Class information for:
Level 1: TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2662 2181 43.9 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
2662 1                   TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA 2181

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TOPOISOMERASE II authKW 1122843 11% 34% 238
2 DNA TOPOISOMERASE II authKW 436323 3% 47% 67
3 TOPOISOMERASE II ALPHA authKW 317345 3% 31% 73
4 ICRF 193 authKW 291563 1% 77% 27
5 TOPOISOMERASE II BETA authKW 249965 1% 71% 25
6 TOPOISOMERASE authKW 211241 5% 14% 105
7 CATALYTIC INHIBITOR authKW 146295 1% 58% 18
8 DNA TOPOISOMERASE II ALPHA authKW 130200 1% 47% 20
9 F 11782 authKW 125990 0% 100% 9
10 BISDIOXOPIPERAZINE authKW 124508 1% 68% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 6127 28% 0% 621
2 Biochemistry & Molecular Biology 4320 39% 0% 841
3 Toxicology 1166 8% 0% 166
4 Pharmacology & Pharmacy 1020 15% 0% 324
5 Cell Biology 970 13% 0% 274
6 Genetics & Heredity 688 9% 0% 190
7 Biophysics 375 6% 0% 127
8 Chemistry, Medicinal 274 4% 0% 89
9 Hematology 85 3% 0% 60
10 Pathology 55 2% 0% 47

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HEMATOL ONCOL DEV THER EUT SECT 41997 0% 100% 3
2 INTER ONCOL 37328 0% 67% 4
3 ENZYMOL ACIDES NUCLCNRSURA 2225 27998 0% 100% 2
4 MED CELLULAR MOL SCI MOL GENET GRP 27998 0% 100% 2
5 MED HEMATOL ONCOL 26858 3% 3% 56
6 MED MYCOL SHOWA KU 21866 0% 31% 5
7 EXPT CANCEROL 1 18664 0% 67% 2
8 BIOL PHARMACOL DNA TOPOISOMERASES 17995 0% 43% 3
9 REG CANC TREATMENT SERV 17995 0% 43% 3
10 13TH FLOOR 13999 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER RESEARCH 8349 7% 0% 154
2 BIOCHEMICAL PHARMACOLOGY 6157 4% 0% 91
3 MOLECULAR PHARMACOLOGY 4742 3% 1% 58
4 ANTI-CANCER DRUG DESIGN 3748 1% 2% 13
5 CANCER CHEMOTHERAPY AND PHARMACOLOGY 2988 2% 1% 40
6 BIOCHEMISTRY 2969 5% 0% 109
7 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 2769 1% 1% 28
8 MUTATION RESEARCH 2176 2% 0% 36
9 JOURNAL OF BIOLOGICAL CHEMISTRY 2151 7% 0% 160
10 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 2025 1% 1% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TOPOISOMERASE II 1122843 11% 34% 238 Search TOPOISOMERASE+II Search TOPOISOMERASE+II
2 DNA TOPOISOMERASE II 436323 3% 47% 67 Search DNA+TOPOISOMERASE+II Search DNA+TOPOISOMERASE+II
3 TOPOISOMERASE II ALPHA 317345 3% 31% 73 Search TOPOISOMERASE+II+ALPHA Search TOPOISOMERASE+II+ALPHA
4 ICRF 193 291563 1% 77% 27 Search ICRF+193 Search ICRF+193
5 TOPOISOMERASE II BETA 249965 1% 71% 25 Search TOPOISOMERASE+II+BETA Search TOPOISOMERASE+II+BETA
6 TOPOISOMERASE 211241 5% 14% 105 Search TOPOISOMERASE Search TOPOISOMERASE
7 CATALYTIC INHIBITOR 146295 1% 58% 18 Search CATALYTIC+INHIBITOR Search CATALYTIC+INHIBITOR
8 DNA TOPOISOMERASE II ALPHA 130200 1% 47% 20 Search DNA+TOPOISOMERASE+II+ALPHA Search DNA+TOPOISOMERASE+II+ALPHA
9 F 11782 125990 0% 100% 9 Search F+11782 Search F+11782
10 BISDIOXOPIPERAZINE 124508 1% 68% 13 Search BISDIOXOPIPERAZINE Search BISDIOXOPIPERAZINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FORTUNE, JM , OSHEROFF, N , (2000) TOPOISOMERASE II AS A TARGET FOR ANTICANCER DRUGS: WHEN ENZYMES STOP BEING NICE.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 64. VOL. 64. ISSUE . P. 221 -253 181 76% 229
2 BAKSHI, RP , GALANDE, S , MUNIYAPPA, K , (2001) FUNCTIONAL AND REGULATORY CHARACTERISTICS OF EUKARYOTIC TYPE II DNA TOPOISOMERASE.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 36. ISSUE 1. P. 1 -37 198 76% 40
3 BURDEN, DA , OSHEROFF, N , (1998) MECHANISM OF ACTION OF EUKARYOTIC TOPOISOMERASE II AND DRUGS TARGETED TO THE ENZYME.BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. VOL. 1400. ISSUE 1-3. P. 139 -154 126 86% 366
4 WANG, JC , (1996) DNA TOPOISOMERASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 635-692 177 36% 1741
5 CHIKAMORI, K , GROZAV, AG , KOZUKI, T , GRABOWSKI, D , GANAPATHI, R , GANAPATHI, MK , (2010) DNA TOPOISOMERASE II ENZYMES AS MOLECULAR TARGETS FOR CANCER CHEMOTHERAPY.CURRENT CANCER DRUG TARGETS. VOL. 10. ISSUE 7. P. 758-771 132 69% 42
6 WILSTERMANN, AM , OSHEROOF, N , (2003) STABILIZATION OF EUKARYOTIC TOPOISOMERASE II-DNA CLEAVAGE COMPLEXES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 3. ISSUE 3. P. 321 -338 134 72% 117
7 CORBETT, AH , OSHEROFF, N , (1993) WHEN GOOD ENZYMES GO BAD - CONVERSION OF TOPOISOMERASE-II TO A CELLULAR TOXIN BY ANTINEOPLASTIC DRUGS.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 6. ISSUE 5. P. 585-597 162 74% 158
8 DEWEESE, JE , OSHEROFF, N , (2009) THE DNA CLEAVAGE REACTION OF TOPOISOMERASE II: WOLF IN SHEEP'S CLOTHING.NUCLEIC ACIDS RESEARCH. VOL. 37. ISSUE 3. P. 738 -748 85 62% 123
9 MCCLENDON, AK , OSHEROFF, N , (2007) DNA TOPOISOMERASE II, GENOTOXICITY, AND CANCER.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. VOL. 623. ISSUE 1-2. P. 83 -97 89 56% 140
10 NITISS, JL , (2009) TARGETING DNA TOPOISOMERASE II IN CANCER CHEMOTHERAPY.NATURE REVIEWS CANCER. VOL. 9. ISSUE 5. P. 338 -350 68 44% 489

Classes with closest relation at Level 1


Rank Class id link
1 7420 TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE
2 6168 DNA GYRASE//GYRASE//REVERSE GYRASE
3 17911 ELLIPTICINE//OLIVACINE//INTOPLICINE
4 33216 BIMOLANE//PROBIMANE//MST 16
5 7272 ACRIDINE//C 1311//PYRAZOLOACRIDINE
6 24385 MANAGEMENT HLTH NPMC//CIPROFLOXACIN//CYST FIBROSIS PULM CLIN TREATMENT
7 1644 CAMPTOTHECIN//SN 38//TOPOTECAN
8 5018 NUCLEAR MATRIX//MATRIX ATTACHMENT REGION//NUCLEAR SCAFFOLD
9 10766 ETOPOSIDE//ETOPOSIDE PHOSPHATE//ORAL ETOPOSIDE
10 8392 PODOPHYLLOTOXIN//DEOXYPODOPHYLLOTOXIN//PODOPHYLLUM HEXANDRUM

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