Class information for:
Level 1: REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12542 898 37.1 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
157 3       JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY//BIOCHEMICAL RESEARCH METHODS//INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 61558
1575 2             AMBIENT IONIZATION//RAPID COMMUNICATIONS IN MASS SPECTROMETRY//AMBIENT MASS SPECTROMETRY 7290
12542 1                   REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB 898

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 REACTIVE METABOLITES authKW 364303 5% 22% 48
2 METABOLITE IDENTIFICATION authKW 188829 3% 18% 31
3 PHARMACOKINET DYNAM METAB address 164816 7% 7% 65
4 TIENILIC ACID authKW 151460 1% 64% 7
5 BIOACTIVATION authKW 116383 4% 10% 33
6 METABOLITES IN SAFETY TESTING authKW 108806 0% 80% 4
7 ICH M3R2 authKW 102007 0% 100% 3
8 MICROPLATE SCINTILLATION COUNTER authKW 102007 0% 100% 3
9 NEUTRAL LOSS FILTER authKW 102007 0% 100% 3
10 PRODUCT ION FILTER authKW 102007 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Analytical 10290 46% 0% 411
2 Biochemical Research Methods 8578 33% 0% 294
3 Spectroscopy 6709 24% 0% 215
4 Toxicology 3477 19% 0% 171
5 Pharmacology & Pharmacy 2783 34% 0% 301
6 Chemistry, Medicinal 2159 15% 0% 135
7 Chemistry, Multidisciplinary 312 15% 0% 132
8 Biochemistry & Molecular Biology 8 8% 0% 70
9 Materials Science, Characterization, Testing 0 0% 0% 2
10 Medicine, Legal -0 0% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET DYNAM METAB 164816 7% 7% 65
2 PHARMACEUT CANDIDATE OPTIMIZAT 97439 3% 11% 25
3 TOXICOKINET BIOTRANSFORMAT 76504 0% 75% 3
4 ANALYT CHEM DMPK 68005 0% 100% 2
5 BIOTRANSFORMAT 67161 3% 8% 26
6 DRUG METAB PHARMACOKINET 55135 8% 2% 69
7 MEDIPOLIS 47218 1% 28% 5
8 DISCOVERY ANALYT CHEM CHEM TECHNOL 45335 0% 67% 2
9 DRUG METAB PHARMACOKINET SSHINAGAWA KU 45335 0% 67% 2
10 DRUG METAB PRECLIN SAFETY 45335 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMICAL RESEARCH IN TOXICOLOGY 69437 11% 2% 103
2 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 59590 14% 1% 125
3 BIOANALYSIS 51561 5% 3% 46
4 DRUG METABOLISM AND DISPOSITION 48088 11% 1% 103
5 JOURNAL OF MASS SPECTROMETRY 13517 4% 1% 36
6 CURRENT DRUG METABOLISM 10035 2% 2% 18
7 LC GC NORTH AMERICA 5771 2% 1% 15
8 JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 4541 3% 1% 25
9 XENOBIOTICA 3843 2% 1% 21
10 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 3500 1% 1% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 REACTIVE METABOLITES 364303 5% 22% 48 Search REACTIVE+METABOLITES Search REACTIVE+METABOLITES
2 METABOLITE IDENTIFICATION 188829 3% 18% 31 Search METABOLITE+IDENTIFICATION Search METABOLITE+IDENTIFICATION
3 TIENILIC ACID 151460 1% 64% 7 Search TIENILIC+ACID Search TIENILIC+ACID
4 BIOACTIVATION 116383 4% 10% 33 Search BIOACTIVATION Search BIOACTIVATION
5 METABOLITES IN SAFETY TESTING 108806 0% 80% 4 Search METABOLITES+IN+SAFETY+TESTING Search METABOLITES+IN+SAFETY+TESTING
6 ICH M3R2 102007 0% 100% 3 Search ICH+M3R2 Search ICH+M3R2
7 MICROPLATE SCINTILLATION COUNTER 102007 0% 100% 3 Search MICROPLATE+SCINTILLATION+COUNTER Search MICROPLATE+SCINTILLATION+COUNTER
8 NEUTRAL LOSS FILTER 102007 0% 100% 3 Search NEUTRAL+LOSS+FILTER Search NEUTRAL+LOSS+FILTER
9 PRODUCT ION FILTER 102007 0% 100% 3 Search PRODUCT+ION+FILTER Search PRODUCT+ION+FILTER
10 MASS DEFECT FILTER 97998 1% 41% 7 Search MASS+DEFECT+FILTER Search MASS+DEFECT+FILTER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ZHANG, HY , ZHANG, DL , RAY, K , ZHU, MS , (2009) MASS DEFECT FILTER TECHNIQUE AND ITS APPLICATIONS TO DRUG METABOLITE IDENTIFICATION BY HIGH-RESOLUTION MASS SPECTROMETRY.JOURNAL OF MASS SPECTROMETRY. VOL. 44. ISSUE 7. P. 999-1016 55 80% 117
2 WEN, B , ZHU, MS , (2015) APPLICATIONS OF MASS SPECTROMETRY IN DRUG METABOLISM: 50 YEARS OF PROGRESS.DRUG METABOLISM REVIEWS. VOL. 47. ISSUE 1. P. 71 -87 69 61% 9
3 MA, SG , ZHU, MS , (2009) RECENT ADVANCES IN APPLICATIONS OF LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY TO THE ANA LYSIS OF REACTIVE DRUG METABOLITES.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 179. ISSUE 1. P. 25 -37 61 76% 62
4 ZHU, MS , ZHANG, HY , HUMPHREYS, WG , (2011) DRUG METABOLITE PROFILING AND IDENTIFICATION BY HIGH-RESOLUTION MASS SPECTROMETRY.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 286. ISSUE 29. P. 25419-25425 49 72% 63
5 JIAN, WY , LIU, HF , ZHAO, WP , JONES, E , ZHU, MS , (2012) SIMULTANEOUS SCREENING OF GLUTATHIONE AND CYANIDE ADDUCTS USING PRECURSOR ION AND NEUTRAL LOSS SCANS-DEPENDENT PRODUCT ION SPECTRAL ACQUISITION AND DATA MINING TOOLS.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. VOL. 23. ISSUE 5. P. 964-976 38 95% 8
6 TOLONEN, A , PELKONEN, O , (2015) ANALYTICAL CHALLENGES FOR CONDUCTING RAPID METABOLISM CHARACTERIZATION FOR QIVIVE.TOXICOLOGY. VOL. 332. ISSUE . P. 20 -29 53 62% 1
7 ZHU, MS , ZHANG, DL , ZHANG, HY , SHYU, WC , (2009) INTEGRATED STRATEGIES FOR ASSESSMENT OF METABOLITE EXPOSURE IN HUMANS DURING DRUG DEVELOPMENT: ANALYTICAL CHALLENGES AND CLINICAL DEVELOPMENT CONSIDERATIONS.BIOPHARMACEUTICS & DRUG DISPOSITION. VOL. 30. ISSUE 4. P. 163 -184 46 81% 13
8 WEN, B , FITCH, WL , (2009) ANALYTICAL STRATEGIES FOR THE SCREENING AND EVALUATION OF CHEMICALLY REACTIVE DRUG METABOLITES.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 5. ISSUE 1. P. 39-55 57 62% 26
9 PRASAD, B , GARG, A , TAKWANI, H , SINGH, S , (2011) METABOLITE IDENTIFICATION BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY.TRAC-TRENDS IN ANALYTICAL CHEMISTRY. VOL. 30. ISSUE 2. P. 360 -387 54 55% 39
10 MA, SG , CHOWDHURY, SK , (2013) DATA ACQUISITION AND DATA MINING TECHNIQUES FOR METABOLITE IDENTIFICATION USING LC COUPLED TO HIGH-RESOLUTION MS.BIOANALYSIS. VOL. 5. ISSUE 10. P. 1285-1297 33 87% 15

Classes with closest relation at Level 1


Rank Class id link
1 14478 ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS
2 8403 ION SUPPRESSION//MATRIX EFFECT//BIOANALYT METAB PHARMACOKINET
3 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
4 27035 CHEMICAL REACTION INTERFACE MASS SPECTROMETRY//PHARMACOL RE6640//SPP301
5 19696 VETERINARY DRUGS//PESTICIDES WATER//MULTICLASS ANALYSIS
6 13921 METABOLITE ANNOTATION//SCRIPPS METABOL MASS SPE OMETRY//ST S DEV BIOL
7 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
8 21041 ANALYT BIOCHEM MASS SPE OMETRY CORE IL//EC MS//LIQUID SAMPLE DESORPTION ELECTROSPRAY IONIZATION
9 34542 THIABENDAZOLE//2 PARA SUBSTITUTED PHENYLTHIAZOLES//4 CHLORO O PHENYLENE DIAMINE
10 24319 ATMOSPHERIC PRESSURE PHOTOIONIZATION//ATMOSPHERIC PRESSURE LASER IONIZATION//APLI

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