Class information for:
Level 1: DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9432 1156 29.4 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
9432 1                   DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL 1156

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIHYDROPYRIMIDINE DEHYDROGENASE authKW 1891378 14% 44% 163
2 DPYD authKW 803299 4% 72% 42
3 5 FLUOROURACIL authKW 474318 24% 6% 280
4 ENILURACIL authKW 317823 2% 63% 19
5 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY authKW 297584 1% 87% 13
6 DPD DEFICIENCY authKW 237718 1% 100% 9
7 DPYD GENE authKW 237718 1% 100% 9
8 DIHYDROURACIL authKW 228562 1% 58% 15
9 DPYS authKW 211305 1% 100% 8
10 BETA UREIDOPROPIONASE authKW 203173 1% 77% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 5335 36% 0% 414
2 Pharmacology & Pharmacy 2648 29% 0% 338
3 Chemistry, Analytical 1049 14% 0% 163
4 Medical Laboratory Technology 674 4% 0% 49
5 Biochemical Research Methods 592 8% 0% 97
6 Medicine, Research & Experimental 280 7% 0% 80
7 Genetics & Heredity 107 5% 0% 63
8 Toxicology 86 3% 0% 39
9 Endocrinology & Metabolism 85 5% 0% 53
10 Chemistry, Medicinal 21 2% 0% 24

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INO F 99551 1% 54% 7
2 ONCOPHARMACOL PHARMACOGENET 79233 1% 50% 6
3 EMMA CHILDRENS HOSP 59649 5% 4% 54
4 ANTICANC PAUL P IN 52826 0% 100% 2
5 TREANT HEALTHGRP 52826 0% 100% 2
6 ONCOPHARMACOL 43839 1% 10% 17
7 GENET METAB DIS 36198 3% 4% 34
8 PDMP 35216 0% 67% 2
9 ONCOPHARMACOL UNIT 33980 1% 12% 11
10 AGII ANARGIRI CANC HOSPBASIC MED SCI BIOL PA 26413 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 12903 5% 1% 60
2 JOURNAL OF INHERITED METABOLIC DISEASE 5931 3% 1% 32
3 CLINICAL COLORECTAL CANCER 4525 1% 2% 9
4 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 4206 4% 0% 44
5 PHARMACOGENOMICS 3330 1% 1% 15
6 THERAPEUTIC DRUG MONITORING 2522 2% 1% 19
7 CLINICAL CANCER RESEARCH 2385 3% 0% 37
8 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1609 1% 0% 17
9 ONCOLOGY-NEW YORK 1441 1% 1% 9
10 JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS 1421 1% 0% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DIHYDROPYRIMIDINE DEHYDROGENASE 1891378 14% 44% 163 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
2 DPYD 803299 4% 72% 42 Search DPYD Search DPYD
3 5 FLUOROURACIL 474318 24% 6% 280 Search 5+FLUOROURACIL Search 5+FLUOROURACIL
4 ENILURACIL 317823 2% 63% 19 Search ENILURACIL Search ENILURACIL
5 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY 297584 1% 87% 13 Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DEFICIENCY Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DEFICIENCY
6 DPD DEFICIENCY 237718 1% 100% 9 Search DPD+DEFICIENCY Search DPD+DEFICIENCY
7 DPYD GENE 237718 1% 100% 9 Search DPYD+GENE Search DPYD+GENE
8 DIHYDROURACIL 228562 1% 58% 15 Search DIHYDROURACIL Search DIHYDROURACIL
9 DPYS 211305 1% 100% 8 Search DPYS Search DPYS
10 BETA UREIDOPROPIONASE 203173 1% 77% 10 Search BETA+UREIDOPROPIONASE Search BETA+UREIDOPROPIONASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 VAN STAVEREN, MC , GUCHELAAR, HJ , VAN KUILENBURG, ABP , GELDERBLOM, H , MARING, JG , (2013) EVALUATION OF PREDICTIVE TESTS FOR SCREENING FOR DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY.PHARMACOGENOMICS JOURNAL. VOL. 13. ISSUE 5. P. 389-395 67 100% 22
2 MEULENDIJKS, D , CATS, A , BEIJNEN, JH , SCHELLENS, JHM , (2016) IMPROVING SAFETY OF FLUOROPYRIMIDINE CHEMOTHERAPY BY INDIVIDUALIZING TREATMENT BASED ON DIHYDROPYRIMIDINE DEHYDROGENASE ACTIVITY - READY FOR CLINICAL PRACTICE?.CANCER TREATMENT REVIEWS. VOL. 50. ISSUE . P. 23 -34 76 88% 0
3 MERCIER, C , CICCOLINI, J , (2006) PROFILING DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY IN PATIENTS WITH CANCER UNDERGOING 5-FLUOROURACIL/CAPECITABINE THERAPY.CLINICAL COLORECTAL CANCER. VOL. 6. ISSUE 4. P. 288-296 96 79% 26
4 AMSTUTZ, U , FROEHLICH, TK , LARGIADER, CR , (2011) DIHYDROPYRIMIDINE DEHYDROGENASE GENE AS A MAJOR PREDICTOR OF SEVERE 5-FLUOROURACIL TOXICITY.PHARMACOGENOMICS. VOL. 12. ISSUE 9. P. 1321-1336 61 82% 59
5 VAN KUILENBURQ, ABP , MARING, JG , (2013) EVALUATION OF 5-FLUOROURACIL PHARMACOKINETIC MODELS AND THERAPEUTIC DRUG MONITORING IN CANCER PATIENTS.PHARMACOGENOMICS. VOL. 14. ISSUE 7. P. 799-811 63 77% 15
6 PLOYLEARMSAENG, SA , FUHR, U , JETTER, A , (2006) HOW MAY ANTICANCER CHEMOTHERAPY WITH FLUOROURACIL BE INDIVIDUALISED?.CLINICAL PHARMACOKINETICS. VOL. 45. ISSUE 6. P. 567-592 80 74% 27
7 VAN KUILENBURG, ABP , MEIJER, J , TANCK, MWT , DOBRITZSCH, D , ZOETEKOUW, L , DEKKERS, LL , ROELOFSEN, J , MEINSMA, R , WYMENGA, M , KULIK, W , ET AL (2016) PHENOTYPIC AND CLINICAL IMPLICATIONS OF VARIANTS IN THE DIHYDROPYRIMIDINE DEHYDROGENASE GENE.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. VOL. 1862. ISSUE 4. P. 754 -762 53 88% 0
8 BREDA, M , BARATTE, S , (2010) A REVIEW OF ANALYTICAL METHODS FOR THE DETERMINATION OF 5-FLUOROURACIL IN BIOLOGICAL MATRICES.ANALYTICAL AND BIOANALYTICAL CHEMISTRY. VOL. 397. ISSUE 3. P. 1191 -1201 65 77% 12
9 CAUDLE, KE , THORN, CF , KLEIN, TE , SWEN, JJ , MCLEOD, HL , DIASIO, RB , SCHWAB, M , (2013) CLINICAL PHARMACOGENETICS IMPLEMENTATION CONSORTIUM GUIDELINES FOR DIHYDROPYRIMIDINE DEHYDROGENASE GENOTYPE AND FLUOROPYRIMIDINE DOSING.CLINICAL PHARMACOLOGY & THERAPEUTICS. VOL. 94. ISSUE 6. P. 640 -645 34 89% 95
10 CICCOLINI, J , GROSS, E , DAHAN, L , LACARELLE, B , MERCIER, C , (2010) ROUTINE DIHYDROPYRIMIDINE DEHYDROGENASE TESTING FOR ANTICIPATING 5-FLUOROURACIL-RELATED SEVERE TOXICITIES: HYPE OR HOPE?.CLINICAL COLORECTAL CANCER. VOL. 9. ISSUE 4. P. 224 -228 45 98% 31

Classes with closest relation at Level 1


Rank Class id link
1 8721 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE
2 22412 F 19 MRS//FLUORONUCLEOTIDES//F 19 MR IMAGING
3 32402 CARMOFUR//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL//HCFU
4 7353 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN
5 24231 CARDIOTOXICITY//INTERNAL MED PERIOPERAT ASSESSMENT//5 FLUOROURACIL
6 747 METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER
7 11797 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102
8 17571 HYDANTOINASE//D HYDANTOINASE//DIHYDROPYRIMIDINASE
9 36617 IRON AND ZINC DETERMINATION//PHARMACEUTICAL MULTIVITAMIN PREPARATIONS//2 MERCAPTO 5 2 4 DIHYDROXY 5 CARBOXYPHENYLAZO 1 1 3 4 TIADIAZOLE
10 16143 SECT PHARMACOL MED ONCOL//INTERDIPARTIMENTALE EPIDEMIOL//NIKAIA GEN HOSP

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