Class information for:
Level 1: TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7420 1369 42.4 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
7420 1                   TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE 1369

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TOPOISOMERASE I authKW 688191 10% 24% 131
2 DNA TOPOISOMERASE I authKW 553183 5% 39% 63
3 INDENOISOQUINOLINE authKW 431785 2% 88% 22
4 TDP1 authKW 317268 2% 68% 21
5 TYROSYL DNA PHOSPHODIESTERASE authKW 312245 1% 100% 14
6 HUMAN TOPOISOMERASE I authKW 273211 1% 88% 14
7 TYROSYL DNA PHOSPHODIESTERASE 1 authKW 247049 1% 92% 12
8 CAMPTOTHECIN authKW 177759 7% 8% 102
9 MOL PHARMACOL address 117467 14% 3% 194
10 DEV THER EUT BRANCH address 110591 2% 20% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 7050 59% 0% 805
2 Chemistry, Medicinal 1721 11% 0% 152
3 Cell Biology 533 12% 0% 163
4 Oncology 487 12% 0% 160
5 Biophysics 462 8% 0% 105
6 Genetics & Heredity 165 6% 0% 82
7 Chemistry, Organic 107 6% 0% 78
8 Pharmacology & Pharmacy 56 7% 0% 89
9 Virology 39 2% 0% 25
10 Toxicology 29 2% 0% 30

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PHARMACOL 117467 14% 3% 194
2 DEV THER EUT BRANCH 110591 2% 20% 25
3 PURDUE CANC 94507 3% 10% 43
4 MED CHEM MOL PHARMACOL 61985 4% 5% 57
5 HELMY 59473 0% 67% 4
6 INTOXCAL 47506 1% 30% 7
7 BIOL INTERUNIV CONSORTIUM 44606 0% 100% 2
8 CNRSLP 9008 44606 0% 100% 2
9 MAMMALIAN GENOME STABIL GRP 44606 0% 100% 2
10 WELLCOME TRUST DNA REPAIR GRP 44606 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEIC ACIDS RESEARCH 6353 8% 0% 107
2 DNA REPAIR 2780 1% 1% 16
3 JOURNAL OF BIOLOGICAL CHEMISTRY 2728 10% 0% 140
4 JOURNAL OF MEDICINAL CHEMISTRY 1947 3% 0% 44
5 MOLECULAR CANCER THERAPEUTICS 1376 1% 0% 16
6 BIOORGANIC & MEDICINAL CHEMISTRY 1208 2% 0% 27
7 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1160 1% 0% 12
8 BIOCHEMISTRY 969 4% 0% 50
9 JOURNAL OF MOLECULAR BIOLOGY 928 2% 0% 32
10 CANCER RESEARCH 724 3% 0% 37

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TOPOISOMERASE I 688191 10% 24% 131 Search TOPOISOMERASE+I Search TOPOISOMERASE+I
2 DNA TOPOISOMERASE I 553183 5% 39% 63 Search DNA+TOPOISOMERASE+I Search DNA+TOPOISOMERASE+I
3 INDENOISOQUINOLINE 431785 2% 88% 22 Search INDENOISOQUINOLINE Search INDENOISOQUINOLINE
4 TDP1 317268 2% 68% 21 Search TDP1 Search TDP1
5 TYROSYL DNA PHOSPHODIESTERASE 312245 1% 100% 14 Search TYROSYL+DNA+PHOSPHODIESTERASE Search TYROSYL+DNA+PHOSPHODIESTERASE
6 HUMAN TOPOISOMERASE I 273211 1% 88% 14 Search HUMAN+TOPOISOMERASE+I Search HUMAN+TOPOISOMERASE+I
7 TYROSYL DNA PHOSPHODIESTERASE 1 247049 1% 92% 12 Search TYROSYL+DNA+PHOSPHODIESTERASE+1 Search TYROSYL+DNA+PHOSPHODIESTERASE+1
8 CAMPTOTHECIN 177759 7% 8% 102 Search CAMPTOTHECIN Search CAMPTOTHECIN
9 HUMAN TOPOISOMERASE IB 89213 0% 100% 4 Search HUMAN+TOPOISOMERASE+IB Search HUMAN+TOPOISOMERASE+IB
10 TYROSYL DNA PHOSPHODIESTERASE 2 89213 0% 100% 4 Search TYROSYL+DNA+PHOSPHODIESTERASE+2 Search TYROSYL+DNA+PHOSPHODIESTERASE+2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 POMMIER, Y , (2009) DNA TOPOISOMERASE I INHIBITORS: CHEMISTRY, BIOLOGY, AND INTERFACIAL INHIBITION.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2894-2902 83 63% 253
2 POMMIER, Y , POURQUIER, P , FAN, Y , STRUMBERG, D , (1998) MECHANISM OF ACTION OF EUKARYOTIC DNA TOPOISOMERASE I AND DRUGS TARGETED TO THE ENZYME.BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. VOL. 1400. ISSUE 1-3. P. 83 -106 130 53% 433
3 POMMIER, Y , HUANG, SYN , GAO, R , DAS, BB , MURAI, J , MARCHAND, C , (2014) TYROSYL-DNA-PHOSPHODIESTERASES (TDP1 AND TDP2).DNA REPAIR. VOL. 19. ISSUE . P. 114 -129 102 54% 30
4 LAEV, SS , SALAKHUTDINOV, NF , LAVRIK, OI , (2016) TYROSYL-DNA PHOSPHODIESTERASE INHIBITORS: PROGRESS AND POTENTIAL.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 24. ISSUE 21. P. 5017 -5027 78 72% 0
5 COMEAUX, EQ , VAN WAARDENBURG, RCAM , (2014) TYROSYL-DNA PHOSPHODIESTERASE I RESOLVES BOTH NATURALLY AND CHEMICALLY INDUCED DNA ADDUCTS AND ITS POTENTIAL AS A THERAPEUTIC TARGET.DRUG METABOLISM REVIEWS. VOL. 46. ISSUE 4. P. 494 -507 77 65% 7
6 BUGREEV, DV , NEVINSKY, GA , (2010) THE STRUCTURE AND MECHANISM OF THE ACTION OF TYPE-IB DNA TOPOISOMERASES.RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY. VOL. 36. ISSUE 3. P. 269-286 74 76% 0
7 DEXHEIMER, TS , POMMIER, Y , (2008) DNA CLEAVAGE ASSAY FOR THE IDENTIFICATION OF TOPOISOMERASE I INHIBITORS.NATURE PROTOCOLS. VOL. 3. ISSUE 11. P. 1736-1750 68 72% 25
8 POMMIER, Y , (2006) TOPOISOMERASE I INHIBITORS: CAMPTOTHECINS AND BEYOND.NATURE REVIEWS CANCER. VOL. 6. ISSUE 10. P. 789 -802 60 43% 786
9 LV, PC , AGAMA, K , MARCHAND, C , POMMIER, Y , CUSHMAN, M , (2014) DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF O-2-MODIFIED INDENOISOQUINOLINES AS DUAL TOPOISOMERASE I-TYROSYL-DNA PHOSPHODIESTERASE I INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 10. P. 4324 -4336 51 77% 6
10 LEPPARD, JB , CHAMPOUX, JJ , (2005) HUMAN DNA TOPOISOMERASE I: RELAXATION, ROLES, AND DAMAGE CONTROL.CHROMOSOMA. VOL. 114. ISSUE 2. P. 75-85 61 70% 119

Classes with closest relation at Level 1


Rank Class id link
1 2662 TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA
2 1644 CAMPTOTHECIN//SN 38//TOPOTECAN
3 6168 DNA GYRASE//GYRASE//REVERSE GYRASE
4 22273 ARSACS//AOA2//SENATAXIN
5 19522 REPLICATION FORK BARRIER//FORK ARREST//REPLICATION TERMINATOR PROTEIN
6 12530 INDOLOCARBAZOLE//REBECCAMYCIN//GRANULATIMIDE
7 7535 SITE SPECIFIC RECOMBINATION//SERINE RECOMBINASE//PHIC31 INTEGRASE
8 25887 MOBILE PHASE SELECTION//HOMOPHTHALIC ANHYDRIDE//CIS ISOQUINOLONIC ACIDS
9 26201 2 4 6 TRIARYLPYRIDINES//TOPOISOMERASE I AND II INHIBITION//KROHNKE PYRIDINES
10 10592 KINETOPLAST//RNA EDITING//KINETOPLAST DNA

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