Class information for:
Level 2: HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1531 7464 53.1 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1531 2             HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR 7464
185 1                   HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR 4003
6500 1                   EPIGENETICS//DNA METHYLATION//HISTONE ACETYLATION 1477
16802 1                   MEF2C//MEF2//MEF2D 635
17566 1                   TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC//HISTONE DEACETYLASE//SURG TRAUMA EMERGENCY SURG SURG CRIT C 593
18909 1                   PROTEIN KINASE D//PROTEIN KINASE D PKD//PROTEIN KINASE C MU 531
27625 1                   METABOLIC MEMORY//IL RISK ASSESSMENT INTERVENT STUDIES//HYPERGLYCEMIC MEMORY 225

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HISTONE DEACETYLASE INHIBITOR authKW 1693713 10% 54% 766
2 HISTONE DEACETYLASE authKW 1376463 10% 44% 766
3 HDAC INHIBITOR authKW 893419 6% 52% 420
4 HDAC authKW 486821 4% 38% 312
5 VORINOSTAT authKW 290365 2% 53% 133
6 SAHA authKW 285632 2% 57% 122
7 EPIGENETICS authKW 240480 11% 7% 799
8 TRICHOSTATIN A authKW 237210 2% 32% 184
9 SUBEROYLANILIDE HYDROXAMIC ACID authKW 186861 1% 57% 80
10 PANOBINOSTAT authKW 164361 1% 59% 68

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 12285 22% 0% 1669
2 Chemistry, Medicinal 6333 9% 0% 692
3 Cell Biology 4787 15% 0% 1091
4 Biochemistry & Molecular Biology 4249 23% 0% 1734
5 Neurosciences 3181 14% 0% 1064
6 Pharmacology & Pharmacy 1803 12% 0% 860
7 Genetics & Heredity 848 6% 0% 438
8 Hematology 845 4% 0% 303
9 Psychiatry 738 5% 0% 351
10 Medicine, Research & Experimental 661 5% 0% 351

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPIGENET HUMAN HLTH DIS 40801 0% 37% 27
2 UNIT SIGNAL TRANSDUCT GASTROINTESTINAL CANC 30917 0% 69% 11
3 SACKLER PROGRAM EPIGENET PSYCHOBIOL 23634 0% 32% 18
4 IL RISK ASSESSMENT INTERVENT STUDIES 20925 0% 39% 13
5 DIPARTIMENTO PATOL GEN 20472 0% 16% 32
6 ROGER WILLIAM MED 20125 0% 62% 8
7 EPIGEN PROFILING IL 18576 0% 45% 10
8 EVELYN F MCKNIGHT BRAIN 18270 1% 12% 38
9 BRUDNICK NEUROPSYCHIAT 18243 0% 17% 27
10 MOL GENET PREPARAT MOL BIOL 17026 0% 42% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPIGENOMICS 17056 1% 10% 44
2 MOLECULAR CANCER THERAPEUTICS 6298 1% 2% 80
3 CLINICAL EPIGENETICS 4833 0% 5% 22
4 INFLAMMOPHARMACOLOGY 4245 0% 9% 12
5 CIBA FOUNDATION SYMPOSIA 4127 1% 2% 53
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3793 2% 1% 158
7 CLINICAL CANCER RESEARCH 3768 2% 1% 120
8 JOURNAL OF MEDICINAL CHEMISTRY 3148 2% 1% 133
9 TRANSLATIONAL PSYCHIATRY 3139 0% 3% 27
10 INVESTIGATIONAL NEW DRUGS 2619 1% 2% 41

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HISTONE DEACETYLASE INHIBITOR 1693713 10% 54% 766 Search HISTONE+DEACETYLASE+INHIBITOR Search HISTONE+DEACETYLASE+INHIBITOR
2 HISTONE DEACETYLASE 1376463 10% 44% 766 Search HISTONE+DEACETYLASE Search HISTONE+DEACETYLASE
3 HDAC INHIBITOR 893419 6% 52% 420 Search HDAC+INHIBITOR Search HDAC+INHIBITOR
4 HDAC 486821 4% 38% 312 Search HDAC Search HDAC
5 VORINOSTAT 290365 2% 53% 133 Search VORINOSTAT Search VORINOSTAT
6 SAHA 285632 2% 57% 122 Search SAHA Search SAHA
7 EPIGENETICS 240480 11% 7% 799 Search EPIGENETICS Search EPIGENETICS
8 TRICHOSTATIN A 237210 2% 32% 184 Search TRICHOSTATIN+A Search TRICHOSTATIN+A
9 SUBEROYLANILIDE HYDROXAMIC ACID 186861 1% 57% 80 Search SUBEROYLANILIDE+HYDROXAMIC+ACID Search SUBEROYLANILIDE+HYDROXAMIC+ACID
10 PANOBINOSTAT 164361 1% 59% 68 Search PANOBINOSTAT Search PANOBINOSTAT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BOLDEN, JE , PEART, MJ , JOHNSTONE, RW , (2006) ANTICANCER ACTIVITIES OF HISTONE DEACETYLASE INHIBITORS.NATURE REVIEWS DRUG DISCOVERY. VOL. 5. ISSUE 9. P. 769-784 140 71% 1602
2 FALKENBERG, KJ , JOHNSTONE, RW , (2014) HISTONE DEACETYLASES AND THEIR INHIBITORS IN CANCER, NEUROLOGICAL DISEASES AND IMMUNE DISORDERS.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 9. P. 673 -691 152 57% 254
3 MOTTAMAL, M , ZHENG, SL , HUANG, TL , WANG, GD , (2015) HISTONE DEACETYLASE INHIBITORS IN CLINICAL STUDIES AS TEMPLATES FOR NEW ANTICANCER AGENTS.MOLECULES. VOL. 20. ISSUE 3. P. 3898 -3941 135 71% 77
4 WEST, AC , JOHNSTONE, RW , (2014) NEW AND EMERGING HDAC INHIBITORS FOR CANCER TREATMENT.JOURNAL OF CLINICAL INVESTIGATION. VOL. 124. ISSUE 1. P. 30-39 96 78% 256
5 KOLLAR, J , FRECER, V , (2015) SELECTIVE INHIBITORS OF ZINC-DEPENDENT HISTONE DEACETYLASES. THERAPEUTIC TARGETS RELEVANT TO CANCER.CURRENT PHARMACEUTICAL DESIGN. VOL. 21. ISSUE 11. P. 1472 -1502 209 80% 0
6 THALER, F , MERCURIO, C , (2014) TOWARDS SELECTIVE INHIBITION OF HISTONE DEACETYLASE ISOFORMS: WHAT HAS BEEN ACHIEVED, WHERE WE ARE AND WHAT WILL BE NEXT.CHEMMEDCHEM. VOL. 9. ISSUE 3. P. 523-536 155 89% 27
7 MANAL, M , CHANDRASEKAR, MJN , PRIYA, JG , NANJAN, MJ , (2016) INHIBITORS OF HISTONE DEACETYLASE AS ANTITUMOR AGENTS: A CRITICAL REVIEW.BIOORGANIC CHEMISTRY. VOL. 67. ISSUE . P. 18 -42 142 78% 6
8 LEE, JH , CHOY, ML , MARKS, PA , (2012) MECHANISMS OF RESISTANCE TO HISTONE DEACETYLASE INHIBITORS.HISTONE DEACETYLASE INHIBITORS AS CANCER THERAPEUTICS. VOL. 116. ISSUE . P. 39-86 186 78% 26
9 WITT, O , DEUBZER, HE , MILDE, T , OEHME, I , (2009) HDAC FAMILY: WHAT ARE THE CANCER RELEVANT TARGETS?.CANCER LETTERS. VOL. 277. ISSUE 1. P. 8-21 100 87% 411
10 ROCHE, J , BERTRAND, P , (2016) INSIDE HDACS WITH MORE SELECTIVE HDAC INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 121. ISSUE . P. 451 -483 141 76% 3

Classes with closest relation at Level 2


Rank Class id link
1 2649 SIRT1//SIRTUINS//SIRT3
2 382 DNA METHYLATION//EPIGENETICS//METHYLATION
3 343 EZH2//CHROMATIN//POLYCOMB
4 3175 ID 1//NRSF//ID1
5 3037 KLF4//KRUPPEL LIKE FACTOR//GADD45
6 1843 ACUTE PROMYELOCYTIC LEUKEMIA//ARSENIC TRIOXIDE//SUMO
7 3321 BLEOMYCIN//MIGRASTATIN//BLEOMYCIN HYDROLASE
8 2158 NF KAPPA B//I KAPPA B//IKK
9 2654 NURR1//NUR77//PGC 1 ALPHA
10 3833 CITED2//BRANCHIO OCULO FACIAL SYNDROME//AP 2 ALPHA

Go to start page