Class information for:
Level 1: MTOR//PIK3CA//PI3K INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1300 2731 47.8 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1220 2             PTEN//MTOR//COWDEN SYNDROME 9128
1300 1                   MTOR//PIK3CA//PI3K INHIBITOR 2731

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MTOR authKW 682746 17% 13% 477
2 PIK3CA authKW 626659 6% 36% 156
3 PI3K INHIBITOR authKW 424572 3% 54% 70
4 PI3K authKW 350195 10% 12% 270
5 CCI 779 authKW 323068 1% 85% 34
6 RAD001 authKW 305685 2% 47% 58
7 P110 ALPHA authKW 260153 1% 73% 32
8 RAPAMYCIN authKW 248014 9% 9% 235
9 TEMSIROLIMUS authKW 229845 3% 24% 84
10 NVP BEZ235 authKW 199172 1% 64% 28

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 39079 61% 0% 1672
2 Chemistry, Medicinal 2519 10% 0% 263
3 Cell Biology 1095 12% 0% 329
4 Hematology 621 5% 0% 147
5 Pharmacology & Pharmacy 473 10% 0% 279
6 Pathology 407 4% 0% 113
7 Biochemistry & Molecular Biology 202 12% 0% 325
8 Chemistry, Organic 131 5% 0% 133
9 Medicine, Research & Experimental 48 3% 0% 77
10 Genetics & Heredity 25 3% 0% 77

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HIGH THROUGHPUT SCREENING MOL PHARMACOL 60861 0% 78% 7
2 CANC METAB DMPK 44717 0% 100% 4
3 SERV MED INTERNE UF HEMATOL 44713 0% 67% 6
4 CANC METAB BIOL 35772 0% 80% 4
5 CANC METAB CHEM 35772 0% 80% 4
6 SMALL MOL TRANSLAT ONCOL 33538 0% 100% 3
7 ONCOL DIS AREA 29404 0% 26% 10
8 DIPARTIMENTO SCI ANAT UMANE 25549 0% 57% 4
9 STRUCT BIOL MOL MODELING 25152 0% 75% 3
10 BIOL ONCOL DRUG DISCOVERY 22358 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 16195 3% 2% 77
2 CLINICAL CANCER RESEARCH 12981 5% 1% 132
3 ONCOTARGET 8272 4% 1% 96
4 CURRENT CANCER DRUG TARGETS 4668 1% 2% 20
5 TARGETED ONCOLOGY 4549 0% 3% 13
6 INVESTIGATIONAL NEW DRUGS 3891 1% 1% 30
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3540 3% 0% 91
8 CANCER BIOLOGY & THERAPY 3076 1% 1% 28
9 CANCER RESEARCH 2718 4% 0% 100
10 TRANSLATIONAL ONCOLOGY 2447 0% 2% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MTOR 682746 17% 13% 477 Search MTOR Search MTOR
2 PIK3CA 626659 6% 36% 156 Search PIK3CA Search PIK3CA
3 PI3K INHIBITOR 424572 3% 54% 70 Search PI3K+INHIBITOR Search PI3K+INHIBITOR
4 PI3K 350195 10% 12% 270 Search PI3K Search PI3K
5 CCI 779 323068 1% 85% 34 Search CCI+779 Search CCI+779
6 RAD001 305685 2% 47% 58 Search RAD001 Search RAD001
7 P110 ALPHA 260153 1% 73% 32 Search P110+ALPHA Search P110+ALPHA
8 RAPAMYCIN 248014 9% 9% 235 Search RAPAMYCIN Search RAPAMYCIN
9 TEMSIROLIMUS 229845 3% 24% 84 Search TEMSIROLIMUS Search TEMSIROLIMUS
10 NVP BEZ235 199172 1% 64% 28 Search NVP+BEZ235 Search NVP+BEZ235

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LIU, Y , WAN, WZ , LI, Y , ZHOU, GL , LIU, XG , (2017) RECENT DEVELOPMENT OF ATP-COMPETITIVE SMALL MOLECULE PHOSPHATIDYLINOSTITOL-3-KINASE INHIBITORS AS ANTICANCER AGENTS.ONCOTARGET. VOL. 8. ISSUE 4. P. 7181 -7200 93 86% 0
2 SCHENONE, S , BRULLO, C , MUSUMECI, F , RADI, M , BOTTA, M , (2011) ATP-COMPETITIVE INHIBITORS OF MTOR: AN UPDATE.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 20. P. 2995-3014 101 71% 52
3 ANDRS, M , KORABECNY, J , JUN, D , HODNY, Z , BARTEK, J , KUCA, K , (2015) PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) AND PHOSPHATIDYLINOSITOL 3-KINASE-RELATED KINASE (PIKK) INHIBITORS: IMPORTANCE OF THE MORPHOLINE RING.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 1. P. 41 -71 100 43% 16
4 WU, P , HU, YZ , (2012) SMALL MOLECULES TARGETING PHOSPHOINOSITIDE 3-KINASES.MEDCHEMCOMM. VOL. 3. ISSUE 11. P. 1337-1355 79 64% 26
5 FRANCIPANE, MG , LAGASSE, E , (2014) MTOR PATHWAY IN COLORECTAL CANCER: AN UPDATE.ONCOTARGET. VOL. 5. ISSUE 1. P. 49 -66 80 50% 38
6 SABBAH, DA , BRATTAIN, MG , ZHONG, H , (2011) DUAL INHIBITORS OF PI3K/MTOR OR MTOR-SELECTIVE INHIBITORS: WHICH WAY SHALL WE GO?.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 36. P. 5528-5544 80 63% 24
7 SUN, ZG , WANG, Z , LIU, XY , WANG, D , (2015) NEW DEVELOPMENT OF INHIBITORS TARGETING THE PI3K/AKT/MTOR PATHWAY IN PERSONALIZED TREATMENT OF NON-SMALL-CELL LUNG CANCER.ANTI-CANCER DRUGS. VOL. 26. ISSUE 1. P. 1 -14 69 59% 9
8 LIU, PX , CHENG, HL , ROBERTS, TM , ZHAO, JJ , (2009) TARGETING THE PHOSPHOINOSITIDE 3-KINASE PATHWAY IN CANCER.NATURE REVIEWS DRUG DISCOVERY. VOL. 8. ISSUE 8. P. 627 -644 64 33% 963
9 ASATI, V , BHARTI, SK , MAHAPATRA, DK , ASATI, V , BUDHWANI, AK , (2016) TRIGGERING PIK3CA MUTATIONS IN PI3K/AKT/MTOR AXIS: EXPLORATION OF NEWER INHIBITORS AND RATIONAL PREVENTIVE STRATEGIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 22. ISSUE 39. P. 6039 -6054 71 59% 1
10 COURTNEY, KD , CORCORAN, RB , ENGELMAN, JA , (2010) THE PI3K PATHWAY AS DRUG TARGET IN HUMAN CANCER.JOURNAL OF CLINICAL ONCOLOGY. VOL. 28. ISSUE 6. P. 1075-1083 48 49% 553

Classes with closest relation at Level 1


Rank Class id link
1 6422 RHEB//RICTOR//REDD1
2 5678 PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA
3 6528 PDK1//AKT//AKT2
4 2908 PTEN//COWDEN SYNDROME//LHERMITTE DUCLOS DISEASE
5 7620 FULVESTRANT//ENDOCRINE RESISTANCE//FASLODEX
6 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2
7 3885 EIF4E//EIF4F//CAP ANALOG
8 35578 PHLPP1//PHLPP//PHLPP2
9 2563 TRASTUZUMAB//LAPATINIB//PERTUZUMAB
10 727 SUNITINIB//METASTATIC RENAL CELL CARCINOMA//RENAL CELL CARCINOMA

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