Class information for:
Level 2: DNA METHYLATION//EPIGENETICS//METHYLATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
382 17086 46.8 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
563 3       DNA METHYLATION//EPIGENETICS//METHYLATION 17086
382 2             DNA METHYLATION//EPIGENETICS//METHYLATION 17086
1631 1                   5 HYDROXYMETHYLCYTOSINE//DNA METHYLATION//5HMC 2562
4391 1                   DE NOVO METHYLATION//MYF 3//DNA METHYLATION 1794
5219 1                   DNA METHYLATION//EWAS//EPIGENOME WIDE ASSOCIATION STUDY 1655
5355 1                   DECITABINE//5 AZA 2 DEOXYCYTIDINE//ZEBULARINE 1635
6372 1                   CELL FREE DNA//CIRCULATING DNA//CIRCULATING CELL FREE DNA 1493
9828 1                   SERRATED ADENOMA//SESSILE SERRATED ADENOMA//HYPERPLASTIC POLYP 1117
10356 1                   METHYLTRANSFERASE ACTIVITY//DNA METHYLATION//METHYL BINDING DOMAIN PROTEIN 1071
14360 1                   GSTP1//UNIDAD DOCENTE BIOQUIM BIOL MOL//DNA METHYLATION 774
15424 1                   RASSF1A//RBM5//RASSF2 714
15761 1                   LUNG CANC PROGRAM//HYPERMETHYLATION//MILTON J DANCE HEAD NECK 693
18199 1                   TRANSGENERATIONAL//METASTABLE EPIALLELE//TRANSGENERATIONAL INHERITANCE 562
19894 1                   CHFR//RING FINGER PROTEIN 180//EPIGEN 485
21195 1                   STOOL DNA//FECAL RNA//STOOL DNA TESTING 429
22078 1                   ICF SYNDROME//EXCELLENCE MOL GENET CANC HUMAN DIS//COBRALINE 1 394
22246 1                   DAP KINASE//DEATH ASSOCIATED PROTEIN KINASE//DAPK 389
25695 1                   IGLON//OPCML//NEUROTRIMIN 274
27163 1                   MOL DIAGNOST RD//P16INK4A METHYLATION//TRIPLE COMBINATION ARRAY 236
27391 1                   EPIGENET CANC STEM CELLS//ZNF582//E2 BINDING SITE 231
28689 1                   UHRF1//ICBP90//UHRF2 201
31059 1                   RLGS//RESTRICTION LANDMARK GENOMIC SCANNING//ZYGOTE ARREST 1 159
31935 1                   DIETARY COMPOUNDS//MIR 1260B//3 UTR LUCIFERASE ASSAY 146
36855 1                   ARHI//APLASIA RAS HOMOLOG MEMBER I//APLASIA RAS HOMOLOGUE MEMBER I ARHI 72

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 DNA METHYLATION authKW 1624241 17% 31% 2965
2 EPIGENETICS authKW 450412 10% 15% 1655
3 METHYLATION authKW 379622 7% 18% 1171
4 5 HYDROXYMETHYLCYTOSINE authKW 214795 1% 81% 148
5 RASSF1A authKW 208858 1% 69% 169
6 CPG ISLAND authKW 188974 2% 38% 279
7 CELL FREE DNA authKW 171757 1% 54% 178
8 DNA METHYLTRANSFERASE authKW 170458 2% 36% 265
9 HYPERMETHYLATION authKW 149393 1% 36% 234
10 CIRCULATING DNA authKW 149061 1% 80% 105

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 53910 30% 1% 5131
2 Genetics & Heredity 28231 18% 1% 3053
3 Biochemistry & Molecular Biology 13181 26% 0% 4466
4 Cell Biology 10694 14% 0% 2472
5 Pathology 3356 5% 0% 792
6 Medical Laboratory Technology 2474 2% 0% 384
7 Biotechnology & Applied Microbiology 2413 6% 0% 1110
8 Gastroenterology & Hepatology 1948 4% 0% 689
9 Medicine, Research & Experimental 1105 4% 0% 719
10 Biochemical Research Methods 993 4% 0% 602

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 EPIGENET 106615 1% 27% 220
2 CANC EPIGENET 52973 1% 26% 116
3 EXCELLENCE MOL GENET CANC HUMAN DIS 37898 0% 59% 36
4 EPIGEN 28526 0% 30% 54
5 CONJOINT GASTROENTEROL 26258 0% 39% 38
6 ENVIRONM EPIGENET 25927 0% 58% 25
7 EPIGENET PROGRAMME 23409 0% 39% 34
8 STAT GENOM GRP 22235 0% 69% 18
9 EPIGENET GRP 20971 0% 37% 32
10 PATHOL 20944 14% 1% 2401

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL EPIGENETICS 125386 1% 42% 169
2 EPIGENOMICS 108845 1% 36% 168
3 EPIGENETICS 56368 1% 35% 90
4 CIBA FOUNDATION SYMPOSIA 44321 2% 10% 261
5 EPIGENETICS & CHROMATIN 16618 0% 18% 52
6 CLINICAL CANCER RESEARCH 8389 2% 2% 271
7 GENOME BIOLOGY 8125 1% 4% 118
8 GENOME RESEARCH 5879 0% 5% 68
9 CANCER RESEARCH 5756 2% 1% 373
10 NUCLEIC ACIDS RESEARCH 5444 2% 1% 366

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 DNA METHYLATION 1624241 17% 31% 2965 Search DNA+METHYLATION Search DNA+METHYLATION
2 EPIGENETICS 450412 10% 15% 1655 Search EPIGENETICS Search EPIGENETICS
3 METHYLATION 379622 7% 18% 1171 Search METHYLATION Search METHYLATION
4 5 HYDROXYMETHYLCYTOSINE 214795 1% 81% 148 Search 5+HYDROXYMETHYLCYTOSINE Search 5+HYDROXYMETHYLCYTOSINE
5 RASSF1A 208858 1% 69% 169 Search RASSF1A Search RASSF1A
6 CPG ISLAND 188974 2% 38% 279 Search CPG+ISLAND Search CPG+ISLAND
7 CELL FREE DNA 171757 1% 54% 178 Search CELL+FREE+DNA Search CELL+FREE+DNA
8 DNA METHYLTRANSFERASE 170458 2% 36% 265 Search DNA+METHYLTRANSFERASE Search DNA+METHYLTRANSFERASE
9 HYPERMETHYLATION 149393 1% 36% 234 Search HYPERMETHYLATION Search HYPERMETHYLATION
10 CIRCULATING DNA 149061 1% 80% 105 Search CIRCULATING+DNA Search CIRCULATING+DNA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WU, H , ZHANG, Y , (2014) REVERSING DNA METHYLATION: MECHANISMS, GENOMICS, AND BIOLOGICAL FUNCTIONS.CELL. VOL. 156. ISSUE 1-2. P. 45-68 164 78% 228
2 FLEISCHHACKER, M , SCHMIDT, B , (2007) CIRCULATING NUCLEIC ACIDS (CNAS) AND CANCER - A SURVEY.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1775. ISSUE 1. P. 181 -232 236 64% 314
3 SCHUBELER, D , (2015) FUNCTION AND INFORMATION CONTENT OF DNA METHYLATION.NATURE. VOL. 517. ISSUE 7534. P. 321 -326 86 74% 197
4 PASTOR, WA , ARAVIND, L , RAO, A , (2013) TETONIC SHIFT: BIOLOGICAL ROLES OF TET PROTEINS IN DNA DEMETHYLATION AND TRANSCRIPTION.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 14. ISSUE 6. P. 341 -356 130 73% 213
5 SMITH, ZD , MEISSNER, A , (2013) DNA METHYLATION: ROLES IN MAMMALIAN DEVELOPMENT.NATURE REVIEWS GENETICS. VOL. 14. ISSUE 3. P. 204 -220 114 58% 500
6 JUNG, K , FLEISCHHACKER, M , RABIEN, A , (2010) CELL-FREE DNA IN THE BLOOD AS A SOLID TUMOR BIOMARKER-A CRITICAL APPRAISAL OF THE LITERATURE.CLINICA CHIMICA ACTA. VOL. 411. ISSUE 21-22. P. 1611-1624 172 83% 113
7 RASMUSSEN, KD , HELIN, K , (2016) ROLE OF TET ENZYMES IN DNA METHYLATION, DEVELOPMENT, AND CANCER.GENES & DEVELOPMENT. VOL. 30. ISSUE 7. P. 733 -750 109 72% 20
8 SCHWARZENBACH, H , HOON, DSB , PANTEL, K , (2011) CELL-FREE NUCLEIC ACIDS AS BIOMARKERS IN CANCER PATIENTS.NATURE REVIEWS CANCER. VOL. 11. ISSUE 6. P. 426 -437 110 66% 606
9 LAIRD, PW , (2010) PRINCIPLES AND CHALLENGES OF GENOME-WIDE DNA METHYLATION ANALYSIS.NATURE REVIEWS GENETICS. VOL. 11. ISSUE 3. P. 191 -203 107 69% 629
10 JURKOWSKA, RZ , JURKOWSKI, TP , JELTSCH, A , (2011) STRUCTURE AND FUNCTION OF MAMMALIAN DNA METHYLTRANSFERASES.CHEMBIOCHEM. VOL. 12. ISSUE 2. P. 206 -222 142 70% 214

Classes with closest relation at Level 2


Rank Class id link
1 2439 GENOMIC IMPRINTING//BECKWITH WIEDEMANN SYNDROME//SILVER RUSSELL SYNDROME
2 1531 HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR
3 1071 LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC
4 343 EZH2//CHROMATIN//POLYCOMB
5 3087 CELL FREE FETAL DNA//NON INVASIVE PRENATAL DIAGNOSIS//FETAL DNA
6 2606 FHIT//WWOX//FRAGILE SITES
7 2034 E CADHERIN//CADHERIN//CATENIN
8 1101 BIOINFORMATICS//COPY NUMBER VARIATION//NEXT GENERATION SEQUENCING
9 1609 RESTRICTION ENDONUCLEASE//BIOTECHNIQUES//RESTRICTION MODIFICATION SYSTEM
10 2147 MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE

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