Class information for:
Level 1: THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15011 736 33.9 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
15011 1                   THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE 736

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THYMIDYLATE SYNTHASE authKW 765523 18% 14% 132
2 THYX authKW 132756 1% 80% 4
3 FLUORODEOXYURIDYLATE authKW 124461 0% 100% 3
4 BIOMED SCI METAB NEURAL SCI address 93344 0% 75% 3
5 DEOXYTUBULOSINE authKW 93344 0% 75% 3
6 HUMAN THYMIDYLATE SYNTHASE authKW 93344 0% 75% 3
7 DIHYDROFOLATE REDUCTASE THYMIDYLATE SYNTHASE authKW 84692 1% 29% 7
8 2 DEOXYURIDINE 5 MONOPHOSPHATE authKW 82974 0% 100% 2
9 5 FLUORO DUMP authKW 82974 0% 100% 2
10 BIFUNCTIONAL DHFR TS authKW 82974 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 4801 65% 0% 482
2 Biophysics 817 13% 0% 95
3 Chemistry, Medicinal 356 7% 0% 53
4 Biochemical Research Methods 89 5% 0% 34
5 CYTOLOGY & HISTOLOGY 81 1% 0% 4
6 Cell Biology 58 7% 0% 49
7 Chemistry, Organic 50 5% 0% 40
8 Parasitiology 49 2% 0% 14
9 Genetics & Heredity 42 5% 0% 34
10 Plant Sciences 37 5% 0% 35

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMED SCI METAB NEURAL SCI 93344 0% 75% 3
2 M NENCKI EXPT BIOL 64786 3% 8% 20
3 BIOCHEM BIOPHYS S960 55315 0% 67% 2
4 AFSSSAUMRMOL BIOL IMMUNOL PARASITES FUNGI 41487 0% 100% 1
5 AVENIR GRP GENET MICROBIOL 41487 0% 100% 1
6 BASCI 41487 0% 100% 1
7 BIOPHYS MOL PHARMACOL 41487 0% 100% 1
8 GENET MICROBIOLCNRSUMR 8621 41487 0% 100% 1
9 GENOM MICROBIAL PHYSIOL 41487 0% 100% 1
10 GOVT FC 41487 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMISTRY 6829 13% 0% 94
2 PTERIDINES 2557 1% 1% 5
3 ADVANCES IN ENZYME REGULATION 2494 1% 1% 6
4 EUROPEAN JOURNAL OF BASIC AND APPLIED HISTOCHEMISTRY 1429 0% 3% 1
5 BIOORGANIC CHEMISTRY 1368 1% 0% 7
6 KOREAN JOURNAL OF BIOCHEMISTRY 1336 0% 3% 1
7 PROTEIN SCIENCE 1274 2% 0% 14
8 ACTA BIOCHIMICA POLONICA 1215 1% 0% 9
9 JOURNAL OF MEDICINAL CHEMISTRY 1078 3% 0% 24
10 INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 1023 1% 0% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THYMIDYLATE SYNTHASE 765523 18% 14% 132 Search THYMIDYLATE+SYNTHASE Search THYMIDYLATE+SYNTHASE
2 THYX 132756 1% 80% 4 Search THYX Search THYX
3 FLUORODEOXYURIDYLATE 124461 0% 100% 3 Search FLUORODEOXYURIDYLATE Search FLUORODEOXYURIDYLATE
4 DEOXYTUBULOSINE 93344 0% 75% 3 Search DEOXYTUBULOSINE Search DEOXYTUBULOSINE
5 HUMAN THYMIDYLATE SYNTHASE 93344 0% 75% 3 Search HUMAN+THYMIDYLATE+SYNTHASE Search HUMAN+THYMIDYLATE+SYNTHASE
6 DIHYDROFOLATE REDUCTASE THYMIDYLATE SYNTHASE 84692 1% 29% 7 Search DIHYDROFOLATE+REDUCTASE+THYMIDYLATE+SYNTHASE Search DIHYDROFOLATE+REDUCTASE+THYMIDYLATE+SYNTHASE
7 2 DEOXYURIDINE 5 MONOPHOSPHATE 82974 0% 100% 2 Search 2+DEOXYURIDINE+5+MONOPHOSPHATE Search 2+DEOXYURIDINE+5+MONOPHOSPHATE
8 5 FLUORO DUMP 82974 0% 100% 2 Search 5+FLUORO+DUMP Search 5+FLUORO+DUMP
9 BIFUNCTIONAL DHFR TS 82974 0% 100% 2 Search BIFUNCTIONAL+DHFR+TS Search BIFUNCTIONAL+DHFR+TS
10 BIFUNCTIONAL POLYPEPTIDE 82974 0% 100% 2 Search BIFUNCTIONAL+POLYPEPTIDE Search BIFUNCTIONAL+POLYPEPTIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CARRERAS, CW , SANTI, DV , (1995) THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 64. ISSUE . P. 721-762 83 72% 497
2 FINER-MOORE, JS , SANTI, DV , STROUD, RM , (2003) LESSONS AND CONCLUSIONS FROM DISSECTING THE MECHANISM OF A BISUBSTRATE ENZYME: THYMIDYLATE SYNTHASE MUTAGENESIS, FUNCTION, AND STRUCTURE.BIOCHEMISTRY. VOL. 42. ISSUE 2. P. 248-256 43 96% 87
3 STROUD, RM , FINER-MOORE, JS , (2003) CONFORMATIONAL DYNAMICS ALONG AN ENZYMATIC REACTION PATHWAY: THYMIDYLATE SYNTHASE, "THE MOVIE".BIOCHEMISTRY. VOL. 42. ISSUE 2. P. 239 -247 44 94% 75
4 KOEHN, EM , PERISSINOTTI, LL , MOGHRAM, S , PRABHAKAR, A , LESLEY, SA , MATHEWS, II , KOHEN, A , (2012) FOLATE BINDING SITE OF FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 109. ISSUE 39. P. 15722-15727 27 84% 8
5 LANDAU, MJ , SHARMA, H , ANDERSON, KS , (2013) SELECTIVE PEPTIDE INHIBITORS OF BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE FROM TOXOPLASMA GONDII PROVIDE INSIGHTS INTO DOMAIN-DOMAIN COMMUNICATION AND ALLOSTERIC REGULATION.PROTEIN SCIENCE. VOL. 22. ISSUE 9. P. 1161-1173 29 76% 2
6 KOEHN, EM , KOHEN, A , (2010) FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE: A NOVEL PATHWAY TOWARDS THYMINE.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 493. ISSUE 1. P. 96-102 28 82% 11
7 SALO-AHEN, OMH , TOCHOWICZ, A , POZZI, C , CARDINALE, D , FERRARI, S , BOUM, Y , MANGANI, S , STROUD, RM , SAXENA, P , MYLLYKALLIO, H , ET AL (2015) HOTSPOTS IN AN OBLIGATE HOMODIMERIC ANTICANCER TARGET. STRUCTURAL AND FUNCTIONAL EFFECTS OF INTERFACIAL MUTATIONS IN HUMAN THYMIDYLATE SYNTHASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 8. P. 3572 -3581 31 62% 3
8 BASTA, T , BOUM, Y , BRIFFOTAUX, J , BECKER, HF , LAMARRE-JOUENNE, I , LAMBRY, JC , SKOULOUBRIS, S , LIEBL, U , GRAILLE, M , VAN TILBEURGH, H , ET AL (2012) MECHANISTIC AND STRUCTURAL BASIS FOR INHIBITION OF THYMIDYLATE SYNTHASE THYX.OPEN BIOLOGY. VOL. 2. ISSUE . P. - 25 78% 7
9 LUCIANI, R , SAXENA, P , SURADE, S , SANTUCCI, M , VENTURELLI, A , BORSARI, C , MARVERTI, G , PONTERINI, G , FERRARI, S , BLUNDELL, TL , ET AL (2016) VIRTUAL SCREENING AND X-RAY CRYSTALLOGRAPHY IDENTIFY NON-SUBSTRATE ANALOG INHIBITORS OF FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 19. P. 9269 -9275 22 76% 1
10 FELDER, T , DUNLAP, RB , DIX, D , SPENCER, T , (2002) DIFFERENCES IN NATURAL LIGAND AND FLUOROPYRIMIDINE BINDING TO HUMAN THYMIDYLATE SYNTHASE IDENTIFIED BY TRANSIENT-STATE SPECTROSCOPIC AND CONTINUOUS VARIATION METHODS.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. VOL. 1597. ISSUE 1. P. 149-156 27 93% 6

Classes with closest relation at Level 1


Rank Class id link
1 8721 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE
2 22052 DCMP HYDROXYMETHYLASE//ACTIVE OXYGEN QUENCHING//ADENINE PHOSPHORIBOSYLTRANFERASE
3 2341 REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//ANTIFOLATE
4 8575 DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD
5 24549 ONE CARBON UNIT TRANSFER//TETRAHYDROFOLATE COENZYME//PPSE
6 17105 HYDROGEN TUNNELLING//PROMOTING VIBRATION//HYDROGEN TUNNELING
7 7353 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN
8 11728 BV ARAU//FURANOPYRIMIDINES//BCNA
9 17768 THYMIDINE KINASE 1//DNA SYNTHESIZING ENZYMES//SERUM THYMIDINE KINASE 1
10 13841 SERINE HYDROXYMETHYLTRANSFERASE//THREONINE ALDOLASE//SHMT

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