Class information for:
Level 1: GENE MED GRP//GENEMED GRP//EXPT TREATMENT CYST FIBROSIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16206 667 46.5 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
419 3       ADENOVIRUS//MERKEL CELL CARCINOMA//GENE THERAPY 28518
564 2             GENE THERAPY//ADENOVIRUS//HUMAN GENE THERAPY 14456
16206 1                   GENE MED GRP//GENEMED GRP//EXPT TREATMENT CYST FIBROSIS 667

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENE MED GRP address 426762 3% 55% 17
2 GENEMED GRP address 235432 1% 86% 6
3 EXPT TREATMENT CYST FIBROSIS address 219724 2% 40% 12
4 UK CYST FIBROSIS GENE THER Y CONSORTIUM address 190744 1% 83% 5
5 AIRWAY GENE TRANSFER authKW 183115 1% 100% 4
6 PROGRAM GENE THER Y address 177542 2% 24% 16
7 ION TRANSPORT UNIT address 172335 1% 47% 8
8 CYSTIC FIBROSIS GENETICS THERAPY authKW 137337 0% 100% 3
9 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENETICS THERAPEUTIC USE authKW 137337 0% 100% 3
10 GRP LUNG DEV address 126766 1% 46% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Research & Experimental 10366 46% 0% 309
2 Genetics & Heredity 7045 43% 0% 285
3 Biotechnology & Applied Microbiology 6935 43% 0% 288
4 Respiratory System 2232 15% 0% 103
5 Biochemistry & Molecular Biology 461 25% 0% 167
6 Critical Care Medicine 123 3% 0% 20
7 Pharmacology & Pharmacy 101 10% 0% 65
8 Cell Biology 59 7% 0% 46
9 Materials Science, Biomaterials 58 2% 0% 12
10 Virology 40 2% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENE MED GRP 426762 3% 55% 17
2 GENEMED GRP 235432 1% 86% 6
3 EXPT TREATMENT CYST FIBROSIS 219724 2% 40% 12
4 UK CYST FIBROSIS GENE THER Y CONSORTIUM 190744 1% 83% 5
5 PROGRAM GENE THER Y 177542 2% 24% 16
6 ION TRANSPORT UNIT 172335 1% 47% 8
7 GRP LUNG DEV 126766 1% 46% 6
8 MOL PULMONOL 124612 1% 39% 7
9 REG RIFERIMENTO FIBROSI CIST 91558 0% 100% 2
10 CF PULM TREATMENT 74902 1% 27% 6

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HUMAN GENE THERAPY 103979 13% 3% 87
2 GENE THERAPY 90635 13% 2% 88
3 JOURNAL OF GENE MEDICINE 42187 5% 3% 36
4 MOLECULAR THERAPY 14033 5% 1% 33
5 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 7583 4% 1% 29
6 CURRENT OPINION IN MOLECULAR THERAPEUTICS 4230 1% 1% 9
7 JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG 3437 1% 1% 7
8 HUMAN GENE THERAPY CLINICAL DEVELOPMENT 2257 0% 2% 2
9 MOLECULAR THERAPY-NUCLEIC ACIDS 1358 0% 1% 3
10 CURRENT GENE THERAPY 1329 1% 1% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 AIRWAY GENE TRANSFER 183115 1% 100% 4 Search AIRWAY+GENE+TRANSFER Search AIRWAY+GENE+TRANSFER
2 CYSTIC FIBROSIS GENETICS THERAPY 137337 0% 100% 3 Search CYSTIC+FIBROSIS+GENETICS+THERAPY Search CYSTIC+FIBROSIS+GENETICS+THERAPY
3 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENETICS THERAPEUTIC USE 137337 0% 100% 3 Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR+GENETICS+THERAPEUTIC+USE Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR+GENETICS+THERAPEUTIC+USE
4 CYSTIC FIBROSIS 115916 23% 2% 152 Search CYSTIC+FIBROSIS Search CYSTIC+FIBROSIS
5 GENE THERAPY 96208 26% 1% 174 Search GENE+THERAPY Search GENE+THERAPY
6 APICAL GENE DELIVERY 91558 0% 100% 2 Search APICAL+GENE+DELIVERY Search APICAL+GENE+DELIVERY
7 CYSTIC FIBROSIS GENE THERAPY 91558 0% 100% 2 Search CYSTIC+FIBROSIS+GENE+THERAPY Search CYSTIC+FIBROSIS+GENE+THERAPY
8 LUNG GENE DELIVERY 91558 0% 100% 2 Search LUNG+GENE+DELIVERY Search LUNG+GENE+DELIVERY
9 LUNG GENE EXPRESSION 91558 0% 100% 2 Search LUNG+GENE+EXPRESSION Search LUNG+GENE+EXPRESSION
10 RESPIRATORY GENE THERAPY 91558 0% 100% 2 Search RESPIRATORY+GENE+THERAPY Search RESPIRATORY+GENE+THERAPY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PAUL-SMITH, MC , BELL, RV , ALTON, WE , ALTON, EWFW , GRIESENBACH, U , (2016) GENE THERAPY FOR CYSTIC FIBROSIS: RECENT PROGRESS AND CURRENT AIMS.EXPERT OPINION ON ORPHAN DRUGS. VOL. 4. ISSUE 6. P. 649 -658 37 57% 3
2 GRIESENBACH, U , PYTEL, KM , ALTON, EWFW , (2015) CYSTIC FIBROSIS GENE THERAPY IN THE UK AND ELSEWHERE.HUMAN GENE THERAPY. VOL. 26. ISSUE 5. P. 266 -275 48 44% 13
3 WEISS, DJ , PILEWSKI, JM , (2003) THE STATUS OF GENE THERAPY FOR CYSTIC FIBROSIS.SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE. VOL. 24. ISSUE 6. P. 749-770 88 40% 6
4 GRIESENBACH, U , ALTON, EWFW , (2009) GENE TRANSFER TO THE LUNG: LESSONS LEARNED FROM MORE THAN 2 DECADES OF CF GENE THERAPY.ADVANCED DRUG DELIVERY REVIEWS. VOL. 61. ISSUE 2. P. 128-139 54 45% 73
5 KIM, N , DUNCAN, GA , HANES, J , SUK, JS , (2016) BARRIERS TO INHALED GENE THERAPY OF OBSTRUCTIVE LUNG DISEASES: A REVIEW.JOURNAL OF CONTROLLED RELEASE. VOL. 240. ISSUE . P. 465 -488 89 23% 1
6 ALTON, EWFW , ARMSTRONG, DK , ASHBY, D , BAYFIELD, KJ , BILTON, D , BLOOMFIELD, EV , BOYD, AC , BRAND, J , BUCHAN, R , CALCEDO, R , ET AL (2015) REPEATED NEBULISATION OF NON-VIRAL CFTR GENE THERAPY IN PATIENTS WITH CYSTIC FIBROSIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2B TRIAL.LANCET RESPIRATORY MEDICINE. VOL. 3. ISSUE 9. P. 684 -691 16 73% 56
7 ARMSTRONG, DK , CUNNINGHAM, S , DAVIES, JC , ALTON, EWFW , (2014) GENE THERAPY IN CYSTIC FIBROSIS.ARCHIVES OF DISEASE IN CHILDHOOD. VOL. 99. ISSUE 5. P. 465 -468 27 66% 19
8 ANEJA, MK , GEIGER, JP , HIMMEL, A , RUDOLPH, C , (2009) TARGETED GENE DELIVERY TO THE LUNG.EXPERT OPINION ON DRUG DELIVERY. VOL. 6. ISSUE 6. P. 567-583 58 39% 13
9 MCLACHLAN, G , DAVIDSON, H , HOLDER, E , DAVIES, LA , PRINGLE, IA , SUMNER-JONES, SG , BAKER, A , TENNANT, P , GORDON, C , VRETTOU, C , ET AL (2011) PRE-CLINICAL EVALUATION OF THREE NON-VIRAL GENE TRANSFER AGENTS FOR CYSTIC FIBROSIS AFTER AEROSOL DELIVERY TO THE OVINE LUNG.GENE THERAPY. VOL. 18. ISSUE 10. P. 996-1005 24 77% 49
10 GRIESENBACH, U , ALTON, EWFW , (2013) MOVING FORWARD: CYSTIC FIBROSIS GENE THERAPY.HUMAN MOLECULAR GENETICS. VOL. 22. ISSUE . P. R52-R58 32 57% 20

Classes with closest relation at Level 1


Rank Class id link
1 6997 MOL MED GENE THER Y UNIT//ADENOVIRUS//HELPER DEPENDENT ADENOVIRAL VECTOR
2 36383 HUMAN MOL GENET PROGRAM//CFTR GENE EXPRESSION//CFTR PROMOTER
3 2198 CATIONIC LIPID//CATIONIC LIPOSOMES//LIPOPLEX
4 2342 CFTR//CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR//CYSTIC FIBROSIS
5 35297 S GAL//3 D REGISTRATION AND RECONSTRUCTION//3 GALACTOSIDASE
6 27919 GENE THER Y SCI//RECOMBINANT SENDAI VIRUS//HVJ E
7 18301 NAKED PLASMID DNA//HYDRODYNAMICS BASED TRANSFECTION//HYDRODYNAMIC GENE DELIVERY
8 6126 AIRWAY SURFACE LIQUID//SUBMUCOSAL GLANDS//CYST FIBROSIS PULM TREATMENT
9 1257 ADENO ASSOCIATED VIRUS//AAV//POWELL GENE THER Y
10 21372 MUCUS PENETRATING PARTICLES//JOHNS HOPKINS ADULT CYST FIBROSIS PROGRAM//MUCUS BARRIER

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