Class information for:
Level 2: THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1176 9333 32.9 70%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
747 1                   METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER 3107
7353 1                   URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN 1377
8721 1                   THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE 1225
9432 1                   DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL 1156
11797 1                   THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102 953
15011 1                   THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE 736
22412 1                   F 19 MRS//FLUORONUCLEOTIDES//F 19 MR IMAGING 382
26291 1                   IN VIVO ANTITUMOUR ACTIVITY//MOUSE LYMPHOID NEOPLASMA P 388//MOUSE MAMMARY CARCINOMA FM 3A 258
32402 1                   CARMOFUR//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL//HCFU 139

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 THYMIDYLATE SYNTHASE authKW 1136811 6% 61% 573
2 THYMIDINE PHOSPHORYLASE authKW 885296 4% 73% 372
3 5 FLUOROURACIL authKW 861633 11% 25% 1073
4 DIHYDROPYRIMIDINE DEHYDROGENASE authKW 852351 3% 84% 311
5 CAPECITABINE authKW 415051 5% 29% 439
6 OXALIPLATIN authKW 369730 5% 23% 502
7 METASTATIC COLORECTAL CANCER authKW 358252 3% 39% 281
8 LEUCOVORIN authKW 324876 2% 43% 230
9 ADVANCED COLORECTAL CANCER authKW 268986 1% 65% 127
10 FLUOROPYRIMIDINES authKW 267898 2% 58% 142

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 103193 54% 1% 5050
2 Pharmacology & Pharmacy 6458 17% 0% 1626
3 Gastroenterology & Hepatology 768 4% 0% 332
4 Biochemistry & Molecular Biology 555 11% 0% 1049
5 Chemistry, Medicinal 343 3% 0% 242
6 Biophysics 205 3% 0% 268
7 Biochemical Research Methods 123 2% 0% 208
8 Medicine, Research & Experimental 100 2% 0% 232
9 Medical Laboratory Technology 76 1% 0% 69
10 Surgery 63 4% 0% 362

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED ONCOL 49783 9% 2% 849
2 TOKUSHIMA 29831 1% 17% 53
3 ONCOPHARMACOL UNIT 29214 0% 31% 29
4 GERCOR 26371 0% 73% 11
5 CANC 2 18830 0% 52% 11
6 DIGEST ONCOL UNIT 16772 0% 16% 32
7 MED ONCOL UNIT 16128 1% 5% 98
8 ONCOPHARMACOL 14686 0% 16% 28
9 ONCOL 14206 6% 1% 569
10 UNITA CHEMIOTER IA 13079 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL COLORECTAL CANCER 98132 1% 25% 119
2 CANCER CHEMOTHERAPY AND PHARMACOLOGY 38932 3% 4% 297
3 ANNALS OF ONCOLOGY 24908 3% 3% 252
4 JOURNAL OF CLINICAL ONCOLOGY 15541 3% 2% 281
5 ANTI-CANCER DRUGS 15208 1% 4% 124
6 EUROPEAN JOURNAL OF CANCER 14989 2% 2% 216
7 ANTICANCER RESEARCH 12922 3% 1% 279
8 ONCOLOGY 11783 1% 3% 120
9 CANCER TREATMENT REPORTS 11341 1% 4% 88
10 ONCOLOGY-NEW YORK 10789 1% 5% 70

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 THYMIDYLATE SYNTHASE 1136811 6% 61% 573 Search THYMIDYLATE+SYNTHASE Search THYMIDYLATE+SYNTHASE
2 THYMIDINE PHOSPHORYLASE 885296 4% 73% 372 Search THYMIDINE+PHOSPHORYLASE Search THYMIDINE+PHOSPHORYLASE
3 5 FLUOROURACIL 861633 11% 25% 1073 Search 5+FLUOROURACIL Search 5+FLUOROURACIL
4 DIHYDROPYRIMIDINE DEHYDROGENASE 852351 3% 84% 311 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
5 CAPECITABINE 415051 5% 29% 439 Search CAPECITABINE Search CAPECITABINE
6 OXALIPLATIN 369730 5% 23% 502 Search OXALIPLATIN Search OXALIPLATIN
7 METASTATIC COLORECTAL CANCER 358252 3% 39% 281 Search METASTATIC+COLORECTAL+CANCER Search METASTATIC+COLORECTAL+CANCER
8 LEUCOVORIN 324876 2% 43% 230 Search LEUCOVORIN Search LEUCOVORIN
9 ADVANCED COLORECTAL CANCER 268986 1% 65% 127 Search ADVANCED+COLORECTAL+CANCER Search ADVANCED+COLORECTAL+CANCER
10 FLUOROPYRIMIDINES 267898 2% 58% 142 Search FLUOROPYRIMIDINES Search FLUOROPYRIMIDINES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LIEKENS, S , BRONCKAERS, A , GAGO, F , BALZARINI, J , (2009) THE DUAL ROLE OF THYMIDINE PHOSPHORYLASE IN CANCER DEVELOPMENT AND CHEMOTHERAPY.MEDICINAL RESEARCH REVIEWS. VOL. 29. ISSUE 6. P. 903 -953 260 72% 70
2 VAN KUILENBURG, ABP , (2004) DIHYDROPYRIMIDINE DEHYDROGENASE AND THE EFFICACY AND TOXICITY OF 5-FLUOROURACIL.EUROPEAN JOURNAL OF CANCER. VOL. 40. ISSUE 7. P. 939-950 107 96% 218
3 MERCIER, C , CICCOLINI, J , (2006) PROFILING DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY IN PATIENTS WITH CANCER UNDERGOING 5-FLUOROURACIL/CAPECITABINE THERAPY.CLINICAL COLORECTAL CANCER. VOL. 6. ISSUE 4. P. 288-296 122 100% 26
4 MEULENDIJKS, D , CATS, A , BEIJNEN, JH , SCHELLENS, JHM , (2016) IMPROVING SAFETY OF FLUOROPYRIMIDINE CHEMOTHERAPY BY INDIVIDUALIZING TREATMENT BASED ON DIHYDROPYRIMIDINE DEHYDROGENASE ACTIVITY - READY FOR CLINICAL PRACTICE?.CANCER TREATMENT REVIEWS. VOL. 50. ISSUE . P. 23 -34 85 99% 0
5 CERSOSIMO, RJ , (2013) MANAGEMENT OF ADVANCED COLORECTAL CANCER, PART 1.AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. VOL. 70. ISSUE 5. P. 395 -406 81 98% 11
6 BERA, H , CHIGURUPATI, S , (2016) RECENT DISCOVERY OF NON-NUCLEOBASE THYMIDINE PHOSPHORYLASE INHIBITORS TARGETING CANCER.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 124. ISSUE . P. 992 -1003 93 85% 0
7 PLOYLEARMSAENG, SA , FUHR, U , JETTER, A , (2006) HOW MAY ANTICANCER CHEMOTHERAPY WITH FLUOROURACIL BE INDIVIDUALISED?.CLINICAL PHARMACOKINETICS. VOL. 45. ISSUE 6. P. 567-592 100 93% 27
8 PANCZYK, M , (2014) PHARMACOGENETICS RESEARCH ON CHEMOTHERAPY RESISTANCE IN COLORECTAL CANCER OVER THE LAST 20 YEARS.WORLD JOURNAL OF GASTROENTEROLOGY. VOL. 20. ISSUE 29. P. 9775 -9827 175 40% 14
9 MARING, JG , GROEN, HJM , WACHTERS, FM , UGES, DRA , DE VRIES, EGE , (2005) GENETIC FACTORS INFLUENCING PYRIMIDINE-ANTAGONIST CHEMOTHERAPY.PHARMACOGENOMICS JOURNAL. VOL. 5. ISSUE 4. P. 226-243 122 70% 71
10 VAN STAVEREN, MC , GUCHELAAR, HJ , VAN KUILENBURG, ABP , GELDERBLOM, H , MARING, JG , (2013) EVALUATION OF PREDICTIVE TESTS FOR SCREENING FOR DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY.PHARMACOGENOMICS JOURNAL. VOL. 13. ISSUE 5. P. 389-395 67 100% 22

Classes with closest relation at Level 2


Rank Class id link
1 1071 LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC
2 1684 METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER
3 1422 XRCC1//GEMCITABINE//ERCC1
4 1026 GASTRIC CANCER//ADVANCED GASTRIC CANCER//GASTRECTOMY
5 3290 HAND FOOT SYNDROME//HYPERSENSITIVITY REACTION//RADIATION RECALL
6 1102 PACLITAXEL//TAXANES//EPOTHILONES
7 444 RADIOFREQUENCY ABLATION//LIVER METASTASES//RADIOEMBOLIZATION
8 327 RECTAL CANCER//TOTAL MESORECTAL EXCISION//DISEASES OF THE COLON & RECTUM
9 3291 PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE
10 2341 RIBONUCLEOTIDE REDUCTASE//POLG//HYDROXYUREA

Go to start page