Class information for:
Level 1: RHEB//RICTOR//REDD1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6422 1485 54.8 95%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1220 2             PTEN//MTOR//COWDEN SYNDROME 9128
6422 1                   RHEB//RICTOR//REDD1 1485

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RHEB authKW 596392 4% 51% 57
2 RICTOR authKW 504464 3% 48% 51
3 REDD1 authKW 375884 2% 63% 29
4 MTORC1 authKW 338720 6% 20% 82
5 MTOR authKW 312548 16% 6% 238
6 MTORC2 authKW 297902 3% 35% 41
7 SESTRIN 2 authKW 283585 1% 69% 20
8 RAG GTPASES authKW 243477 1% 79% 15
9 PRAS40 authKW 200589 1% 51% 19
10 SESTRIN authKW 191892 1% 67% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 12126 46% 0% 685
2 Biochemistry & Molecular Biology 4742 47% 0% 705
3 Oncology 547 12% 0% 176
4 Developmental Biology 411 4% 0% 55
5 Endocrinology & Metabolism 345 7% 0% 105
6 Genetics & Heredity 264 7% 0% 103
7 Biophysics 125 4% 0% 66
8 Medicine, Research & Experimental 89 4% 0% 61
9 Physiology 45 3% 0% 44
10 Nutrition & Dietetics 20 2% 0% 24

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SIGNAL TRANSDUCT CANC METAB 61683 0% 100% 3
2 MRC GHF 52864 0% 43% 6
3 CLIN COLORECTAL TUMOR 41122 0% 100% 2
4 TRANSDUCC SENALES CANC 41122 0% 100% 2
5 GOODWIN S 26432 0% 43% 3
6 CANC STEM CELL PROGRAM 23121 0% 19% 6
7 GENET COMPLEX DIS 21359 1% 5% 22
8 ABORAT INNOVAT MOL DIAG 20561 0% 100% 1
9 BETH ISRAEL DEACONESS MED CT MED 20561 0% 100% 1
10 BIOL ERS BASIC BIOL 20561 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CELL 6910 3% 1% 43
2 CELL METABOLISM 6199 1% 1% 21
3 CELLULAR SIGNALLING 5734 2% 1% 35
4 JOURNAL OF BIOLOGICAL CHEMISTRY 2764 10% 0% 147
5 SCIENCE SIGNALING 2586 1% 1% 14
6 CELL REPORTS 1792 1% 1% 17
7 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1473 1% 0% 19
8 NATURE CELL BIOLOGY 1473 1% 1% 14
9 MOLECULAR AND CELLULAR BIOLOGY 1344 3% 0% 39
10 GENES & DEVELOPMENT 1183 1% 0% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RHEB 596392 4% 51% 57 Search RHEB Search RHEB
2 RICTOR 504464 3% 48% 51 Search RICTOR Search RICTOR
3 REDD1 375884 2% 63% 29 Search REDD1 Search REDD1
4 MTORC1 338720 6% 20% 82 Search MTORC1 Search MTORC1
5 MTOR 312548 16% 6% 238 Search MTOR Search MTOR
6 MTORC2 297902 3% 35% 41 Search MTORC2 Search MTORC2
7 SESTRIN 2 283585 1% 69% 20 Search SESTRIN+2 Search SESTRIN+2
8 RAG GTPASES 243477 1% 79% 15 Search RAG+GTPASES Search RAG+GTPASES
9 PRAS40 200589 1% 51% 19 Search PRAS40 Search PRAS40
10 SESTRIN 191892 1% 67% 14 Search SESTRIN Search SESTRIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LAPLANTE, M , SABATINI, DM , (2012) MTOR SIGNALING IN GROWTH CONTROL AND DISEASE.CELL. VOL. 149. ISSUE 2. P. 274-293 74 43% 2214
2 SHIMOBAYASHI, M , HALL, MN , (2016) MULTIPLE AMINO ACID SENSING INPUTS TO MTORC1.CELL RESEARCH. VOL. 26. ISSUE 1. P. 7 -20 74 65% 12
3 DIBBLE, CC , MANNING, BD , (2013) SIGNAL INTEGRATION BY MTORC1 COORDINATES NUTRIENT INPUT WITH BIOSYNTHETIC OUTPUT.NATURE CELL BIOLOGY. VOL. 15. ISSUE 6. P. 555-564 85 59% 161
4 HUANG, KZ , FINGAR, DC , (2014) GROWING KNOWLEDGE OF THE MTOR SIGNALING NETWORK.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 36. ISSUE . P. 79 -90 97 61% 53
5 ZONCU, R , EFEYAN, A , SABATINI, DM , (2011) MTOR: FROM GROWTH SIGNAL INTEGRATION TO CANCER, DIABETES AND AGEING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 12. ISSUE 1. P. 21 -35 65 38% 1560
6 KIM, SG , BUEL, GR , BLENIS, J , (2013) NUTRIENT REGULATION OF THE MTOR COMPLEX 1 SIGNALING PATHWAY.MOLECULES AND CELLS. VOL. 35. ISSUE 6. P. 463-473 81 75% 65
7 FOSTER, KG , FINGAR, DC , (2010) MAMMALIAN TARGET OF RAPAMYCIN (MTOR): CONDUCTING THE CELLULAR SIGNALING SYMPHONY.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 285. ISSUE 19. P. 14071-14077 71 74% 241
8 BAR-PELED, L , SABATINI, DM , (2014) REGULATION OF MTORC1 BY AMINO ACIDS.TRENDS IN CELL BIOLOGY. VOL. 24. ISSUE 7. P. 400 -406 54 64% 138
9 KENNEDY, BK , LAMMING, DW , (2016) THE MECHANISTIC TARGET OF RAPAMYCIN: THE GRAND CONDUCTOR OF METABOLISM AND AGING.CELL METABOLISM. VOL. 23. ISSUE 6. P. 990 -1003 76 48% 11
10 ZHENG, X , LIANG, Y , HE, QBR , YAO, RL , BAO, WL , BAO, LL , WANG, YF , WANG, ZG , (2014) CURRENT MODELS OF MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1 (MTORC1) ACTIVATION BY GROWTH FACTORS AND AMINO ACIDS.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. VOL. 15. ISSUE 11. P. 20753 -20769 77 74% 13

Classes with closest relation at Level 1


Rank Class id link
1 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
2 1300 MTOR//PIK3CA//PI3K INHIBITOR
3 16746 T CELL METABOLISM//IMMUNOMETABOLISM//VANDERBILT IMMUNOBIOL
4 2838 TUBEROUS SCLEROSIS//TUBEROUS SCLEROSIS COMPLEX//SUBEPENDYMAL GIANT CELL ASTROCYTOMA
5 13989 BLSC//EDISON BIOTECHNOL//AMES DWARF
6 24668 ATG8//CHLOROPHAGY//ATATG18
7 6528 PDK1//AKT//AKT2
8 35578 PHLPP1//PHLPP//PHLPP2
9 3120 MUSCLE PROTEIN SYNTHESIS//EXERCISE METAB GRP//LEUCINE
10 3885 EIF4E//EIF4F//CAP ANALOG

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