Class information for:
Level 1: PRESENILIN//GAMMA SECRETASE//PRESENILIN 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1390 2684 48.7 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
49 3       ALZHEIMERS DISEASE//AMYOTROPHIC LATERAL SCLEROSIS//DEMENTIA 92146
35 2             ALZHEIMERS DISEASE//AMYLOID PRECURSOR PROTEIN//TAU 32531
1390 1                   PRESENILIN//GAMMA SECRETASE//PRESENILIN 1 2684

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 PRESENILIN authKW 3175439 18% 57% 492
2 GAMMA SECRETASE authKW 2191604 13% 55% 352
3 PRESENILIN 1 authKW 1702019 9% 60% 251
4 NICASTRIN authKW 780103 3% 87% 79
5 PRESENILIN 2 authKW 536672 3% 69% 68
6 GAMMA SECRETASE MODULATOR authKW 504213 2% 85% 52
7 GAMMA SECRETASE INHIBITOR authKW 297050 3% 36% 73
8 FAMILIAL ALZHEIMERS DISEASE authKW 293759 3% 38% 68
9 ALZHEIMERS DISEASE authKW 275392 38% 2% 1018
10 NEUROPATHOL NEUROSCI address 272518 3% 32% 76

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Neurosciences 10620 37% 0% 1002
2 Biochemistry & Molecular Biology 5695 40% 0% 1066
3 Clinical Neurology 2007 13% 0% 354
4 Cell Biology 1516 14% 0% 372
5 Geriatrics & Gerontology 1215 4% 0% 104
6 Chemistry, Medicinal 1203 7% 0% 187
7 Biophysics 246 5% 0% 123
8 Genetics & Heredity 193 5% 0% 134
9 Developmental Biology 132 2% 0% 48
10 Chemistry, Organic 94 4% 0% 119

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROPATHOL NEUROSCI 272518 3% 32% 76
2 NEUROL DIS 142706 5% 9% 143
3 ADOLF BUTENANDT 135904 3% 14% 83
4 ALZHEIMERS PARKINSONS DIS 122648 1% 28% 39
5 NEURONAL CELL BIOL GENE TRANSFER 88240 1% 52% 15
6 MOL BIOL GENET NEURODEGENERAT 66177 0% 73% 8
7 MOL NEURODEGENERAT GRP 61927 0% 78% 7
8 NEURODEGENERAT DIS 56733 5% 4% 129
9 DEMYELINATING DIS AGING 48281 1% 22% 19
10 GRP CHEM BIOL NEURODEGENERAT DIS 47394 0% 83% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ALZHEIMERS DISEASE 11198 2% 1% 67
2 NEURODEGENERATIVE DISEASES 11127 1% 4% 26
3 JOURNAL OF NEUROCHEMISTRY 6827 4% 1% 113
4 JOURNAL OF BIOLOGICAL CHEMISTRY 6002 11% 0% 290
5 NEUROBIOLOGY OF AGING 5266 2% 1% 52
6 MOLECULAR NEURODEGENERATION 5188 1% 3% 16
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 4284 4% 0% 99
8 ALZHEIMERS REPORTS 4115 0% 5% 7
9 NEUROBIOLOGY OF DISEASE 3537 1% 1% 34
10 ALZHEIMERS RESEARCH & THERAPY 2607 0% 3% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 PRESENILIN 3175439 18% 57% 492 Search PRESENILIN Search PRESENILIN
2 GAMMA SECRETASE 2191604 13% 55% 352 Search GAMMA+SECRETASE Search GAMMA+SECRETASE
3 PRESENILIN 1 1702019 9% 60% 251 Search PRESENILIN+1 Search PRESENILIN+1
4 NICASTRIN 780103 3% 87% 79 Search NICASTRIN Search NICASTRIN
5 PRESENILIN 2 536672 3% 69% 68 Search PRESENILIN+2 Search PRESENILIN+2
6 GAMMA SECRETASE MODULATOR 504213 2% 85% 52 Search GAMMA+SECRETASE+MODULATOR Search GAMMA+SECRETASE+MODULATOR
7 GAMMA SECRETASE INHIBITOR 297050 3% 36% 73 Search GAMMA+SECRETASE+INHIBITOR Search GAMMA+SECRETASE+INHIBITOR
8 FAMILIAL ALZHEIMERS DISEASE 293759 3% 38% 68 Search FAMILIAL+ALZHEIMERS+DISEASE Search FAMILIAL+ALZHEIMERS+DISEASE
9 ALZHEIMERS DISEASE 275392 38% 2% 1018 Search ALZHEIMERS+DISEASE Search ALZHEIMERS+DISEASE
10 PEN 2 251996 1% 92% 24 Search PEN+2 Search PEN+2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BRUNKAN, AL , GOATE, AM , (2005) PRESENILIN FUNCTION AND GAMMA-SECRETASE ACTIVITY.JOURNAL OF NEUROCHEMISTRY. VOL. 93. ISSUE 4. P. 769-792 211 79% 91
2 CRUMP, CJ , JOHNSON, DS , LI, YM , (2013) DEVELOPMENT AND MECHANISM OF GAMMA-SECRETASE MODULATORS FOR ALZHEIMER'S DISEASE.BIOCHEMISTRY. VOL. 52. ISSUE 19. P. 3197-3216 138 84% 32
3 DE STROOPER, B , IWATSUBO, T , WOLFE, MS , (2012) PRESENILINS AND GAMMA-SECRETASE: STRUCTURE, FUNCTION, AND ROLE IN ALZHEIMER DISEASE.COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. VOL. 2. ISSUE 1. P. - 123 76% 107
4 DE STROOPER, B , GUTIERREZ, LC , (2015) LEARNING BY FAILING: IDEAS AND CONCEPTS TO TACKLE GAMMA-SECRETASES IN ALZHEIMER'S DISEASE AND BEYOND.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55. VOL. 55. ISSUE . P. 419 -437 107 80% 24
5 LARNER, AJ , DORAN, M , (2006) CLINICAL PHENOTYPIC HETEROGENEITY OF ALZHEIMER'S DISEASE ASSOCIATED WITH MUTATIONS OF THE PRESENILIN-1 GENE.JOURNAL OF NEUROLOGY. VOL. 253. ISSUE 2. P. 139-158 135 90% 113
6 JORISSEN, E , DE STROOPER, B , (2010) GAMMA-SECRETASE AND THE INTRAMEMBRANE PROTEOLYSIS OF NOTCH.NOTCH SIGNALING. VOL. 92. ISSUE . P. 201-230 155 78% 25
7 WOLFE, MS , (2013) TOWARD THE STRUCTURE OF PRESENILIN/GAMMA-SECRETASE AND PRESENILIN HOMOLOGS.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. VOL. 1828. ISSUE 12. P. 2886-2897 130 84% 17
8 ZHANG, X , LI, YF , XU, HX , ZHANG, YW , (2014) THE GAMMA-SECRETASE COMPLEX: FROM STRUCTURE TO FUNCTION.FRONTIERS IN CELLULAR NEUROSCIENCE. VOL. 8. ISSUE . P. - 140 74% 11
9 EVIN, G , SERNEE, MF , MASTERS, CL , (2006) INHIBITION OF GAMMA-SECRETASE AS A THERAPEUTIC INTERVENTION FOR ALZHEIMER'S DISEASE - PROSPECTS, LIMITATIONS AND STRATEGIES.CNS DRUGS. VOL. 20. ISSUE 5. P. 351-372 161 75% 70
10 STEINER, H , (2008) THE CATALYTIC CORE OF GAMMA-SECRETASE: PRESENILIN REVISITED.CURRENT ALZHEIMER RESEARCH. VOL. 5. ISSUE 2. P. 147-157 138 85% 21

Classes with closest relation at Level 1


Rank Class id link
1 9059 BACE1//BETA SECRETASE//BACE1 INHIBITOR
2 9210 FE65//AMYLOID PRECURSOR PROTEIN//APP
3 19190 CALHM1//CALCIUM HOMEOSTASIS MODULATOR 1//MOL NEUROPATHOGENESIS
4 35314 UBIQUILIN//UBIQUILIN 1//UBQLN1
5 1430 AMYLOID PRECURSOR PROTEIN//BETA AMYLOID PRECURSOR PROTEIN//ALZHEIMERS DISEASE
6 20963 GLUTAMINYL CYCLASE//INTRANEURONAL A BETA//PYROGLUTAMATE
7 31869 FAMILIAL BRITISH DEMENTIA//FAMILIAL DANISH DEMENTIA//BRI2
8 11336 SORL1//TOMM40//PICALM
9 3379 ALZHEIMERS DISEASE//BAPINEUZUMAB//AMYLOID BETA
10 22032 ALPHA 1 ANTICHYMOTRYPSIN//ALPHA1 ANTICHYMOTRYPSIN POLYMORPHISM//SERUM ALPHA1 ANTICHYMOTRYPSIN

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