Acoustic Response of Pickering Perfluoropentane Droplets
Description
Ultrasound contrast agents have been used in clinical settings for many years, thanks to their ability to improve image contrast and visualize structures not attainable otherwise. Recently, a novel type of contrast agents has been developed, in which a liquid hydrophobic core is stabilized by cellulose nanofibers via a Pickering mechanism. Cellulose nanofibers are advantageous for ultrasound-mediated clinical applications due to their biocompatibility and potential to chemically modify the surface for target-specific binding.
This project aims at understanding the acoustic response of these droplets. We study how the threshold for acoustic droplet vaporization changes between bulk and confined medium, investigate how various parameters influence the resonance frequency of these droplets, and develop an imaging sequence that successfully image the droplets before and after vaporization.
Publications
K. Loskutova et al., "A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media." ACS omega 6.8 (2021): 5670-5678.
Collaborations
- Shanghai Jiao Tong University, Shanghai, China
- The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Thesis projects
Ksenia Loskutova, doctoral dissertation project, ongoing.
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