Class information for:
Level 1: THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8721 1225 39.9 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
109 3       RECTAL CANCER//COLORECTAL CANCER//COLONOSCOPY 71522
1176 2             THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL 9333
8721 1                   THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE 1225

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THYMIDYLATE SYNTHASE authKW 3772230 31% 40% 378
2 DIHYDROPYRIMIDINE DEHYDROGENASE authKW 827617 9% 30% 111
3 OROTATE PHOSPHORIBOSYLTRANSFERASE authKW 745778 4% 62% 48
4 5 FLUOROURACIL authKW 296681 19% 5% 228
5 TS authKW 204140 3% 26% 32
6 THYMIDYLATE SYNTHASE TS authKW 195401 1% 56% 14
7 DIHYDROPYRIMIDINE DEHYDROGENASE DPD authKW 175503 1% 54% 13
8 TS POLYMORPHISM authKW 174476 1% 100% 7
9 OPRT authKW 168241 1% 75% 9
10 TYMS authKW 153242 1% 36% 17

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 20624 66% 0% 811
2 Pharmacology & Pharmacy 565 15% 0% 181
3 Gastroenterology & Hepatology 296 5% 0% 67
4 Genetics & Heredity 110 5% 0% 66
5 Pathology 107 3% 0% 41
6 Medicine, Research & Experimental 39 3% 0% 41
7 Surgery 36 5% 0% 65
8 Respiratory System 24 2% 0% 22
9 Biotechnology & Applied Microbiology 23 3% 0% 42
10 Cell Biology 17 4% 0% 51

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OPTIMAL MED 74776 0% 100% 3
2 CANC 2 58149 1% 33% 7
3 UNITA CHEMIOTER IA 56080 0% 75% 3
4 CLIN ONCOL MED ONCOL 49850 0% 100% 2
5 TOKUSHIMA 39255 2% 7% 22
6 PL ONCOL 36648 0% 29% 5
7 LUNG CHEST CANC 33232 0% 67% 2
8 VA CT CANC 33232 0% 67% 2
9 DRUG ISTANCE GRP 31149 0% 25% 5
10 ANAT HIST PATHOL 24925 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENOMICS 12622 2% 2% 30
2 PHARMACOGENOMICS JOURNAL 10200 1% 2% 18
3 ONCOLOGY REPORTS 7825 5% 1% 56
4 ANTICANCER RESEARCH 5787 5% 0% 67
5 CLINICAL CANCER RESEARCH 5585 5% 0% 58
6 INTERNATIONAL JOURNAL OF ONCOLOGY 3532 3% 0% 37
7 CLINICAL COLORECTAL CANCER 3371 1% 2% 8
8 PHARMACOGENETICS AND GENOMICS 3144 1% 1% 12
9 CANCER CHEMOTHERAPY AND PHARMACOLOGY 2621 2% 0% 28
10 EUROPEAN JOURNAL OF CANCER 2206 2% 0% 30

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THYMIDYLATE SYNTHASE 3772230 31% 40% 378 Search THYMIDYLATE+SYNTHASE Search THYMIDYLATE+SYNTHASE
2 DIHYDROPYRIMIDINE DEHYDROGENASE 827617 9% 30% 111 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
3 OROTATE PHOSPHORIBOSYLTRANSFERASE 745778 4% 62% 48 Search OROTATE+PHOSPHORIBOSYLTRANSFERASE Search OROTATE+PHOSPHORIBOSYLTRANSFERASE
4 5 FLUOROURACIL 296681 19% 5% 228 Search 5+FLUOROURACIL Search 5+FLUOROURACIL
5 TS 204140 3% 26% 32 Search TS Search TS
6 THYMIDYLATE SYNTHASE TS 195401 1% 56% 14 Search THYMIDYLATE+SYNTHASE+TS Search THYMIDYLATE+SYNTHASE+TS
7 DIHYDROPYRIMIDINE DEHYDROGENASE DPD 175503 1% 54% 13 Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DPD Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DPD
8 TS POLYMORPHISM 174476 1% 100% 7 Search TS+POLYMORPHISM Search TS+POLYMORPHISM
9 OPRT 168241 1% 75% 9 Search OPRT Search OPRT
10 TYMS 153242 1% 36% 17 Search TYMS Search TYMS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KRISTENSEN, MH , WEIDINGER, M , BZOREK, M , PEDERSEN, PL , MEJER, J , (2010) CORRELATION BETWEEN THYMIDYLATE SYNTHASE GENE VARIANTS, RNA AND PROTEIN LEVELS IN PRIMARY COLORECTAL ADENOCARCINOMAS.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. VOL. 38. ISSUE 2. P. 484-497 55 85% 8
2 SHOWALTER, SL , SHOWALTER, TN , WITKIEWICZ, A , HAVENS, R , KENNEDY, EP , HUCL, T , KERN, SE , YEO, CJ , BRODY, JR , (2008) EVALUATING THE DRUG-TARGET RELATIONSHIP BETWEEN THYMIDYLATE SYNTHASE EXPRESSION AND TUMOR RESPONSE TO 5-FLUOROURACIL.CANCER BIOLOGY & THERAPY. VOL. 7. ISSUE 7. P. 986-994 58 71% 25
3 MARING, JG , GROEN, HJM , WACHTERS, FM , UGES, DRA , DE VRIES, EGE , (2005) GENETIC FACTORS INFLUENCING PYRIMIDINE-ANTAGONIST CHEMOTHERAPY.PHARMACOGENOMICS JOURNAL. VOL. 5. ISSUE 4. P. 226-243 85 49% 71
4 PANCZYK, M , (2014) PHARMACOGENETICS RESEARCH ON CHEMOTHERAPY RESISTANCE IN COLORECTAL CANCER OVER THE LAST 20 YEARS.WORLD JOURNAL OF GASTROENTEROLOGY. VOL. 20. ISSUE 29. P. 9775 -9827 120 27% 14
5 CHEN, Y , YI, CH , LIU, L , LI, B , WANG, YW , WANG, XW , (2012) THYMIDYLATE SYNTHASE EXPRESSION AND PROGNOSIS IN COLORECTAL CANCER: A META-ANALYSIS OF COLORECTAL CANCER SURVIVAL DATA.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS. VOL. 27. ISSUE 3. P. 203-211 41 87% 3
6 JENNINGS, BA , KWOK, CS , WILLIS, G , MATTHEWS, V , WAWRUCH, P , LOKE, YK , (2012) FUNCTIONAL POLYMORPHISMS OF FOLATE METABOLISM AND RESPONSE TO CHEMOTHERAPY FOR COLORECTAL CANCER, A SYSTEMATIC REVIEW AND META-ANALYSIS.PHARMACOGENETICS AND GENOMICS. VOL. 22. ISSUE 4. P. 290-304 43 78% 16
7 SCARTOZZI, M , MACCARONI, E , GIAMPIERI, R , PISTELLI, M , BITTONI, A , DEL PRETE, M , BERARDI, R , CASCINU, S , (2011) 5-FLUOROURACIL PHARMACOGENOMICS: STILL ROCKING AFTER ALL THESE YEARS?.PHARMACOGENOMICS. VOL. 12. ISSUE 2. P. 251-265 47 71% 24
8 FARINA-SARASQUETA, A , GOSENS, MJEM , MOERLAND, E , VAN LIJNSCHOTEN, I , LEMMENS, VEPP , SLOOTER, GD , RUTTEN, HJT , VAN DEN BRULE, AJC , (2011) TS GENE POLYMORPHISMS ARE NOT GOOD MARKERS OF RESPONSE TO 5-FU THERAPY IN STAGE III COLON CANCER PATIENTS.CELLULAR ONCOLOGY. VOL. 34. ISSUE 4. P. 327-335 42 84% 3
9 JENSEN, SA , VAINER, B , SORENSEN, JB , (2007) THE PROGNOSTIC SIGNIFICANCE OF THYMIDYLATE SYNTHASE AND DIHYDROPYRIMIDINE DEHYDROGENASE IN COLORECTAL CANCER OF 303 PATIENTS ADJUVANTLY TREATED WITH 5-FLUOROURACIL.INTERNATIONAL JOURNAL OF CANCER. VOL. 120. ISSUE 3. P. 694-701 40 91% 29
10 FARINA-SARASQUETA, A , GOSENS, MJEM , MOERLAND, E , VAN LIJNSCHOTEN, I , LEMMENS, VEPP , SLOOTER, GD , RUTTEN, HJT , VAN DEN BRULE, AJC , (2010) TS GENE POLYMORPHISMS ARE NOT GOOD MARKERS OF RESPONSE TO 5-FU THERAPY IN STAGE III COLON CANCER PATIENTS.ANALYTICAL CELLULAR PATHOLOGY. VOL. 33. ISSUE 1. P. 1-11 42 84% 1

Classes with closest relation at Level 1


Rank Class id link
1 9432 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//5 FLUOROURACIL
2 13007 ERCC1//RRM1//MED OVARIAN CANC SECT
3 15011 THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE
4 11797 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//TAS 102
5 7353 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN
6 22701 PEMETREXED//MULTITARGETED ANTIFOLATE//AFFILIATED JIANGSU CANC HOSP
7 3501 MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE
8 27700 JOINT SERV BIOMARKER EVALUAT ONCOL//KI67 SCORE//LOCDIR
9 747 METASTATIC COLORECTAL CANCER//OXALIPLATIN//ADVANCED COLORECTAL CANCER
10 14067 GILBERTS SYNDROME//UGT1A1//UGT1A1 GENE

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