Class information for:
Level 2: MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2147 5031 33.5 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
142 3       DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH 64602
2147 2             MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 5031
1097 1                   MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 2856
13533 1                   TRIAZENE//BIS TRIAZENE//TRIAZENIDE COMPLEXES 830
16078 1                   S 2250 KAWAGISHI//TAUROMUSTINE//SARCNU 674
21701 1                   DIPARTIMENTO FARMACOCHIM TOSSICOL BIOL//MTIC//SEZ CHIM FARMACEUT BIOL 409
26128 1                   CLORETAZINE//VNP40101M//NEW ANTICANCER AGENT 262

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MGMT authKW 544645 5% 38% 239
2 O 6 METHYLGUANINE DNA METHYLTRANSFERASE authKW 470629 3% 58% 133
3 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE authKW 447303 2% 87% 85
4 TRIAZENE authKW 352527 2% 52% 111
5 ALKYLTRANSFERASE authKW 305896 1% 92% 55
6 O 6 BENZYLGUANINE authKW 298995 1% 79% 62
7 O 6 METHYLGUANINE authKW 256905 1% 63% 67
8 TEMOZOLOMIDE authKW 137057 4% 12% 194
9 CANC UK CARCINOGENESIS GRP address 127503 1% 62% 34
10 BIS TRIAZENE authKW 109216 0% 100% 18

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 22376 35% 0% 1771
2 Toxicology 4712 10% 0% 493
3 Chemistry, Medicinal 2118 7% 0% 341
4 Genetics & Heredity 1863 9% 0% 468
5 Pharmacology & Pharmacy 1189 11% 0% 575
6 Chemistry, Organic 963 8% 0% 395
7 Biochemistry & Molecular Biology 932 16% 0% 786
8 Chemistry, Multidisciplinary 616 10% 0% 512
9 Chemistry, Inorganic & Nuclear 571 5% 0% 244
10 Crystallography 244 3% 0% 128

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK CARCINOGENESIS GRP 127503 1% 62% 34
2 DIPARTIMENTO FARMACOCHIM TOSSICOL BIOL 37710 1% 22% 28
3 S 2250 KAWAGISHI 30338 0% 100% 5
4 PL TOXICOL 28051 1% 18% 26
5 SECT GENOME DAMAGE REPAIR 27697 0% 35% 13
6 BEIJING ENVIRONM VIRAL ONCOL 26369 0% 43% 10
7 SEZ CHIM FARMACEUT BIOL 24564 0% 45% 9
8 MED BIOREGULAT BIOCHEM 24270 0% 100% 4
9 PATERSON CANC 20339 1% 6% 60
10 MOL CELL BIOL CHEM CARCINOGENESIS 18203 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARCINOGENESIS 50352 6% 3% 311
2 MUTATION RESEARCH 24270 4% 2% 181
3 CANCER RESEARCH 11936 6% 1% 281
4 CANCER CHEMOTHERAPY AND PHARMACOLOGY 9839 2% 2% 110
5 ANTI-CANCER DRUG DESIGN 6000 0% 4% 25
6 MUTATION RESEARCH-DNA REPAIR 4461 0% 4% 19
7 DNA REPAIR 4018 1% 2% 37
8 CHEMICAL RESEARCH IN TOXICOLOGY 2605 1% 1% 48
9 CLINICAL CANCER RESEARCH 2483 2% 1% 80
10 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 2131 1% 1% 26

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MGMT 544645 5% 38% 239 Search MGMT Search MGMT
2 O 6 METHYLGUANINE DNA METHYLTRANSFERASE 470629 3% 58% 133 Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE
3 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 447303 2% 87% 85 Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE
4 TRIAZENE 352527 2% 52% 111 Search TRIAZENE Search TRIAZENE
5 ALKYLTRANSFERASE 305896 1% 92% 55 Search ALKYLTRANSFERASE Search ALKYLTRANSFERASE
6 O 6 BENZYLGUANINE 298995 1% 79% 62 Search O+6+BENZYLGUANINE Search O+6+BENZYLGUANINE
7 O 6 METHYLGUANINE 256905 1% 63% 67 Search O+6+METHYLGUANINE Search O+6+METHYLGUANINE
8 TEMOZOLOMIDE 137057 4% 12% 194 Search TEMOZOLOMIDE Search TEMOZOLOMIDE
9 BIS TRIAZENE 109216 0% 100% 18 Search BIS+TRIAZENE Search BIS+TRIAZENE
10 O 6 ALKYLGUANINE 91368 0% 94% 16 Search O+6+ALKYLGUANINE Search O+6+ALKYLGUANINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PEGG, AE , DOLAN, ME , MOSCHEL, RC , (1995) STRUCTURE, FUNCTION, AND INHIBITION OF O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 51. VOL. 51. ISSUE . P. 167 -223 219 89% 355
2 PEGG, AE , (2011) MULTIFACETED ROLES OF ALKYLTRANSFERASE AND RELATED PROTEINS IN DNA REPAIR, DNA DAMAGE, RESISTANCE TO CHEMOTHERAPY, AND RESEARCH TOOLS.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 24. ISSUE 5. P. 618-639 184 74% 66
3 GNEWUCH, CT , SOSNOVSKY, G , (1997) A CRITICAL APPRAISAL OF THE EVOLUTION OF N-NITROSOUREAS AS ANTICANCER DRUGS.CHEMICAL REVIEWS. VOL. 97. ISSUE 3. P. 829-1013 290 68% 122
4 PEGG, AE , (1990) MAMMALIAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE - REGULATION AND IMPORTANCE IN RESPONSE TO ALKYLATING CARCINOGENIC AND THERAPEUTIC AGENTS.CANCER RESEARCH. VOL. 50. ISSUE 19. P. 6119-6129 150 93% 754
5 KAINA, B , MARGISON, GP , CHRISTMANN, M , (2010) TARGETING O (6)-METHYLGUANINE-DNA METHYLTRANSFERASE WITH SPECIFIC INHIBITORS AS A STRATEGY IN CANCER THERAPY.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 67. ISSUE 21. P. 3663 -3681 115 86% 47
6 CHRISTMANN, M , VERBEEK, B , ROOS, WP , KAINA, B , (2011) O-6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) IN NORMAL TISSUES AND TUMORS: ENZYME ACTIVITY, PROMOTER METHYLATION AND IMMUNOHISTOCHEMISTRY.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1816. ISSUE 2. P. 179-190 122 73% 59
7 PEGG, AE , (2000) REPAIR OF O-6-ALKYLGUANINE BY ALKYLTRANSFERASES.MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. VOL. 462. ISSUE 2-3. P. 83 -100 116 86% 374
8 GERSON, SL , (2004) MGMT: ITS ROLE IN CANCER AETIOLOGY AND CANCER THERAPEUTICS.NATURE REVIEWS CANCER. VOL. 4. ISSUE 4. P. 296-307 99 84% 397
9 RABIK, CA , NJOKU, MC , DOLAN, ME , (2006) INACTIVATION OF O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE AS A MEANS TO ENHANCE CHEMOTHERAPY.CANCER TREATMENT REVIEWS. VOL. 32. ISSUE 4. P. 261-276 124 83% 56
10 KAINA, B , CHRISTMANN, M , NAUMANN, S , ROOS, WP , (2007) MGMT: KEY NODE IN THE BATTLE AGAINST GENOTOXICITY, CARCINOGENICITY AND APOPTOSIS INDUCED BY ALKYLATING AGENTS.DNA REPAIR. VOL. 6. ISSUE 8. P. 1079 -1099 117 59% 243

Classes with closest relation at Level 2


Rank Class id link
1 2281 N NITROSAMINES//NITROSAMINES//NDMA
2 1228 BASE EXCISION REPAIR//DNA GLYCOSYLASE//OXIDATIVE DNA DAMAGE
3 3633 GENE POINT MUTATIONS//HETEROKARYON 12//AD 3A LOCUS
4 2496 IFOSFAMIDE//CHEMOSENSITIVITY TEST//MESNA
5 1593 XERODERMA PIGMENTOSUM//COCKAYNE SYNDROME//NUCLEOTIDE EXCISION REPAIR
6 102 GLIOBLASTOMA//GLIOMA//MEDULLOBLASTOMA
7 4008 DIHYDRALAZINE SULFATE//DRUG INDUCED LUPUS//HYDRALAZINE HYDROCHLORIDE
8 1239 HETEROCYCLIC AMINES//HETEROCYCLIC AROMATIC AMINES//PHIP
9 160 WERNER SYNDROME//DNA POLYMERASE//DNA REPAIR
10 469 MUTATION RESEARCH//MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS//COMET ASSAY

Go to start page