Class information for:
Level 1: THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11797 953 31.0 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
11797 1                   THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102 953

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THYMIDINE PHOSPHORYLASE authKW 6745301 34% 64% 328
2 PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR authKW 1868964 7% 83% 70
3 TAS 102 authKW 988646 4% 86% 36
4 THYMIDINE PHOSPHORYLASE INHIBITOR authKW 770185 3% 96% 25
5 5 DEOXY 5 FLUOROURIDINE authKW 655090 3% 66% 31
6 PD ECGF authKW 584148 3% 65% 28
7 GLIOSTATIN authKW 450558 2% 94% 15
8 DOXIFLURIDINE authKW 431657 3% 42% 32
9 PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE authKW 292922 2% 57% 16
10 TRIFLUOROTHYMIDINE authKW 241224 2% 47% 16

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 9919 53% 0% 501
2 Chemistry, Medicinal 379 7% 0% 63
3 Pharmacology & Pharmacy 359 14% 0% 130
4 Pathology 84 3% 0% 32
5 Biochemistry & Molecular Biology 65 12% 0% 111
6 Gastroenterology & Hepatology 56 3% 0% 30
7 Obstetrics & Gynecology 26 2% 0% 23
8 Biophysics 23 3% 0% 28
9 Medicine, Research & Experimental 22 3% 0% 29
10 Rheumatology 20 1% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KAJIWARA 200 96119 0% 100% 3
2 MED BIOREGULAT MIZUHO KU 96119 0% 100% 3
3 MOL ONCOLFIELD ONCOL 64080 0% 100% 2
4 UROLFIELD ONCOL 64080 0% 100% 2
5 CYTOSTAT GRP 51259 0% 40% 4
6 TOKUSHIMA 45985 2% 7% 21
7 ST NIKOLAS HISTOPATHOL UNIT 42718 0% 67% 2
8 AUBU KU 32040 0% 100% 1
9 BIOREGULAT MIZUHO KU 32040 0% 100% 1
10 CANC UKMOL ANGIOGENESIS GRP 32040 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOLOGY REPORTS 9731 6% 1% 55
2 CANCER CHEMOTHERAPY AND PHARMACOLOGY 3145 3% 0% 27
3 ANTICANCER RESEARCH 2907 4% 0% 42
4 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2198 2% 0% 18
5 JAPANESE JOURNAL OF CANCER RESEARCH 2011 2% 0% 15
6 INTERNATIONAL JOURNAL OF ONCOLOGY 1902 3% 0% 24
7 BRITISH JOURNAL OF CANCER 1676 3% 0% 31
8 CANCER LETTERS 1249 2% 0% 22
9 CLINICAL CANCER RESEARCH 1011 2% 0% 22
10 ANTI-CANCER DRUGS 964 1% 0% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THYMIDINE PHOSPHORYLASE 6745301 34% 64% 328 Search THYMIDINE+PHOSPHORYLASE Search THYMIDINE+PHOSPHORYLASE
2 PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR 1868964 7% 83% 70 Search PLATELET+DERIVED+ENDOTHELIAL+CELL+GROWTH+FACTOR Search PLATELET+DERIVED+ENDOTHELIAL+CELL+GROWTH+FACTOR
3 TAS 102 988646 4% 86% 36 Search TAS+102 Search TAS+102
4 THYMIDINE PHOSPHORYLASE INHIBITOR 770185 3% 96% 25 Search THYMIDINE+PHOSPHORYLASE+INHIBITOR Search THYMIDINE+PHOSPHORYLASE+INHIBITOR
5 5 DEOXY 5 FLUOROURIDINE 655090 3% 66% 31 Search 5+DEOXY+5+FLUOROURIDINE Search 5+DEOXY+5+FLUOROURIDINE
6 PD ECGF 584148 3% 65% 28 Search PD+ECGF Search PD+ECGF
7 GLIOSTATIN 450558 2% 94% 15 Search GLIOSTATIN Search GLIOSTATIN
8 DOXIFLURIDINE 431657 3% 42% 32 Search DOXIFLURIDINE Search DOXIFLURIDINE
9 PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE 292922 2% 57% 16 Search PYRIMIDINE+NUCLEOSIDE+PHOSPHORYLASE Search PYRIMIDINE+NUCLEOSIDE+PHOSPHORYLASE
10 TRIFLUOROTHYMIDINE 241224 2% 47% 16 Search TRIFLUOROTHYMIDINE Search TRIFLUOROTHYMIDINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LIEKENS, S , BRONCKAERS, A , GAGO, F , BALZARINI, J , (2009) THE DUAL ROLE OF THYMIDINE PHOSPHORYLASE IN CANCER DEVELOPMENT AND CHEMOTHERAPY.MEDICINAL RESEARCH REVIEWS. VOL. 29. ISSUE 6. P. 903 -953 237 65% 70
2 BERA, H , CHIGURUPATI, S , (2016) RECENT DISCOVERY OF NON-NUCLEOBASE THYMIDINE PHOSPHORYLASE INHIBITORS TARGETING CANCER.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 124. ISSUE . P. 992 -1003 89 81% 0
3 LIEKENS, S , BRONCKAERS, A , PEREZ-PEREZ, MJ , BALZARINI, J , (2007) TARGETING PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR THYMIDINE PHOSPHORYLASE FOR CANCER THERAPY.BIOCHEMICAL PHARMACOLOGY. VOL. 74. ISSUE 11. P. 1555-1567 85 82% 44
4 PEREZ-PEREZ, MJ , PRIEGO, EM , HERNANDEZ, AI , CAMARASA, MJ , BALZARINI, J , LIEKENS, S , (2005) THYMIDINE PHOSPHORYLASE INHIBITORS: RECENT DEVELOPMENTS AND POTENTIAL THERAPEUTIC APPLICATIONS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 5. ISSUE 12. P. 1113-1123 58 94% 28
5 PETERS, GJ , (2015) THERAPEUTIC POTENTIAL OF TAS-102 IN THE TREATMENT OF GASTROINTESTINAL MALIGNANCIES.THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. VOL. 7. ISSUE 6. P. 340 -356 55 71% 3
6 COLE, C , FOSTER, AJ , FREEMAN, S , JAFFAR, M , MURRAY, PE , STRATFORD, IJ , (1999) THE ROLE OF THYMIDINE PHOSPHORYLASE/PD-ECGF IN CANCER CHEMOTHERAPY: A CHEMICAL PERSPECTIVE.ANTI-CANCER DRUG DESIGN. VOL. 14. ISSUE 5. P. 383-392 60 77% 19
7 AKIYAMA, S , FURUKAWA, T , SUMIZAWA, T , TAKEBAYASHI, Y , NAKAJIMA, Y , SHIMAOKA, S , HARAGUCHI, M , (2004) THE ROLE OF THYMIDINE PHOSPHORYLASE,, AN ANGIOGENIC ENZYME, IN TUMOR PROGRESSION.CANCER SCIENCE. VOL. 95. ISSUE 11. P. 851-857 42 82% 56
8 TOI, M , RAHMAN, MA , BANDO, H , CHOW, LWC , (2005) THYMIDINE PHOSPHORYLASE (PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH FACTOR) IN CANCER BIOLOGY AND TREATMENT.LANCET ONCOLOGY. VOL. 6. ISSUE 3. P. 158-166 50 60% 89
9 UBOHA, N , HOCHSTER, HS , (2016) TAS-102: A NOVEL ANTIMETABOLITE FOR THE 21ST CENTURY.FUTURE ONCOLOGY. VOL. 12. ISSUE 2. P. 153 -163 36 72% 0
10 KUBIAK, R , MISZCZAK-ZABORSKA, E , SMOLAREK, M , WOJCIK-KROWIRANDA, K , BARTKOWIAK, J , (2009) THE THYMIDINE PHOSPHORYLASE AS THE PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR OF ENDOMETRIAL CANCER.GINEKOLOGIA POLSKA. VOL. 80. ISSUE 8. P. 596 -601 34 87% 0

Classes with closest relation at Level 1


Rank Class id link
1 8721 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE
2 6121 MICROVESSEL DENSITY//ANGIOGENESIS//MICROVESSEL COUNT
3 7353 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN
4 32402 CARMOFUR//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL//HCFU
5 9432 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL
6 22412 F 19 MRS//FLUORONUCLEOTIDES//F 19 MR IMAGING
7 9868 PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//NUCLEOSIDE HYDROLASE
8 747 METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER
9 16143 SECT PHARMACOL MED ONCOL//INTERDIPARTIMENTALE EPIDEMIOL//NIKAIA GEN HOSP
10 2966 METASTATIC BREAST CANCER//VINORELBINE//DOCETAXEL

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