Class information for:
Level 1: GLUTAMINYL CYCLASE//INTRANEURONAL A BETA//PYROGLUTAMATE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
20963 439 50.8 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
49 3       ALZHEIMERS DISEASE//AMYOTROPHIC LATERAL SCLEROSIS//DEMENTIA 92146
35 2             ALZHEIMERS DISEASE//AMYLOID PRECURSOR PROTEIN//TAU 32531
20963 1                   GLUTAMINYL CYCLASE//INTRANEURONAL A BETA//PYROGLUTAMATE 439

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GLUTAMINYL CYCLASE authKW 1473815 6% 76% 28
2 INTRANEURONAL A BETA authKW 896759 4% 68% 19
3 PYROGLUTAMATE authKW 559722 6% 31% 26
4 PYROGLUTAMATE A BETA authKW 494616 2% 89% 8
5 N TRUNCATED A BETA authKW 486890 2% 100% 7
6 GLUTAMINE CYCLOTRANSFERASE authKW 417334 1% 100% 6
7 CELLULAR NEUROL address 319919 5% 20% 23
8 INTRACELLULAR ABETA authKW 278223 1% 100% 4
9 INTRANEURONAL authKW 278219 1% 67% 6
10 ALZHEIMER PHD address 227631 1% 55% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 3627 53% 0% 231
2 Geriatrics & Gerontology 757 7% 0% 32
3 Biochemistry & Molecular Biology 654 34% 0% 150
4 Pathology 518 10% 0% 45
5 Clinical Neurology 458 15% 0% 67
6 Cell Biology 69 8% 0% 37
7 Medicine, Research & Experimental 52 5% 0% 23
8 Biophysics 51 5% 0% 22
9 Biochemical Research Methods 39 4% 0% 18
10 Chemistry, Medicinal 29 3% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR NEUROL 319919 5% 20% 23
2 ALZHEIMER PHD 227631 1% 55% 6
3 ALZHEIMERS DIS NEUROBIOL 185479 1% 67% 4
4 MOL PSYCHIAT ALZHEIMER 139111 0% 100% 2
5 UNIV GOTTINGEN 102281 1% 29% 5
6 CHIM GEN 1 92740 0% 67% 2
7 PROTEOLYT NEUROSCI 81609 3% 8% 14
8 MOL PSYCHIAT 77604 8% 3% 35
9 ADV BIOTECHNOL SECT PHARMACOL 69556 0% 100% 1
10 AFFIRIS AG 69556 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ALZHEIMERS DISEASE 9596 6% 1% 25
2 NEUROBIOLOGY OF AGING 6945 5% 0% 24
3 NEURODEGENERATIVE DISEASES 6454 2% 1% 8
4 MOLECULAR NEURODEGENERATION 6094 2% 1% 7
5 ACTA NEUROPATHOLOGICA 5249 5% 0% 21
6 CURRENT ALZHEIMER RESEARCH 2638 1% 1% 6
7 FRONTIERS IN AGING NEUROSCIENCE 1600 1% 0% 5
8 BRAIN PATHOLOGY 1152 1% 0% 5
9 NEUROFORUM 807 0% 1% 1
10 ALZHEIMERS RESEARCH & THERAPY 789 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GLUTAMINYL CYCLASE 1473815 6% 76% 28 Search GLUTAMINYL+CYCLASE Search GLUTAMINYL+CYCLASE
2 INTRANEURONAL A BETA 896759 4% 68% 19 Search INTRANEURONAL+A+BETA Search INTRANEURONAL+A+BETA
3 PYROGLUTAMATE 559722 6% 31% 26 Search PYROGLUTAMATE Search PYROGLUTAMATE
4 PYROGLUTAMATE A BETA 494616 2% 89% 8 Search PYROGLUTAMATE+A+BETA Search PYROGLUTAMATE+A+BETA
5 N TRUNCATED A BETA 486890 2% 100% 7 Search N+TRUNCATED+A+BETA Search N+TRUNCATED+A+BETA
6 GLUTAMINE CYCLOTRANSFERASE 417334 1% 100% 6 Search GLUTAMINE+CYCLOTRANSFERASE Search GLUTAMINE+CYCLOTRANSFERASE
7 INTRACELLULAR ABETA 278223 1% 100% 4 Search INTRACELLULAR+ABETA Search INTRACELLULAR+ABETA
8 INTRANEURONAL 278219 1% 67% 6 Search INTRANEURONAL Search INTRANEURONAL
9 INTRANEURONAL A BETA 42 208667 1% 100% 3 Search INTRANEURONAL+A+BETA+42 Search INTRANEURONAL+A+BETA+42
10 5 OXO L PROLINE 156499 1% 75% 3 Search 5+OXO+L+PROLINE Search 5+OXO+L+PROLINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MORAWSKI, M , SCHILLING, S , KREUZBERGER, M , WANIEK, A , JAGER, C , KOCH, B , CYNIS, H , KEHLEN, A , ARENDT, T , HARTLAGE-RUBSAMEN, M , ET AL (2014) GLUTAMINYL CYCLASE IN HUMAN CORTEX: CORRELATION WITH (PGLU)-AMYLOID-BETA LOAD AND COGNITIVE DECLINE IN ALZHEIMER'S DISEASE.JOURNAL OF ALZHEIMERS DISEASE. VOL. 39. ISSUE 2. P. 385-400 35 70% 15
2 PEREZ-GARMENDIA, R , GEVORKIAN, G , (2013) PYROGLUTAMATE-MODIFIED AMYLOID BETA PEPTIDES: EMERGING TARGETS FOR ALZHEIMER'S DISEASE IMMUNOTHERAPY.CURRENT NEUROPHARMACOLOGY. VOL. 11. ISSUE 5. P. 491-498 49 53% 8
3 JAWHAR, S , WIRTHS, O , SCHILLING, S , GRAUBNER, S , DEMUTH, HU , BAYER, TA , (2011) OVEREXPRESSION OF GLUTAMINYL CYCLASE, THE ENZYME RESPONSIBLE FOR PYROGLUTAMATE A BETA FORMATION, INDUCES BEHAVIORAL DEFICITS, AND GLUTAMINYL CYCLASE KNOCK-OUT RESCUES THE BEHAVIORAL PHENOTYPE IN 5XFAD MICE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 286. ISSUE 6. P. 4454-4460 31 78% 21
4 HOFLING, C , INDRISCHEK, H , HOPCKE, T , WANIEK, A , CYNIS, H , KOCH, B , SCHILLING, S , MORAWSKI, M , DEMUTH, HU , ROSSNER, S , ET AL (2014) MOUSE STRAIN AND BRAIN REGION-SPECIFIC EXPRESSION OF THE GLUTAMINYL CYCLASES QC AND ISOQC.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. VOL. 36. ISSUE . P. 64 -73 36 65% 1
5 WIRTHS, O , BREYHAN, H , CYNIS, H , SCHILLING, S , DEMUTH, HU , BAYER, TA , (2009) INTRANEURONAL PYROGLUTAMATE-ABETA 3-42 TRIGGERS NEURODEGENERATION AND LETHAL NEUROLOGICAL DEFICITS IN A TRANSGENIC MOUSE MODEL.ACTA NEUROPATHOLOGICA. VOL. 118. ISSUE 4. P. 487 -496 40 58% 51
6 WIRTHS, O , BETHGE, T , MARCELLO, A , HARMEIER, A , JAWHAR, S , LUCASSEN, PJ , MULTHAUP, G , BRODY, DL , ESPARZA, T , INGELSSON, M , ET AL (2010) PYROGLUTAMATE ABETA PATHOLOGY IN APP/PS1KI MICE, SPORADIC AND FAMILIAL ALZHEIMER'S DISEASE CASES.JOURNAL OF NEURAL TRANSMISSION. VOL. 117. ISSUE 1. P. 85 -96 38 59% 36
7 KOCH, B , BUCHHOLZ, M , WERMANN, M , HEISER, U , SCHILLING, S , DEMUTH, HU , (2012) PROBING SECONDARY GLUTAMINYL CYCLASE (QC) INHIBITOR INTERACTIONS APPLYING AN IN SILICO-MODELING/SITE-DIRECTED MUTAGENESIS APPROACH: IMPLICATIONS FOR DRUG DEVELOPMENT.CHEMICAL BIOLOGY & DRUG DESIGN. VOL. 80. ISSUE 6. P. 937 -946 26 90% 2
8 HARTLAGE-RUBSAMEN, M , WANIEK, A , MEISSNER, J , MORAWSKI, M , SCHILLING, S , JAGER, C , KLEINSCHMIDT, M , CYNIS, H , KEHLEN, A , ARENDT, T , ET AL (2015) ISOGLUTAMINYL CYCLASE CONTRIBUTES TO CCL2-DRIVEN NEUROINFLAMMATION IN ALZHEIMER'S DISEASE.ACTA NEUROPATHOLOGICA. VOL. 129. ISSUE 4. P. 565 -583 35 58% 1
9 WITTNAM, JL , PORTELIUS, E , ZETTERBERG, H , GUSTAVSSON, MK , SCHILLING, S , KOCH, B , DEMUTH, HU , BLENNOW, K , WIRTHS, O , BAYER, TA , (2012) PYROGLUTAMATE AMYLOID BETA (A BETA) AGGRAVATES BEHAVIORAL DEFICITS IN TRANSGENIC AMYLOID MOUSE MODEL FOR ALZHEIMER DISEASE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 287. ISSUE 11. P. 8154 -8162 33 59% 24
10 RUIZ-CARRILLO, D , KOCH, B , PARTHIER, C , WERMANN, M , DAMBE, T , BUCHHOLZ, M , LUDWIG, HH , HEISER, U , RAHFELD, JU , STUBBS, MT , ET AL (2011) STRUCTURES OF GLYCOSYLATED MAMMALIAN GLUTAMINYL CYCLASES REVEAL CONFORMATIONAL VARIABILITY NEAR THE ACTIVE CENTER.BIOCHEMISTRY. VOL. 50. ISSUE 28. P. 6280-6288 23 92% 9

Classes with closest relation at Level 1


Rank Class id link
1 31869 FAMILIAL BRITISH DEMENTIA//FAMILIAL DANISH DEMENTIA//BRI2
2 3379 ALZHEIMERS DISEASE//BAPINEUZUMAB//AMYLOID BETA
3 478 AMYLOID BETA PEPTIDE//AMYLOID BETA PROTEIN//ALZHEIMERS DISEASE
4 22367 CELLULAR NEUROSCI NEURODEGENERAT REPAIR PROGRAM//AMYLOID BETA PEPTIDE 25 35//AMYLOID BETA PROTEIN OLIGOMERS
5 1430 AMYLOID PRECURSOR PROTEIN//BETA AMYLOID PRECURSOR PROTEIN//ALZHEIMERS DISEASE
6 9059 BACE1//BETA SECRETASE//BACE1 INHIBITOR
7 10591 STUDY NEURODEGENERAT DIS//BURKE MED//MITOCHONDRIA
8 17975 COGNITIVE DYSFUNCTION SYNDROME//BRAIN AGING DEMENTIA//AGED DOG
9 1390 PRESENILIN//GAMMA SECRETASE//PRESENILIN 1
10 9210 FE65//AMYLOID PRECURSOR PROTEIN//APP

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