 32
2 PRECISION CUT LIVER SLICES authKW 680757 5% 41% 19
3 PRECISION CUT TISSUE SLICES authKW 555181 2% 80% 8
4 RAT LIVER SLICES authKW 505514 4% 45% 13
5 LIVER SLICES PRECISION CUT authKW 346990 1% 100% 4
6 PRECISION CUT SLICES authKW 346986 2% 67% 6
7 OPTIMAL SLICE VIABILITY authKW 260243 1% 100% 3
8 PRECISION CUT INTESTINAL SLICES authKW 240961 1% 56% 5
9 PRECISION CUT RAT LIVER SLICES authKW 231324 1% 67% 4
10 ETHOXYCOUMARIN O DEETHYLATION authKW 195180 1% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 10068 50% 0% 177
2 Pharmacology & Pharmacy 1684 41% 0% 144
3 Pathology 202 7% 0% 26
4 Physiology 66 6% 0% 20
5 Medicine, Research & Experimental 52 6% 0% 20
6 Cell & Tissue Engineering 45 1% 0% 4
7 Integrative & Complementary Medicine 39 1% 0% 5
8 Cell Biology 26 7% 0% 23
9 Biology 26 3% 0% 11
10 Biochemical Research Methods 19 3% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET DRUG DELIVERY 150268 5% 10% 18
2 PRECLIN DRUG VALIDAT UNIT 115662 1% 67% 2
3 PHARMACOKINET TOXICOL TARGETING 93199 3% 9% 12
4 ABTE TOXEMAC EA4651 86748 0% 100% 1
5 AZ VET DIAGNOST 86748 0% 100% 1
6 CLIN PHARMACOL TECHNOL 86748 0% 100% 1
7 DEV ORGAN REGENERAT ORGAN TRANSPLANTS RECONS 86748 0% 100% 1
8 DIRECTOR EXPT BIOLMIDORI KU 86748 0% 100% 1
9 DYNAM PATHOL KAMIGYO KU 86748 0% 100% 1
10 GOODMAN INVESTMENT MANAGEMENT 86748 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 XENOBIOTICA 30693 11% 1% 37
2 TOXICOLOGY IN VITRO 30529 11% 1% 39
3 DRUG METABOLISM AND DISPOSITION 9049 8% 0% 28
4 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 6787 3% 1% 12
5 CELL BIOLOGY AND TOXICOLOGY 4733 2% 1% 8
6 TOXICOLOGY METHODS 3957 1% 2% 3
7 CRYOBIOLOGY 3826 3% 0% 11
8 IN VITRO TOXICOLOGY 3211 0% 4% 1
9 INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY 2796 0% 3% 1
10 TOXICOLOGY 2784 4% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LIVER SLICES 998043 9% 36% 32 Search LIVER+SLICES Search LIVER+SLICES
2 PRECISION CUT LIVER SLICES 680757 5% 41% 19 Search PRECISION+CUT+LIVER+SLICES Search PRECISION+CUT+LIVER+SLICES
3 PRECISION CUT TISSUE SLICES 555181 2% 80% 8 Search PRECISION+CUT+TISSUE+SLICES Search PRECISION+CUT+TISSUE+SLICES
4 RAT LIVER SLICES 505514 4% 45% 13 Search RAT+LIVER+SLICES Search RAT+LIVER+SLICES
5 LIVER SLICES PRECISION CUT 346990 1% 100% 4 Search LIVER+SLICES+PRECISION+CUT Search LIVER+SLICES+PRECISION+CUT
6 PRECISION CUT SLICES 346986 2% 67% 6 Search PRECISION+CUT+SLICES Search PRECISION+CUT+SLICES
7 OPTIMAL SLICE VIABILITY 260243 1% 100% 3 Search OPTIMAL+SLICE+VIABILITY Search OPTIMAL+SLICE+VIABILITY
8 PRECISION CUT INTESTINAL SLICES 240961 1% 56% 5 Search PRECISION+CUT+INTESTINAL+SLICES Search PRECISION+CUT+INTESTINAL+SLICES
9 PRECISION CUT RAT LIVER SLICES 231324 1% 67% 4 Search PRECISION+CUT+RAT+LIVER+SLICES Search PRECISION+CUT+RAT+LIVER+SLICES
10 ETHOXYCOUMARIN O DEETHYLATION 195180 1% 75% 3 Search ETHOXYCOUMARIN+O+DEETHYLATION Search ETHOXYCOUMARIN+O+DEETHYLATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GRAAF, IAM , GROOTHUIS, GMM , OLINGA, P , (2007) PRECISION-CUT TISSUE SLICES AS A TOOL TO PREDICT METABOLISM OF NOVEL DRUGS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 3. ISSUE 6. P. 879 -898 95 55% 24
2 LERCHE-LANGRAND, C , TOUTAIN, HJ , (2000) PRECISION-CUT LIVER SLICES: CHARACTERISTICS AND USE FOR IN VITRO PHARMACO-TOXICOLOGY.TOXICOLOGY. VOL. 153. ISSUE 1-3. P. 221 -253 98 48% 119
3 DE GRAAF, IAM , KOSTER, HJ , (2003) CRYOPRESERVATION OF PRECISION-CUT TISSUE SLICES FOR APPLICATION IN DRUG METABOLISM RESEARCH.TOXICOLOGY IN VITRO. VOL. 17. ISSUE 1. P. 1 -17 62 73% 21
4 LAKE, BG , PRICE, RJ , (2013) EVALUATION OF THE METABOLISM AND HEPATOTOXICITY OF XENOBIOTICS UTILIZING PRECISION-CUT SLICES.XENOBIOTICA. VOL. 43. ISSUE 1. P. 41-53 57 56% 10
5 IOANNIDES, C , (2013) UP-REGULATION OF CYTOCHROME P450 AND PHASE II ENZYMES BY XENOBIOTICS IN PRECISION-CUT TISSUE SLICES.XENOBIOTICA. VOL. 43. ISSUE 1. P. 15-28 47 64% 7
6 DE GRAAF, IAM , OLINGA, P , DE JAGER, MH , MEREMA, MT , DE KANTER, R , VAN DE KERKHOF, EG , GROOTHUIS, GMM , (2010) PREPARATION AND INCUBATION OF PRECISION-CUT LIVER AND INTESTINAL SLICES FOR APPLICATION IN DRUG METABOLISM AND TOXICITY STUDIES.NATURE PROTOCOLS. VOL. 5. ISSUE 9. P. 1540-1551 48 55% 57
7 FISHER, RL , ULREICH, JB , NAKAZATO, PZ , BRENDEL, K , (2001) HISTOLOGICAL AND BIOCHEMICAL EVALUATION OF PRECISION-CUT LIVER SLICES.TOXICOLOGY METHODS. VOL. 11. ISSUE 2. P. 59 -79 57 63% 14
8 DE KANTER, R , MONSHOUWER, M , MEIJER, DKF , GROOTHUIS, GMM , (2002) PRECISION-CUT ORGAN SLICES AS A TOOL TO STUDY TOXICITY AND METABOLISM OF XENOBIOTICS WITH SPECIAL REFERENCE TO NON-HEPATIC TISSUES.CURRENT DRUG METABOLISM. VOL. 3. ISSUE 1. P. 39 -59 66 35% 44
9 UMACHANDRAN, M , HOWARTH, J , IOANNIDES, C , (2004) METABOLIC AND STRUCTURAL VIABILITY OF PRECISION-CUT RAT LUNG SLICES IN CULTURE.XENOBIOTICA. VOL. 34. ISSUE 8. P. 771-780 23 96% 21
10 DE GRAAF, IAM , DRAAISMA, AL , SCHOEMAN, O , FAHY, GM , GROOTHUIS, GMM , KOSTER, HJ , (2007) CRYOPRESERVATION OF RAT PRECISION-CUT LIVER AND KIDNEY SLICES BY RAPID FREEZING AND VITRIFICATION.CRYOBIOLOGY. VOL. 54. ISSUE 1. P. 1 -12 26 65% 27

Classes with closest relation at Level 1


Rank Class id link
1 15462 IN VITRO MITOGENIC STIMULATION//UMR 0938//URIDINE UPTAKE ASSAY
2 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
3 32486 HUMAN GENET TOXICOL SECT GENET//17 HYDROXY 3 OXOPREGNA 4 6 DIENE DERIVATIVES//ABERRANT METAPHASE NUMBER
4 3584 BIOARTIFICIAL LIVER//HEPATOCYTES//PORCINE HEPATOCYTES
5 10654 INTERSPECIES SCALING//VOLUME OF DISTRIBUTION//STEADY STATE VOLUME OF DISTRIBUTION
6 28612 AIR LIQUID INTERFACE//DIRECT EXPOSURE METHODS//CSAT S
7 7599 CRYOBIOLOGY//INTRACELLULAR ICE FORMATION//CRYO-LETTERS
8 8674 HEPATOCYTE TRANSPLANTATION//MARION BESSIN LIVER//LIVER REPOPULATION
9 25846 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE
10 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT

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