Class information for:
Level 1: FARNESOID X RECEPTOR//FXR//TGR5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5462 1620 51.4 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
212 3       GASTROENTEROLOGY & HEPATOLOGY//LAPAROSCOPIC CHOLECYSTECTOMY//PRIMARY BILIARY CIRRHOSIS 51420
1019 2             BILE ACIDS//FARNESOID X RECEPTOR//CHOLESTASIS 10277
5462 1                   FARNESOID X RECEPTOR//FXR//TGR5 1620

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FARNESOID X RECEPTOR authKW 2684813 13% 69% 205
2 FXR authKW 1535570 8% 60% 136
3 TGR5 authKW 1050551 4% 77% 72
4 BILE ACIDS authKW 580826 19% 10% 304
5 SMALL HETERODIMER PARTNER authKW 480979 2% 73% 35
6 FARNESOID X RECEPTOR FXR authKW 368599 2% 67% 29
7 GW4064 authKW 314115 1% 83% 20
8 EXPT MOL HEPATOL address 205815 2% 38% 29
9 BILE ACID RECEPTOR authKW 193854 1% 86% 12
10 NUCLEAR RECEPTOR authKW 179398 10% 6% 160

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Gastroenterology & Hepatology 8344 22% 0% 358
2 Biochemistry & Molecular Biology 1842 31% 0% 495
3 Endocrinology & Metabolism 1496 13% 0% 206
4 Chemistry, Medicinal 1234 9% 0% 143
5 Pharmacology & Pharmacy 752 15% 0% 240
6 Cell Biology 591 12% 0% 188
7 Physiology 389 6% 0% 102
8 Biophysics 187 5% 0% 81
9 Medicine, Research & Experimental 113 4% 0% 70
10 Toxicology 89 3% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT MOL HEPATOL 205815 2% 38% 29
2 GENE REGULAT DRUG DISCOVERY 165023 1% 49% 18
3 PHARMACEUT DEV PHYS PROPERTIES DEVELOPABIL 78529 0% 83% 5
4 INTEGRAT MED SCI 60077 2% 9% 37
5 MOL DISCOVERY BIOL REAGENTS ASSAY DEV 56542 0% 100% 3
6 MOL DISCOVERY COMPUTAT STRUCT CHEM 56542 0% 100% 3
7 LIVER DIGEST METAB DIS 55562 2% 9% 33
8 UNITE RECH 545 52349 0% 56% 5
9 TEXAS CHILDRENS LIVER 52339 1% 28% 10
10 PHARMACOL TOXICOL THER EUT 48253 3% 5% 52

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 10445 4% 1% 59
2 HEPATOLOGY 7706 4% 1% 70
3 JOURNAL OF LIPID RESEARCH 6870 3% 1% 56
4 MOLECULAR ENDOCRINOLOGY 4054 2% 1% 35
5 DIGESTIVE DISEASES 3877 1% 1% 19
6 CELL METABOLISM 2889 1% 1% 15
7 JOURNAL OF HEPATOLOGY 2496 2% 0% 32
8 GASTROENTEROLOGY 1322 2% 0% 31
9 JOURNAL OF BIOLOGICAL CHEMISTRY 1275 7% 0% 107
10 JOURNAL OF MEDICINAL CHEMISTRY 690 2% 0% 29

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FARNESOID X RECEPTOR 2684813 13% 69% 205 Search FARNESOID+X+RECEPTOR Search FARNESOID+X+RECEPTOR
2 FXR 1535570 8% 60% 136 Search FXR Search FXR
3 TGR5 1050551 4% 77% 72 Search TGR5 Search TGR5
4 BILE ACIDS 580826 19% 10% 304 Search BILE+ACIDS Search BILE+ACIDS
5 SMALL HETERODIMER PARTNER 480979 2% 73% 35 Search SMALL+HETERODIMER+PARTNER Search SMALL+HETERODIMER+PARTNER
6 FARNESOID X RECEPTOR FXR 368599 2% 67% 29 Search FARNESOID+X+RECEPTOR+FXR Search FARNESOID+X+RECEPTOR+FXR
7 GW4064 314115 1% 83% 20 Search GW4064 Search GW4064
8 BILE ACID RECEPTOR 193854 1% 86% 12 Search BILE+ACID+RECEPTOR Search BILE+ACID+RECEPTOR
9 NUCLEAR RECEPTOR 179398 10% 6% 160 Search NUCLEAR+RECEPTOR Search NUCLEAR+RECEPTOR
10 GPBAR1 162890 1% 79% 11 Search GPBAR1 Search GPBAR1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MAZUY, C , HELLEBOID, A , STAELS, B , LEFEBVRE, P , (2015) NUCLEAR BILE ACID SIGNALING THROUGH THE FARNESOID X RECEPTOR.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 72. ISSUE 9. P. 1631 -1650 150 70% 13
2 LEFEBVRE, P , CARIOU, B , LIEN, F , KUIPERS, F , STAELS, B , (2009) ROLE OF BILE ACIDS AND BILE ACID RECEPTORS IN METABOLIC REGULATION.PHYSIOLOGICAL REVIEWS. VOL. 89. ISSUE 1. P. 147 -191 156 46% 495
3 LI, TG , CHIANG, JYL , (2014) BILE ACID SIGNALING IN METABOLIC DISEASE AND DRUG THERAPY.PHARMACOLOGICAL REVIEWS. VOL. 66. ISSUE 4. P. 948 -983 167 41% 46
4 POREZ, G , PRAWITT, J , GROSS, B , STAELS, B , (2012) BILE ACID RECEPTORS AS TARGETS FOR THE TREATMENT OF DYSLIPIDEMIA AND CARDIOVASCULAR DISEASE.JOURNAL OF LIPID RESEARCH. VOL. 53. ISSUE 9. P. 1723 -1737 108 69% 75
5 MATSUBARA, T , LI, F , GONZALEZ, FJ , (2013) FXR SIGNALING IN THE ENTEROHEPATIC SYSTEM.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 368. ISSUE 1-2. P. 17-29 98 70% 57
6 THOMAS, C , PELLICCIARI, R , PRUZANSKI, M , AUWERX, J , SCHOONJANS, K , (2008) TARGETING BILE-ACID SIGNALLING FOR METABOLIC DISEASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 7. ISSUE 8. P. 678 -693 90 62% 376
7 XU, YP , (2016) RECENT PROGRESS ON BILE ACID RECEPTOR MODULATORS FOR TREATMENT OF METABOLIC DISEASES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 14. P. 6553 -6579 74 93% 1
8 SCHAAP, FG , TRAUNER, M , JANSEN, PLM , (2014) BILE ACID RECEPTORS AS TARGETS FOR DRUG DEVELOPMENT.NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. VOL. 11. ISSUE 1. P. 55-67 86 54% 89
9 FIORUCCI, S , MENCARELLI, A , DISTRUTTI, E , PALLADINO, G , CIPRIANI, S , (2010) TARGETING FARNESOID-X-RECEPTOR: FROM MEDICINAL CHEMISTRY TO DISEASE TREATMENT.CURRENT MEDICINAL CHEMISTRY. VOL. 17. ISSUE 2. P. 139-159 98 75% 40
10 LAMERS, C , SCHUBERT-ZSILAVECZ, M , MERK, D , (2014) MEDICINAL CHEMISTRY AND PHARMACOLOGICAL EFFECTS OF FARNESOID X RECEPTOR (FXR) ANTAGONISTS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 19. P. 2188 -2205 92 79% 2

Classes with closest relation at Level 1


Rank Class id link
1 16617 BILE ACID MALABSORPTION//SEHCAT//ASBT
2 23438 BILE ACID SEQUESTRANT//COLESEVELAM HCL//COLESEVELAM
3 9748 INTRAHEPATIC CHOLESTASIS OF PREGNANCY//PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS//ABCB11
4 9039 CEREBROTENDINOUS XANTHOMATOSIS//CHOLESTEROL 7 ALPHA HYDROXYLASE//STEROL 27 HYDROXYLASE
5 14626 FGF21//FIBROBLAST GROWTH FACTOR 21//FGF 21
6 9757 URSODEOXYCHOLIC ACID//TAUROURSODEOXYCHOLIC ACID//BILE ACIDS
7 3955 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
8 5778 BILE ACIDS//SULFATED BILE ACID//TAURINE CONJUGATE
9 10090 LIVER X RECEPTOR//LXR//T0901317
10 22595 GUGGULSTERONE//COMMIPHORA WIGHTII//COMMIPHORA MUKUL

Go to start page