Class information for: |
Basic class information |
Class id | #P | Avg. number of references |
Database coverage of references |
---|---|---|---|
6528 | 1473 | 48.3 | 94% |
Hierarchy of classes |
The table includes all classes above and classes immediately below the current class. |
Cluster id | Level | Cluster label | #P |
---|---|---|---|
0 | 4 | BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY | 4064930 |
262 | 3 | AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR | 44558 |
1220 | 2 | PTEN//MTOR//COWDEN SYNDROME | 9128 |
6528 | 1 | PDK1//AKT//AKT2 | 1473 |
Terms with highest relevance score |
rank | Term | termType | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|---|
1 | PDK1 | authKW | 587694 | 4% | 44% | 65 |
2 | AKT | authKW | 270825 | 21% | 4% | 307 |
3 | AKT2 | authKW | 194764 | 2% | 28% | 34 |
4 | AKT1 | authKW | 191103 | 3% | 18% | 51 |
5 | PKB | authKW | 186320 | 3% | 18% | 49 |
6 | AKT ISOFORMS | authKW | 184661 | 1% | 64% | 14 |
7 | PROTEIN KINASE B | authKW | 164281 | 5% | 12% | 67 |
8 | AGC KINASE | authKW | 145730 | 1% | 47% | 15 |
9 | AKT INHIBITOR | authKW | 125375 | 1% | 28% | 22 |
10 | 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 | authKW | 104494 | 1% | 46% | 11 |
Web of Science journal categories |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | Cell Biology | 4848 | 30% | 0% | 444 |
2 | Oncology | 4151 | 29% | 0% | 420 |
3 | Biochemistry & Molecular Biology | 3100 | 40% | 0% | 583 |
4 | Chemistry, Medicinal | 1010 | 8% | 0% | 124 |
5 | Biophysics | 138 | 5% | 0% | 68 |
6 | Genetics & Heredity | 116 | 5% | 0% | 76 |
7 | Pathology | 74 | 3% | 0% | 40 |
8 | Medicine, Research & Experimental | 63 | 4% | 0% | 54 |
9 | Chemistry, Organic | 51 | 4% | 0% | 65 |
10 | Developmental Biology | 21 | 1% | 0% | 17 |
Address terms |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | GRP PHOSPHOSITES | 98696 | 1% | 48% | 10 |
2 | PROT PHOSPHORYLAT UNIT | 62554 | 2% | 8% | 36 |
3 | ONCOL DRUG METAB PHARMACOKINET | 62185 | 0% | 100% | 3 |
4 | STRUCT BIOCHEM UNIT | 57574 | 0% | 56% | 5 |
5 | MOL CELLULAR BIOL NUTR SCI | 41457 | 0% | 100% | 2 |
6 | SELECTSCREEN SERV | 41457 | 0% | 100% | 2 |
7 | ONCOL BIOL | 32907 | 1% | 18% | 9 |
8 | PHARMACOLMETAB DIS CELL SIGNALING | 31090 | 0% | 50% | 3 |
9 | CELL BIOL INTEGRAT REGENERAT MED IGEN | 27636 | 0% | 67% | 2 |
10 | PATHOL INTERDISCIPLINARY ONCOL | 27636 | 0% | 67% | 2 |
Journals |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | CELLULAR SIGNALLING | 4827 | 2% | 1% | 32 |
2 | ONCOGENE | 2362 | 3% | 0% | 46 |
3 | CURRENT CANCER DRUG TARGETS | 1750 | 1% | 1% | 9 |
4 | MOLECULAR CANCER THERAPEUTICS | 1621 | 1% | 0% | 18 |
5 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1526 | 3% | 0% | 44 |
6 | JOURNAL OF BIOLOGICAL CHEMISTRY | 1423 | 7% | 0% | 107 |
7 | SCIENCE SIGNALING | 1071 | 1% | 1% | 9 |
8 | MOLECULAR AND CELLULAR BIOLOGY | 844 | 2% | 0% | 31 |
9 | CANCER RESEARCH | 828 | 3% | 0% | 41 |
10 | COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES | 584 | 1% | 0% | 12 |
Author Key Words |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
LCSH search | Wikipedia search |
---|---|---|---|---|---|---|---|
1 | PDK1 | 587694 | 4% | 44% | 65 | Search PDK1 | Search PDK1 |
2 | AKT | 270825 | 21% | 4% | 307 | Search AKT | Search AKT |
3 | AKT2 | 194764 | 2% | 28% | 34 | Search AKT2 | Search AKT2 |
4 | AKT1 | 191103 | 3% | 18% | 51 | Search AKT1 | Search AKT1 |
5 | PKB | 186320 | 3% | 18% | 49 | Search PKB | Search PKB |
6 | AKT ISOFORMS | 184661 | 1% | 64% | 14 | Search AKT+ISOFORMS | Search AKT+ISOFORMS |
7 | PROTEIN KINASE B | 164281 | 5% | 12% | 67 | Search PROTEIN+KINASE+B | Search PROTEIN+KINASE+B |
8 | AGC KINASE | 145730 | 1% | 47% | 15 | Search AGC+KINASE | Search AGC+KINASE |
9 | AKT INHIBITOR | 125375 | 1% | 28% | 22 | Search AKT+INHIBITOR | Search AKT+INHIBITOR |
10 | 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 | 104494 | 1% | 46% | 11 | Search 3+PHOSPHOINOSITIDE+DEPENDENT+PROTEIN+KINASE+1 | Search 3+PHOSPHOINOSITIDE+DEPENDENT+PROTEIN+KINASE+1 |
Core articles |
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c: (1) Number of references referring to publications in the class. (2) Share of total number of active references referring to publications in the class. (3) Age of the article. New articles get higher score than old articles. (4) Citation rate, normalized to year. |
Rank | Reference | # ref. in cl. |
Shr. of ref. in cl. |
Citations |
---|---|---|---|---|
1 | NITULESCU, GM , MARGINA, D , JUZENAS, P , PENG, Q , OLARU, OT , SALOUSTROS, E , FENGA, C , SPANDIDOS, DA , LIBRA, M , TSATSAKIS, AM , (2016) AKT INHIBITORS IN CANCER TREATMENT: THE LONG JOURNEY FROM DRUG DISCOVERY TO CLINICAL USE.INTERNATIONAL JOURNAL OF ONCOLOGY. VOL. 48. ISSUE 3. P. 869 -885 | 66 | 53% | 9 |
2 | CHEN, SF , CHEN, JZ , (2013) DEVELOPMENT FOR ANTICANCER THERAPY: SMALL-MOLECULE INHIBITORS TARGETING PROTEIN KINASE B.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 9. P. 1272-1294 | 68 | 66% | 3 |
3 | MATTMANN, ME , STOOPS, SL , LINDSLEY, CW , (2011) INHIBITION OF AKT WITH SMALL MOLECULES AND BIOLOGICS: HISTORICAL PERSPECTIVE AND CURRENT STATUS OF THE PATENT LANDSCAPE.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 21. ISSUE 9. P. 1309 -1338 | 70 | 63% | 19 |
4 | LI, Q , (2007) RECENT PROGRESS IN THE DISCOVERY OF AKT INHIBITORS AS ANTICANCER AGENTS.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 17. ISSUE 9. P. 1077-1130 | 101 | 46% | 32 |
5 | HERS, I , VINCENT, EE , TAVARE, JM , (2011) AKT SIGNALLING IN HEALTH AND DISEASE.CELLULAR SIGNALLING. VOL. 23. ISSUE 10. P. 1515 -1527 | 73 | 32% | 309 |
6 | LINDSLEY, CW , (2010) THE AKT/PKB FAMILY OF PROTEIN KINASES: A REVIEW OF SMALL MOLECULE INHIBITORS AND PROGRESS TOWARDS TARGET VALIDATION: A 2009 UPDATE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 4. P. 458-477 | 65 | 56% | 70 |
7 | BELLACOSA, A , KUMAR, CC , DI CRISTOFANO, A , TESTA, JR , (2005) ACTIVATION OF AKT KINASES IN CANCER: IMPLICATIONS FOR THERAPEUTIC TARGETING.ADVANCES IN CANCER RESEARCH, VOL 94. VOL. 94. ISSUE . P. 29 -+ | 78 | 35% | 440 |
8 | MORROW, JK , DU-CUNY, L , CHEN, L , MEUILLET, EJ , MASH, EA , POWIS, G , ZHANG, SX , (2011) RECENT DEVELOPMENT OF ANTICANCER THERAPEUTICS TARGETING AKT.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 6. ISSUE 1. P. 146-159 | 53 | 66% | 12 |
9 | COLLINS, I , (2009) TARGETED SMALL-MOLECULE INHIBITORS OF PROTEIN KINASE B AS ANTICANCER AGENTS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 1. P. 32-50 | 63 | 58% | 17 |
10 | DATTA, SR , BRUNET, A , GREENBERG, ME , (1999) CELLULAR SURVIVAL: A PLAY IN THREE AKTS.GENES & DEVELOPMENT. VOL. 13. ISSUE 22. P. 2905 -2927 | 58 | 25% | 3070 |
Classes with closest relation at Level 1 |
Rank | Class id | link |
---|---|---|
1 | 35578 | PHLPP1//PHLPP//PHLPP2 |
2 | 1300 | MTOR//PIK3CA//PI3K INHIBITOR |
3 | 34692 | PKN//PRK1//PKN ALPHA |
4 | 33666 | GIRDIN//GIV//GROWTH FACTOR RECEPTOR TYROSINE KINASE |
5 | 20223 | SGK1//SERUM AND GLUCOCORTICOID INDUCIBLE KINASE//SGK |
6 | 5678 | PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA |
7 | 2908 | PTEN//COWDEN SYNDROME//LHERMITTE DUCLOS DISEASE |
8 | 6422 | RHEB//RICTOR//REDD1 |
9 | 14515 | S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2 |
10 | 8936 | FOXO1//FOXO//FOXO3A |