Class information for:
Level 1: NAKED PLASMID DNA//HYDRODYNAMICS BASED TRANSFECTION//HYDRODYNAMIC GENE DELIVERY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18301 557 37.5 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
227 3       MICRORNA//MIRNA//GENE DELIVERY 49432
476 2             GENE DELIVERY//CELL PENETRATING PEPTIDE//CATIONIC LIPID 15822
18301 1                   NAKED PLASMID DNA//HYDRODYNAMICS BASED TRANSFECTION//HYDRODYNAMIC GENE DELIVERY 557

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NAKED PLASMID DNA authKW 780363 4% 65% 22
2 HYDRODYNAMICS BASED TRANSFECTION authKW 501197 3% 57% 16
3 HYDRODYNAMIC GENE DELIVERY authKW 493368 3% 60% 15
4 HYDRODYNAMICS BASED PROCEDURE authKW 442208 2% 73% 11
5 HYDRODYNAMIC DELIVERY authKW 402796 2% 57% 13
6 NAKED DNA authKW 343044 6% 19% 33
7 INTRANUCLEAR DISPOSITION authKW 318948 1% 73% 8
8 HYDRODYNAMIC INJECTION authKW 314100 3% 30% 19
9 LIVER SURFACE authKW 296021 2% 60% 9
10 BIOPHARMACEUT DRUG METAB address 274378 5% 17% 29

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Research & Experimental 7076 42% 0% 234
2 Biotechnology & Applied Microbiology 5230 41% 0% 229
3 Genetics & Heredity 5090 40% 0% 222
4 Pharmacology & Pharmacy 577 21% 0% 115
5 Biochemistry & Molecular Biology 220 20% 0% 113
6 Gastroenterology & Hepatology 25 3% 0% 16
7 Transplantation 19 2% 0% 9
8 Cell & Tissue Engineering 13 1% 0% 3
9 Materials Science, Biomaterials 8 1% 0% 5
10 Biophysics 7 3% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPHARMACEUT DRUG METAB 274378 5% 17% 29
2 WAISMAN 355 164460 1% 100% 3
3 HEPATOL TRANSPLANTAT 159466 1% 36% 8
4 LIVER TRANSPLANTAT HEPATOBILIARY SURG SERV 109640 0% 100% 2
5 GENE THER Y GRP 75358 2% 13% 11
6 CONVERGENT CONSORTIUM IMMUNOL DISCISTEM 73092 0% 67% 2
7 UNIDAD FARMACOGENET 58469 1% 27% 4
8 AREA CLIN MEDICAMENTO 54820 0% 100% 1
9 BIOL IMAGINE 54820 0% 100% 1
10 BIOMOL IMAGING BIOPHYS PROGRAM 54820 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF GENE MEDICINE 68795 8% 3% 42
2 MOLECULAR THERAPY 28581 8% 1% 43
3 GENE THERAPY 25879 8% 1% 43
4 HUMAN GENE THERAPY 22484 7% 1% 37
5 ADVANCES IN GENETICS 12779 2% 3% 9
6 CURRENT GENE THERAPY 9984 2% 2% 10
7 MOLECULAR THERAPY-NUCLEIC ACIDS 6523 1% 2% 6
8 BIOLOGICAL & PHARMACEUTICAL BULLETIN 5338 5% 0% 29
9 HUMAN GENE THERAPY METHODS 2966 1% 2% 3
10 MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 2705 1% 2% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NAKED PLASMID DNA 780363 4% 65% 22 Search NAKED+PLASMID+DNA Search NAKED+PLASMID+DNA
2 HYDRODYNAMICS BASED TRANSFECTION 501197 3% 57% 16 Search HYDRODYNAMICS+BASED+TRANSFECTION Search HYDRODYNAMICS+BASED+TRANSFECTION
3 HYDRODYNAMIC GENE DELIVERY 493368 3% 60% 15 Search HYDRODYNAMIC+GENE+DELIVERY Search HYDRODYNAMIC+GENE+DELIVERY
4 HYDRODYNAMICS BASED PROCEDURE 442208 2% 73% 11 Search HYDRODYNAMICS+BASED+PROCEDURE Search HYDRODYNAMICS+BASED+PROCEDURE
5 HYDRODYNAMIC DELIVERY 402796 2% 57% 13 Search HYDRODYNAMIC+DELIVERY Search HYDRODYNAMIC+DELIVERY
6 NAKED DNA 343044 6% 19% 33 Search NAKED+DNA Search NAKED+DNA
7 INTRANUCLEAR DISPOSITION 318948 1% 73% 8 Search INTRANUCLEAR+DISPOSITION Search INTRANUCLEAR+DISPOSITION
8 HYDRODYNAMIC INJECTION 314100 3% 30% 19 Search HYDRODYNAMIC+INJECTION Search HYDRODYNAMIC+INJECTION
9 LIVER SURFACE 296021 2% 60% 9 Search LIVER+SURFACE Search LIVER+SURFACE
10 HYDRODYNAMICS BASED INJECTION 219280 1% 100% 4 Search HYDRODYNAMICS+BASED+INJECTION Search HYDRODYNAMICS+BASED+INJECTION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SUDA, T , LIU, D , (2007) HYDRODYNAMIC GENE DELIVERY: ITS PRINCIPLES AND APPLICATIONS.MOLECULAR THERAPY. VOL. 15. ISSUE 12. P. 2063-2069 68 50% 102
2 KANEFUJI, T , YOKOO, T , SUDA, T , ABE, H , KAMIMURA, K , LIU, DX , (2014) HEMODYNAMICS OF A HYDRODYNAMIC INJECTION.MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. VOL. 1. ISSUE . P. - 33 83% 3
3 SUDA, T , LIU, DX , (2015) HYDRODYNAMIC DELIVERY.NONVIRAL VECTORS FOR GENE THERAPY: PHYSICAL METHODS AND MEDICAL TRANSLATION. VOL. 89. ISSUE . P. 89 -111 57 44% 3
4 NISHIDA, K , (2009) DEVELOPMENT OF DRUG DELIVERY SYSTEM BY UTILIZING ABSORPTION FROM LIVER SURFACE AND ITS APPLICATION.YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. VOL. 129. ISSUE 8. P. 925 -932 31 89% 0
5 SENDRA, L , MIGUEL, A , PEREZ-ENGUIX, D , HERRERO, MJ , MONTALVA, E , GARCIA-GIMENO, MA , NOGUERA, I , DIAZ, A , PEREZ, J , SANZ, P , ET AL (2016) STUDYING CLOSED HYDRODYNAMIC MODELS OF "IN VIVO" DNA PERFUSION IN PIG LIVER FOR GENE THERAPY TRANSLATION TO HUMANS.PLOS ONE. VOL. 11. ISSUE 10. P. - 25 89% 0
6 AL-DOSARI, MS , KNAPP, JE , LIU, DX , (2005) HYDRODYNAMIC DELIVERY.NON-VIRAL VECTORS FOR GENE THERAPY, SECOND EDITION: PART 2. VOL. 54. ISSUE . P. 65-82 51 50% 27
7 KOBAYASHI, N , NISHIKAWA, M , TAKAKURA, Y , (2005) THE HYDRODYNAMICS-BASED PROCEDURE FOR CONTROLLING THE PHARMACOKINETICS OF GENE MEDICINES AT WHOLE BODY, ORGAN AND CELLULAR LEVELS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 57. ISSUE 5. P. 713-731 66 36% 39
8 KAMIMURA, K , ZHANG, GS , LIU, DX , (2010) IMAGE-GUIDED, INTRAVASCULAR HYDRODYNAMIC GENE DELIVERY TO SKELETAL MUSCLE IN PIGS.MOLECULAR THERAPY. VOL. 18. ISSUE 1. P. 93-100 23 88% 15
9 SAWYER, GJ , RELA, M , DAVENPORT, M , WHITEHORNE, M , ZHANG, XH , FABRE, JW , (2009) HYDRODYNAMIC GENE DELIVERY TO THE LIVER: THEORETICAL AND PRACTICAL ISSUES FOR CLINICAL APPLICATION.CURRENT GENE THERAPY. VOL. 9. ISSUE 2. P. 128 -135 26 76% 28
10 SENDRA, L , PEREZ, D , MIGUEL, A , HERRERO, MJ , NOGUERA, I , DIAZ, A , BARETTINO, D , MARTI-BONMATI, L , ALINO, SF , (2016) HUMAN AAT GENE TRANSFER TO PIG LIVER IMPROVED BY USING A PERFUSION ISOLATED ORGAN ENDOVASCULAR PROCEDURE.EUROPEAN RADIOLOGY. VOL. 26. ISSUE 1. P. 95 -102 19 90% 0

Classes with closest relation at Level 1


Rank Class id link
1 24340 HUMAN ARTIFICIAL CHROMOSOME//REGENERAT MED BIOFUNCT//CHROMOSOME ENGN
2 16206 GENE MED GRP//GENEMED GRP//EXPT TREATMENT CYST FIBROSIS
3 6997 MOL MED GENE THER Y UNIT//ADENOVIRUS//HELPER DEPENDENT ADENOVIRAL VECTOR
4 12652 PLASMID PURIFICATION//PLASMID DNA//SUPERCOILED PLASMID DNA
5 168 GENE DELIVERY//POLYETHYLENIMINE//POLYPLEX
6 2198 CATIONIC LIPID//CATIONIC LIPOSOMES//LIPOPLEX
7 9628 MARINER//SLEEPING BEAUTY//TRANSPOSON
8 3573 DNA VACCINE//DNA IMMUNIZATION//DNA VACCINATION
9 21790 N SUCCINYL CHITOSAN//DEXTRAN PRODRUGS//BIOPHARMACEUT DRUG METAB
10 25514 HERPES SIMPLEX VIRUS VECTOR//W ROXBURY VA HOSP//HELPER VIRUS FREE PACKAGING

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