Class information for:
Level 1: CAMPTOTHECIN//SN 38//TOPOTECAN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1644 2558 34.6 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
1644 1                   CAMPTOTHECIN//SN 38//TOPOTECAN 2558

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CAMPTOTHECIN authKW 1902625 18% 35% 456
2 SN 38 authKW 1077500 6% 57% 159
3 TOPOTECAN authKW 1017414 10% 32% 267
4 CPT 11 authKW 729450 6% 39% 155
5 IRINOTECAN authKW 605825 12% 16% 317
6 TOPOISOMERASE I INHIBITOR authKW 377194 3% 44% 72
7 9 NITROCAMPTOTHECIN authKW 358253 2% 73% 41
8 9 AMINOCAMPTOTHECIN authKW 271275 1% 78% 29
9 TOPOISOMERASE I authKW 269097 4% 20% 112
10 HOMOCAMPTOTHECIN authKW 266409 1% 89% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 25811 52% 0% 1325
2 Pharmacology & Pharmacy 6234 30% 0% 769
3 Chemistry, Medicinal 2290 9% 0% 243
4 Chemistry, Organic 740 9% 0% 236
5 Biochemical Research Methods 365 5% 0% 126
6 Chemistry, Analytical 287 6% 0% 155
7 Hematology 230 4% 0% 95
8 Chemistry, Multidisciplinary 109 7% 0% 191
9 Toxicology 22 2% 0% 44
10 Materials Science, Biomaterials 15 1% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DANIEL DEN HOED KLIN 95537 1% 26% 31
2 STEHLIN FDN CANC 60415 0% 56% 9
3 PEDIAT PHARMACOKINET THER EUT 36111 1% 17% 18
4 LBI ONCOL 23871 0% 100% 2
5 NEUROSURG UNIT MED 23871 0% 100% 2
6 PHARMACOKINET METAB BIOANALYT 23871 0% 100% 2
7 UNITE BIOSPECT 23871 0% 100% 2
8 PROGRAM MOL THER EUT DRUG DISCOVERY 23863 0% 33% 6
9 JOINT GREEN CHEM 21481 0% 60% 3
10 ROTTERDAM CANC 16793 0% 14% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 42581 6% 2% 162
2 ANTI-CANCER DRUGS 14894 3% 2% 64
3 CLINICAL CANCER RESEARCH 12836 5% 1% 127
4 INVESTIGATIONAL NEW DRUGS 7419 2% 2% 40
5 ONCOLOGY-NEW YORK 7264 1% 2% 30
6 JOURNAL OF CLINICAL ONCOLOGY 6113 4% 1% 92
7 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2607 2% 0% 52
8 CANCER RESEARCH 2508 4% 0% 93
9 ANNALS OF ONCOLOGY 2143 2% 0% 39
10 JAPANESE JOURNAL OF CANCER RESEARCH 1592 1% 1% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CAMPTOTHECIN 1902625 18% 35% 456 Search CAMPTOTHECIN Search CAMPTOTHECIN
2 SN 38 1077500 6% 57% 159 Search SN+38 Search SN+38
3 TOPOTECAN 1017414 10% 32% 267 Search TOPOTECAN Search TOPOTECAN
4 CPT 11 729450 6% 39% 155 Search CPT+11 Search CPT+11
5 IRINOTECAN 605825 12% 16% 317 Search IRINOTECAN Search IRINOTECAN
6 TOPOISOMERASE I INHIBITOR 377194 3% 44% 72 Search TOPOISOMERASE+I+INHIBITOR Search TOPOISOMERASE+I+INHIBITOR
7 9 NITROCAMPTOTHECIN 358253 2% 73% 41 Search 9+NITROCAMPTOTHECIN Search 9+NITROCAMPTOTHECIN
8 9 AMINOCAMPTOTHECIN 271275 1% 78% 29 Search 9+AMINOCAMPTOTHECIN Search 9+AMINOCAMPTOTHECIN
9 TOPOISOMERASE I 269097 4% 20% 112 Search TOPOISOMERASE+I Search TOPOISOMERASE+I
10 HOMOCAMPTOTHECIN 266409 1% 89% 25 Search HOMOCAMPTOTHECIN Search HOMOCAMPTOTHECIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VENDITTO, VJ , SIMANEK, EE , (2010) CANCER THERAPIES UTILIZING THE CAMPTOTHECINS: A REVIEW OF THE IN VIVO LITERATURE.MOLECULAR PHARMACEUTICS. VOL. 7. ISSUE 2. P. 307-349 186 65% 108
2 GARCIA-CARBONERO, R , SUPKO, JG , (2002) CURRENT PERSPECTIVES ON THE CLINICAL EXPERIENCE, PHARMACOLOGY, AND CONTINUED DEVELOPMENT OF THE CAMPTOTHECINS.CLINICAL CANCER RESEARCH. VOL. 8. ISSUE 3. P. 641 -661 114 74% 304
3 MATHIJSSEN, RHJ , VAN ALPHEN, RJ , VERWEIJ, J , LOOS, WJ , NOOTER, K , STOTER, G , SPARREBOOM, A , (2001) CLINICAL PHARMACOKINETICS AND METABOLISM OF IRINOTECAN (CPT-11).CLINICAL CANCER RESEARCH. VOL. 7. ISSUE 8. P. 2182 -2194 101 77% 385
4 KEHRER, DFS , SOEPENBERG, O , LOOS, WJ , VERWEIJ, J , SPARREBOOM, A , (2001) MODULATION OF CAMPTOTHECIN ANALOGS IN THE TREATMENT OF CANCER: A REVIEW.ANTI-CANCER DRUGS. VOL. 12. ISSUE 2. P. 89-105 126 83% 73
5 MATHIJSSEN, RHJ , LOOS, WJ , VERWEIJ, J , SPARREBOOM, A , (2002) PHARMACOLOGY OF TOPOISOMERASE I INHIBITORS IRINOTECAN (CPT-11) AND TOPOTECAN.CURRENT CANCER DRUG TARGETS. VOL. 2. ISSUE 2. P. 103-123 140 70% 75
6 LIU, YQ , LI, WQ , MORRIS-NATSCHKE, SL , QIAN, KD , YANG, L , ZHU, GX , WU, XB , CHEN, AL , ZHANG, SY , NAN, X , ET AL (2015) PERSPECTIVES ON BIOLOGICALLY ACTIVE CAMPTOTHECIN DERIVATIVES.MEDICINAL RESEARCH REVIEWS. VOL. 35. ISSUE 4. P. 753 -789 81 70% 17
7 HUANG, QQ , WANG, L , LU, W , (2013) EVOLUTION IN MEDICINAL CHEMISTRY OF E-RING-MODIFIED CAMPTOTHECIN ANALOGS AS ANTICANCER AGENTS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 63. ISSUE . P. 746 -757 88 73% 9
8 DU, W , (2003) TOWARDS NEW ANTICANCER DRUGS: A DECADE OF ADVANCES IN SYNTHESIS OF CAMPTOTHECINS AND RELATED ALKALOIDS.TETRAHEDRON. VOL. 59. ISSUE 44. P. 8649-8687 91 77% 139
9 ROBERT, J , RIVORY, L , (1998) PHARMACOLOGY OF IRINOTECAN.DRUGS OF TODAY. VOL. 34. ISSUE 9. P. 777 -803 126 74% 12
10 IYER, L , RATAIN, MJ , (1998) CLINICAL PHARMACOLOGY OF CAMPTOTHECINS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 42. ISSUE . P. S31 -S43 86 92% 52

Classes with closest relation at Level 1


Rank Class id link
1 7420 TOPOISOMERASE I//DNA TOPOISOMERASE I//INDENOISOQUINOLINE
2 14067 GILBERTS SYNDROME//UGT1A1//UGT1A1 GENE
3 2662 TOPOISOMERASE II//DNA TOPOISOMERASE II//TOPOISOMERASE II ALPHA
4 12461 CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2
5 747 METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER
6 9334 ABCG2//BCRP//BREAST CANCER RESISTANCE PROTEIN
7 1615 OVARIAN CANCER//RECURRENT OVARIAN CANCER//PEGYLATED LIPOSOMAL DOXORUBICIN
8 8461 HPMA COPOLYMER//POLYMER THER EUT//HPMA
9 1350 SMALL CELL LUNG CANCER//AMRUBICIN//PROPHYLACTIC CRANIAL IRRADIATION
10 10766 ETOPOSIDE//ETOPOSIDE PHOSPHATE//ORAL ETOPOSIDE

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