Class information for:
Level 1: PDK1//AKT//AKT2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6528 1473 48.3 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1220 2             PTEN//MTOR//COWDEN SYNDROME 9128
6528 1                   PDK1//AKT//AKT2 1473

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PDK1 authKW 587694 4% 44% 65
2 AKT authKW 270825 21% 4% 307
3 AKT2 authKW 194764 2% 28% 34
4 AKT1 authKW 191103 3% 18% 51
5 PKB authKW 186320 3% 18% 49
6 AKT ISOFORMS authKW 184661 1% 64% 14
7 PROTEIN KINASE B authKW 164281 5% 12% 67
8 AGC KINASE authKW 145730 1% 47% 15
9 AKT INHIBITOR authKW 125375 1% 28% 22
10 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 authKW 104494 1% 46% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 4848 30% 0% 444
2 Oncology 4151 29% 0% 420
3 Biochemistry & Molecular Biology 3100 40% 0% 583
4 Chemistry, Medicinal 1010 8% 0% 124
5 Biophysics 138 5% 0% 68
6 Genetics & Heredity 116 5% 0% 76
7 Pathology 74 3% 0% 40
8 Medicine, Research & Experimental 63 4% 0% 54
9 Chemistry, Organic 51 4% 0% 65
10 Developmental Biology 21 1% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GRP PHOSPHOSITES 98696 1% 48% 10
2 PROT PHOSPHORYLAT UNIT 62554 2% 8% 36
3 ONCOL DRUG METAB PHARMACOKINET 62185 0% 100% 3
4 STRUCT BIOCHEM UNIT 57574 0% 56% 5
5 MOL CELLULAR BIOL NUTR SCI 41457 0% 100% 2
6 SELECTSCREEN SERV 41457 0% 100% 2
7 ONCOL BIOL 32907 1% 18% 9
8 PHARMACOLMETAB DIS CELL SIGNALING 31090 0% 50% 3
9 CELL BIOL INTEGRAT REGENERAT MED IGEN 27636 0% 67% 2
10 PATHOL INTERDISCIPLINARY ONCOL 27636 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR SIGNALLING 4827 2% 1% 32
2 ONCOGENE 2362 3% 0% 46
3 CURRENT CANCER DRUG TARGETS 1750 1% 1% 9
4 MOLECULAR CANCER THERAPEUTICS 1621 1% 0% 18
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1526 3% 0% 44
6 JOURNAL OF BIOLOGICAL CHEMISTRY 1423 7% 0% 107
7 SCIENCE SIGNALING 1071 1% 1% 9
8 MOLECULAR AND CELLULAR BIOLOGY 844 2% 0% 31
9 CANCER RESEARCH 828 3% 0% 41
10 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 584 1% 0% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PDK1 587694 4% 44% 65 Search PDK1 Search PDK1
2 AKT 270825 21% 4% 307 Search AKT Search AKT
3 AKT2 194764 2% 28% 34 Search AKT2 Search AKT2
4 AKT1 191103 3% 18% 51 Search AKT1 Search AKT1
5 PKB 186320 3% 18% 49 Search PKB Search PKB
6 AKT ISOFORMS 184661 1% 64% 14 Search AKT+ISOFORMS Search AKT+ISOFORMS
7 PROTEIN KINASE B 164281 5% 12% 67 Search PROTEIN+KINASE+B Search PROTEIN+KINASE+B
8 AGC KINASE 145730 1% 47% 15 Search AGC+KINASE Search AGC+KINASE
9 AKT INHIBITOR 125375 1% 28% 22 Search AKT+INHIBITOR Search AKT+INHIBITOR
10 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 104494 1% 46% 11 Search 3+PHOSPHOINOSITIDE+DEPENDENT+PROTEIN+KINASE+1 Search 3+PHOSPHOINOSITIDE+DEPENDENT+PROTEIN+KINASE+1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 NITULESCU, GM , MARGINA, D , JUZENAS, P , PENG, Q , OLARU, OT , SALOUSTROS, E , FENGA, C , SPANDIDOS, DA , LIBRA, M , TSATSAKIS, AM , (2016) AKT INHIBITORS IN CANCER TREATMENT: THE LONG JOURNEY FROM DRUG DISCOVERY TO CLINICAL USE.INTERNATIONAL JOURNAL OF ONCOLOGY. VOL. 48. ISSUE 3. P. 869 -885 66 53% 9
2 CHEN, SF , CHEN, JZ , (2013) DEVELOPMENT FOR ANTICANCER THERAPY: SMALL-MOLECULE INHIBITORS TARGETING PROTEIN KINASE B.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 9. P. 1272-1294 68 66% 3
3 MATTMANN, ME , STOOPS, SL , LINDSLEY, CW , (2011) INHIBITION OF AKT WITH SMALL MOLECULES AND BIOLOGICS: HISTORICAL PERSPECTIVE AND CURRENT STATUS OF THE PATENT LANDSCAPE.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 21. ISSUE 9. P. 1309 -1338 70 63% 19
4 LI, Q , (2007) RECENT PROGRESS IN THE DISCOVERY OF AKT INHIBITORS AS ANTICANCER AGENTS.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 17. ISSUE 9. P. 1077-1130 101 46% 32
5 HERS, I , VINCENT, EE , TAVARE, JM , (2011) AKT SIGNALLING IN HEALTH AND DISEASE.CELLULAR SIGNALLING. VOL. 23. ISSUE 10. P. 1515 -1527 73 32% 309
6 LINDSLEY, CW , (2010) THE AKT/PKB FAMILY OF PROTEIN KINASES: A REVIEW OF SMALL MOLECULE INHIBITORS AND PROGRESS TOWARDS TARGET VALIDATION: A 2009 UPDATE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 4. P. 458-477 65 56% 70
7 BELLACOSA, A , KUMAR, CC , DI CRISTOFANO, A , TESTA, JR , (2005) ACTIVATION OF AKT KINASES IN CANCER: IMPLICATIONS FOR THERAPEUTIC TARGETING.ADVANCES IN CANCER RESEARCH, VOL 94. VOL. 94. ISSUE . P. 29 -+ 78 35% 440
8 MORROW, JK , DU-CUNY, L , CHEN, L , MEUILLET, EJ , MASH, EA , POWIS, G , ZHANG, SX , (2011) RECENT DEVELOPMENT OF ANTICANCER THERAPEUTICS TARGETING AKT.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 6. ISSUE 1. P. 146-159 53 66% 12
9 COLLINS, I , (2009) TARGETED SMALL-MOLECULE INHIBITORS OF PROTEIN KINASE B AS ANTICANCER AGENTS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 1. P. 32-50 63 58% 17
10 DATTA, SR , BRUNET, A , GREENBERG, ME , (1999) CELLULAR SURVIVAL: A PLAY IN THREE AKTS.GENES & DEVELOPMENT. VOL. 13. ISSUE 22. P. 2905 -2927 58 25% 3070

Classes with closest relation at Level 1


Rank Class id link
1 35578 PHLPP1//PHLPP//PHLPP2
2 1300 MTOR//PIK3CA//PI3K INHIBITOR
3 34692 PKN//PRK1//PKN ALPHA
4 33666 GIRDIN//GIV//GROWTH FACTOR RECEPTOR TYROSINE KINASE
5 20223 SGK1//SERUM AND GLUCOCORTICOID INDUCIBLE KINASE//SGK
6 5678 PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA
7 2908 PTEN//COWDEN SYNDROME//LHERMITTE DUCLOS DISEASE
8 6422 RHEB//RICTOR//REDD1
9 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
10 8936 FOXO1//FOXO//FOXO3A

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