MUMI2D - Microdevice for ultrasound mediated imaging and drug delivery
Description (background and methods)
A continuous development of new therapeutic agents has made novel drugs available for a variety of diseases. However, a wide spectrum of active molecules alone does not guarantee optimal therapic effect as other relevant factors, such as bioavailability and release mechanism, come into play. The “drug” has rather become a “complex” whose therapeutic efficacy is obtained with the collaborative action of a compound and a delivery system.
The current project introduces a new class of microdevices providing integrated diagnostic and therapeutic applications, i.e., theranostics using microbubble-based ultrasound contrast agent loaded with therapeutic compound. A gas core makes microbubbles to an efficient ultrasound contrast agent. Application of therapeutic gas opens new possibilities for local, specific drug delivery triggered by ultrasound.
The objective of the current project is to further improve existing and develop new contrast pulse sequences for diagnostic and therapy using the preclinical ultrasound imaging platform Verasonics.
In particular the work will be carried out on:
- Development and design new contrast pulse sequences using single crystal set-up and extend this knowledge towards programmable ultrasound system Verasonics.
- Matematical modelling of wave propagating
- Experimental work on acoustic droplet evaporation using the developed sequences.
- Fabrication of the tissue mimicking phantom
- Design of the new experimental sep-up for demonstration of complex acoustic phenomenon.
Collaborations
- Department of Fibre and Polymer Technology,CBH, KTH
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Contributors
