Class information for:
Level 2: DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1654 6885 30.9 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1654 2             DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE 6885
3208 1                   MINOR GROOVE BINDER//DISTAMYCIN//PYRROLE IMIDAZOLE POLYAMIDE 2039
7272 1                   ACRIDINE//C 1311//PYRAZOLOACRIDINE 1387
9157 1                   SABARUBICIN//BARMINOMYCIN//ACTINOMYCIN 1182
10232 1                   MITOXANTRONE//PIXANTRONE//PIROXANTRONE 1079
19395 1                   ECHINOMYCIN//STREPTOMYCES ALBOFLAVUS 313//PIPERAZIC ACID 507
21187 1                   HETERO ASSOCIATION//NOVATRONE//STACKING COMPLEXES 429
29974 1                   CI 958//ARYLMETHYLAMINOPROPANEDIOLS//SR271425 177
36153 1                   ACTINOCIN//A2780 HUMAN OVARIAN CANCER//ACTINOCINE MONOAMIDES 85

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DISTAMYCIN authKW 177500 1% 69% 58
2 MINOR GROOVE BINDER authKW 171436 1% 54% 72
3 PYRROLE IMIDAZOLE POLYAMIDE authKW 143626 1% 90% 36
4 ACRIDINE authKW 136088 2% 26% 118
5 NETROPSIN authKW 122159 1% 66% 42
6 MITOXANTRONE authKW 99118 2% 15% 146
7 ANTI-CANCER DRUG DESIGN journal 94950 2% 19% 116
8 C 1311 authKW 93096 0% 100% 21
9 HETERO ASSOCIATION authKW 85626 0% 60% 32
10 PYRAZOLOACRIDINE authKW 84229 0% 100% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Chemistry, Medicinal 14965 14% 0% 987
2 Biochemistry & Molecular Biology 8034 31% 0% 2126
3 Chemistry, Organic 6061 15% 0% 1012
4 Biophysics 5552 11% 0% 770
5 Oncology 5340 16% 0% 1109
6 Pharmacology & Pharmacy 4076 16% 0% 1125
7 Chemistry, Multidisciplinary 1733 13% 0% 898
8 Toxicology 266 3% 0% 184
9 Biochemical Research Methods 185 3% 0% 188
10 Chemistry, Physical 128 6% 0% 441

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUT TECHNOL BIOCHEM 46572 1% 16% 64
2 VALORISAT CHIM FINE 34374 0% 48% 16
3 AUCKLAND CANC SOC 31023 1% 10% 67
4 MED CHEM DRUG TECHNOL 29081 0% 41% 16
5 CANC UK DRUG DNA INTERACT GRP 22071 0% 28% 18
6 PHARMACOL ANTITUMORALE 15700 0% 15% 23
7 THER EUT AREA ONCOL IMMUNOL 13299 0% 100% 3
8 ADV SCI HUMANITIES 9871 0% 11% 20
9 SHENZHEN ANTITUMOR DRUG DEV ENGN 9230 0% 42% 5
10 BERKBECK 8866 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTI-CANCER DRUG DESIGN 94950 2% 19% 116
2 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 33766 2% 5% 155
3 STUDIA BIOPHYSICA 27604 2% 6% 109
4 CANCER TREATMENT REPORTS 27363 2% 5% 117
5 INVESTIGATIONAL NEW DRUGS 16528 1% 4% 98
6 BIOORGANIC & MEDICINAL CHEMISTRY 9953 3% 1% 173
7 JOURNAL OF MEDICINAL CHEMISTRY 8207 3% 1% 203
8 CANCER CHEMOTHERAPY AND PHARMACOLOGY 7943 2% 2% 116
9 BIOPOLYMERS 5500 1% 1% 91
10 BIOCHEMISTRY 5062 4% 0% 256

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DISTAMYCIN 177500 1% 69% 58 Search DISTAMYCIN Search DISTAMYCIN
2 MINOR GROOVE BINDER 171436 1% 54% 72 Search MINOR+GROOVE+BINDER Search MINOR+GROOVE+BINDER
3 PYRROLE IMIDAZOLE POLYAMIDE 143626 1% 90% 36 Search PYRROLE+IMIDAZOLE+POLYAMIDE Search PYRROLE+IMIDAZOLE+POLYAMIDE
4 ACRIDINE 136088 2% 26% 118 Search ACRIDINE Search ACRIDINE
5 NETROPSIN 122159 1% 66% 42 Search NETROPSIN Search NETROPSIN
6 MITOXANTRONE 99118 2% 15% 146 Search MITOXANTRONE Search MITOXANTRONE
7 C 1311 93096 0% 100% 21 Search C+1311 Search C+1311
8 HETERO ASSOCIATION 85626 0% 60% 32 Search HETERO+ASSOCIATION Search HETERO+ASSOCIATION
9 PYRAZOLOACRIDINE 84229 0% 100% 19 Search PYRAZOLOACRIDINE Search PYRAZOLOACRIDINE
10 ECHINOMYCIN 73859 0% 56% 30 Search ECHINOMYCIN Search ECHINOMYCIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BAILLY, C , CHAIRES, JB , (1998) SEQUENCE-SPECIFIC DNA MINOR GROOVE BINDERS. DESIGN AND SYNTHESIS OF NETROPSIN AND DISTAMYCIN ANALOGUES.BIOCONJUGATE CHEMISTRY. VOL. 9. ISSUE 5. P. 513 -538 201 79% 231
2 NEIDLE, S , (2001) DNA MINOR-GROOVE RECOGNITION BY SMALL MOLECULES.NATURAL PRODUCT REPORTS. VOL. 18. ISSUE 3. P. 291 -309 168 73% 299
3 GALLMEIER, HC , KONIG, B , (2003) HETEROAROMATIC OLIGOAMIDES WITH DDNA AFFINITY.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. VOL. . ISSUE 18. P. 3473 -3483 126 91% 15
4 DAWSON, S , MALKINSON, JP , PAUMIER, D , SEARCEY, M , (2007) BISINTERCALATOR NATURAL PRODUCTS WITH POTENTIAL THERAPEUTIC APPLICATIONS: ISOLATION, STRUCTURE DETERMINATION, SYNTHETIC AND BIOLOGICAL STUDIES.NATURAL PRODUCT REPORTS. VOL. 24. ISSUE 1. P. 109-126 101 92% 56
5 BLACKLEDGE, MS , MELANDER, C , (2013) PROGRAMMABLE DNA-BINDING SMALL MOLECULES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 21. ISSUE 20. P. 6101-6114 84 91% 26
6 REDDY, BSP , SONDHI, SM , LOWN, JW , (1999) SYNTHETIC DNA MINOR GROOVE-BINDING DRUGS.PHARMACOLOGY & THERAPEUTICS. VOL. 84. ISSUE 1. P. 1 -111 175 53% 155
7 JIANG, SK , WANG, P , WU, YL , ZHANG, W , (2011) THE ROLE OF ALIPHATIC CHAINS IN PYRROLE-IMIDAZOLE POLYAMIDES AND THEIR CONJUGATES BINDING TO DNA.PROGRESS IN CHEMISTRY. VOL. 23. ISSUE 11. P. 2339 -2352 84 92% 0
8 KASHIWAZAKI, G , CHANDRAN, A , ASAMITSU, S , KAWASE, T , KAWAMOTO, Y , SAWATANI, Y , HASHIYA, K , BANDO, T , SUGIYAMA, H , (2016) COMPARATIVE ANALYSIS OF DNA-BINDING SELECTIVITY OF HAIRPIN AND CYCLIC PYRROLE-IMIDAZOLE POLYAMIDES BASED ON NEXT-GENERATION SEQUENCING.CHEMBIOCHEM. VOL. 17. ISSUE 18. P. 1752 -1758 67 94% 0
9 DERVAN, PB , EDELSON, BS , (2003) RECOGNITION OF THE DNA MINOR GROOVE BY PYRROLE-IMIDAZOLE POLYAMIDES.CURRENT OPINION IN STRUCTURAL BIOLOGY. VOL. 13. ISSUE 3. P. 284-299 64 90% 400
10 OELKE, AJ , FRANCE, DJ , HOFMANN, T , WUITSCHIK, G , LEY, SV , (2011) PIPERAZIC ACID-CONTAINING NATURAL PRODUCTS: ISOLATION, BIOLOGICAL RELEVANCE AND TOTAL SYNTHESIS.NATURAL PRODUCT REPORTS. VOL. 28. ISSUE 8. P. 1445 -1471 92 70% 25

Classes with closest relation at Level 2


Rank Class id link
1 2252 ANGUCYCLINE//IDARUBICIN//ANGUCYCLINONE
2 3321 BLEOMYCIN//MIGRASTATIN//BLEOMYCIN HYDROLASE
3 1488 CAMPTOTHECIN//TOPOISOMERASE I//SN 38
4 2227 CARDIOTOXICITY//ANTHRACYCLINES//DOXORUBICIN
5 740 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS//SINGLE MOLECULE FORCE SPECTROSCOPY//Z DNA
6 1439 DNA BINDING//RESONANCE LIGHT SCATTERING//RESONANCE RAYLEIGH SCATTERING
7 2728 G QUADRUPLEX//QUADRUPLEX//G QUADRUPLEX DNA
8 3633 GENE POINT MUTATIONS//HETEROKARYON 12//AD 3A LOCUS
9 3694 GUANIDINOBENZOATASE//CELL SURFACE PROTEASE//MURINE MODELS OF SLE
10 1235 INDOLE//BISINDOLYLMETHANES//ELLIPTICINE

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