CATAMARAN - Contrast Agents for Theranostics of Atherosclerosis using Microbubbles and Recent Advanced Nanotechnology
Description (background and methods)
Atherosclerosis is a chronic, inflammatory, fibroproliferative disease. It can strike suddenly in the form of an acute myocardial infarction or stroke with high initial mortality up to 40 % before reaching the hospital. Atherosclerosis remains the main cause of death both in western and developing countries. The damage could be largely averted, if timely diagnosis and local treatment was available.
Ultrasound is a common imaging approach for fast diagnosis and monitoring of atherosclerosis, with efficiency greatly improved by ultrasound contrast agents (UCAs), presently used for passive enhancement of blood echoes in flow, perfusion and delineation studies.
In the current project the novel application areas such as targeted molecular imaging, hybrid multimodal imaging, local and controlled drug delivery will be developed.
In particular the work will be carried out on:
- Chemical preparation, size and morphology characterization
- Acoustic and mechanical characterization
- Development of specific contrast pulse sequence for efficient imaging and controlled drug delivery.
- Translational research from the tissue mimicking phantom to preclinical research even further towards early stage clinical study
(Preliminary) results and publications
V. V. S. N. Kothapalli et al., Unique pumping-out fracturing mechanism of a polymer- shelled contrast agent : An acoustic characterization and optical visualization, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 62, no. 3, s. 451- 462, 2014.
D. Grishenkov, G. Adrian och B. Janerot Sjöberg, In search of the optimal ultrasound heart perfusion imaging platform, Journal of ultrasound in medicine, vol. 34, no. 9, s. 1599-1605, 2015.
D. Grishenkov et al., Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice : Theranostic contrast agent loaded with nitric oxide, Drug Design, Development and Therapy, vol. 9, s. 2409-2419, 2015.
G. Tamadapu, D. Grishenkov och A. Eriksson, Modeling and parametric investigation of thick encapsulated microbubble's nonspherical oscillations, Journal of the Acoustical Society of America, vol. 140, no. 5, s. 3884-3895, 2016.
Collaborations
- Division of Functional Imaging and Technology | Dept. of Clinical Science, Intervention and Technology (CLINTEC) | Karolinska Institutet
- Dept. of Clinical Physiology | Karolinska University Hospital | C1-88 Huddinge
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