Class information for:
Level 2: CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3716 1078 30.9 57%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
471 3       ACETYLCHOLINESTERASE//PARAOXONASE//SULFUR MUSTARD 23986
3716 2             CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2 1078
12461 1                   CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2 904
30106 1                   COMPARATIVE ENZYMOLOGY//REVERSIBLE INHIBITORS//INSECTOACARICIDES 174

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARBOXYLESTERASE authKW 1215922 16% 25% 172
2 DRUG METAB BIOPHARMACEUT address 203926 1% 60% 12
3 CES2 authKW 169946 1% 100% 6
4 HUMAN CARBOXYLESTERASE 2 authKW 169946 1% 100% 6
5 CES1 authKW 163870 1% 64% 9
6 CARBOXYLESTERASE 2 authKW 139437 1% 62% 8
7 ARYLACETAMIDE DEACETYLASE authKW 138785 1% 70% 7
8 HUMAN CARBOXYLESTERASE 1 authKW 118017 0% 83% 5
9 CES1A2 authKW 113297 0% 100% 4
10 DRUG HYDROLYSIS authKW 90636 0% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 3457 34% 0% 367
2 Biochemistry & Molecular Biology 1906 37% 0% 396
3 Toxicology 640 8% 0% 86
4 Biophysics 505 9% 0% 95
5 Chemistry, Medicinal 398 6% 0% 69
6 Evolutionary Biology 258 4% 0% 39
7 Genetics & Heredity 143 6% 0% 67
8 Physiology 107 4% 0% 48
9 Chemistry, Multidisciplinary 72 8% 0% 91
10 Zoology 46 3% 0% 33

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METAB BIOPHARMACEUT 203926 1% 60% 12
2 PHARMACOGENOM MOL THER Y 88510 0% 63% 5
3 PHARMACOGEN MOL THER Y 64368 0% 45% 5
4 DRUG METAB TOXICOL 40809 1% 21% 7
5 CIHR GRP MOL CELL BIOL LIPIDS 36408 1% 21% 6
6 IM SECHENOV EVOLUTIONARY PHYSIOL BIOCHEM 28853 3% 4% 29
7 A N NESMEYANOV ORGANOELEMENT CPDS 28324 0% 100% 1
8 BIOMED PHAMACEUT SCI 28324 0% 100% 1
9 BIOSIGNALING ENVIRONM CHEM EXPOSURE ASS 28324 0% 100% 1
10 BUSAN BRANCH FORENS CHEM 28324 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DOKLADY BIOCHEMISTRY AND BIOPHYSICS 18243 2% 3% 24
2 JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY 16161 3% 2% 33
3 DRUG METABOLISM AND DISPOSITION 14925 6% 1% 63
4 BIOCHEMICAL GENETICS 7943 2% 1% 25
5 BIOCHEMICAL PHARMACOLOGY 5093 5% 0% 58
6 REVIEWS IN BIOCHEMICAL TOXICOLOGY 4717 0% 8% 2
7 RESEARCH COMMUNICATIONS IN ALCOHOL AND SUBSTANCES OF ABUSE 2631 0% 5% 2
8 XENOBIOTICA 2611 2% 0% 19
9 BIOORGANICHESKAYA KHIMIYA 2484 2% 1% 17
10 UKRAINSKII BIOKHIMICHESKII ZHURNAL 1556 1% 1% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CARBOXYLESTERASE 1215922 16% 25% 172 Search CARBOXYLESTERASE Search CARBOXYLESTERASE
2 CES2 169946 1% 100% 6 Search CES2 Search CES2
3 HUMAN CARBOXYLESTERASE 2 169946 1% 100% 6 Search HUMAN+CARBOXYLESTERASE+2 Search HUMAN+CARBOXYLESTERASE+2
4 CES1 163870 1% 64% 9 Search CES1 Search CES1
5 CARBOXYLESTERASE 2 139437 1% 62% 8 Search CARBOXYLESTERASE+2 Search CARBOXYLESTERASE+2
6 ARYLACETAMIDE DEACETYLASE 138785 1% 70% 7 Search ARYLACETAMIDE+DEACETYLASE Search ARYLACETAMIDE+DEACETYLASE
7 HUMAN CARBOXYLESTERASE 1 118017 0% 83% 5 Search HUMAN+CARBOXYLESTERASE+1 Search HUMAN+CARBOXYLESTERASE+1
8 CES1A2 113297 0% 100% 4 Search CES1A2 Search CES1A2
9 DRUG HYDROLYSIS 90636 0% 80% 4 Search DRUG+HYDROLYSIS Search DRUG+HYDROLYSIS
10 CES1A1 84973 0% 100% 3 Search CES1A1 Search CES1A1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HOSOKAWA, M , (2008) STRUCTURE AND CATALYTIC PROPERTIES OF CARBOXYLESTERASE ISOZYMES INVOLVED IN METABOLIC ACTIVATION OF PRODRUGS.MOLECULES. VOL. 13. ISSUE 2. P. 412-431 79 84% 103
2 SATOH, T , HOSOKAWA, M , (2009) CARBOXYLESTERASES: STRUCTURE, FUNCTION AND POLYMORPHISM.BIOMOLECULES & THERAPEUTICS. VOL. 17. ISSUE 4. P. 335-347 82 81% 2
3 SATOH, T , HOSOKAWA, M , (1998) THE MAMMALIAN CARBOXYLESTERASES: FROM MOLECULES TO FUNCTIONS.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 38. ISSUE . P. 257-288 94 62% 435
4 SATOH, T , HOSOKAWA, M , (2010) CARBOXYLESTERASES: STRUCTURE, FUNCTION AND POLYMORPHISM IN MAMMALS.JOURNAL OF PESTICIDE SCIENCE. VOL. 35. ISSUE 3. P. 218-228 78 80% 10
5 SATOH, T , HOSOKAWA, M , (2006) STRUCTURE, FUNCTION AND REGULATION OF CARBOXYLESTERASES.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 162. ISSUE 3. P. 195-211 62 77% 203
6 XU, YJ , ZHANG, CL , HE, WX , LIU, D , (2016) REGULATIONS OF XENOBIOTICS AND ENDOBIOTICS ON CARBOXYLESTERASES: A COMPREHENSIVE REVIEW.EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. VOL. 41. ISSUE 4. P. 321 -330 57 83% 0
7 HOLMES, RS , WRIGHT, MW , LAULEDERKIND, SJF , COX, LA , HOSOKAWA, M , IMAI, T , ISHIBASHI, S , LEHNER, R , MIYAZAKI, M , PERKINS, EJ , ET AL (2010) RECOMMENDED NOMENCLATURE FOR FIVE MAMMALIAN CARBOXYLESTERASE GENE FAMILIES: HUMAN, MOUSE, AND RAT GENES AND PROTEINS.MAMMALIAN GENOME. VOL. 21. ISSUE 9-10. P. 427 -441 60 74% 50
8 IMAI, T , HOSOKAWA, M , (2010) PRODRUG APPROACH USING CARBOXYLESTERASES ACTIVITY: CATALYTIC PROPERTIES AND GENE REGULATION OF CARBOXYLESTERASE IN MAMMALIAN TISSUE.JOURNAL OF PESTICIDE SCIENCE. VOL. 35. ISSUE 3. P. 229-239 49 83% 7
9 LAIZURE, SC , HERRING, V , HU, ZY , WITBRODT, K , PARKER, RB , (2013) THE ROLE OF HUMAN CARBOXYLESTERASES IN DRUG METABOLISM: HAVE WE OVERLOOKED THEIR IMPORTANCE?.PHARMACOTHERAPY. VOL. 33. ISSUE 2. P. 210-222 49 54% 46
10 HOSOKAWA, M , FURIHATA, T , YAGINUMA, Y , YAMAMOTO, N , KOYANO, N , FUJII, A , NAGAHARA, Y , SATOH, T , CHIBA, K , (2007) GENOMIC STRUCTURE AND TRANSCRIPTIONAL REGULATION OF THE RAT, MOUSE, AND HUMAN CARBOXYLESTERASE GENES.DRUG METABOLISM REVIEWS. VOL. 39. ISSUE 1. P. 1-15 44 79% 42

Classes with closest relation at Level 2


Rank Class id link
1 3950 KURLOFF CELL//ALPHA NAPHTHYL ACETATE ESTERASE//ANAE
2 3405 LOTEPREDNOL ETABONATE//PRODRUG//ANTEDRUG
3 3247 PARAOXONASE//PARAOXONASE 1//PON1
4 1217 ORGANOPHOSPHATE//SOMAN//CHLORPYRIFOS
5 1440 ACETYLCHOLINESTERASE//BUTYRYLCHOLINESTERASE//TACRINE
6 1488 CAMPTOTHECIN//TOPOISOMERASE I//SN 38
7 2176 LIPASE//UPR 9025//COLIPASE
8 3770 DISSOLVENCE//FLUORINATED UREAS//GRP PHARMACOCHEM
9 3617 Q BETA REPLICASE//NICOTINE VACCINE//IMMUNOPHARMACOTHERAPY
10 1628 LIPID DROPLETS//CARDIOLIPIN//PERILIPIN

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