Class information for:
Level 1: URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7353 1377 30.9 51%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
7353 1                   URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN 1377

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 URIDINE PHOSPHORYLASE authKW 546617 3% 57% 43
2 5 PHENYLTHIOACYCLOURIDINE authKW 133042 0% 100% 6
3 LEUCOVORIN authKW 112608 4% 10% 52
4 PALA authKW 99766 1% 38% 12
5 ALPHA D RIBOSE 1 PHOSPHATE authKW 88694 0% 100% 4
6 BIOCHEMICAL MODULATION authKW 76620 2% 16% 22
7 5 FLUOROURACIL authKW 68192 8% 3% 116
8 5 PHENYLSELENENYLACYCLOURIDINE authKW 66521 0% 100% 3
9 FDCYD authKW 66521 0% 100% 3
10 URIDINE PHOSPHORYLASE INHIBITOR authKW 66521 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 14587 53% 0% 730
2 Pharmacology & Pharmacy 2439 26% 0% 359
3 Biochemistry & Molecular Biology 258 16% 0% 216
4 Biophysics 148 5% 0% 67
5 Chemistry, Medicinal 44 2% 0% 34
6 Biochemical Research Methods 38 3% 0% 38
7 Crystallography 21 2% 0% 24
8 Chemistry, Analytical 6 3% 0% 35
9 Hematology 5 1% 0% 20
10 Medicine, Research & Experimental 1 2% 0% 23

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOL BIOCIENCIAS RIO CLARO 22174 0% 100% 1
2 BRAIN KOREA CHUNGBUK BIOMED SCI 21 22174 0% 100% 1
3 CANC THER EUT DRUG DISCOVERY PROGRAM 22174 0% 100% 1
4 CHEM S HIROMACHI 1258 SHINAGAWA KU 22174 0% 100% 1
5 CLIN CANC NURSING SERV 22174 0% 100% 1
6 CLIN PHARMACOL BRANCH CANC TREATMENT 22174 0% 100% 1
7 COMPREHENS CANC K4 666 22174 0% 100% 1
8 CORP DEV UBE 22174 0% 100% 1
9 FARMACIOL 22174 0% 100% 1
10 GALEN FARM TECNOL FARMACEUT 22174 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER TREATMENT REPORTS 38623 5% 3% 62
2 CANCER CHEMOTHERAPY AND PHARMACOLOGY 17390 6% 1% 76
3 CANCER RESEARCH 9070 9% 0% 127
4 BIOCHEMICAL PHARMACOLOGY 7599 6% 0% 80
5 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 7322 2% 1% 25
6 AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 3971 2% 1% 27
7 SELECTIVE CANCER THERAPEUTICS 3266 0% 5% 3
8 CHEMIOTERAPIA 3030 1% 2% 7
9 INVESTIGATIONAL NEW DRUGS 2785 1% 1% 18
10 CANCER COMMUNICATIONS 1951 0% 3% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 URIDINE PHOSPHORYLASE 546617 3% 57% 43 Search URIDINE+PHOSPHORYLASE Search URIDINE+PHOSPHORYLASE
2 5 PHENYLTHIOACYCLOURIDINE 133042 0% 100% 6 Search 5+PHENYLTHIOACYCLOURIDINE Search 5+PHENYLTHIOACYCLOURIDINE
3 LEUCOVORIN 112608 4% 10% 52 Search LEUCOVORIN Search LEUCOVORIN
4 PALA 99766 1% 38% 12 Search PALA Search PALA
5 ALPHA D RIBOSE 1 PHOSPHATE 88694 0% 100% 4 Search ALPHA+D+RIBOSE+1+PHOSPHATE Search ALPHA+D+RIBOSE+1+PHOSPHATE
6 BIOCHEMICAL MODULATION 76620 2% 16% 22 Search BIOCHEMICAL+MODULATION Search BIOCHEMICAL+MODULATION
7 5 FLUOROURACIL 68192 8% 3% 116 Search 5+FLUOROURACIL Search 5+FLUOROURACIL
8 5 PHENYLSELENENYLACYCLOURIDINE 66521 0% 100% 3 Search 5+PHENYLSELENENYLACYCLOURIDINE Search 5+PHENYLSELENENYLACYCLOURIDINE
9 FDCYD 66521 0% 100% 3 Search FDCYD Search FDCYD
10 URIDINE PHOSPHORYLASE INHIBITOR 66521 0% 100% 3 Search URIDINE+PHOSPHORYLASE+INHIBITOR Search URIDINE+PHOSPHORYLASE+INHIBITOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 AL SAFARJALANI, ON , RAIS, R , NAGUIB, FNM , EL KOUNI, MH , (2012) POTENT COMBINATION THERAPY FOR HUMAN BREAST TUMORS WITH HIGH DOSES OF 5-FLUOROURACIL: REMISSION AND LACK OF HOST TOXICITY.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 69. ISSUE 6. P. 1449 -1455 44 96% 3
2 AL SAFARJALANI, ON , RAIS, R , SHI, JX , SCHINAZI, RF , NAGUIB, FNM , EL KOUNI, MH , (2006) MODULATION OF 5-FLUOROURACIL HOST-TOXICITY AND CHEMOTHERAPEUTIC EFFICACY AGAINST HUMAN COLON TUMORS BY 5-(PHENYLTHIO)ACYCLOURIDINE, A URIDINE PHOSPHORYLASE INHIBITOR.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 58. ISSUE 5. P. 692-698 44 94% 9
3 AL SAFARJALANI, ON , ZHOU, XJ , RAIS, RH , SHI, JX , SCHINAZI, RF , NAGUIB, FNM , EL KOUNI, MH , (2005) 5-(PHENYLTHIO)ACYCLOURIDINE: A POWERFUL ENHANCER OF ORAL URIDINE BIOAVAILABILITY: RELEVANCE TO CHEMOTHERAPY WITH 5-FLUOROURACIL AND OTHER URIDINE RESCUE REGIMENS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 55. ISSUE 6. P. 541 -551 49 77% 32
4 PARKER, WB , CHENG, YC , (1990) METABOLISM AND MECHANISM OF ACTION OF 5-FLUOROURACIL.PHARMACOLOGY & THERAPEUTICS. VOL. 48. ISSUE 3. P. 381-395 71 70% 229
5 LASHKOV, AA , ZHUKHLISTOVA, NE , SEREGINA, TA , GABDULKHAKOV, AG , MIKHAILOV, AM , (2011) URIDINE PHOSPHORYLASE IN BIOMEDICAL, STRUCTURAL, AND FUNCTIONAL ASPECTS: A REVIEW.CRYSTALLOGRAPHY REPORTS. VOL. 56. ISSUE 4. P. 560-589 47 66% 4
6 GREM, JL , KING, SA , ODWYER, PJ , LEYLANDJONES, B , (1988) BIOCHEMISTRY AND CLINICAL ACTIVITY OF N-(PHOSPHONACETYL)-L-ASPARTATE - A REVIEW.CANCER RESEARCH. VOL. 48. ISSUE 16. P. 4441-4454 84 76% 64
7 WECKBECKER, G , (1991) BIOCHEMICAL PHARMACOLOGY AND ANALYSIS OF FLUOROPYRIMIDINES ALONE AND IN COMBINATION WITH MODULATORS.PHARMACOLOGY & THERAPEUTICS. VOL. 50. ISSUE 3. P. 367-424 114 44% 83
8 ODWYER, PJ , (1990) THE ROLE OF LOW-DOSE PALA IN BIOCHEMICAL MODULATION.PHARMACOLOGY & THERAPEUTICS. VOL. 48. ISSUE 3. P. 371-380 64 89% 8
9 AL SAFARJALANI, ON , ZHOU, XJ , NAGUIB, FNM , SHI, JX , SCHINAZI, RF , EL KOUNI, MH , (2001) ENHANCEMENT OF THE BIOAVAILABILITY OF ORAL URIDINE BY COADMINISTRATION OF 5-(PHENYLTHIO) ACYCLOURIDINE, A URIDINE PHOSPHORYLASE INHIBITOR: IMPLICATIONS FOR URIDINE RESCUE REGIMENS IN CHEMOTHERAPY.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 48. ISSUE 5. P. 389-397 44 79% 7
10 ASHOUR, OM , NAGUIB, FNM , GOUDGAON, NM , SCHINAZI, RF , EL KOUNI, MH , (2000) EFFECT OF 5-(PHENYLSELENENYL)ACYCLOURIDINE, AN INHIBITOR OF URIDINE PHOSPHORYLASE, ON PLASMA CONCENTRATION OF URIDINE RELEASED FROM 2 ',3 ',5 '-TRI-O-ACETYLURIDINE, A PRODRUG OF URIDINE: RELEVANCE TO URIDINE RESCUE IN CHEMOTHERAPY.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 46. ISSUE 3. P. 235-240 36 92% 5

Classes with closest relation at Level 1


Rank Class id link
1 32402 CARMOFUR//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL//HCFU
2 9432 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL
3 22412 F 19 MRS//FLUORONUCLEOTIDES//F 19 MR IMAGING
4 11797 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102
5 16143 SECT PHARMACOL MED ONCOL//INTERDIPARTIMENTALE EPIDEMIOL//NIKAIA GEN HOSP
6 8721 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE
7 747 METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER
8 23401 CYCLOPENTENYL CYTOSINE//CTP SYNTHASE//CTP SYNTHETASE
9 24391 HALOGENATED PYRIMIDINES//EXPT ONCOL RADIOBIOL LEXOR EXPT MOL MED//IPDR
10 15011 THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE

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