Class information for:
Level 2: PTEN//MTOR//COWDEN SYNDROME

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1220 9128 46.2 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1220 2             PTEN//MTOR//COWDEN SYNDROME 9128
1300 1                   MTOR//PIK3CA//PI3K INHIBITOR 2731
2908 1                   PTEN//COWDEN SYNDROME//LHERMITTE DUCLOS DISEASE 2116
6422 1                   RHEB//RICTOR//REDD1 1485
6528 1                   PDK1//AKT//AKT2 1473
14515 1                   S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2 765
23185 1                   WIP1//PPM1D//CELL CYCLE CONTROL TUMORIGENESIS GRP 355
34692 1                   PKN//PRK1//PKN ALPHA 108
35578 1                   PHLPP1//PHLPP//PHLPP2 95

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PTEN authKW 964710 9% 33% 863
2 MTOR authKW 566621 9% 21% 795
3 COWDEN SYNDROME authKW 267900 1% 70% 115
4 AKT authKW 246886 8% 10% 731
5 LHERMITTE DUCLOS DISEASE authKW 217933 1% 88% 74
6 PIK3CA authKW 209522 2% 38% 165
7 PI3K authKW 191042 4% 16% 365
8 RAPAMYCIN authKW 190580 4% 15% 377
9 COWDEN DISEASE authKW 179991 1% 77% 70
10 MTORC2 authKW 133214 1% 59% 68

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 38795 34% 0% 3146
2 Cell Biology 19058 24% 0% 2235
3 Biochemistry & Molecular Biology 10960 31% 0% 2852
4 Genetics & Heredity 1716 7% 0% 647
5 Chemistry, Medicinal 1454 4% 0% 410
6 Pathology 965 4% 0% 329
7 Biophysics 593 4% 0% 370
8 Medicine, Research & Experimental 353 4% 0% 324
9 Hematology 343 3% 0% 248
10 Developmental Biology 276 1% 0% 136

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN CANC GENET PROGRAM 42370 0% 30% 42
2 STANLEY SHALOM ZIELONY NURSING EXCELLENCE 33413 0% 50% 20
3 CELL CYCLE CONTROL TUMORIGENESIS GRP 30090 0% 100% 9
4 HUMAN CANC GENET GRP 29552 0% 27% 33
5 GRP PHOSPHOSITES 22915 0% 57% 12
6 HIGH THROUGHPUT SCREENING MOL PHARMACOL 18199 0% 78% 7
7 CHARLES A DANA HUMAN CANC GENET UNIT 16844 0% 46% 11
8 PROT PHOSPHORYLAT UNIT 15701 0% 10% 45
9 STANLEY SHALOM ZIELONY NURSING 13929 0% 83% 5
10 CANC METAB DMPK 13373 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 8382 2% 1% 217
2 MOLECULAR CANCER THERAPEUTICS 8380 1% 3% 102
3 CLINICAL CANCER RESEARCH 6697 2% 1% 176
4 ONCOTARGET 6462 2% 1% 157
5 CANCER RESEARCH 5473 3% 1% 262
6 CELLULAR SIGNALLING 5400 1% 2% 85
7 JOURNAL OF BIOLOGICAL CHEMISTRY 4702 5% 0% 496
8 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 4199 1% 2% 80
9 CURRENT CANCER DRUG TARGETS 3322 0% 3% 31
10 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2397 2% 1% 141

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PTEN 964710 9% 33% 863 Search PTEN Search PTEN
2 MTOR 566621 9% 21% 795 Search MTOR Search MTOR
3 COWDEN SYNDROME 267900 1% 70% 115 Search COWDEN+SYNDROME Search COWDEN+SYNDROME
4 AKT 246886 8% 10% 731 Search AKT Search AKT
5 LHERMITTE DUCLOS DISEASE 217933 1% 88% 74 Search LHERMITTE+DUCLOS+DISEASE Search LHERMITTE+DUCLOS+DISEASE
6 PIK3CA 209522 2% 38% 165 Search PIK3CA Search PIK3CA
7 PI3K 191042 4% 16% 365 Search PI3K Search PI3K
8 RAPAMYCIN 190580 4% 15% 377 Search RAPAMYCIN Search RAPAMYCIN
9 COWDEN DISEASE 179991 1% 77% 70 Search COWDEN+DISEASE Search COWDEN+DISEASE
10 MTORC2 133214 1% 59% 68 Search MTORC2 Search MTORC2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LAPLANTE, M , SABATINI, DM , (2012) MTOR SIGNALING IN GROWTH CONTROL AND DISEASE.CELL. VOL. 149. ISSUE 2. P. 274-293 92 53% 2214
2 MAGNUSON, B , EKIM, B , FINGAR, DC , (2012) REGULATION AND FUNCTION OF RIBOSOMAL PROTEIN S6 KINASE (S6K) WITHIN MTOR SIGNALLING NETWORKS.BIOCHEMICAL JOURNAL. VOL. 441. ISSUE . P. 1 -21 164 73% 254
3 LIU, PX , CHENG, HL , ROBERTS, TM , ZHAO, JJ , (2009) TARGETING THE PHOSPHOINOSITIDE 3-KINASE PATHWAY IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 8. ISSUE 8. P. 627 -644 117 60% 963
4 ZONCU, R , EFEYAN, A , SABATINI, DM , (2011) MTOR: FROM GROWTH SIGNAL INTEGRATION TO CANCER, DIABETES AND AGEING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 12. ISSUE 1. P. 21 -35 86 51% 1560
5 GUERTIN, DA , SABATINI, DM , (2007) DEFINING THE ROLE OF MTOR IN CANCER.CANCER CELL. VOL. 12. ISSUE 1. P. 9 -22 86 66% 1505
6 HOLLANDER, MC , BLUMENTHAL, GM , DENNIS, PA , (2011) PTEN LOSS IN THE CONTINUUM OF COMMON CANCERS, RARE SYNDROMES AND MOUSE MODELS.NATURE REVIEWS CANCER. VOL. 11. ISSUE 4. P. 289 -301 118 62% 308
7 SALMENA, L , CARRACEDO, A , PANDOLFI, PP , (2008) TENETS OF PTEN TUMOR SUPPRESSION.CELL. VOL. 133. ISSUE 3. P. 403 -414 93 79% 541
8 HASSAN, B , AKCAKANAT, A , HOLDER, AM , MERIC-BERNSTAM, F , (2013) TARGETING THE PI3-KINASE/AKT/MTOR SIGNALING PATHWAY.SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA. VOL. 22. ISSUE 4. P. 641 -+ 142 71% 27
9 HUANG, KZ , FINGAR, DC , (2014) GROWING KNOWLEDGE OF THE MTOR SIGNALING NETWORK.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 36. ISSUE . P. 79 -90 112 71% 53
10 LESLIE, NR , LONGY, M , (2016) INHERITED PTEN MUTATIONS AND THE PREDICTION OF PHENOTYPE.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 52. ISSUE . P. 30 -38 90 78% 7

Classes with closest relation at Level 2


Rank Class id link
1 3108 FOXM1//FOXO1//FOXO
2 536 X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN
3 1632 EIF4E//TRANSLATION INITIATION//IRES
4 1854 ANGIOMYOLIPOMA//TUBEROUS SCLEROSIS//TUBEROUS SCLEROSIS COMPLEX
5 2357 PEUTZ JEGHERS SYNDROME//AMPK//LKB1
6 4146 PIM KINASE//PIM 1//PIM 2
7 1128 AUTOPHAGY//BECLIN 1//LC3
8 2150 HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1
9 1195 JNK//ERK5//MAP KINASE
10 652 HER2//TRASTUZUMAB//HER 2 NEU

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