Class information for:
Level 2: METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1684 6769 34.6 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
316 3       RHEUMATOLOGY//RHEUMATOID ARTHRITIS//RHEUMATOL 39766
1684 2             METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER 6769
2341 1                   REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//ANTIFOLATE 2275
3319 1                   METHOTREXATE//RHEUMATOID ARTHRITIS//METHOTREXATE POLYGLUTAMATES 2010
10553 1                   FOLATE RECEPTOR//FOLATE BINDING PROTEIN//FOLATE RECEPTOR ALPHA 1054
15824 1                   HIGH DOSE METHOTREXATE//7 HYDROXYMETHOTREXATE//METHOTREXATE 690
19906 1                   TENIDAP//SULFASALAZINE//SULPHASALAZINE 484
26370 1                   METHOTREXATE//INTESTINAL DAMAGE//ABSORPTIVE FUNCTION OF THE INTESTINE 256

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 METHOTREXATE authKW 1256543 18% 23% 1217
2 FOLATE RECEPTOR authKW 636641 4% 58% 245
3 REDUCED FOLATE CARRIER authKW 325555 1% 74% 98
4 ANTIFOLATE authKW 226539 2% 39% 129
5 FOLYLPOLYGLUTAMATE SYNTHETASE authKW 163268 1% 77% 47
6 FOLATE BINDING PROTEIN authKW 149374 1% 61% 54
7 7 HYDROXYMETHOTREXATE authKW 135891 1% 84% 36
8 FOLATE RECEPTOR ALPHA authKW 132543 1% 70% 42
9 PROTON COUPLED FOLATE TRANSPORTER authKW 114022 0% 82% 31
10 METHOTREXATE POLYGLUTAMATES authKW 108391 0% 96% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Rheumatology 76273 19% 1% 1314
2 Oncology 7362 19% 0% 1261
3 Pharmacology & Pharmacy 6488 20% 0% 1352
4 Chemistry, Medicinal 1404 5% 0% 339
5 Dermatology 828 3% 0% 215
6 Biochemistry & Molecular Biology 584 12% 0% 840
7 Hematology 363 3% 0% 208
8 Medicine, General & Internal 318 5% 0% 335
9 Medicine, Research & Experimental 271 4% 0% 243
10 Medical Laboratory Technology 266 1% 0% 88

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT CLIN THER EUT PROGRAM 72122 0% 57% 28
2 PROGRAM MOL PHARMACOL EXPT THER EUT 36057 0% 50% 16
3 FRED WYSZKOWSKI CANC 26892 0% 30% 20
4 AUTOIMMUNE SEROL 22536 0% 50% 10
5 PENNY COLE HEMATOL 14428 0% 80% 4
6 GRACE CANC DRUG 14335 0% 13% 25
7 RADIOPHARMACEUT SCI ETH PSI USZ 12270 0% 21% 13
8 TRANSLAT MED DIAGNOST 12022 0% 67% 4
9 ETH PSI USZ 11588 0% 43% 6
10 RHEUMATOL 11524 5% 1% 327

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF RHEUMATOLOGY 30476 4% 2% 295
2 BRITISH JOURNAL OF RHEUMATOLOGY 27760 2% 5% 117
3 CANCER CHEMOTHERAPY AND PHARMACOLOGY 16694 2% 2% 166
4 ARTHRITIS AND RHEUMATISM 10189 2% 2% 154
5 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 10120 2% 2% 112
6 ANNALS OF THE RHEUMATIC DISEASES 6877 2% 1% 118
7 ADVANCES IN ENZYME REGULATION 6308 0% 5% 29
8 JOURNAL OF MEDICINAL CHEMISTRY 6018 3% 1% 173
9 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 5781 1% 2% 62
10 ZEITSCHRIFT FUR RHEUMATOLOGIE 5543 1% 2% 54

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 METHOTREXATE 1256543 18% 23% 1217 Search METHOTREXATE Search METHOTREXATE
2 FOLATE RECEPTOR 636641 4% 58% 245 Search FOLATE+RECEPTOR Search FOLATE+RECEPTOR
3 REDUCED FOLATE CARRIER 325555 1% 74% 98 Search REDUCED+FOLATE+CARRIER Search REDUCED+FOLATE+CARRIER
4 ANTIFOLATE 226539 2% 39% 129 Search ANTIFOLATE Search ANTIFOLATE
5 FOLYLPOLYGLUTAMATE SYNTHETASE 163268 1% 77% 47 Search FOLYLPOLYGLUTAMATE+SYNTHETASE Search FOLYLPOLYGLUTAMATE+SYNTHETASE
6 FOLATE BINDING PROTEIN 149374 1% 61% 54 Search FOLATE+BINDING+PROTEIN Search FOLATE+BINDING+PROTEIN
7 7 HYDROXYMETHOTREXATE 135891 1% 84% 36 Search 7+HYDROXYMETHOTREXATE Search 7+HYDROXYMETHOTREXATE
8 FOLATE RECEPTOR ALPHA 132543 1% 70% 42 Search FOLATE+RECEPTOR+ALPHA Search FOLATE+RECEPTOR+ALPHA
9 PROTON COUPLED FOLATE TRANSPORTER 114022 0% 82% 31 Search PROTON+COUPLED+FOLATE+TRANSPORTER Search PROTON+COUPLED+FOLATE+TRANSPORTER
10 METHOTREXATE POLYGLUTAMATES 108391 0% 96% 25 Search METHOTREXATE+POLYGLUTAMATES Search METHOTREXATE+POLYGLUTAMATES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GONEN, N , ASSARAF, YG , (2012) ANTIFOLATES IN CANCER THERAPY: STRUCTURE, ACTIVITY AND MECHANISMS OF DRUG RESISTANCE.DRUG RESISTANCE UPDATES. VOL. 15. ISSUE 4. P. 183 -210 258 72% 85
2 ZHAO, RB , GOLDMAN, ID , (2003) RESISTANCE TO ANTIFOLATES.ONCOGENE. VOL. 22. ISSUE 47. P. 7431-7457 227 74% 145
3 MATHERLY, LH , WILSON, MR , HOU, ZJ , (2014) THE MAJOR FACILITATIVE FOLATE TRANSPORTERS SOLUTE CARRIER 19A1 AND SOLUTE CARRIER 46A1: BIOLOGY AND ROLE IN ANTIFOLATE CHEMOTHERAPY OF CANCER.DRUG METABOLISM AND DISPOSITION. VOL. 42. ISSUE 4. P. 632 -649 172 82% 6
4 MATHERLY, LH , GOLDMAN, D , (2003) MEMBRANE TRANSPORT OF FOLATES.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 66. VOL. 66. ISSUE . P. 403 -456 175 75% 227
5 ASSARAF, YG , (2007) MOLECULAR BASIS OF ANTIFOLATE RESISTANCE.CANCER AND METASTASIS REVIEWS. VOL. 26. ISSUE 1. P. 153-181 157 73% 141
6 HOU, ZJ , MATHERLY, LH , (2014) BIOLOGY OF THE MAJOR FACILITATIVE FOLATE TRANSPORTERS SLC19A1 AND SLC46A1.EXCHANGERS. VOL. 73. ISSUE . P. 175 -204 114 92% 16
7 MCGUIRE, JJ , (2003) ANTICANCER ANTIFOLATES: CURRENT STATUS AND FUTURE DIRECTIONS..CURRENT PHARMACEUTICAL DESIGN. VOL. 9. ISSUE 31. P. 2593 -2613 136 78% 185
8 ELNAKAT, H , RATNAM, M , (2004) DISTRIBUTION, FUNCTIONALITY AND GENE REGULATION OF FOLATE RECEPTOR ISOFORMS: IMPLICATIONS IN TARGETED THERAPY.ADVANCED DRUG DELIVERY REVIEWS. VOL. 56. ISSUE 8. P. 1067-1084 112 81% 296
9 RAZ, S , STARK, M , ASSARAF, YG , (2016) FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE: A KEY DETERMINANT OF FOLATE HOMEOSTASIS AND ANTIFOLATE RESISTANCE IN CANCER.DRUG RESISTANCE UPDATES. VOL. 28. ISSUE . P. 43 -64 142 65% 0
10 ZHAO, RB , MATHERLY, LH , GOLDMAN, ID , (2009) MEMBRANE TRANSPORTERS AND FOLATE HOMEOSTASIS: INTESTINAL ABSORPTION AND TRANSPORT INTO SYSTEMIC COMPARTMENTS AND TISSUES.EXPERT REVIEWS IN MOLECULAR MEDICINE. VOL. 11. ISSUE . P. - 118 66% 104

Classes with closest relation at Level 2


Rank Class id link
1 3354 DIHYDROFOLATE REDUCTASE//HPPK//DHFR
2 3271 6 MERCAPTOPURINE//THIOPURINE METHYLTRANSFERASE//AZATHIOPRINE
3 3663 BUCILLAMINE//AZECINES//LE300
4 3449 INFLIXIMAB//ETANERCEPT//ADALIMUMAB
5 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
6 195 RHEUMATOID ARTHRITIS//RHEUMATOLOGY//RHEUMATOL
7 2798 LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE
8 254 HOMOCYSTEINE//FOLATE//FOLIC ACID
9 3001 HYDROXYCHLOROQUINE//DRIED BLOOD SPOTS//CHLOROQUINE
10 1922 RHEUMATOID ARTHRITIS//RADIATION SYNOVECTOMY//RHEUMATOLOGY

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