Class information for:
Level 1: BACE1//BETA SECRETASE//BACE1 INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9059 1191 47.9 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
49 3       ALZHEIMERS DISEASE//AMYOTROPHIC LATERAL SCLEROSIS//DEMENTIA 92146
35 2             ALZHEIMERS DISEASE//AMYLOID PRECURSOR PROTEIN//TAU 32531
9059 1                   BACE1//BETA SECRETASE//BACE1 INHIBITOR 1191

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BACE1 authKW 3665964 23% 53% 269
2 BETA SECRETASE authKW 2971415 18% 53% 218
3 BACE1 INHIBITOR authKW 1274864 5% 84% 59
4 BACE authKW 1194930 7% 55% 85
5 PROT STUDIES PROGRAM address 493557 3% 51% 38
6 MEMAPSIN 2 authKW 435826 1% 100% 17
7 BACE2 authKW 413596 2% 73% 22
8 BETA SECRETASE INHIBITOR authKW 231352 2% 48% 19
9 BACE INHIBITOR authKW 207656 1% 90% 9
10 SECRETASE authKW 200099 4% 17% 46

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 8837 26% 0% 307
2 Neurosciences 2732 29% 0% 347
3 Biochemistry & Molecular Biology 1723 34% 0% 402
4 Chemistry, Organic 889 14% 0% 163
5 Geriatrics & Gerontology 179 2% 0% 28
6 Cell Biology 175 8% 0% 98
7 Pharmacology & Pharmacy 146 9% 0% 108
8 Biophysics 101 4% 0% 53
9 Clinical Neurology 77 5% 0% 61
10 Biochemical Research Methods 37 3% 0% 34

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROT STUDIES PROGRAM 493557 3% 51% 38
2 PEPTIDE SCI 74570 1% 36% 8
3 PROTEOM SCI 68362 0% 67% 4
4 GLYCO CHAIN FUNCT 64087 0% 50% 5
5 GRP QUIM BIOORGAN 57681 0% 75% 3
6 NEUROSCI WORLDWIDE MED CHEM 57681 0% 75% 3
7 MUNICH BIOCHEM 51274 0% 100% 2
8 OKLAHOMA MED FDN 47432 2% 10% 18
9 HALDEMAN MOL DIAGNOST THER EUT 46144 0% 60% 3
10 NEUROL GASTROINTESTINAL EXCELLENCE DRUG DIS 38247 1% 15% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14349 10% 0% 119
2 MOLECULAR NEURODEGENERATION 13245 1% 3% 17
3 JOURNAL OF MEDICINAL CHEMISTRY 4819 5% 0% 64
4 CURRENT ALZHEIMER RESEARCH 3883 1% 1% 12
5 JOURNAL OF ALZHEIMERS DISEASE 2709 2% 0% 22
6 NEURODEGENERATIVE DISEASES 1812 1% 1% 7
7 JOURNAL OF NEUROCHEMISTRY 1542 3% 0% 36
8 JOURNAL OF MOLECULAR NEUROSCIENCE 1123 1% 0% 11
9 BIOORGANIC & MEDICINAL CHEMISTRY 1007 2% 0% 23
10 JOURNAL OF BIOLOGICAL CHEMISTRY 895 6% 0% 77

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BACE1 3665964 23% 53% 269 Search BACE1 Search BACE1
2 BETA SECRETASE 2971415 18% 53% 218 Search BETA+SECRETASE Search BETA+SECRETASE
3 BACE1 INHIBITOR 1274864 5% 84% 59 Search BACE1+INHIBITOR Search BACE1+INHIBITOR
4 BACE 1194930 7% 55% 85 Search BACE Search BACE
5 MEMAPSIN 2 435826 1% 100% 17 Search MEMAPSIN+2 Search MEMAPSIN+2
6 BACE2 413596 2% 73% 22 Search BACE2 Search BACE2
7 BETA SECRETASE INHIBITOR 231352 2% 48% 19 Search BETA+SECRETASE+INHIBITOR Search BETA+SECRETASE+INHIBITOR
8 BACE INHIBITOR 207656 1% 90% 9 Search BACE+INHIBITOR Search BACE+INHIBITOR
9 SECRETASE 200099 4% 17% 46 Search SECRETASE Search SECRETASE
10 HYDROXYETHYLAMINE 186058 1% 48% 15 Search HYDROXYETHYLAMINE Search HYDROXYETHYLAMINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GHOSH, AK , OSSWALD, HL , (2014) BACE1 (BETA-SECRETASE) INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE.CHEMICAL SOCIETY REVIEWS. VOL. 43. ISSUE 19. P. 6765 -6813 157 77% 53
2 BUTINI, S , BROGI, S , NOVELLINO, E , CAMPIANI, G , GHOSH, AK , BRINDISI, M , GEMMA, S , (2013) THE STRUCTURAL EVOLUTION OF BETA-SECRETASE INHIBITORS: A FOCUS ON THE DEVELOPMENT OF SMALL-MOLECULE INHIBITORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 15. P. 1787-1807 113 93% 14
3 STOCKLEY, JH , O'NEILL, C , (2008) UNDERSTANDING BACE1: ESSENTIAL PROTEASE FOR AMYLOID-BETA PRODUCTION IN ALZHEIMER'S DISEASE.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 65. ISSUE 20. P. 3265 -3289 153 66% 55
4 KANDALEPAS, PC , VASSAR, R , (2014) THE NORMAL AND PATHOLOGIC ROLES OF THE ALZHEIMER'S BETA-SECRETASE, BACE1.CURRENT ALZHEIMER RESEARCH. VOL. 11. ISSUE 5. P. 441 -449 110 82% 9
5 HAMADA, Y , KISO, Y , (2013) ADVANCES IN THE IDENTIFICATION OF BETA-SECRETASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 8. ISSUE 6. P. 709-731 93 89% 9
6 YUAN, J , VENKATRAMAN, S , ZHENG, YJ , MCKEEVER, BM , DILLARD, LW , SINGH, SB , (2013) STRUCTURE-BASED DESIGN OF BETA-SITE APP CLEAVING ENZYME 1 (BACE1) INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 11. P. 4156-4180 94 73% 43
7 GHOSH, AK , BRINDISI, M , TANG, J , (2012) DEVELOPING SS-SECRETASE INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE.JOURNAL OF NEUROCHEMISTRY. VOL. 120. ISSUE . P. 71-83 65 90% 108
8 XU, YC , LI, MJ , GREENBLATT, H , CHEN, WY , PAZ, A , DYM, O , PELEG, Y , CHEN, TT , SHEN, X , HE, JH , ET AL (2012) FLEXIBILITY OF THE FLAP IN THE ACTIVE SITE OF BACE1 AS REVEALED BY CRYSTAL STRUCTURES AND MOLECULAR DYNAMICS SIMULATIONS.ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. VOL. 68. ISSUE . P. 13 -25 85 81% 23
9 YAN, RQ , VASSAR, R , (2014) TARGETING THE BETA SECRETASE BACE1 FOR ALZHEIMER'S DISEASE THERAPY.LANCET NEUROLOGY. VOL. 13. ISSUE 3. P. 319 -329 50 79% 112
10 VASSAR, R , KUHN, PH , HAASS, C , KENNEDY, ME , RAJENDRAN, L , WONG, PC , LICHTENTHALER, SF , (2014) FUNCTION, THERAPEUTIC POTENTIAL AND CELL BIOLOGY OF BACE PROTEASES: CURRENT STATUS AND FUTURE PROSPECTS.JOURNAL OF NEUROCHEMISTRY. VOL. 130. ISSUE 1. P. 4-28 94 46% 71

Classes with closest relation at Level 1


Rank Class id link
1 1390 PRESENILIN//GAMMA SECRETASE//PRESENILIN 1
2 9210 FE65//AMYLOID PRECURSOR PROTEIN//APP
3 20963 GLUTAMINYL CYCLASE//INTRANEURONAL A BETA//PYROGLUTAMATE
4 1430 AMYLOID PRECURSOR PROTEIN//BETA AMYLOID PRECURSOR PROTEIN//ALZHEIMERS DISEASE
5 3379 ALZHEIMERS DISEASE//BAPINEUZUMAB//AMYLOID BETA
6 30760 ACIDIC OLIGOSACCHARIDE SUGAR CHAIN//HEPARIN DERIVED OLIGOSACCHARIDE//NEUROPATHOL S
7 31869 FAMILIAL BRITISH DEMENTIA//FAMILIAL DANISH DEMENTIA//BRI2
8 37080 7 8 DIHYDROXYFLAVONE//8 DIHYDROXYFLAVONE//TRKB AGONIST
9 22367 CELLULAR NEUROSCI NEURODEGENERAT REPAIR PROGRAM//AMYLOID BETA PEPTIDE 25 35//AMYLOID BETA PROTEIN OLIGOMERS
10 478 AMYLOID BETA PEPTIDE//AMYLOID BETA PROTEIN//ALZHEIMERS DISEASE

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