Class information for:
Level 1: DNA GYRASE//GYRASE//REVERSE GYRASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6168 1519 40.1 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
6168 1                   DNA GYRASE//GYRASE//REVERSE GYRASE 1519

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DNA GYRASE authKW 923119 7% 41% 113
2 GYRASE authKW 497868 3% 49% 51
3 REVERSE GYRASE authKW 276616 1% 81% 17
4 TOPOISOMERASE authKW 163118 5% 11% 77
5 TOPOISOMERASE IV authKW 147712 1% 35% 21
6 COUMERMYCIN authKW 143061 1% 65% 11
7 SUPERCOILING authKW 138257 2% 20% 34
8 DNA SUPERCOILING authKW 134496 2% 19% 35
9 CLOROBIOCIN authKW 125237 1% 69% 9
10 TOPA authKW 118230 1% 59% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 7250 57% 0% 863
2 Microbiology 6168 27% 0% 414
3 Chemistry, Medicinal 1590 10% 0% 155
4 Pharmacology & Pharmacy 390 12% 0% 179
5 Biophysics 381 7% 0% 103
6 Chemistry, Organic 147 6% 0% 93
7 Cell Biology 143 7% 0% 107
8 Genetics & Heredity 132 5% 0% 81
9 Biochemical Research Methods 95 4% 0% 55
10 Biology 47 2% 0% 35

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENZYMOL ACIDES NUCL 107198 1% 67% 8
2 PHARMAZEUT BIOL PHARMAZEUT 60302 0% 100% 3
3 INFECT DIS CEDD 51680 0% 43% 6
4 MICROBIOL CELL BIOL 45498 3% 5% 47
5 DIS DEV WORLD CEDD 40201 0% 100% 2
6 DIS DEVELOPING WORLD CEDD 40201 0% 100% 2
7 FRE 2445EQUIPE MICROBIOL 40201 0% 100% 2
8 GENET MICROBIOL ENZYMOL ACIDES NUCL 40201 0% 100% 2
9 GRP IMMUNOTECHNOL 40201 0% 100% 2
10 ORSAY GENET MICROBIOL 40201 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 7731 6% 0% 96
2 NUCLEIC ACIDS RESEARCH 7450 8% 0% 122
3 MOLECULAR MICROBIOLOGY 6218 4% 1% 61
4 JOURNAL OF BACTERIOLOGY 5019 6% 0% 92
5 JOURNAL OF MOLECULAR BIOLOGY 3337 4% 0% 63
6 JOURNAL OF BIOLOGICAL CHEMISTRY 2148 9% 0% 132
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1408 3% 0% 43
8 MOLECULAR & GENERAL GENETICS 982 1% 0% 11
9 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 777 1% 0% 11
10 BIOCHEMISTRY 758 3% 0% 47

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DNA GYRASE 923119 7% 41% 113 Search DNA+GYRASE Search DNA+GYRASE
2 GYRASE 497868 3% 49% 51 Search GYRASE Search GYRASE
3 REVERSE GYRASE 276616 1% 81% 17 Search REVERSE+GYRASE Search REVERSE+GYRASE
4 TOPOISOMERASE 163118 5% 11% 77 Search TOPOISOMERASE Search TOPOISOMERASE
5 TOPOISOMERASE IV 147712 1% 35% 21 Search TOPOISOMERASE+IV Search TOPOISOMERASE+IV
6 COUMERMYCIN 143061 1% 65% 11 Search COUMERMYCIN Search COUMERMYCIN
7 SUPERCOILING 138257 2% 20% 34 Search SUPERCOILING Search SUPERCOILING
8 DNA SUPERCOILING 134496 2% 19% 35 Search DNA+SUPERCOILING Search DNA+SUPERCOILING
9 CLOROBIOCIN 125237 1% 69% 9 Search CLOROBIOCIN Search CLOROBIOCIN
10 TOPA 118230 1% 59% 10 Search TOPA Search TOPA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MAYER, C , JANIN, YL , (2014) NON-QUINOLONE INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES: A FEAT OF BIOISOSTERISM.CHEMICAL REVIEWS. VOL. 114. ISSUE 4. P. 2313 -2342 150 54% 35
2 COLLIN, F , KARKARE, S , MAXWELL, A , (2011) EXPLOITING BACTERIAL DNA GYRASE AS A DRUG TARGET: CURRENT STATE AND PERSPECTIVES.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. VOL. 92. ISSUE 3. P. 479 -497 91 60% 83
3 SISSI, C , PALUMBO, M , (2010) IN FRONT OF AND BEHIND THE REPLICATION FORK: BACTERIAL TYPE IIA TOPOISOMERASES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 67. ISSUE 12. P. 2001 -2024 108 61% 26
4 SCHOEFFLER, AJ , BERGER, JM , (2008) DNA TOPOISOMERASES: HARNESSING AND CONSTRAINING ENERGY TO GOVERN CHROMOSOME TOPOLOGY.QUARTERLY REVIEWS OF BIOPHYSICS. VOL. 41. ISSUE 1. P. 41-101 119 43% 204
5 NOLLMANN, M , CRISONA, NJ , ARIMONDO, PB , (2007) THIRTY YEARS OF ESCHERICHIA COLI DNA GYRASE: FROM IN VIVO FUNCTION TO SINGLE-MOLECULE MECHANISM.BIOCHIMIE. VOL. 89. ISSUE 4. P. 490-499 77 81% 67
6 CHAMPOUX, JJ , (2001) DNA TOPOISOMERASES: STRUCTURE, FUNCTION, AND MECHANISM.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 70. ISSUE . P. 369-413 81 44% 1421
7 TOMASIC, T , MASIC, LP , (2014) PROSPECTS FOR DEVELOPING NEW ANTIBACTERIALS TARGETING BACTERIAL TYPE IIA TOPOISOMERASES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 1. P. 130 -151 81 60% 14
8 LULCHEV, P , KLOSTERMEIER, D , (2014) REVERSE GYRASE-RECENT ADVANCES AND CURRENT MECHANISTIC UNDERSTANDING OF POSITIVE DNA SUPERCOILING.NUCLEIC ACIDS RESEARCH. VOL. 42. ISSUE 13. P. 8200 -8213 52 81% 6
9 GUBAEV, A , KLOSTERMEIER, D , (2014) THE MECHANISM OF NEGATIVE DNA SUPERCOILING: A CASCADE OF DNA-INDUCED CONFORMATIONAL CHANGES PREPARES GYRASE FOR STRAND PASSAGE.DNA REPAIR. VOL. 16. ISSUE . P. 23-34 58 73% 5
10 BISACCHI, GS , MANCHESTER, JI , (2015) A NEW-CLASS ANTIBACTERIAL-ALMOST. LESSONS IN DRUG DISCOVERY AND DEVELOPMENT: A CRITICAL ANALYSIS OF MORE THAN 50 YEARS OF EFFORT TOWARD ATPASE INHIBITORS OF DNA GYRASE AND TOPOISOMERASE IV.ACS INFECTIOUS DISEASES. VOL. 1. ISSUE 1. P. 4 -41 65 56% 11

Classes with closest relation at Level 1


Rank Class id link
1 2662 TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA
2 7420 TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE
3 14430 QNR//AAC6 IB CR//PLASMID MEDIATED QUINOLONE RESISTANCE
4 30741 OFF RISK ASSESSMENT COORDINAT//ANTIOXIDANTS REDOX BIOL TOXICOL//VITAS PHARMA PRIVATE LTD
5 8709 H NS//HISTONE LIKE PROTEIN//NUCLEOID ASSOCIATED PROTEIN
6 11697 N SUBSTITUTED PIPERAZINYL QUINOLONES//S ENOKI 3394//FLUOROQUINOLONES
7 19522 REPLICATION FORK BARRIER//FORK ARREST//REPLICATION TERMINATOR PROTEIN
8 3327 GEMIFLOXACIN//CEFDITOREN//GEMIFLOXACIN MESYLATE
9 9979 DNA SEGREGATION//FTSK//PARB
10 8862 ORIC//DNAA//DNAA PROTEIN

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